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Displaying drugs 2251 - 2275 of 14991 in total

Etranacogene dezaparvovec

Hemophilia B - also called factor IX deficiency or Christmas disease - is an X-linked genetic disorder resulting in an absence or deficiency of clotting factor IX. Clotting factors, including factor IX, are necessary components of the signaling cascade responsible for blood clotting and subsequent wound healing. Symptoms of hemophilia...
Approved
Investigational
Matched Description: … including factor IX, are necessary components of the signaling cascade responsible for blood clotting and ... recommended etranacogene dezaparvovec be granted marketing authorization for the treatment of severe and ... [L45255] Etranacogene dezaparvovec was approved by the EMA in February 2023[L45439,L45444] and by Health …
Matched Categories: … Cellular and Gene Therapy ... Blood and Blood Forming Organs …

Carboprost tromethamine

A nonsteroidal abortifacient agent that is effective in both the first and second trimesters of pregnancy.
Approved
Matched Iupac: … -7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-3-methyloct-1-en-1-yl]cyclopentyl]hept-5-enoic acid …
Matched Description: … A nonsteroidal abortifacient agent that is effective in both the first and second trimesters of pregnancy …
Matched Categories: … Genito Urinary System and Sex Hormones …

Ergoloid mesylate

Ergoloid Mesylate is an equiproportional preparation of three different ergotamantriones: dihydroergocornine, dihydroergocristine, and dihydroergocryptine. All these components are produced by the fungus Claviceps purpurea and are all derivatives of the tetracyclic compound 6-methylergonovine. The derivatives of this fungus are identified to be about 350 different substances from which the components...
Approved
Matched Description: … [A32912] All these components are produced by the fungus _Claviceps purpurea_ and are all derivatives ... equiproportional preparation of three different ergotamantriones: dihydroergocornine, dihydroergocristine, and ... [A32914] The mixture of ergoloid mesylate was first developed by Novartis and FDA approved on November …
Matched Categories: … Ergot Alkaloids and Derivatives …

Eptotermin alfa

A bone morphogenetic protein that is widely expressed during EMBRYONIC DEVELOPMENT. It is both a potent osteogenic factor and a specific regulator of nephrogenesis. Eptotermin alfa is an ingredient in the EMA-withdrawn product Osigraft.
Approved
Investigational
Withdrawn
Matched Description: … It is both a potent osteogenic factor and a specific regulator of nephrogenesis. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Intercellular Signaling Peptides and Proteins ... Drugs Affecting Bone Structure and Mineralization …

Dibotermin alfa

Dibotermin alfa is a recombinant human bone morphogenetic protein-2 (rhBMP-2) derived from a recombinant Chinese Hamster Ovary (CHO) cell line [FDA Label]. It is implanted in patients undergoing bone surgeries or those with fractures. BMPs are subfamily of the transforming growth factor-β (TGF-β) superfamily that have different actions on the...
Approved
Investigational
Matched Description: … In 2004, it was approved by the FDA and is marketed as Infuse. ... critical role in the differentiation of osteoprogenitor cells into osteoblasts, thus promoting bone and ... at the site of implantation, dibotermin alfa accelerates the healing of open tibial shaft fractures and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Intercellular Signaling Peptides and Proteins ... Drugs Affecting Bone Structure and Mineralization …

Dasiglucagon

Dasiglucagon is a glucagon analog that acts to increase blood sugar levels. It consists of 29 amino acids similar to endogenous glucagon; however, it contains seven substituted amino acids for improved physical and chemical stability in its drug formulation. In March 2021, the FDA approved dasiglucagon to treat severe hypoglycemia...
Approved
Investigational
Matched Description: … similar to endogenous glucagon; however, it contains seven substituted amino acids for improved physical and ... L39195] In March 2021, the FDA approved dasiglucagon to treat severe hypoglycemia in patients six years and ... Hypoglycemia is a common side effect of antidiabetic treatments, most notably insulin and sulfonylureas …
Matched Categories: … Sex Hormones and Insulins ... Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Magnesium glycinate

Magnesium glycinate is a magnesium salt of glycine that is available as dietary supplements as a source of magnesium. It is used in the treatment of magnesium deficiency.
Approved

Cladribine

Cladribine is a purine analogue or a chlorinated derivative of adenine that causes apoptosis of B and T lymphocytes. Cladribine was first approved in the United States in 1993 initially as a treatment for a number of hematological malignancies; currently, it is approved for the treatment of hairy cell leukemia....
Approved
Investigational
Matched Description: … Cladribine is a purine analogue or a chlorinated derivative of adenine [A263733] that causes apoptosis of B and ... [A263733] In 2017 in Europe and in 2019 in the United States, cladribine was also approved for the treatment …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Nucleic Acids, Nucleotides, and Nucleosides …

Colistin

Cyclic polypeptide antibiotic from Bacillus colistinus. It is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes. Colistin is less toxic than Polymyxin B, but otherwise similar; the methanesulfonate is used orally.
Approved
Matched Description: … It is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes …
Matched Categories: … Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins …

Lomustine

An alkylating agent of value against both hematologic malignancies and solid tumors.
Approved
Investigational
Matched Description: … An alkylating agent of value against both hematologic malignancies and solid tumors. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Anistreplase

Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. Eminase is a lyophilized (freeze-dried) formulation of anistreplase, the p-anisoyl derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and streptokinase). A p-anisoyl group is chemically conjugated to a complex of bacterial-derived streptokinase and human Plasma-derived...
Approved
Matched Description: … A p-anisoyl group is chemically conjugated to a complex of bacterial-derived streptokinase and human ... derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and …
Matched Categories: … Enzymes and Coenzymes ... Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …

Tisagenlecleucel

Tisagenlecleucel is a CD19-directed genetically modified autologous T cell immunotherapy, or a CAR-T cell therapy for B-cell acute lymphoblastic leukemia. It was granted approval by FDA in August 2017 under the market name Kymriah. Tisagenlecleucel is an immunocellular therapy that involves autologous T cells that are collected from each individual...
Approved
Investigational
Matched Description: … These CD19-directed chimeric antigen receptors (CD19 CAR-T cells) direct the T cells to target and kill ... immunocellular therapy that involves autologous T cells that are collected from each individual patient and ... In a multicenter clinical trial involving pediatric and young adult patients with relapsed or refractory …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic cell and gene therapy ... Antineoplastic and Immunomodulating Agents …

Bemiparin

Bemiparin is an antithrombotic and belongs to the group of drugs known as the low molecular weight heparins (LMWH). Like semuloparin, bemiparin is classified as an ultra-LMH because of its low mean molecular mass of 3600 daltons, which is a unique property of this class . These heparins have lower...
Approved
Investigational
Matched Description: … Bemiparin is an antithrombotic and belongs to the group of drugs known as the low molecular weight heparins ... These heparins have lower anti-thrombin activity than the traditional low molecular weight heparins and ... Interestingly, current research is underway for the potential benefit of bemiparin in the treatment of tumors and …
Matched Categories: … Heparin and similars ... Blood and Blood Forming Organs …

Polistes metricus venom protein

Polistes metricus venom protein is an extract of Polistes metricus venom. Polistes metricus venom protein is used in allergenic testing.
Approved
Matched Categories: … Bee and Wasp Venom …

Sarracenia Purpurea

Sarracenia purpurea, commonly known as the purple pitcher plant, northern pitcher plant, turtle socks, or side-saddle flower, is a perennial carnivorous plant in the family Sarraceniaceae. Sarracenia purpurea attract and trap insects within their pitchers, or fused leaves, to consume nitrogen during the digestion process . It is widely distributed...
Approved
Experimental
Matched Description: … It is widely distributed across North America and has been used as a traditional medicinal herb in many ... It was used as an injectable pain reliever and during the 19th century, _Sarracenia purpurea_ was used ... Compounds extracted from _Sarracenia purpurea_ include phenolic glycosides, flavonoid glycosides, and …
Matched Categories: … Miscellaneous Analgesics and Antipyretics …

Tilbroquinol

Tilbroquinol was approved in France, Morocco, and Saudi Arabia but it has been withdrawn in France and Saudi Arabia markets mainly due to its hepatotoxicity risk outweighing the drug benefit . In Morocco, the drug has been limited to use in the treatment of intestinal amoebiasis.
Approved
Matched Description: … Tilbroquinol was approved in France, Morocco, and Saudi Arabia but it has been withdrawn in France and …
Matched Categories: … tilbroquinol and tiliquinol ... Antiparasitic Products, Insecticides and Repellents …

Noxytiolin

Local antibacterial that probably acts by releasing formaldehyde in aqueous solutions. It is used for THERAPEUTIC IRRIGATION of infected body cavities - bladder, peritoneum, etc. and as a spray for burns.
Approved
Matched Description: … It is used for THERAPEUTIC IRRIGATION of infected body cavities - bladder, peritoneum, etc. and as a …
Matched Categories: … Blood and Blood Forming Organs ... Blood Substitutes and Perfusion Solutions …

Streptokinase

Streptokinase, is a sterile, purified preparation of a bacterial protein elaborated by group C (beta) -hemolytic streptococci.
Approved
Investigational
Matched Categories: … Enzymes and Coenzymes ... Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …

Insulin pork

Insulin isolated from pig pancreas. Composed of alpha and beta chains, processed from pro-insulin. Forms a hexameric structure.
Approved
Matched Description: … Composed of alpha and beta chains, processed from pro-insulin. Forms a hexameric structure. …
Matched Categories: … Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins ... Insulins and Analogues for Injection, Fast-Acting ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Clioquinol

Clioquinol was withdrawn in 1983 due to neurotoxicity.
Approved
Vet approved
Withdrawn
Matched Categories: … Antiseptics and Disinfectants ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics ... Antiparasitic Products, Insecticides and Repellents …

Bucetin

Bucetin is an analgesic and antipyretic medication which was approved for use in Germany but was withdrawn from the market in 1986 due to renal toxicity caused by the medication.
Approved
Withdrawn
Matched Description: … Bucetin is an analgesic and antipyretic medication which was approved for use in Germany but was withdrawn …

Sertaconazole

Sertaconazole nitrate is an antifungal medication of the imidazole class. It is available in topical formulations for the treatment of skin infections such as athlete's foot.
Approved
Investigational
Matched Categories: … Imidazole and Triazole Derivatives ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …

Isoconazole

Isoconazole is an azole antifungal drug that has similar effectiveness to clotrimazole in the treatment of foot and vaginal infections.
Approved
Matched Description: … is an azole antifungal drug that has similar effectiveness to clotrimazole in the treatment of foot and …
Matched Categories: … Imidazole and Triazole Derivatives ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …

Epcoritamab

Epcoritamab is an IgG1-bispecific antibody that simultaneously binds to CD3 on T-cells and CD20 on B-cells.[A259736,A258488,A259761,L46516] Epcoritamab promotes the activation and expansion of T-cells and, by being able to bind to both CD20 and CD3, it leads to the T-cell–mediated killing of CD20+ malignant B cells.[A259761,L46516] Diffuse large B-cell lymphoma...
Approved
Investigational
Matched Description: … [A259736,A258488,A259761,L46516] Epcoritamab promotes the activation and expansion of T-cells and, by ... [L46516] It is administered subcutaneously and is currently being evaluated as a monotherapy and in combination ... Epcoritamab is an IgG1-bispecific antibody that simultaneously binds to CD3 on T-cells and CD20 on B-cells …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …

Polistes exclamans venom protein

Polistes exclamans venom protein is an extract of Polistes exclamans venom. Polistes exclamans venom protein is used in allergenic testing.
Approved
Matched Categories: … Bee and Wasp Venom …
Displaying drugs 2251 - 2275 of 14991 in total