Displaying drugs 151 - 175 of 836 in total
Eliglustat
Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher disease, the accumulation of glucosylceramide leads to...
Approved
Investigational
Matched Description: … accumulation of glucosylceramide leads to the formation of Gaucher cells that infiltrate the liver, spleen …
Titanium dioxide
Titanium dioxide, also known as titanium(IV) oxide or titania, is the naturally occurring oxide of titanium. It is used as a pigment under the names titanium white, Pigment White 6 (PW6), or CI 77891. It is typically extracted from ilmenite, rutile and anatase.
Approved
Bemotrizinol
Bemotrizinol, or bis-ethylhexyloxyphenol methoxyphenyl triazine, is an organic UV filter found in over-the-counter sunscreen products. It primarily absorbs UV-A rays. Compared to older broad-spectrum chemical agents, bemotrizinol is more more fat soluble (oil soluble in cosmetic oils) to aid in efficacy and broad-spectrum activity . It is claimed to be...
Approved
Matched Description: … Bemotrizinol, or bis-ethylhexyloxyphenol methoxyphenyl triazine, is an organic UV filter found in over-the-counter …
Galsulfase
Galsufase is a variant form of the polymorphic human enzyme N-acetylgalactosamine 4-sulfatase of recombinant DNA origin. Galsulfase is a glycoprotein with a molecular weight of approximately 56 kD. The recombinant protein is comprised of 495 amino acids and contains six asparagine-linked glycosylation sites, four of which carry a bis mannose-6-phosphate...
Approved
Investigational
Matched Description: … comprised of 495 amino acids and contains six asparagine-linked glycosylation sites, four of which carry a bis …
Dihydroergocornine
Dihydroergocornine is one of the dihydrogenated ergot compounds that present very large hypotensive effects. It is an artificial derivative of the crude extract of ergot and later purified, ergocornine. The formation of dihydroergocornine implies the hydrogenation of the double bonds in the lysergic acid. Dihydroergocornine presents a formula of 9,10...
Approved
Matched Iupac: … (2R,4R,7R)-N-[(1S,2S,4R,7S)-2-hydroxy-5,8-dioxo-4,7-bis(propan-2-yl)-3-oxa-6,9-diazatricyclo[7.3.0.0^ …
Matched Description: … [A32965] Dihydroergocornine presents a formula of 9,10 alpha-dihydro-12'-hydroxy-2',5'alpha-bis(1-methylethyl …
Matched Description: … [A32965] Dihydroergocornine presents a formula of 9,10 alpha-dihydro-12'-hydroxy-2',5'alpha-bis(1-methylethyl …
Ozanimod
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada...
Approved
Investigational
Magnesium Aluminum Silicate
Magnesium aluminum silicate is a naturally occurring mineral obtained from silicate ores of the montmorillonite group . It is refined to a powder for use in cosmetic and pharmaceutical applications as an absorbent, anticaking agent, opacifying agent, viscosity-increasing agent, suspending agent, tablet and capsule disintegrant, and
tablet binder. It also...
Approved
Pentetic acid
Pentetic acid, also known as diethylenetriaminepentaacetic acid (DTPA), is a synthetic polyamino carboxylic acid with eight coordinate bond forming sites that can sequester metal ions and form highly stable DTPA-metal ion complexes. DTPA, along with its calcium and zinc trisodium salts, are the only FDA approved agents for the treatment...
Approved
Matched Iupac: … 2-[bis({2-[bis(carboxymethyl)amino]ethyl})amino]acetic acid …
Gadopentetic acid
A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid (DTPA see pentetic acid), that is given to enhance the image in cranial and spinal MRIs. (From Martindale, The Extra Pharmacopoeia, 30th ed, p706)
Approved
Matched Iupac: … gadolinium(3+) 2-[bis({2-[bis(carboxymethyl)amino]ethyl})amino]acetate …
Sonidegib
Sonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) developed as an anticancer agent by Novartis. It was FDA approved in 2015 for the treatment of basal cell carcinoma.
Approved
Investigational
Guaiacol
Guaiacol is an agent thought to have disinfectant properties and used as an expectorant. Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin. Guaiacol is also present in wood smoke, as a product of pyrolysis of lignin. Guaiacol has been found in the...
Approved
Calcium lactate
Calcium lactate is a salt that consists of two lactate anions for each calcium cation (Ca2+). It is prepared commercially by the neutralization of lactic acid with calcium carbonate or calcium hydroxide. Approved by the FDA as a direct food substance affirmed as generally recognized as safe, calcium lactate is...
Approved
Investigational
Vet approved
Matched Iupac: … calcium bis(2-hydroxypropanoate) …
Calcium levulinate
The relatively new calcium levulinate is produced from a direct reaction between L- or levulinic acid levulose and calcium hydroxide . The resultant calcium levulinate formulation, when used as a calcium supplement, possesses a high calcium content that is observed to be 14.8% higher than the content typically found in...
Approved
Experimental
Matched Iupac: … calcium bis(4-oxopentanoate) …
Isoflurophate
An irreversible cholinesterase inhibitor with actions similar to those of echothiophate. It is a powerful miotic used mainly in the treatment of glaucoma. Its vapor is highly toxic and it is recommended that only solutions in arachis oil be used therapeutically. (From Martindale, The Extra Pharmacopoeia, 29th ed, p1330)
Approved
Investigational
Withdrawn
Matched Iupac: … bis(propan-2-yl) phosphorofluoridate …
Magnesium glycinate
Magnesium glycinate is a magnesium salt of glycine that is available as dietary supplements as a source of magnesium. It is used in the treatment of magnesium deficiency.
Approved
Matched Iupac: … magnesium(2+) ion bis(2-aminoacetate) …
Iopodic acid
Iopodic acid, also known by the name of ipodate, is classified as a cholecystographic agent formed by a weak organic acid that contains a tri-iodinated benzene ring with iodine at positions 2, 4 and 6. Due to its particular structure, it presents a high degree of lipid solubility and a...
Approved
Investigational
Withdrawn
Potassium aspartate
Approved
Experimental
Matched Iupac: … dipotassium dihydrogen bis((2S)-2-aminobutanedioate) hydrate …
Irinotecan
Irinotecan is a topoisomerase inhibitor used for chemotherapy. It is a water-soluble analogue of camptothecin, which is extracted from the Chinese tree Camptotheca acuminate. The bis-piperidine side chain in the structure of irinotecan bestows enhanced water solubility. As an anticancer drug, irinotecan was first commercially available in Japan in 1994...
Approved
Investigational
Matched Description: … [A263376] The bis-piperidine side chain in the structure of irinotecan bestows enhanced water solubility …
DL-dimyristoylphosphatidylglycerol
DL-dimyristoylphosphatidylglycerol is a phospholipid used in commercially available pharmaceutical preparations to solubilize drugs for injection.
Approved
Matched Iupac: … [2,3-bis(tetradecanoyloxy)propoxy](2,3-dihydroxypropoxy)phosphinic acid …
Ferrous glycine sulfate
Approved
Matched Iupac: … lambda2-iron(2+) sulfuric acid bis(2-aminoacetate) …
Prenylamine
Prenylamine was withdrawn from the Canadian, US, and UK markets in 1988 due to concerns regarding cardiac arrhythmias.
Approved
Withdrawn
Iobenguane sulfate I-123
Iobenguane sulfate I-123 is a radiopharmaceutical used in gamma-scintigraphy of adrenergically inervated tissues [FDA Label].
Approved
Investigational
Matched Iupac: … bis(N-{[3-(¹²³I)iodophenyl]methyl}guanidine); sulfuric acid …
Manganese gluconate
Manganese gluconate is a manganese salt of gluconic acid with the chemical formula C12H22MnO14 x 2H2O. It is typically obtained by reacting manganese carbonate with gluconic acid in aqueous medium and then crystallizing the product to form a slightly pink powder. Manganese gluconate is a direct ingredient in food substances...
Approved
Matched Iupac: … manganese(2+) bis((2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate) …
DL-dimyristoylphosphatidylcholine
A synthetic phospholipid used in liposomes and lipid bilayers for the study of biological membranes. It is used in commercial drug preparations to solubilize drugs for injection
Approved
Matched Iupac: … (2-{[2,3-bis(tetradecanoyloxy)propyl phosphono]oxy}ethyl)trimethylazanium …
Displaying drugs 151 - 175 of 836 in total