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Displaying drugs 201 - 225 of 10358 in total

Pretomanid

Persistent forms of tuberculosis (TB) have proven to be a major cause of global morbidity and mortality and a cause for significant concern. Research in recent years has been geared toward the development of novel therapies that target persistent forms of this disease, which have shown resistance to standard therapy...
Approved
Matched Description: … Persistent forms of tuberculosis (TB) have proven to be a major cause of global morbidity and mortality ... forms of this disease, which have shown resistance to standard therapy regimens. ... Research in recent years has been geared toward the development of novel therapies that target persistent …
Matched Categories: … Drugs for Treatment of Tuberculosis …

Corifollitropin alfa

Corifollitropin alfa, also known as Elonva is used in women undergoing fertility treatment to stimulate the development of more than one mature egg (oocyte) at a time in the ovaries. This drug used together with a gonadotropin-releasing hormone (GnRH) antagonist, a type of medicine also used in fertility treatments. Elonva...
Approved
Investigational
Matched Description: … risk of ovarian hyperstimulation in the high responder study group of women [L2276], [A32526]. ... effectiveness of this drug, however, warns at the same time against the possibility of an increased ... In July 2014, Merck announced the receipt of a Complete Response Letter (CRL) from the U.S. …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Sodium zirconium cyclosilicate

Sodium zirconium cyclosilicate is approved as the trade product Lokelma developed by AstraZeneca - an insoluble, non-absorbed sodium zirconium silicate, formulated as a powder for oral suspension that acts as a highly selective potassium removing agent. It is administered orally and is odorless, tasteless, and stable at room temperature. Approval...
Approved
Investigational
Matched Description: … time to achieving normal potassium levels in the blood was 2.2 hours, with 92% of patients achieving ... [L2933] Approval of the medication is supported by data from three double-blind, placebo-controlled trials ... and two open-label trials which showed that the onset of action was approximately 1.0 hour and the median …
Matched Categories: … Drugs for Treatment of Hyperkalemia and Hyperphosphatemia …

Lithium citrate

Approved
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Articaine

Articaine is a dental local anesthetic. Articaine is widely used around the world and is the most popular local anesthetic in many European countries.
Approved
Matched Mixtures name: … Ultracaine D-S Injection ... Ultracaine D-S Forte Injection ... ULTRAVER D-S 80 MG + 0,01819 MG / 2 ML ENJEKSİYONLUK ÇÖZELTİ, 20 ADET …

Levetiracetam

Levetiracetam is a drug within the pyrrolidine class that is used to treat various types of seizures stemming from epileptic disorders. It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated to other anti-epileptic drugs (AEDs).[L8606,L8600,L8615] Levetiracetam possesses a wide therapeutic index[L8615,A185918]...
Approved
Matched Description: … Levetiracetam is a drug within the pyrrolidine class that is used to treat various types of seizures ... interactions[L8606,L8600,L8615] - these characteristics make it a desirable choice over other AEDs, a class of …
Matched Products: … TAMLET-S …

Fluconazole

Fluconazole, commonly known as Diflucan, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an azole antifungal, in the same drug family as ketoconazole and itraconazole. Fluconazole...
Approved
Investigational
Matched Description: … The side effect profile of this drug is minimal. ... and superficial fungal infections in a variety of tissues. ... Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic …
Matched Mixtures name: … FUNEX® - S TABLETA ... BATEN ® S TABLETAS RECUBIERTAS …

Sotagliflozin

Sotagliflozin is a dual inhibitor of SGLT1 and SGLT2, the first of its kind, which is approved for use in the EU, in combination with insulin, to improve glycemic control in patients with type 1 diabetes mellitus (T1DM) and a BMI ≥27 kg/m2. Its potency in inhibiting SGLT2 is similar...
Approved
Investigational
Matched Description: … Sotagliflozin is a dual inhibitor of SGLT1 and SGLT2, the first of its kind,[A244499] which is approved ... [L39739] On March 22, 2022, the marketing authorization of sotagliflozin for the treatment of type 1 ... the approval because the data submitted did not show that it was safe under the proposed conditions of …

Carbenicillin

Broad-spectrum semisynthetic penicillin derivative used parenterally. It is susceptible to gastric juice and penicillinase and may damage platelet function.
Approved
Investigational
Matched Categories: … combinations of penicillins …

Ethionamide

A second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. (From Smith and Reynard, Textbook of Pharmacology, 1992, p868)
Approved
Matched Description: … It also may be used for treatment of leprosy. ... (From Smith and Reynard, Textbook of Pharmacology, 1992, p868) …
Matched Categories: … Drugs for Treatment of Tuberculosis …

Pivmecillinam

Pivmecillinam is a mecillinam prodrug, a pivaloyloxymethyl ester of amdinocillin that is well absorbed orally, but broken down to amdinocillin in the intestinal mucosa. It is active against gram-negative organisms and used as for amdinocillin. [PubChem]
Approved
Matched Description: … Pivmecillinam is a mecillinam prodrug, a pivaloyloxymethyl ester of amdinocillin that is well absorbed …
Matched Categories: … combinations of penicillins …

Methoxyphenamine

Approved
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Sibutramine

Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled substance in the...
Approved
Illicit
Investigational
Withdrawn
Matched Description: … heart attack and stroke in patients with a history of heart disease. ... usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of ... Sibutramine was withdrawn from Canadian and U.S. markets due to concerns that the drug increases the risk of …
Matched Categories: … Combined Inhibitors of Serotonin/Norepinephrine Reuptake ... Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Phenyl salicylate

Phenyl salicylate is a 2-hydroxybenzoic acid phenyl ester. It is utilized in some manufacturing processes of polymers, lacquers, adhesives, waxes, as well as polishes. It is an active ingredient in some pharmaceutical products as a mild analgesic for pain relief by releasing salicylate (found in DB00945 ). Phenyl salicylate may...
Approved
Matched Description: … This compound belongs to the class of organic compounds known as depsides and depsidones. ... It is utilized in some manufacturing processes of polymers, lacquers, adhesives, waxes, as well as polishes ... These are polycyclic compounds that is either a polyphenolic compound composed of two or more monocyclic …
Matched Mixtures name: … Urin D/S ... Uretron D/S …

Esculin

Esculin is found in barley. Vitamin C2 is generally considered a bioflavanoid, related to vitamin P esculin is a glucoside that naturally occurs in the horse chestnut (Aesculus hippocastanum), California Buckeye (Aesculus californica) and in daphnin (the dark green resin of Daphne mezereum). Esculin belongs to the family of Glycosyl...
Approved
Matched Description: … derivatives in which a sugar group is bonded through its anmoeric carbonA to another group via a C-, S- ... Esculin belongs to the family of Glycosyl Compounds. ... Aesculus hippocastanum), California Buckeye (Aesculus californica) and in daphnin (the dark green resin of …

Pefloxacin

A synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positive bacteria.
Approved
Matched Categories: … Metabolic Side Effects of Drugs and Substances …

Demeclocycline

A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.
Approved
Matched Description: … it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of …
Matched Categories: … combinations of tetracyclines …

Technetium Tc-99m exametazime

Technetium Tc-99m exametazime is a radiopharmaceutical sold under the trade name Ceretec used in the detection of altered regional cerebral perfusion in stroke and other cerebrovascular diseases. It can also be used for the labelling of leukocytes to localise intra-abdominal infections and inflammatory bowel disease. Exametazime, also known as hexamethylpropyleneamine...
Approved
Matched Description: … Tc-99m exametazime is a radiopharmaceutical sold under the trade name Ceretec used in the detection of ... It can also be used for the labelling of leukocytes to localise intra-abdominal infections and inflammatory …
Matched Categories: … Diagnostic Uses of Chemicals …

Technetium Tc-99m succimer

Technetium Tc-99m (99mTc) succimer, also known as technetium Tc-99m dimercaptosuccinic acid (DMSA), is a radioactive diagnostic agent used to evaluate functional renal tissue and tubular function in patients with renal parenchymal disorders. It works by binding to the cortical region of the kidneys. Technetium Tc-99m succimer is used with gamma...
Approved
Matched Description: … [L40558] The use of technetium Tc-99m succimer for the detection of kidney cortical defects was first ... It works by binding to the cortical region of the kidneys. …
Matched Categories: … Diagnostic Uses of Chemicals …

Delandistrogene moxeparvovec

Delandistrogene moxeparvovec is an adeno-associated virus vector-based gene therapy developed by Sarepta Therapeutics. It was granted accelerated approval by the FDA on June 22, 2023, as the first gene therapy to treat Duchenne Muscular Dystrophy (DMD). DMD is an X-linked genetic disorder characterized by mutations in the dystrophin gene, leading...
Approved
Investigational
Matched Description: … Microdystrophin is a truncated, functional form of dystrophin.[A260256, L47021] ... protein responsible for muscle function; thus, patients with DMD experience a progressive deterioration of ... virus serotype rh74 (AAVrh74) based vector containing the microdystrophin transgene under the control of …

Thalidomide

A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating the release of inflammatory mediators like tumor necrosis factor-alpha...
Approved
Investigational
Withdrawn
Matched Description: … It has been reintroduced and used for a number of inflammatory disorders and cancers. ... Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating the release of ... Due to severe teratogenicity, pregnancy must be excluded before the start of treatment and patients must …

Chloroprocaine

Chloroprocaine is an ester local anesthetic commonly available in its salt form, chloroprocaine hydrochloride. Similar to other local anesthetics, it increases the threshold for electrical excitation in nerves by slowing the propagation of the nerve impulse and reducing the rate of rise of the action potential. The pharmacological profile of...
Approved
Investigational
Matched Description: … the nerve impulse and reducing the rate of rise of the action potential. ... anesthetics, it increases the threshold for electrical excitation in nerves by slowing the propagation of ... [L43402] The pharmacological profile of chloroprocaine is characterized by a short latency and duration …
Matched Categories: … Esters of Aminobenzoic Acid …

Quinethazone

Quinethazone, marketed as Hydromox, is a thiazide diuretic indicated for hypertension. Patients may experience adverse reactions such as dizziness, dry mouth, nausea, and hypokalemia.
Approved
Matched Categories: … combinations of sulfonamides …

Alfacalcidol

Alfacalcidol, or 1-alpha-hydroxycholecalciferol or 1-alpha-hydroxyvitamin D3, is a non-endogenous analogue of vitamin D. It plays an essential function in calcium homeostasis and bone metabolism. Alfacaldisol is activated by the enzyme 25-hydroxylase in the liver to mediate its effects in the body, or most importantly, the kidneys and bones. The pharmacological...
Approved
Nutraceutical
Matched Description: … mechanism regulates the final activation step of vitamin D in the kidneys. ... Alfacalcidol, or 1-alpha-hydroxycholecalciferol or 1-alpha-hydroxyvitamin D3, is a non-endogenous analogue of ... The pharmacological actions of alfacalcidol are prolonged than vitamin D because a negative feedback …
Matched Categories: … Drugs for Treatment of Bone Diseases …

Denosumab

Denosumab is a novel, fully human IgG2 monoclonal antibody specific to receptor activator of nuclear factor kappa-B ligand (RANKL), suppresses bone resorption via inhibiting RANK-mediated activation of osteoclasts. It is the first and currently the only RANKL inhibitor approved to prevent osteoclast-mediated bone loss. Chemically, it consists of 2 heavy...
Approved
Matched Description: … [A263071] Chemically, it consists of 2 heavy and 2 light chains, with each light chain consisting of ... Denosumab is a novel, fully human IgG2 monoclonal antibody specific to receptor activator of nuclear ... factor kappa-B ligand (RANKL), suppresses bone resorption via inhibiting RANK-mediated activation of …
Matched Categories: … Drugs for Treatment of Bone Diseases …
Displaying drugs 201 - 225 of 10358 in total