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Displaying drugs 2051 - 2075 of 15322 in total

Ceftaroline fosamil

Ceftaroline fosamil is a cephalosporin antibacterial indicated for the treatment of the following infections caused by designated susceptible bacteria: Acute bacterial skin and skin structure infections. Community-acquired bacterial pneumonia.
Approved
Investigational
Matched Description: … treatment of the following infections caused by designated susceptible bacteria: Acute bacterial skin and …
Matched Categories: … Sulfur Compounds …

Grazoprevir

Grazoprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common...
Approved
Matched Description: … Subtitutions at amino acid positions 155, 156, or 168 are known to confer resistance. ... with or without [DB00811] depending on the the presence of resistance associated amino acid substitutions ... to achieve a SVR between 94% and 97% for genotype 1 and 97% and 100% for genotype 4 after 12 weeks of …
Matched Categories: … Sulfur Compounds ... elbasvir and grazoprevir …

Diethylcarbamazine

An anthelmintic used primarily as the citrate in the treatment of filariasis, particularly infestations with Wucheria bancrofti or Loa loa.
Approved
Investigational
Vet approved
Matched Categories: … Piperazine and Derivatives ... Antiparasitic Products, Insecticides and Repellents …

Telavancin

Telavancin is a semi-synthetic derivative of vanocymycin that has bactericidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) and other gram-positive bacteria. MRSA is an important pathogen capable of causing hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and skin and subcutaneous tissue infections among others.
Approved
Matched Iupac: … }.0^{34,39}]pentaconta-3,5,8,10,12(48),14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid …
Matched Description: … skin and subcutaneous tissue infections among others. ... vanocymycin that has bactericidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) and ... pathogen capable of causing hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Tritoqualine

Approved
Matched Categories: … Cholagogues and Choleretics …

Diacetyl benzoyl lathyrol

Diacetyl benzoyl lathyrol is an active ingredient in whitening creams. It is also reported to be a skin conditioning agent.
Approved

Spirapril

Spirapril is an ACE inhibitor antihypertensive drug used to treat hypertension. Spirapril is converted to the active spiraprilat after administration. ACE inhibitors are used primarily in treatment of hypertension and congestive heart failure.
Approved
Matched Iupac: … 2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid …
Matched Description: … ACE inhibitors are used primarily in treatment of hypertension and congestive heart failure. …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Epinastine

Epinastine is used for the prevention of itching associated with allergic conjunctivitis. It has a multi-action effect that inhibits the allergic response in 3 ways: 1. stabilizes mast cells by preventing mast cell degranulation to control the allergic response, 2. prevents histamine binding to both the H1- and H2-receptors to...
Approved
Investigational
Matched Description: … H2-receptors to stop itching and provide lasting protection, and 3. prevents the release of proinflammatory ... cell degranulation to control the allergic response, 2. prevents histamine binding to both the H1- and …
Matched Categories: … Acid Reducers ... Decongestants and Antiallergics …

Estradiol dienanthate

Estradiol Dienanthate is a pro-drug ester of DB00783, a naturally occurring hormone that circulates endogenously within the human body. Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex hormone. As a pro-drug of estradiol, estradiol benzoate therefore has the same downstream...
Approved
Investigational
Vet approved
Matched Description: … a chance to enter systemic circulation and exert its estrogenic effects [A12102]. ... Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex ... same downstream effects within the body through binding to the Estrogen Receptor (ER) including ERα and …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …

Netarsudil

A Rho kinase inhibitor with norepinephrine transport inhibitory activity that reduces production of aqueous As of December 18, 2017 the FDA approved Aerie Pharmaceutical's Rhopressa (netarsudil ophthalmic solution) 0.02% for the indication of reducing elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Acting as both a rho...
Approved
Matched Description: … Acting as both a rho kinase inhibitor and a norepinephrine transport inhibitor, Netarsudil is a novel ... conventional trabecular pathway of aqueous humour outflow to act as an inhibitor to the rho kinase and …
Matched Categories: … latanoprost and netarsudil ... Amino Acids, Peptides, and Proteins ... Antiglaucoma Preparations and Miotics …

Everolimus

Everolimus is a derivative of Rapamycin (sirolimus), and works similarly to Rapamycin as an mTOR (mammalian target of rapamycin) inhibitor. It is currently used as an immunosuppressant to prevent rejection of organ transplants. In a similar fashion to other mTOR inhibitors Everolimus' effect is solely on the mTORC1 protein and...
Approved
Matched Description: … Everolimus is a derivative of Rapamycin (sirolimus), and works similarly to Rapamycin as an mTOR (mammalian ... In a similar fashion to other mTOR inhibitors Everolimus' effect is solely on the mTORC1 protein and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Quinupristin

Quinupristin/dalfopristin is a combination of two antibiotics used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome and quinupristin inhibits the late phase of protein synthesis. The combination of the two components acts synergistically and is more...
Approved
Matched Description: … Quinupristin/dalfopristin is a combination of two antibiotics used to treat infections by staphylococci and ... Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome and quinupristin ... The combination of the two components acts synergistically and is more effective in vitro than each component …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Antrafenine

Antrafenine is a piperazine derivative drug that acts as an analgesic and anti-inflammatory drug with similar efficacy to naproxen. It is not widely used as it has largely been replaced by newer drugs.
Approved
Matched Description: … Antrafenine is a piperazine derivative drug that acts as an analgesic and anti-inflammatory drug with …

Dabigatran etexilate

Dabigatran etexilate is an oral prodrug that is hydrolyzed to the competitive and reversible direct thrombin inhibitor dabigatran.[A177463, A6970, L34675, L34680] Dabigatran etexilate may be used to decrease the risk of venous thromboembolic events in patients in whom anticoagulation therapy is indicated. In contrast to warfarin, because its anticoagulant effects...
Approved
Matched Description: … Dabigatran etexilate is an oral prodrug that is hydrolyzed to the competitive and reversible direct thrombin …
Matched Categories: … Blood and Blood Forming Organs …

Mumps virus strain B level jeryl lynn live antigen

Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease.
Approved
Investigational
Matched Mixtures name: … PROQUAD® ( Measles, Mumps, Rubella AND Varicella (Oka/Merck) Virus Vaccine Live, MSD) LYOPHILIZED VACCINE …

Cannabidiol

Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact...
Approved
Investigational
Matched Description: … CBD are obtained through conversion from their precursors, tetrahydrocannabinolic acid-A (THCA-A) and ... acid (GABA), and cellular uptake of anandamide, acts on mitochondria Ca2+ stores, blocks low-voltage-activated ... cannabidiolic acid (CBDA), through decarboxylation reactions. …
Matched Categories: … Cannabinoids and similars …

Insulin detemir

Insulin detemir is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A2358, A2359, A2360, A44] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta...
Approved
Matched Description: … amino acid at position B29. ... [A2358, A2359, A2360, A44] This insulin analogue has a 14-C fatty acid, myristic acid, bound to the lysine ... tissues such as the liver, fat cells, and skeletal muscle. …
Matched Categories: … Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Perazine

Perazine has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders, among others.
Approved
Investigational
Matched Description: … been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and …
Matched Categories: … Sulfur Compounds …

Framycetin

A component of neomycin that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed)
Approved
Matched Description: … On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed) …

Voxilaprevir

Voxilaprevir is a Direct-Acting Antiviral (DAA) medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common...
Approved
Investigational
Matched Description: … mature virus: NS3, NS4A, NS4B, NS5A, and NS5B [A19643]. ... categorized into nine distinct genotypes, with genotype 1 being the most common in the United States, and ... genetic material into the following structural and nonstructural proteins required for assembly into …
Matched Categories: … Sulfur Compounds ... Amino Acids, Peptides, and Proteins ... sofosbuvir, velpatasvir and voxilaprevir …

Thrombin alfa

Thrombin Alfa is a human coagulation protein produced via recombinant DNA technology from a genetically modified CHO cell line. Thrombin Alfa is identical in amino acid sequence and structurally similar to naturally occurring human thrombin. Thrombin Alfa precursor is secreted to culture medium as single chain form that is proteolytically...
Approved
Matched Description: … Thrombin Alfa is identical in amino acid sequence and structurally similar to naturally occurring human ... that is proteolytically converted to a two-chain active form (using a protein derived from snakes) and ... The purification process includes solvent-detergent treatment and nano-filtration steps dedicated to …
Matched Categories: … Enzymes and Coenzymes ... Amino Acids, Peptides, and Proteins …

Levacetylmethadol

Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased...
Approved
Investigational
Withdrawn
Matched Description: … Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. …

Ethoheptazine

Ethoheptazine is marketed under the name Zactane. It is a phenazepine based opioid analgesic. It was invented in the 1950s and is related to other drugs such as proheptazine. Ethoheptazine is no longer marketed in the United States.
Approved
Withdrawn
Matched Description: … It was invented in the 1950s and is related to other drugs such as proheptazine. …

Toremifene

Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like tamoxifen, toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has estrogenic (agonist) activity on the cardiovascular system and on bone...
Approved
Investigational
Matched Description: … Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to ... possesses tissue-specific actions: it has estrogenic (agonist) activity on the cardiovascular system and ... on bone tissue and it has weak estrogenic effects on uterine tissue, however, it also has antiestrogenic …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Hormone Antagonists and Related Agents ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Apomorphine

Apomorphine is a non-ergoline dopamine D2 agonist indicated to treat hypomobility associated with Parkinson's. It was first synthesized in 1845 and first used in Parkinson's disease in 1884. Apomorphine has also been investigated as an emetic, a sedative, a treatment for alcoholism, and a treatment of other movement disorders.[A203597,A203618] Apomorphine...
Approved
Investigational
Matched Description: … It was first synthesized in 1845 and first used in Parkinson's disease in 1884. ... A203618] Apomorphine has also been investigated as an emetic, a sedative, a treatment for alcoholism, and …
Matched Categories: … Genito Urinary System and Sex Hormones …
Displaying drugs 2051 - 2075 of 15322 in total