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Displaying drugs 201 - 225 of 8039 in total

Doxepin

Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to cidoxepin. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepressant but...
Approved
Investigational
Matched Description: … [L5971] However, in 2010 it was approved for the treatment of insomnia. ... properties with members of the drug family including [amitriptyline], [clomipramine], [desipramine], ... is not a tricyclic antidepressant but it is commonly associated with the class since it shares a lot of …
Matched Categories: … Combined Inhibitors of Serotonin/Norepinephrine Reuptake ... Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Desogestrel

Desogestrel, a prodrug, is a third generation progestogen and hence, a member of the gonane family which was largely used in Europe before being approved in the US and Canada. It was firstly generated from a study that showed that 11-beta and 11-alkylidene substituent in nortestosterone can enhance the biological...
Approved
Matched Description: … Desogestrel, a prodrug, is a third generation progestogen[A176315] and hence, a member of the gonane …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Palonosetron

Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first...
Approved
Investigational
Matched Description: … appear more than 24 hours after the first dose of a course of chemotherapy and is the only drug of its ... and treatment of chemotherapy-induced nausea and vomiting (CINV). ... As of 2008, it is the most recent 5-HT3 antagonist to enter clinical use. …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Pergolide

Pergolide is a long-acting dopamine agonist approved in 1982 for the treatment of Parkinson’s Disease. It is an ergot derivative that acts on the dopamine D2 and D3, alpha2- and alpha1-adrenergic, and 5-hydroxytryptamine (5-HT) receptors. It was indicated as adjunct therapy with levodopa/carbidopa in the symptomatic treatment of parkinsonian syndrome....
Approved
Investigational
Vet approved
Withdrawn
Matched Description: … It was later found that pergolide increased the risk of cardiac valvulopathy. ... Pergolide is a long-acting dopamine agonist approved in 1982 for the treatment of Parkinson’s Disease ... It was indicated as adjunct therapy with levodopa/carbidopa in the symptomatic treatment of parkinsonian …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Hydromorphone

Hydromorphone is a pure opioid, a semi-synthetic hydrogenated ketone derivative of morphine that has been available clinically since 1920. Structurally, hydromorphone derived from morphine in the modification of the hydroxyl group in the carbon 6 to a carbonyl and the absence of a double bond between the carbon 7 and...
Approved
Illicit
Matched Description: … carbon 6 to a carbonyl and the absence of a double bond between the carbon 7 and 8. ... Hydromorphone is a pure opioid,[A176468] a semi-synthetic hydrogenated ketone derivative of [morphine ... Structurally, hydromorphone derived from [morphine] in the modification of the hydroxyl group in the …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Levonorgestrel

Levonorgestrel (LNG) is a synthetic progestogen similar to Progesterone used in contraception and hormone therapy.[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. Some of these devices...
Approved
Investigational
Matched Description: … Some of these devices are known as Jaydess, Kyleena, and Mirena. ... A subdermal implant of levonorgestrel that slowly releases the hormone over a long-term period is also ... [L7823] In addition to the above uses, levonorgestrel is used as a component of long-term combination …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Bosentan

Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure.
Approved
Investigational
Matched Description: … would otherwise promote narrowing of the blood vessels and lead to high blood pressure. ... Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that …
Matched Categories: … combinations of sulfonamides …

Granisetron

A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
Approved
Investigational
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Dextrose, unspecified form

Glucose is a simple sugar (monosaccharide) generated during phosynthesis involving water, carbon and sunlight in plants. It is produced in humans via hepatic gluconeogenesis and breakdown of polymeric glucose forms (glycogenolysis). It circulates in human circulation as blood glucose and acts as an essential energy source for many organisms through...
Approved
Vet approved
Matched Description: … Glucose is listed on the World Health Organization's List of Essential Medicines. ... Its aldohexose stereoisomer, dextrose or D-glucose, is the most commonly occurring isomer of glucose ... The unspecified form of glucose is commonly supplied as an injection for nutritional supplementation …
Matched Mixtures name: … SOLUTION OF DEXTROSE 5 % IN NORMAL SALINE 0.9 % ... SOLUTION OF DEXTROSE 10 % IN NORMAL SALINE 0.9 % …

Acetaminophen

Acetaminophen (paracetamol), also commonly known as Tylenol, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the U.S. FDA...
Approved
Matched Description: … [L5783] Confusion about dosing of this drug may be caused by the availability of different formulas, ... strengths, and dosage instructions for children of different ages. ... FDA in 1951 and is available in a variety of forms including syrup form, regular tablets, effervescent …
Matched Mixtures name: … Hot Lemon Relief for Symptoms Of Cold and Flu ... Hot Lemon Relief for Symptoms Of Cold and Flu Forte ... Hot Lemon Relief for Symptoms Of Cough, Cold and Flu …

Sulfadiazine

One of the short-acting sulfonamides used in combination with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections.
Approved
Investigational
Vet approved
Matched Description: … One of the short-acting sulfonamides used in combination with pyrimethamine to treat toxoplasmosis in …
Matched Categories: … combinations of sulfonamides …

Clofazimine

Clofazimine is a highly lipophilic antimicrobial riminophenazine dye used in combination with other agents, such as dapsone, for the treatment of leprosy. It was originally described in 1957 and was the prototypical riminophenazine dye - a bright-red dye that, in its clinical use, results in long-lasting discoloration of the skin...
Approved
Investigational
Matched Description: … antimicrobial riminophenazine dye used in combination with other agents, such as [dapsone], for the treatment of ... riminophenazine dye - a bright-red dye that, in its clinical use, results in long-lasting discoloration of …
Matched Categories: … Drugs for Treatment of Lepra …

Grazoprevir

Grazoprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common...
Approved
Matched Description: … alter the affinity of the drug for NS3/4A or the activity of the enzyme itself. ... another class of DAAs [A19593]. ... The barrier for develoment of resistance to NS3/4A inhibitors is lower than that of NS5B inhibitors, …
Matched Categories: … Antivirals for treatment of HCV infections …

Velpatasvir

Velpatasvir is a Direct-Acting Antiviral (DAA) medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common...
Approved
Investigational
Matched Description: … ), after 12 weeks of daily therapy. ... reduced liver-related damage, improved quality of life, reduced incidence of Hepatocellular Carcinoma ... Epclusa is the first combination HCV product indicated for the treatment of all genotypes of Hepatitis …
Matched Categories: … Antivirals for treatment of HCV infections …

Conjugated estrogens

The conjugated estrogens are noncrystalline mixtures of purified female sex hormones obtained either by its isolation from the urine of pregnant mares or by synthetic generation from vegetal material. Both of these products are later conjugated to natrium sulfate by ester bonds in order to make them more water soluble.[L5605,...
Approved
Matched Description: … , 3% of equilenin sulfate, 5% of 17-alpha and 17-beta-dihydroequilenin sulfate, 2% of 17-alpha-estradiolsulfate ... and 3% of 17-beta-estradiolsulfate. ... represented by estrone sulfate followed by 25% of equilin sulfate, 15% of 17-alpha-dehydroequilenin sulfate …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Secobarbital

Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom.
Approved
Vet approved
Matched Categories: … combinations of barbiturates …

Estrone

Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion of adrostenedione....
Approved
Matched Description: … Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and ... in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion of …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Cyproterone acetate

An anti-androgen that, in the form of its acetate (cyproterone acetate), also has progestational properties. It is used in the treatment of hypersexuality in males, as a palliative in prostatic carcinoma, and, in combination with estrogen, for the therapy of severe acne and hirsutism in females.
Approved
Investigational
Matched Description: … in combination with estrogen, for the therapy of severe acne and hirsutism in females. ... An anti-androgen that, in the form of its acetate (cyproterone acetate), also has progestational properties ... It is used in the treatment of hypersexuality in males, as a palliative in prostatic carcinoma, and, …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Apomorphine

Apomorphine is a non-ergoline dopamine D2 agonist indicated to treat hypomobility associated with Parkinson's. It was first synthesized in 1845 and first used in Parkinson's disease in 1884. Apomorphine has also been investigated as an emetic, a sedative, a treatment for alcoholism, and a treatment of other movement disorders.[A203597,A203618] Apomorphine...
Approved
Investigational
Matched Description: … Apomorphine has also been investigated as an emetic, a sedative, a treatment for alcoholism, and a treatment of …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Metamfetamine

Metamfetamine (methamphetamine) is a psychostimulant and sympathomimetic drug, and a member of the amphetamine group of sympathomimetic amines. Methamphetamine can induce effects such as euphoria, increased alertness and energy, and enhanced self-esteem. It is a scheduled drug in most countries due to its high potential for addiction and abuse. The...
Approved
Illicit
Withdrawn
Matched Description: … group of sympathomimetic amines. ... Metamfetamine (methamphetamine) is a psychostimulant and sympathomimetic drug, and a member of the amphetamine ... The FDA withdrew its approval for the use of all parenteral drug products containing methamphetamine …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Paritaprevir

Paritaprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common...
Approved
Investigational
Matched Description: … Lack of significant side effects and short duration of therapy is a considerable advantage over older ... reduced liver-related damage, improved quality of life, reduced incidence of Hepatocellular Carcinoma ... Paritaprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic …
Matched Categories: … Antivirals for treatment of HCV infections …

Indapamide

The most significant modifiable risk factor for cardiovascular disease and the most prominent contributor to all-cause mortality is hypertension. Characterized by an office blood pressure of ≥140/90, hypertension is pervasive and impacts an estimated 25% of adults globally. Treatment for hypertension should include a number of lifestyle changes (ie. reduced...
Approved
Matched Description: … an estimated 25% of adults globally. ... [A204155] Characterized by an office blood pressure of ≥140/90, hypertension is pervasive and impacts ... [A204155] Treatment for hypertension should include a number of lifestyle changes (ie. reduced sodium …
Matched Categories: … combinations of sulfonamides …

Maprotiline

Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does not appear to block serotonin reuptake. Maprotiline may be used...
Approved
Investigational
Matched Description: … Maprotiline is effective at reducing symptoms of anxiety associated with depression. …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Hydrocodone

Hydrocodone is a synthetic opioid derivative of codeine. It is commonly used in combination with acetaminophen to control moderate to severe pain. Historically, hydrocodone has been used as a cough suppressant although this has largely been replaced by dextromethorphan in current cough and cold formulations. Hydrocodone's more potent metabolite, hydromorphone...
Approved
Illicit
Investigational
Matched Description: … The FDA first approved Hydrocodone for use as part of the cough suppressant syrup Hycodan in March of ... Hydrocodone is a synthetic opioid derivative of codeine. ... metabolite, [hydromorphone] has also found wide use as an analgesic and is frequently used in cases of …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Clindamycin

Clindamycin is a semi-synthetic lincosamide antibiotic used in the treatment of a variety of serious infections due to susceptible microorganisms[L11599,L11596] as well as topically for acne vulgaris. It has a relatively narrow spectrum of activity that includes anaerobic bacteria as well as gram-positive cocci and bacilli and gram-negative bacilli. Interestingly,...
Approved
Vet approved
Matched Description: … Clindamycin is a semi-synthetic lincosamide antibiotic used in the treatment of a variety of serious ... [L11593] It has a relatively narrow spectrum of activity that includes anaerobic bacteria as well as ... and has largely replaced, [lincomycin], a naturally occurring lincosamide and the eponymous member of …
Matched Categories: … Antiinfectives for Treatment of Acne …
Displaying drugs 201 - 225 of 8039 in total