Displaying drugs 2426 - 2450 of 15068 in total
Etrasimod
Etrasimod is a synthetic next-generation selective Sphingosine 1-phosphate (S1P) receptor modulator that targets the S1P1,4,5 with no detectable activity on S1P2 and S1P3 receptors. S1P receptors are membrane-derived lysophospholipid signaling molecules that are involved in the sequestration of circulating peripheral lymphocytes in lymph nodes. Therefore, S1P receptor modulators like etrasimod...
Approved
Matched Iupac: … 3R)-7-{[4-cyclopentyl-3-(trifluoromethyl)phenyl]methoxy}-1H,2H,3H,4H-cyclopenta[b]indol-3-yl]acetic acid …
Matched Description: … 26% remission rate observed in UC 52 and UC 12 trials respectively. ... receptor modulator that targets the S1P1,4,5 with no detectable activity on S1P2 and ... obtained from Pfizer’s Elevate UC Phase III registrational program, consisting of the Elevate UC 52 and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Description: … 26% remission rate observed in UC 52 and UC 12 trials respectively. ... receptor modulator that targets the S1P1,4,5 with no detectable activity on S1P2 and ... obtained from Pfizer’s Elevate UC Phase III registrational program, consisting of the Elevate UC 52 and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Selexipag
Selexipag was approved by the United States FDA on December 22, 2015 for the treatment of pulmonary arterial hypertension (PAH) to delay disease progression and reduce risk of hospitalization. PAH is a relatively rare disease with usually a poor prognosis requiring more treatment options to prolong long-term outcomes. Marketed by...
Approved
Matched Description: … December 22, 2015 for the treatment of pulmonary arterial hypertension (PAH) to delay disease progression and ... Marketed by Actelion Pharmaceuticals under brand name Uptravi, selexipag and its active metabolite, ACT ... act as agonists of the prostacyclin receptor to increase vasodilation in the pulmonary circulation and …
Matched Categories: … Blood and Blood Forming Organs …
Matched Categories: … Blood and Blood Forming Organs …
Risdiplam
Risdiplam is an orally bioavailable mRNA splicing modifier used for the treatment of spinal muscular atrophy (SMA). It increases systemic SMN protein concentrations by improving the efficiency of SMN2 gene transcription. This mechanism of action is similar to its predecessor nusinersen, the biggest difference being their route of administration: nusinersen...
Approved
Investigational
Matched Description: … substantially cheaper than other available SMA therapies,[L15351] risdiplam appears to provide a novel and …
Primidone
Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954.
Approved
Vet approved
Matched Description: … [L11112] Primidone was developed by J Yule Bogue and H C Carrington in 1949. ... Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and …
Matched Categories: … Barbiturates and Derivatives ... Hypnotics and Sedatives ... Phenobarbital and similars …
Matched Categories: … Barbiturates and Derivatives ... Hypnotics and Sedatives ... Phenobarbital and similars …
Aprepitant
Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective high-affinity antagonist of human substance...
Approved
Investigational
Matched Description: … delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy ... targets of existing therapies for chemotherapy-induced nausea and vomiting (CI NV). ... antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and …
Matched Categories: … Aprepitant and Prodrugs ... Alimentary Tract and Metabolism ... Antiemetics and Antinauseants …
Matched Categories: … Aprepitant and Prodrugs ... Alimentary Tract and Metabolism ... Antiemetics and Antinauseants …
Hepatitis A Vaccine
Hepatitis A viral infection can lead to significant morbidity and mortality, with signs and symptoms that include anorexia, nausea, vomiting, and liver failure. Known by several trade names, such as Havrix and Twinrix, the Hepatitis A vaccine has been formulated for immunization against hepatitis A virus (HAV) infection and safely...
Approved
Matched Description: … Hepatitis A viral infection can lead to significant morbidity and mortality, with signs and symptoms ... that include anorexia, nausea, vomiting, and liver failure. ... [A199182] Known by several trade names, such as Havrix and Twinrix, the Hepatitis A vaccine has been …
Mequinol
Mequinol is a phenol used in various applications. It is used as an inhibitor for acrylic monomers and acrylonitirles, as a stabilizer for chlorinated hydrocarbons and ethyl cellulose, as an ultraviolet inhibitor, as a chemical intermediate in the manufacture of antioxidants, pharmaceuticals, plasticizers, and dyestuffs . It is found as...
Approved
Matched Description: … , pharmaceuticals, plasticizers, and dyestuffs [L993]. ... It is used as an inhibitor for acrylic monomers and acrylonitirles, as a stabilizer for chlorinated hydrocarbons ... and ethyl cellulose, as an ultraviolet inhibitor, as a chemical intermediate in the manufacture of antioxidants …
Miocamycin
Miocamycin is a macrolide type antimicrobial . This drug may be marketed in Japan for clinical use as it is listed in the Japanese pharmacopeia . It has shown to be effective against several gram-positive and gram-negative microbes and may be useful in the treatment of upper and lower respiratory...
Approved
Matched Description: … It has shown to be effective against several gram-positive and gram-negative microbes and may be useful ... in the treatment of upper and lower respiratory tract infections, and urogenital tract infections or …
Matched Categories: … Macrolides, Lincosamides and Streptogramins …
Matched Categories: … Macrolides, Lincosamides and Streptogramins …
Aluminum sulfate
Aluminum (Al), also spelled aluminum, chemical element, a lightweight, silvery-white metal of main Group 13 (IIIa, or boron group) of the periodic table .
It is a chemical agent used in water purification, the pH regulation of garden soil, and other commercial or industrial applications. Medically, it is primarily used...
Approved
Matched Description: … , and tap water. ... bone and the central nervous system [L2145]. ... Aluminum (Al) is ubiquitous and represents the third most common element in the Earth’s crust. …
Xenon-133
Xenon-133 is an inhaled radionuclide used for lung imaging, imaging blood flow in the brain, and to assess pulmonary function.
Approved
Matched Description: … Xenon-133 is an inhaled radionuclide used for lung imaging, imaging blood flow in the brain, and to assess …
Zavegepant
Zavegepant (BHV-3500) is a calcitonin gene-related peptide (CGRP) receptor antagonist. CGRP is released from sensory nerves and acts as a strong vasodilator, and thanks to these properties, it is involved in pain pathways. CGRP receptors are expressed in the central and peripheral nervous system; however, CGRP does not cross the...
Approved
Investigational
Matched Description: … [L45505] CGRP is released from sensory nerves and acts as a strong vasodilator, and thanks to these properties ... oral zavegepant in migraine prevention, and another one (NCT04987944) is evaluating the safety and efficacy ... other drugs such as [rimegepant] and [ubrogepant]. …
Matched Salts name: … Zavegepant hydrochloride …
Matched Salts name: … Zavegepant hydrochloride …
Echothiophate
A potent, long-acting irreversible cholinesterase inhibitor used as an ocular hypertensive in the treatment of glaucoma. Occasionally used for accomodative esotropia.
Approved
Matched Categories: … Antiglaucoma Preparations and Miotics …
Brolucizumab
Brolucizumab, also known as RTH258 or ESBA1008, is a monoclonal antibody indicated to treat neovascular age related macular degeneration. Brolucizumab was granted FDA approval in October 2019.
Approved
Investigational
Matched Categories: … Amino Acids, Peptides, and Proteins …
Pentosan polysulfate
Pentosan polysulfate is a sulfated pentosyl polysaccharide with heparin-like properties.
Approved
Matched Iupac: … hydroxy-2-{[(3R,4S,5R,6R)-6-hydroxy-4,5-bis(sulfooxy)oxan-3-yl]oxy}-4-(sulfooxy)oxan-3-yl]oxidanesulfonic acid …
Matched Categories: … Genito Urinary System and Sex Hormones …
Matched Categories: … Genito Urinary System and Sex Hormones …
Trolamine polypeptide oleate condensate
Various ear diseases and infections are treated with eardrops containing triethanolamine polypeptide oleate-condensate, such as Cerumenex in the United States and Canada.
Approved
Vet approved
Matched Description: … oleate-condensate, such as Cerumenex in the United States and Canada. ... Various ear diseases and infections are treated with eardrops containing triethanolamine polypeptide …
Carvedilol
Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is advantageous in combination therapies as...
Approved
Investigational
Matched Description: … , and the R(+) enantiomer is an alpha-1 adrenoceptor blocker. ... Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker ... [L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension …
Matched Categories: … carvedilol and ivabradine ... Alpha and Beta Blocking Agents ... Calcium-Regulating Hormones and Agents …
Matched Categories: … carvedilol and ivabradine ... Alpha and Beta Blocking Agents ... Calcium-Regulating Hormones and Agents …
Fusidic acid
An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed) It acts by inhibiting translocation during protein synthesis. It is often used topically in creams and eyedrops but is available in systemic formulations including tablets and injections.
Approved
Investigational
Matched Synonyms: … Fucidin acid ... Fusidic acid …
Matched Name: … Fusidic acid …
Matched Iupac: … dihydroxy-3a,3b,6,9a-tetramethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-1-ylidene]-6-methylhept-5-enoic acid …
Matched Description: … tablets and injections. ... It is often used topically in creams and eyedrops but is available in systemic formulations including …
Matched Mixtures name: … BACTAFUZ-B Fusidic Acid and Betamethasone Valerate Cream ... AXCEL FUSIDIC ACID-B CREAM …
Matched Salts name: … Fusidic acid hemihydrate …
Matched Categories: … fusidic acid ... fusidic acid ... fusidic acid ... fusidic acid …
Matched Products: … FUSIDIC ACID ... Taro-fusidic Acid ... AXCEL FUSIDIC ACID CREAM …
Matched Name: … Fusidic acid …
Matched Iupac: … dihydroxy-3a,3b,6,9a-tetramethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-1-ylidene]-6-methylhept-5-enoic acid …
Matched Description: … tablets and injections. ... It is often used topically in creams and eyedrops but is available in systemic formulations including …
Matched Mixtures name: … BACTAFUZ-B Fusidic Acid and Betamethasone Valerate Cream ... AXCEL FUSIDIC ACID-B CREAM …
Matched Salts name: … Fusidic acid hemihydrate …
Matched Categories: … fusidic acid ... fusidic acid ... fusidic acid ... fusidic acid …
Matched Products: … FUSIDIC ACID ... Taro-fusidic Acid ... AXCEL FUSIDIC ACID CREAM …
Agkistrodon piscivorus antivenin
Agkistrodon piscivorus antivenin is derived and purified immunoglobulin fragments obtained from other domestic animals such as sheep previously immunized with Agkistrodon piscivorus (Cottonmouth or Water Moccasin snake). The final purified antivenin product is obtained by mixing other different monospecific snake antivenins and isolating the antivenin of interest through fractionation and...
Approved
Experimental
Matched Description: … Sistrurus spp.) and the copperheads and cottonmouth water moccasins (Agkistrodon spp.) ... isolating the antivenin of interest through fractionation and chromatography techniques. ... Agkistrodon piscivorus antivenin is derived and purified immunoglobulin fragments obtained from other …
Tedizolid phosphate
Drug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, and penicillin-resistant Streptococcus penumoniae, represent a massive public health threat.[A199086, A199131] Tedizolid is a member of the oxazolidinone class of antibiotics, which includes the previously approved linezolid and is generally effective against multidrug-resistant Gram-positive bacteria. Tedizolid is indicated for the...
Approved
Matched Iupac: … 2-methyl-2H-1,2,3,4-tetrazol-5-yl)pyridin-3-yl]phenyl}-2-oxo-1,3-oxazolidin-5-yl]methoxy}phosphonic acid …
Matched Description: … ) and is generally more effective and more tolerable than [linezolid]. ... such as methicillin-resistant _Staphylococcus aureus_, vancomycin-resistant _Enterococcus faecium_, and ... member of the oxazolidinone class of antibiotics, which includes the previously approved [linezolid] and …
Matched Description: … ) and is generally more effective and more tolerable than [linezolid]. ... such as methicillin-resistant _Staphylococcus aureus_, vancomycin-resistant _Enterococcus faecium_, and ... member of the oxazolidinone class of antibiotics, which includes the previously approved [linezolid] and …
Bithionol
Bithionol, formerly marketed as an active ingredient in various topical drug products, was shown to be a potent photosensitizer with the potential to cause serious skin disorders. Approvals of the NDA's for bithionol drug products were withdrawn on October 24, 1967 (see the Federal Register of October 31, 1967 (32...
Approved
Withdrawn
Matched Categories: … Antiparasitic Products, Insecticides and Repellents …
Fludeoxyglucose (18F)
Fludeoxyglucose F 18 Injection is a positron emitting radiopharmaceutical containing no-carrier added radioactive 2-deoxy-2-[18F]fluoro-D-g1ucose, which is used for diagnostic purposes in conjunction with Positron Emission Tomography (PET). It is administered by intravenous injection.
Approved
Investigational
Matched Categories: … Indicators and Reagents …
Human papillomavirus type 6 L1 capsid protein antigen
Human papillomavirus type 6 L1 capsid protein antigen is contained in Gardasil, or a recombinant Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus...
Approved
Investigational
Matched Description: … by Human Papillomavirus (HPV) types 6, 11, 16 and 18. ... antigen is contained in Gardasil, or a recombinant Human Papillomavirus Quadrivalent (Types 6, 11, 16, and ... It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused …
Phenytoin
Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for several other indications such as...
Approved
Vet approved
Matched Description: … Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one ... [A189219,A35884] Both parenteral and oral formulations of phenytoin are available on the market. ... has also been investigated for several other indications such as bipolar disorder, retina protection, and …
Matched Categories: … Phenytoin and Prodrugs ... Metabolic Side Effects of Drugs and Substances …
Matched Categories: … Phenytoin and Prodrugs ... Metabolic Side Effects of Drugs and Substances …
Povidone K30
A polyvinyl polymer of variable molecular weight; used as suspending and dispersing agent and vehicle for pharmaceuticals; also used as blood volume expander. See povidone for full details.
Approved
Experimental
Matched Description: … A polyvinyl polymer of variable molecular weight; used as suspending and dispersing agent and vehicle …
Pimozide
A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994,...
Approved
Matched Description: … for the suppression of vocal and motor tics in patients with Tourette syndrome. ... A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol …
Displaying drugs 2426 - 2450 of 15068 in total