Displaying drugs 1701 - 1725 of 2959 in total
Lisinopril
Lisinopril is an angiotensin converting enzyme inhibitor (ACEI) used to treat hypertension, heart failure, and myocardial infarction.[L8384,L8387,L8390] Lisinopril and captopril are the only ACEIs that are not prodrugs. It functions by inhibition of angiotensin converting enzyme as well as the renin angiotensin aldosterone system.[A184781,A184808,A184817] ACEIs are commonly used as a...
Approved
Investigational
Epoprostenol
A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension.
Approved
Sulfamethoxazole
Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that interferes with folic acid synthesis in susceptible bacteria. It is generally given in combination with trimethoprim, which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps in the biosynthesis of nucleic acids and...
Approved
Sirolimus
Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria Streptomyces hygroscopicus, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after its potent antitumor...
Approved
Investigational
Prednisolone acetate
Prednisolone acetate is a prednisolone molecule bound to an acetate functional group by an ester bond. Prednisolone acetate was granted FDA approval in 1955.
Approved
Vet approved
Sorafenib
Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular carcinoma, sorafenib is also...
Approved
Investigational
Bretylium
Bretylium blocks the release of noradrenaline from the peripheral sympathetic nervous system, and is used in emergency medicine, cardiology, and other specialties for the acute management of ventricular tachycardia and ventricular fibrillation. The primary mode of action for bretylium is thought to be inhibition of voltage-gated K(+) channels. Recent evidence...
Approved
Omacetaxine mepesuccinate
Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the plant, Cephalotaxus species. In October 2005, omacetaxine mepesuccinate...
Approved
Investigational
Gallium nitrate
Gallium nitrate is a nitrate salt of DB14524, a heavy metal that has been used as a diagnostic agent. Gallium nitrate is reported to possess antiresorptive and hypocalcemic effects on bone. GANITE, a product of gallium nitrate previously used to treat cancer-related hypercalcemia, was discontinued from marketing in the US...
Approved
Investigational
Dexlansoprazole
Dexlansoprazole is a new-generation proton pump inhibitor (PPI) used for the management of symptoms associated with gastroesophageal reflux disease (GERD) and erosive esophagitis. Dexlansoprazole is the R-enantiomer of DB00448, which is composed of a racemic mixture of the R- and S-enantiomers. Compared to the older generation of PPIs (which includes...
Approved
Investigational
Dipotassium phosphate
Dipotassium phosphate (K2HPO4) is a highly water-soluble salt often used as a fertilizer and food additive as a source of phosphorus and potassium as well as a buffering agent.
Approved
Matched Mixtures name: … Dextrose 50% Inj W Electrolytes PF Abbovac …
Brexpiprazole
Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. Although it is structurally similar to aripiprazole, brexpiprazole has different binding affinities for dopamine and serotonin receptors. Compared...
Approved
Investigational
Acetyl sulfisoxazole
Sulfisoxazole acetyl is an ester of sulfisoxazole, a broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with antibacterial activity. Sulfisoxazole acetyl competes with PABA for the bacterial enzyme, dihydropteroate synthase, preventing the incorporation of PABA into dihydrofolic acid, which is the precursor of folic acid. This process causes...
Approved
Vet approved
Irbesartan
Irbesartan is an angiotensin receptor blocker (ARB) indicated to treat hypertension or diabetic nephropathy.[L7456,L7459] It can also be used as part of a combination product with hydrochlorothiazide for patients not well controlled or not expected to be well controlled on monotherapy. Unlike angiotensin converting enzyme inhibitors, ARBs are not associated...
Approved
Investigational
Abametapir
Abametapir is a novel pediculicidal metalloproteinase inhibitor used to treat infestations of head lice. The life cycle of head lice (Pediculus capitis) is approximately 30 days, seven to twelve of which are spent as eggs laid on hair shafts near the scalp. Topical pediculicides generally lack adequate ovicidal activity, including...
Approved
Investigational
Polymyxin B
Polymyxin B was discovered in the 1940s . They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes . Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic[A176426,FDA Label]. All gram-positive bacteria, fungi, and the gram-negative cocci,...
Approved
Vet approved
Matched Mixtures name: … 50 Person ANSI …
8-Chloroadenosine
8-Chloroadenosine is under investigation in clinical trial NCT02509546 (8-chloroadenosine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia).
Investigational
Matched Synonyms: … Adenosine, 8-chloro- …
Matched Name: … 8-Chloroadenosine …
Matched Iupac: … (2R,3R,4S,5R)-2-(6-amino-8-chloro-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol …
Matched Description: … 8-Chloroadenosine is under investigation in clinical trial NCT02509546 (8-chloroadenosine in Treating …
Matched Name: … 8-Chloroadenosine …
Matched Iupac: … (2R,3R,4S,5R)-2-(6-amino-8-chloro-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol …
Matched Description: … 8-Chloroadenosine is under investigation in clinical trial NCT02509546 (8-chloroadenosine in Treating …
8-chlorotheophylline
8-Chlorotheophylline is a stimulant drug of the xanthine chemical class, with physiological effects similar to caffeine. Its main use is in combination with Diphenhydramine as the antiemetic drug Dimenhydrinate. The stimulant properties of 8-chlorotheophylline are thought to ward off the drowsiness caused by diphenhydramine's anti-histamine activity in the central nervous...
Experimental
Matched Synonyms: … 1,3-dimethyl-8-chloroxanthine ... 8-chloro-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione …
Matched Name: … 8-chlorotheophylline …
Matched Iupac: … 8-chloro-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione …
Matched Description: … 8-Chlorotheophylline is a stimulant drug of the xanthine chemical class, with physiological effects similar ... anti-histamine activity in the central nervous system. 8-chlorotheophylline produces a number of ... The stimulant properties of 8-chlorotheophylline are thought to ward off the drowsiness caused by diphenhydramine's …
Matched Name: … 8-chlorotheophylline …
Matched Iupac: … 8-chloro-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione …
Matched Description: … 8-Chlorotheophylline is a stimulant drug of the xanthine chemical class, with physiological effects similar ... anti-histamine activity in the central nervous system. 8-chlorotheophylline produces a number of ... The stimulant properties of 8-chlorotheophylline are thought to ward off the drowsiness caused by diphenhydramine's …
8-Aminotheophylline
Experimental
Matched Synonyms: … 8-Amino-1,3-dimethyl-3,7-dihydropurine-2,6-dione …
Matched Name: … 8-Aminotheophylline …
Matched Iupac: … 8-imino-1,3-dimethyl-2,3,6,7,8,9-hexahydro-1H-purine-2,6-dione …
Matched Name: … 8-Aminotheophylline …
Matched Iupac: … 8-imino-1,3-dimethyl-2,3,6,7,8,9-hexahydro-1H-purine-2,6-dione …
8-azaguanine
8-azaguanine is one of the early purine analogs showing antineoplastic activity. It functions as an antimetabolite and is easily incorporated into ribonucleic acids.
Experimental
Matched Synonyms: … 8 AG ... Azaguanine-8 …
Matched Name: … 8-azaguanine …
Matched Description: … 8-azaguanine is one of the early purine analogs showing antineoplastic activity. …
Matched Name: … 8-azaguanine …
Matched Description: … 8-azaguanine is one of the early purine analogs showing antineoplastic activity. …
8-epi-Cyanocobalamin
Experimental
Matched Synonyms: … 8-Epicobalamine ... Cyano-8-epicobalamin …
Matched Name: … 8-epi-Cyanocobalamin …
Matched Name: … 8-epi-Cyanocobalamin …
8-oxo-dGMP
Experimental
Matched Synonyms: … 8-OH-Dgmp ... 2'-deoxy-7,8-dihydro-8-oxo-5'-guanylic acid ... 8-hydroxydeoxyguanosine 5'-monophosphate …
Matched Name: … 8-oxo-dGMP …
Matched Name: … 8-oxo-dGMP …
8-hydroxy-2'-deoxyguanosine
Experimental
Matched Synonyms: … 8-OHdG ... 8-Oxo-dG ... 8-Oxoguanosine …
Matched Name: … 8-hydroxy-2'-deoxyguanosine …
Matched Iupac: … 2-amino-8-hydroxy-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-1H-purin-6-one …
Matched Name: … 8-hydroxy-2'-deoxyguanosine …
Matched Iupac: … 2-amino-8-hydroxy-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-1H-purin-6-one …
AAV2/8.TBG.hARSB
Investigational
Matched Synonyms: … Adeno-associated viral vector serotype 8 with liver-specific thyroxinebinding globulin (TBG) promoter …
Matched Name: … AAV2/8.TBG.hARSB …
Matched Name: … AAV2/8.TBG.hARSB …
Displaying drugs 1701 - 1725 of 2959 in total