Displaying drugs 1876 - 1900 of 5888 in total
Belumosudil
Belumosudil is used in the treatment of chronic graft-versus-host disease (GVHD) and has been investigated for the treatment of pulmonary arterial hypertension. It is an inhibitor of rho-associated coiled-coil-containing protein kinases (ROCK), with significantly more selectivity for ROCK2 as compared to ROCK1 (IC50 100 nM vs. 3 μM, respectively). In...
Approved
Investigational
Matched Iupac: … 2-(3-{4-[(1H-indazol-5-yl)amino]quinazolin-2-yl}phenoxy)-N-(propan-2-yl)acetamide …
Matched Description: … ROCK), with significantly more selectivity for ROCK2 as compared to ROCK1 (IC50 100 nM vs. 3 …
Matched Description: … ROCK), with significantly more selectivity for ROCK2 as compared to ROCK1 (IC50 100 nM vs. 3 …
Brodalumab
Brodalumab has been used in trials studying the treatment of Asthma, Psoriasis, Crohn's Disease, Psoriatic Arthritis, and Rheumatoid Arthritis. Brodalumab was FDA approved in February, 2017 as Siliq for the treatment of moderate-to-severe plaque psoriasis.
Approved
Investigational
Atazanavir
Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses per day)...
Approved
Investigational
Matched Iupac: … methyl N-[(1S)-1-{N'-[(2S,3S)-2-hydroxy-3-[(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanamido]-4- …
Matched Description: … Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). …
Matched Description: … Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). …
Hydroxychloroquine
Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like chloroquine. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxychloroquine is also used for the prophylaxis of malaria in...
Approved
Brincidofovir
Brincidofovir is an oral antiviral drug used in the treatment of human smallpox infections. It is a lipid conjugate pro-drug of the acyclic nucleotide analogue cidofovir[L34404,A235725] - this lipid conjugate improves drug delivery to the target cells and significantly reduces the nephrotoxicity typically associated with cidofovir therapy.[A235725,A235735] Due to its...
Approved
Investigational
Matched Iupac: … ({[(2S)-1-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3-hydroxypropan-2-yl]oxy}methyl)[3-(hexadecyloxy) …
Matched Description: … (BKV), adenoviruses (AdV), and Epstein-Barr virus (EBV), amongst others. ... resulting in brincidofovir being investigated for the prevention and treatment of cytomegalovirus (CMV), BK Virus …
Matched Description: … (BKV), adenoviruses (AdV), and Epstein-Barr virus (EBV), amongst others. ... resulting in brincidofovir being investigated for the prevention and treatment of cytomegalovirus (CMV), BK Virus …
Diclofenac
Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first line therapy for acute and chronic pain and inflammation...
Approved
Vet approved
Matched Mixtures name: … DICLOVITH-B ... AFTOJEL % 0,1 + %3 JEL (5 G) ... DICLOVITH-B-FRT …
Matched Products: … ./3 ML. ... 3-A OFTENO ... 3- A OFTENO …
Matched Products: … ./3 ML. ... 3-A OFTENO ... 3- A OFTENO …
Benzhydrocodone
Benzhydrocodone is a benzylic prodrug of hydrocodone. It was developed in an effort to reduce parenteral bioavailability of the active metabolite as a deterrent to abuse. Benzhydrocodone is indicated for use in the short-term management of pain. It was first approved by the FDA in February 2018 in combination with...
Approved
Adenosine phosphate
Adenosine phosphate, or adenylic acid, is an adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position. Adenosine phosphate was withdrawn by the FDA since it was considered neither safe nor effective for its intended uses as a vasodilator and an anti-inflammatory.
Approved
Investigational
Nutraceutical
Withdrawn
Matched International brands: … My-B-Den …
Matched Description: … an adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3& …
Matched Description: … an adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3& …
Etoposide
A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division,...
Approved
Matched Synonyms: … O-Ethylidine-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3' …
Anti-inhibitor coagulant complex
Anti-inhibitor coagulant complex, also known as FEIBA (factor eight inhibitor bypassing activity), contains several proteins involved in the prothrombinase complex. It is used to control bleeding in hemophilia A and B patients with inhibitors.
Approved
Investigational
Matched Description: … It is used to control bleeding in hemophilia A and B patients with inhibitors. …
Favipiravir
Discovered by Toyama Chemical Co., Ltd. in Japan, favipiravir is a modified pyrazine analog that was initially approved for therapeutic use in resistant cases of influenza.[A191688,A191721] The antiviral targets RNA-dependent RNA polymerase (RdRp) enzymes, which are necessary for the transcription and replication of viral genomes.[A191688,A191772,A191775]
Not only does favipiravir inhibit...
Approved
Investigational
Matched Iupac: … 6-fluoro-3-hydroxypyrazine-2-carboxamide …
Matched Description: … , Lassa virus, and now COVID-19. ... [A191688,A191772,A191775] Not only does favipiravir inhibit replication of influenza A and B, but ... L12090] Favipiravir has been investigated for the treatment of life-threatening pathogens such as Ebola virus …
Matched Description: … , Lassa virus, and now COVID-19. ... [A191688,A191772,A191775] Not only does favipiravir inhibit replication of influenza A and B, but ... L12090] Favipiravir has been investigated for the treatment of life-threatening pathogens such as Ebola virus …
Floxuridine
An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection. Floxuridine is available as a sterile, nonpyrogenic, lyophilized powder for reconstitution. When administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for...
Approved
Diphenylpyraline
Diphenylpyraline is an antihistamine. Antihistamines used in the treatment of allergy act by competing with histamine for H 1-receptor sites on effector cells. Antihistamines prevent, but do not reverse, responses mediated by histamine alone. Antihistamines antagonize, in varying degrees, most of the pharmacological effects of histamine, including urticaria and pruritus.
Approved
Investigational
Matched Salts cas: … 132-18-3 …
Matched Mixtures name: … Eucillin "B" - Salbe …
Matched Mixtures name: … Eucillin "B" - Salbe …
Odesivimab
Ebola virus (EBOV) remains an important human pathogen within the Ebolavirus genus, having been responsible for at least 17 known outbreaks with an average case fatality rate of 43.92%. Immune therapy using monoclonal antibodies (mAbs) is becoming an increasingly attractive therapeutic method to combat infectious diseases due to its rapid...
Approved
Matched Description: … Ebola virus (EBOV) remains an important human pathogen within the _Ebolavirus_ genus, having been responsible …
Matched Categories: … Treatments for Ebola Virus Disease …
Matched Categories: … Treatments for Ebola Virus Disease …
Flumazenil
Fumazenil is an imidazobenzodiazepine derivative and a potent benzodiazepine receptor antagonist that competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine receptor complex, thereby reversing the effects of benzodiazepine on the central nervous system.
Approved
Matched Products: … FLUMAZENIL B. BRAUN ... Flumazenil B. Braun 0,1 mg/ml Injektionslösung und Konzentrat zur Herstellung einer Infusionslösung …
Voxilaprevir
Voxilaprevir is a Direct-Acting Antiviral (DAA) medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common...
Approved
Investigational
Matched Iupac: … 12),4,6,8,10-pentaene-27-carboxamide ... methoxy-22,25-dioxo-2,21-dioxa-4,11,23,26-tetraazapentacyclo[24.2.1.0^{3,12}.0^{5,10}.0^{18,20}]nonacosa-3( …
Matched Description: … replication of HCV genetic material and translation into a single polypeptide, Nonstructural Protein 3 ... Vosevi is approved for the treatment of adult patients with chronic HCV infection with genotype 1, 2, 3, ... genotypes 1-6 who have been previously treated with an NS5A inhibitor, or patients with genotypes 1a or 3 …
Matched Description: … replication of HCV genetic material and translation into a single polypeptide, Nonstructural Protein 3 ... Vosevi is approved for the treatment of adult patients with chronic HCV infection with genotype 1, 2, 3, ... genotypes 1-6 who have been previously treated with an NS5A inhibitor, or patients with genotypes 1a or 3 …
Hydrocortisone succinate
Approved
Matched Products: … HYDROCORTISONE SODIUM SUCCINATE FOR INJECTION B. P …
Dexamethasone
Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like hydrocortisone and prednisolone. Dexamethasone was granted FDA approval on 30 October 1958....
Approved
Investigational
Vet approved
Matched Mixtures name: … Rheumesser 3 ml - Ampullen ... DEXAVITAL TOBRAMICIDADEXAMETASONA(3 MG+1MG)/ML ... Neo/Poly-B/Dex Ophth Oint …
Stannous fluoride
Stannous Fluoride, or Tn(II) Fluoride, is a compound commonly used in toothpastes for the prevention of gingivitis, dental infections, cavities, and to relieve dental hypersensitivity. Although similar in function and activity to Sodium Fluoride (NaF), the conventionally added ingredient in toothpastes, stannous fluoride has been shown to be more effective...
Approved
Matched Products: … H E B Restore and Defend ... Gel-kam Fluorocare Part B-mint ... Gel-kam Fluorocare Part B-bubblegum …
Efavirenz
Efavirenz (brand names Sustiva® and Stocrin®) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and is used as part of highly active antiretroviral therapy (HAART) for the treatment of a human immunodeficiency virus (HIV) type 1.
For HIV infection that has not previously been treated, efavirenz and lamivudine in combination with...
Approved
Investigational
Matched Description: … part of highly active antiretroviral therapy (HAART) for the treatment of a human immunodeficiency virus …
Matched Mixtures name: … TOLAK ®3 TABLETAS RECUBIERTAS ... TOLAK ®3 TABLETAS RECUBIERTAS …
Matched Categories: … Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor …
Matched Products: … SUSTIVA 600MG 3 MON PACK …
Matched Mixtures name: … TOLAK ®3 TABLETAS RECUBIERTAS ... TOLAK ®3 TABLETAS RECUBIERTAS …
Matched Categories: … Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor …
Matched Products: … SUSTIVA 600MG 3 MON PACK …
Dequalinium
Dequalinium is an antibacterial agent with multi-targeted actions. It also possesses antifungal, antiparasitic, antiviral, anticancer, and neuroprotective properties. It is a quaternary ammonium compound, as it consists of an amphipathic cation with two aminoquinaldinium rings at both ends of a long hydrophobic hydrocarbon chain. Due to its flexible structure, dequalinium...
Approved
Investigational
Matched Mixtures name: … Eucillin "B" - Salbe …
Anthrax immune globulin human
Anthrax immune globulin is a human antibody given with antibiotics for the treatment of anthrax. It is derived from the plasma of humans immunized with BioThrax (adsorbed anthrax vaccine), which is then further purified. Available as the product Anthrasil (FDA), the result is a solution for slow IV infusion containing...
Approved
Matched Description: … result is a solution for slow IV infusion containing polyclonal antibodies that bind the protective antigen …
Ibutilide
Ibutilide is a Class III antiarrhythmic agent available in intravenous formulations. It is indicated for the conversion of acute atrial flutter and recent onset atrial fibrillation to normal sinus rhythm (NSR).
Approved
Benzyl benzoate
Benzyl benzoate is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei. It is characterised by severe itching (particularly at night), red spots, and may lead to a secondary infection. Benzyl benzoate is lethal to this mite and so...
Approved
Displaying drugs 1876 - 1900 of 5888 in total