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Displaying drugs 151 - 175 of 9336 in total

Calcium lactate

Calcium lactate is a salt that consists of two lactate anions for each calcium cation (Ca2+). It is prepared commercially by the neutralization of lactic acid with calcium carbonate or calcium hydroxide. Approved by the FDA as a direct food substance affirmed as generally recognized as safe, calcium lactate is...
Approved
Investigational
Vet approved
Matched Description: … is used as a firming agent, flavoring agent, leavening agent, stabilizer, and thickener [L2741]. ... Approved by the FDA as a direct food substance affirmed as generally recognized as safe, calcium lactate …

Fluoroestradiol F-18

Fluoroestradiol F-18 is an imaging agent used with positron emission tomography (PET) to detect estrogen receptor-positive breast cancer lesions. The ability to image ER-positive tumors in vivo is advantageous in that, while helping to visualize tumor progression/regression, it may also be used to assess for heterogeneity in ER expression across...
Approved
Matched Description: … Fluoroestradiol F-18 is an imaging agent used with positron emission tomography (PET) to detect estrogen …
Matched Categories: … Radioactive Diagnostic Agent …

Tocainide

An antiarrhythmic agent which exerts a potential- and frequency-dependent block of sodium channels.
Approved
Matched Description: … An antiarrhythmic agent which exerts a potential- and frequency-dependent block of sodium channels. …

Medifoxamine

Medifoxamine was marketed as an atypical antidepressant, with anxiolyitc properties in France, Spain, and Morrocco in the 1990s but was later withdrawn from the market due to it causing cases of hepatotoxicity [L5461, A174976].
Approved
Matched Description: … Medifoxamine was marketed as an atypical antidepressant, with anxiolyitc properties in France, Spain, …
Matched Categories: … Antidepressive Agents …

Macitentan

Macitentan is a dual endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension (PAH). It was first approved by the FDA in 2013. Macitentan differs from its predecessor bosentan in part due to its lower risk of hepatotoxicity. A combination product (Opsynvi) comprising macitentan and tadalafil was approved...
Approved
Matched Description: … [L35890] It was first approved by the FDA in 2013. ... [L39105] It was subsequently approved by the FDA in March 2024.[L50622] ... A combination product (Opsynvi) comprising macitentan and [tadalafil] was approved in Canada in October …

Strontium chloride Sr-89

Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stages of the disease. It...
Approved
Investigational
Matched Description: … Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option …
Matched Categories: … Radioactive Therapeutic Agent …

Isosorbide

Isosorbide was previously available in an oral formulation for the reduction of intraocular pressure. It was approved by the FDA in 1980, but has since been discontinued. Currently, isosorbide is an organic nitrate currently available in the isosorbide mononitrate and isosorbide dinitrate forms, and is used for the prevention of...
Approved
Investigational
Matched Description: … It was approved by the FDA in 1980, but has since been discontinued. ... Isosorbide was previously available in an oral formulation for the reduction of intraocular pressure. ... Currently, isosorbide is an organic nitrate currently available in the [isosorbide mononitrate] and [ …

Stannous chloride

Stannous chloride is used as a source of tin in radiopharmaceutical kits. Tin reduces technetium-99m, the active radiological agent, allowing it to form a complex with phosphate-containing moeities . These complexes localize primarily in bone (40-50%) and infracted myocardium (0.01-0.02%/g of tissue) allowing for imaging of areas of altered osteogenesis...
Approved
Matched Description: … Tin reduces technetium-99m, the active radiological agent, allowing it to form a complex with phosphate-containing …

Montelukast

Montelukast was first approved for clinical use by the US FDA in 1998 as Merck's brand name Singulair. The medication is a member of the leukotriene receptor antagonist (LTRA) category of drugs.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] Although capable of demonstrating effectiveness, the use of such LTRAs like montelukast is typically in addition to or...
Approved
Matched Description: … Montelukast was first approved for clinical use by the US FDA in 1998 as Merck's brand name Singulair ... [L6301] The medication is a member of the leukotriene receptor antagonist (LTRA) category of drugs. …

Butenafine

Butenafine hydrochloride is a synthetic benzylamine antifungal agent. Butenafine's mechanism of action is believed to involve the synthesis inhibition of sterols. In particular, butenafine acts to inhibit the activity of the squalene epoxidase enzyme that is essential in the formation of sterols necessary for fungal cell membranes.
Approved
Matched Description: … Butenafine hydrochloride is a synthetic benzylamine antifungal agent. …

Decitabine

Myelodysplastic syndromes (MDS) are a heterogeneous group of hematopoietic neoplasms with variable underlying etiology and presentation, including neutropenia and thrombocytopenia. Further mutations leading to increased proliferation of cancerous cells can eventually lead to secondary acute myeloid leukemia, which has a poor prognosis.[A215082, A215092] Among treatment options, nucleoside analogues such as...
Approved
Investigational
Matched Description: … Myelodysplastic syndromes (MDS) are a heterogeneous group of hematopoietic neoplasms with variable underlying ... [L14962] It is also available as an oral combination product together with the cytidine deaminase inhibitor ... A2263, A2264, A2265, A215317, L14962] Decitabine was developed by MGI Pharma/SuperGen Inc. and was approved …

Midostaurin

Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hematopoietic tumors . It was...
Approved
Investigational
Matched Description: … AML as an adjunct therapy along with chemotherapeutic agents. ... It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward ... It was approved on April 28, 2017 and has shown to increase the overall survival rate in patients with …

DaxibotulinumtoxinA

DaxibotulinumtoxinA is an acetylcholine release inhibitor and neuromuscular blocking agent. It is a botulinum toxin without accessory proteins purified from the bacterium Clostridium botulinum type A, the gram-positive anaerobic bacterium primarily present in soil. C. botulinum is known to produce toxins that can cause botulism in humans.[A261075, L47860] DaxibotulinumtoxinA was...
Approved
Matched Description: … DaxibotulinumtoxinA is an acetylcholine release inhibitor and neuromuscular blocking agent. ... [L47865] On August 14, 2023, the drug was also approved for the treatment of cervical dystonia. ... [A261075, L47860] DaxibotulinumtoxinA was first approved by the FDA on September 8, 2022, for the …

Zuclopenthixol

Zuclopenthixol, also known as Zuclopentixol or Zuclopenthixolum, is an antipsychotic agent. Zuclopenthixol is a thioxanthene-based neuroleptic with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors. Major brands of zuclopenthixol are Cisordinol, Acuphase, and Clopixol. This drug is a liquid. This compound...
Approved
Investigational
Matched Description: … Zuclopenthixol, also known as Zuclopentixol or Zuclopenthixolum, is an antipsychotic agent. ... Zuclopenthixol was approved for use in Canada in 2011, but is not approved for use in the United States ... It is an antagonist at D1 and D2 dopamine receptors. …
Matched Categories: … Antidepressive Agents …

Carbon dioxide

Carbon dioxide is a colorless, odorless gas vital to life on Earth. This naturally occurring chemical compound is composed of a carbon atom covalently double bonded to two oxygen atoms. Medical Carbon Dioxide is a liquefied medicinal gas, supplied in cylinders filled to a high pressure. Medical Carbon Dioxide may...
Approved
Investigational
Vet approved
Matched Categories: … Radiographic Contrast Agent …

Topotecan

An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I.
Approved
Investigational
Matched Description: … An antineoplastic agent used to treat ovarian cancer. …

Valrubicin

Valrubicin (N-trifluoroacetyladriamycin-14-valerate) is a chemotherapy drug commonly marketed under the trade name VALSTAR. It is a semisynthetic analog of the doxorubicin, which is an anthracycline drug. Used in the treatment of the bladder cancer, valrubicin is administered by direct infusion into the bladder.
Approved
Matched Description: … It is a semisynthetic analog of the [doxorubicin], which is an anthracycline drug. …

Tiopronin

Tiopronin is a prescription thiol drug used primarily in the treatment of severe homozygous cystinuria. Patients with cystinuria excrete high levels of cystine in their urine and are at risk for kidney stone formation. Tiopronin is used as a second-line therapy to control the rate of cystine precipitation and excretion,...
Approved
Investigational
Matched Description: … It has been investigated for use in the treatment of arthritis and as a neuroprotective agent in aneurysmal ... Tiopronin is dosed on an individual basis using close monitoring of urinary cystine concentrations and ... As cystinuria is a relatively rare disease, tiopronin is classified as an orphan drug and is not patented …

Trabectedin

Trabectedin, also referred as ET-743 during its development, is a marine-derived antitumor agent discovered in the Carribean tunicate Ecteinascidia turbinata and now produced synthetically. Trabectedin has a unique mechanism of action. It binds to the minor groove of DNA interfering with cell division and genetic transcription processes and DNA repair...
Approved
Investigational
Matched Description: … Food and Drug Administration (FDA) have approved trabectedin as an orphan drug in soft tissue sarcomas ... Trabectedin, also referred as ET-743 during its development, is a marine-derived antitumor agent discovered ... On October 23, 2015, the FDA approved trabectedin, (as Yondelis), for the treatment of specific soft …

Manganese cation

Manganese is a transition metal that was first described in the 19th and 20th centuries. It is environmentally abundant, being the fifth most abundant metal and the twelfth most abundant element overall on Earth.[A263657, A263667] Manganese intake primarily occurs through the diet, as it is found at low levels in...
Approved
Nutraceutical
Matched Description: … physiological processes by acting as a cofactor for proteins [A263657, A263662, A263667] making it an …
Matched Categories: … Paramagnetic Contrast Agent …

Natalizumab

Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA reintroduced the drug to the...
Approved
Investigational
Matched Description: … [L48041] Natalizumab was approved by the European Commission on September 22, 2023.[L49096] ... [L48041] While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it ... [A261326] Natalizumab was further approved by the FDA for the treatment of Crohn's Disease in January …

Inulin

A starch found in the tubers and roots of many plants. Since it is hydrolyzable to fructose, it is classified as a fructosan. It has been used in physiologic investigation for determination of the rate of glomerular function.
Approved
Investigational
Nutraceutical

Diatrizoate

A commonly used x-ray contrast medium. As diatrizoate meglumine and as Diatrizoate sodium, it is used for gastrointestinal studies, angiography, and urography.
Approved
Vet approved
Matched Categories: … Radiographic Contrast Agent …

Mebeverine

Mebeverine has been investigated for the treatment of Irritable Bowel Syndrome and Post-cholecystectomy Gastrointestinal Spasms.
Approved
Investigational
Matched Categories: … Synthetic Anticholinergics, Esters With Tertiary Amino Group …

Ancrod

Ancrod, marketed as Viprinex, is a defibrinogenating agent derived from Malayan pit viper venom. The defribrinogenation of blood results in an anticoagulant effect. Currently, Viprinex®/ancrod is not approved or marketed in any country, but is being investigated as a stroke treatment in worldwide clinical trials. In January 2005, the U.S....
Approved
Investigational
Matched Description: … The defribrinogenation of blood results in an anticoagulant effect. ... Ancrod, marketed as Viprinex, is a defibrinogenating agent derived from Malayan pit viper venom. ... Currently, Viprinex®/ancrod is not approved or marketed in any country, but is being investigated as …
Displaying drugs 151 - 175 of 9336 in total