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Displaying drugs 1901 - 1925 of 15886 in total

Teniposide

Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic...
Approved
Matched Description: … Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead ... to cell death. ... Teniposide acts primarily in the G2 and S phases of the cycle. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Zinc dibutyldithiocarbamate

Zinc dibutyldithiocarbamate is a dermatological sensitizer and allergen. Sensitivity to zinc dibutyldithiocarbamate may be identified with a clinical patch test.
Approved
Experimental
Matched Description: … Zinc dibutyldithiocarbamate is a dermatological sensitizer and allergen. …
Matched Categories: … Cell-mediated Immunity ... Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …

Thiram

Thiram may be used in dermatology as a scabicide . Thiram is mainly used as a fungicide for plants and treatment for seeds, however, this use is being investigated for safety in many markets including Canada .
Approved
Experimental
Matched Description: … Thiram is mainly used as a fungicide for plants and treatment for seeds, however, this use is being investigated …
Matched Categories: … Cell-mediated Immunity ... Scabicides, Insecticides and Repellents ... Antiparasitic Products, Insecticides and Repellents …

Tofacitinib

Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant to methotrexate....
Approved
Investigational
Matched Iupac: … 3-[(3R,4R)-4-methyl-3-[methyl({7H-pyrrolo[2,3-d]pyrimidin-4-yl})amino]piperidin-1-yl]-3-oxopropanenitrile …
Matched Description: … immune cell function. ... Known adverse effects include nausea and headache as well as more serious immunologic and hematological ... kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Coccidioides immitis spherule

Coccidioides immitis spherule is a skin test antigen indicated to detect delayed-type hypersensitivity to Coccidioides immitis in individuals with a history of pulmonary coccidioidomycosis.
Approved
Matched Categories: … Cell-mediated Immunity …

Benazepril

Benazepril, brand name Lotensin, is a medication used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure[A838,A837]. Upon cleavage of its ester group by the liver, benazepril is converted into its active form benazeprilat, a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor .
Approved
Investigational
Matched Iupac: … [(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid …
Matched Description: … Lotensin, is a medication used to treat high blood pressure (hypertension), congestive heart failure, and …
Matched Mixtures name: … Benazepril and Hydrochlorothiazide ... Benazepril and Hydrochlorothiazide ... Benazepril and Hydrochlorothiazide …
Matched Categories: … ACE Inhibitors and Diuretics ... benazepril and diuretics ... benazepril and amlodipine ... ACE Inhibitors and Calcium Channel Blockers …

Triamterene

Triamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management of hypertension. It works by promoting the excretion of sodium ions and water while decreasing the potassium excretion in the distal part of the nephron in the kidneys by working on the lumenal side. Since it acts on...
Approved
Matched Description: … Triamterene is a weak antagonist of folic acid, and a photosensitizing drug. ... [L6163] Triamterene was approved by the Food and Drug Administration in the U.S. in 1964. ... is approved for use with other diuretics to enhance diuretic and potassium-sparing effects. …
Matched Mixtures name: … Triamterene and Hydrochlorothiazide ... Triamterene and Hydrochlorothiazide ... Triamterene and Hydrochlorothiazide …

Ouabain

A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like digitalis. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-exchanging ATPase.
Approved
Matched Iupac: … 4-[(1R,3aS,3bR,5aS,7S,9R,9aR,9bS,10R,11aR)-3a,5a,9,10-tetrahydroxy-9a-(hydroxymethyl)-11a-methyl-7-{[ …
Matched Description: … It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-exchanging ATPase. ... gratus and other plants of the Apocynaceae; used like digitalis. ... A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus …

Dextroamphetamine

Dextroamphetamine is the dextrorotatory enantiomer of amphetamine . Dextroamphetamine was approved by the FDA in 2001 for the treatment of attention deficit hyperactivity disorder[L6010,Label].
Approved
Illicit
Matched Mixtures name: … Dextroamphetamine Saccharate and Amphetamine Aspartate and Dextroamphetamine Sulfate and Amphetamine ... Dextroamphetamine Saccharate and Amphetamine Aspartate and Dextroamphetamine Sulfate and Amphetamine ... Dextroamphetamine Saccharate and Amphetamine Aspartate and Dextroamphetamine Sulfate and Amphetamine …
Matched Categories: … Psychostimulants, Agents Used for ADHD and Nootropics …

Vinblastine

Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)
Approved
Matched Iupac: … methyl (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-(methoxycarbonyl ... diazatetracyclo[13.3.1.0^{4,12}.0^{5,10}]nonadeca-4(12),5(10),6,8-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Atropine

Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosseous, endotracheal and ophthalmic methods. Oral atropine is only available...
Approved
Vet approved
Matched Iupac: … (1R,3S,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate …
Matched Description: … , subcutaneous, intramuscular, intraosseous, endotracheal and ophthalmic methods. ... It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active ... [A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous …
Matched Mixtures name: … Diphenoxylate Hcl and Atropine Sulfate ... Diphenoxylate Hydrochloride and Atropine Sulfate ... Diphenoxylate Hydrochloride and Atropine Sulfate …
Matched Categories: … pralidoxime and atropine ... Alimentary Tract and Metabolism ... atropine and psycholeptics ... Mydriatics and Cycloplegics ... Belladonna and Derivatives, Plain …

Somatostatin

Somatostatin, also known as growth hormone-inhibiting hormone, is a naturally-occurring peptide hormone of 14 or 28 amino acid residues that regulates the endocrine system. It is secreted by the D cells of the islets to inhibit the release of insulin and glucagon, and is also generated in the hypothalamus, where...
Approved
Investigational
Matched Iupac: … -tribenzyl-31-(carbamoylmethyl)-10,16-bis[(1R)-1-hydroxyethyl]-7-(hydroxymethyl)-22-[(1H-indol-3-yl)methyl ... 6,9,12,15,18,21,24,27,30,33,36-undecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecaazacyclooctatriacontane-4-carboxylic acid …
Matched Description: … , GEP-NETs, paragangliomas, carcinoids, breast cancers, malignant lymphoma and small-cell lung cancers ... known as growth hormone-inhibiting hormone, is a naturally-occurring peptide hormone of 14 or 28 amino acid ... Somatostatin is initially secreted as a 116 amino acid precursor, preprosomatostatin, which undergoes …
Matched Categories: … Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins ... Somatostatin and Analogues ... Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Triprolidine

First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness.
Approved
Matched Description: … It is a component of cough and cold medicines. It may cause drowsiness. ... First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. …
Matched Mixtures name: … and Flu Clear and Cool ... Mucus DM Fast Max Day Cold and Flu and Night Cold and Flu ... Mucinex Fast-Max Cold and Flu and Mucinex NightShift Cold and Flu …

Neomycin

Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products of Streptomyces fradiae. Neomycin is a complex comprised of three components, neomycin A, B, and C. Neomycin B, also known as framycetin, is the most active component of the complex and neomycin C is the isomer...
Approved
Vet approved
Matched Description: … [A175042] Neomycin is active against both gram-positive and gram-negative organisms and mediates its ... [L11979] Neomycin is a complex comprised of three components, neomycin A, B, and C. ... preparations for use in the treatment of inflammatory conditions and infections in the eye. …
Matched Mixtures name: … Neomycin and Polymyxin B Sulfates and Bacitracin Zinc ... Neomycin and Polymyxin B Sulfates and Dexamethasone ... Neomycin and Polymyxin B Sulfates and Hydrocortisone …
Matched Categories: … Alimentary Tract and Metabolism ... Blood and Blood Forming Organs ... Blood Substitutes and Perfusion Solutions ... Ophthalmological and Otological Preparations ... Antiinfectives and Antiseptics for Local Oral Treatment …

Tramadol

Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to codeine and morphine. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatment of moderate to severe pain. It is considered...
Approved
Investigational
Matched Iupac: … 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexan-1-ol …
Matched Description: … of and response to pain. ... such as [duloxetine] and [venlafaxine]. ... ) that is structurally related to [codeine] and [morphine]. …
Matched Mixtures name: … Tramadol HCl and Acetaminophen ... Tramadol Hydrochloride and Acetaminophen ... Tramadol Hydrochloride and Acetaminophen …
Matched Categories: … tramadol and celecoxib ... tramadol and paracetamol ... tramadol and dexketoprofen …

Brexanolone

As of March 2019, brexanolone - developed and made available commercially by Sage Therapeutics Inc. as the brand name product Zulresso - is the first drug to have ever been approved by the US FDA specifically for the treatment of postpartum depression (PPD) in adult females . Since PPD, like...
Approved
Investigational
Matched Description: … provides a new and promising therapy where few existed before [F4066]. ... As of March 2019, brexanolone - developed and made available commercially by Sage Therapeutics Inc. as ... depression, is characterized by feelings of sadness, worthlessness or guilt, cognitive impairment, and …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists ... Neuroactive Steroid Gamma-Aminobutyric Acid A Receptor Positive Modulator ... Neuroactive Steroid Gamma-Aminobutyric Acid (GABA) A Receptor Positive Modulators …

Atenolol

Atenolol is a cardioselective beta-blocker used in a variety of cardiovascular conditions. Sir James Black, a Scottish pharmacologist, pioneered the use of beta-blockers for the management of angina pectoris in 1958 for which he received the Nobel Prize. Beta-blockers quickly became popular in clinical use and where subsequently investigated for...
Approved
Matched Description: … use in myocardial infarction, arrhythmias, and hypertension during the 1960s. ... [A178429] Beta-blockers quickly became popular in clinical use and where subsequently investigated for ... widely prescribed beta blockers, evidence suggests atenolol may not significantly reduce mortality, and …
Matched Mixtures name: … Atenolol and Chlorthalidone ... Atenolol and Chlorthalidone ... Atenolol and Chlorthalidone …
Matched Categories: … atenolol and thiazides ... atenolol and nifedipine ... atenolol and other diuretics ... Beta Blocking Agents and Thiazides ... atenolol, thiazides and other diuretics …

Esterified estrogens

Esterified estrogens contain a mixture of estrogenic substances; the principle component is estrone. Preparations contain 75% to 85% sodium estrone sulfate and 6% to 15% sodium equilin sulfate such that the total is not <90%. Esterified estrogens are a man-made mixture of estrogens that are used to treat symptoms of...
Approved
Matched Description: … It is being also for the prevention and treatment of osteoporosis. ... Preparations contain 75% to 85% sodium estrone sulfate and 6% to 15% sodium equilin sulfate such that …
Matched Mixtures name: … Esterified Estrogens and Methyltestosterone ... Esterified Estrogens and Methyltestosterone ... Esterified Estrogens and Methyltestosterone …

Chlorthalidone

Chlorthalidone is a thiazide-like diuretic used for the treatment of hypertension and for management of edema caused by conditions such as heart failure or renal impairment. Chlorthalidone improves blood pressure and swelling by preventing water absorption from the kidneys through inhibition of the Na+/Cl− symporter in the distal convoluted tubule...
Approved
Matched Description: … Chlorthalidone is a thiazide-like diuretic used for the treatment of hypertension and for management ... effect is under debate, however, it is thought that increased diuresis results in decreased plasma and ... Chlorthalidone improves blood pressure and swelling by preventing water absorption from the kidneys through …
Matched Mixtures name: … Atenolol and Chlorthalidone ... Atenolol and Chlorthalidone ... Atenolol and Chlorthalidone …
Matched Categories: … chlortalidone and potassium ... chlortalidone and potassium-sparing agents ... Low-Ceiling Diuretics and Potassium-Sparing Agents …

Antipyrine

An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
Approved
Investigational
Matched Description: … An analgesic and antipyretic that has been given by mouth and as ear drops. …
Matched Mixtures name: … Antipyrine and Benzocaine ... Antipyrine and Benzocaine ... Antipyrine and Benzocaine …
Matched Categories: … Analgesics and Anesthetics …

Levodopa

Levodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability to cross the blood-brain barrier[Label]. Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prevent...
Approved
Matched Iupac: … (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid …
Matched Description: … Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally ... Once past the blood-brain barrier, levodopa is metabolized to dopamine and supplements the low endogenous ... The first developed drug product that was approved by the FDA was a levodopa and carbidopa combined product …
Matched Mixtures name: … Carbidopa and Levodopa ... Carbidopa and Levodopa ... Carbidopa and Levodopa …
Matched Categories: … Dopa and Dopa Derivatives ... Amino Acids, Peptides, and Proteins ... levodopa and decarboxylase inhibitor ... levodopa, decarboxylase inhibitor and COMT inhibitor …

Fosinopril

Fosinopril is a phosphinic acid-containing ester prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly hydrolyzed to fosinoprilat, its principle active metabolite. Fosinoprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and...
Approved
Matched Iupac: … -2-carboxylic acid ... (2S,4S)-4-cyclohexyl-1-(2-{[(1S)-2-methyl-1-(propanoyloxy)propoxy](4-phenylbutyl)phosphoryl}acetyl)pyrrolidine …
Matched Description: … Fosinopril is a phosphinic acid-containing ester prodrug that belongs to the angiotensin-converting enzyme ... ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS ... to treat mild to moderate hypertension, as an adjunct in the treatment of congestive heart failure, and …
Matched Mixtures name: … Fosinopril Sodium and Hydrochlorothiazide ... Fosinopril Sodium and Hydrochlorothiazide ... Fosinopril Sodium and Hydrochlorothiazide …
Matched Categories: … ACE Inhibitors and Diuretics ... fosinopril and diuretics ... Amino Acids, Peptides, and Proteins …

Atovaquone

Atovaquone is a hydroxynaphthoquinone, or an analog of ubiquinone, that has antimicrobial and antipneumocystis activity. It is being used in antimalarial protocols.
Approved
Matched Description: … Atovaquone is a hydroxynaphthoquinone, or an analog of ubiquinone, that has antimicrobial and antipneumocystis …
Matched Mixtures name: … Atovaquone and Proguanil HCl ... Atovaquone and Proguanil HCl ... Atovaquone and Proguanil HCl …
Matched Categories: … proguanil and atovaquone ... Antiparasitic Products, Insecticides and Repellents …

Oxtriphylline

Oxtriphylline is the choline salt form of theophylline. Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Its main physiological reponse is to dilate the bronchioles. As such, oxytriphylline is indicated mainly for asthma, bronchospasm, and COPD (i.e. all...
Approved
Matched Description: … blocker, and histone deacetylase activator. ... Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor ... It is marketed under the name Choledyl SA, and several forms of oxytriphylline have been discontinued …
Matched Categories: … Xanthines and Adrenergics ... choline theophyllinate and adrenergics …

Liraglutide

Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist.[Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmitic acid) with a glutamic acid...
Approved
Matched Description: … Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as ... [A6932] Liraglutide is made by attaching a C-16 fatty acid (palmitic acid) with a glutamic acid spacer …
Matched Categories: … Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins ... insulin degludec and liraglutide ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Displaying drugs 1901 - 1925 of 15886 in total