Displaying drugs 1 - 25 of 1275 in total
Anti-inhibitor coagulant complex
Anti-inhibitor coagulant complex, also known as FEIBA (factor eight inhibitor bypassing activity), contains several proteins involved in the prothrombinase complex. It is used to control bleeding in hemophilia A and B patients with inhibitors.
Approved
Investigational
Matched Synonyms: … Factor VIII inhibitor bypassing activity ... Factor VIII inhibitor bypassing fraction …
Matched Name: … Anti-inhibitor coagulant complex …
Matched Description: … Anti-inhibitor coagulant complex, also known as FEIBA (factor eight inhibitor bypassing activity), contains …
Matched Categories: … factor VIII inhibitor bypassing activity …
Matched Products: … FEIBA (Factor VIII Inhibitor Bypassing Activity) 25U/ml Powder and solvent for solution for infusion ... FEIBA (Factor VIII Inhibitor Bypassing Activity) 50U/ml Powder and solvent for solution for infusion …
Matched Name: … Anti-inhibitor coagulant complex …
Matched Description: … Anti-inhibitor coagulant complex, also known as FEIBA (factor eight inhibitor bypassing activity), contains …
Matched Categories: … factor VIII inhibitor bypassing activity …
Matched Products: … FEIBA (Factor VIII Inhibitor Bypassing Activity) 25U/ml Powder and solvent for solution for infusion ... FEIBA (Factor VIII Inhibitor Bypassing Activity) 50U/ml Powder and solvent for solution for infusion …
Aprotinin
Aprotinin is a protein-based drug that is also known as bovine pancreatic trypsin inhibitor (BPTI). Since it demonstrates the capacity to slow fibrinolysis, it has been employed to reduce bleeding during complex surgery such as heart and liver surgery. For this use, it is typically administered by injection. The goal...
Approved
Investigational
Withdrawn
Matched Synonyms: … Fibrinolysis inhibitor ... Bovine pancreatic trypsin inhibitor ... Trypsin inhibitor, pancreatic basic …
Matched Description: … Aprotinin is a protein-based drug that is also known as bovine pancreatic trypsin inhibitor (BPTI). …
Matched Description: … Aprotinin is a protein-based drug that is also known as bovine pancreatic trypsin inhibitor (BPTI). …
Andexanet alfa
Andexanet alfa is a recombinant human coagulation Factor Xa that promotes blood coagulation. It was developed by Portola Pharmaceuticals and was approved in in May 2018. It is marketed as Andexxa for intravenous injection or infusion and is indicated for the reversal of anticoagulation in combination with rivaroxaban and apixaban...
Approved
Investigational
Matched Synonyms: … rfXa Inhibitor Antidote …
Sotorasib
Sotorasib, also known as AMG-510, is an acrylamide-derived KRAS inhibitor developed by Amgen.[A187547,A187556] It is indicated in the treatment of adult patients with KRAS G12C mutant non-small cell lung cancer. This mutation makes up >50% of all KRAS mutations. Mutant KRAS discovered in 1982 but was not considered a druggable...
Approved
Investigational
Matched Synonyms: … Kras G12C inhibitor 9 …
Matched Description: … [A235168] It is the first experimental KRAS inhibitor. ... Sotorasib, also known as AMG-510, is an acrylamide-derived KRAS inhibitor developed by Amgen. …
Matched Description: … [A235168] It is the first experimental KRAS inhibitor. ... Sotorasib, also known as AMG-510, is an acrylamide-derived KRAS inhibitor developed by Amgen. …
Adagrasib
Adagrasib (MRTX849) is an oral, small-molecule KRAS inhibitor developed by Mirati Therapeutics. KRAS mutations are highly common in cancer and account for approximately 85% of all RAS family mutations. However, the development of KRAS inhibitors has been challenging due to their high affinity for guanosine triphosphate (GTP) and guanosine diphosphate...
Approved
Investigational
Matched Synonyms: … KRAS G12C inhibitor MRTX849 …
Matched Description: … Adagrasib (MRTX849) is an oral, small-molecule KRAS inhibitor developed by Mirati Therapeutics. ... [L44361,L44366] Adagrasib joins [sotorasib] as another KRASG12C inhibitor approved by the …
Matched Description: … Adagrasib (MRTX849) is an oral, small-molecule KRAS inhibitor developed by Mirati Therapeutics. ... [L44361,L44366] Adagrasib joins [sotorasib] as another KRASG12C inhibitor approved by the …
Anastrozole
Anastrozole is a non-steroidal aromatase inhibitor (AI), similar to letrozole, used to decrease circulating estrogen levels in the treatment of postmenopausal women with estrogen-responsive breast cancer. Anastrozole is also related to exemestane, a steroidal AI, but its non-steroidal nature provides stark advantages including a lack of steroid-associated adverse effects such...
Approved
Investigational
Matched Description: … Anastrozole is a non-steroidal aromatase inhibitor (AI), similar to [letrozole], used to decrease circulating ... [A186865] Aromatase inhibitors, including anastrozole, have become endocrine drugs of choice in the treatment …
Matched Categories: … Aromatase Inhibitors …
Matched Categories: … Aromatase Inhibitors …
Coagulation factor VII human
Coagulation factor VII is human serine protease type enzyme that is involved in the extrinsic coagulation cascade which results in blood clotting.
Approved
Investigational
Matched Mixtures name: … Feiba Vh Immuno Anti Inhibitor …
Prothrombin
Prothrombin Complex Concentrate (Human), is indicated for the urgent reversal of acquired coagulation factor deficiency induced by Vitamin K antagonist (VKA, e.g., warfarin) therapy in adult patients with acute major bleeding.
Approved
Matched Mixtures name: … Feiba Vh Immuno Anti Inhibitor …
Antihemophilic factor human
Antihemophilic factor human, also known as Coagulation Factor VIII or Anti-Hemophilic Factor (AHF), is a non-recombinant, lyophilized concentrate of coagulation factor VIII, an endogenous protein and essential component of the coagulation cascade. Antihemophilic factor is manufactured with reduced amounts of von Willebrand Factor antigen (VWF:Ag) and purified from extraneous plasma-derived...
Approved
Matched Mixtures name: … Feiba Vh Immuno Anti Inhibitor …
Saquinavir
Saquinavir is an HIV-1 protease inhibitor used in combination with ritonavir and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due to a...
Approved
Investigational
Matched Description: … Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals ... In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in ... approximately 4%),[L3450] its current indications require the co-administration of ritonavir - a potent enzyme inhibitor …
Levodopa
Levodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability to cross the blood-brain barrier[Label]. Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prevent...
Approved
Matched Description: … either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor …
Matched Categories: … levodopa, decarboxylase inhibitor and COMT inhibitor ... levodopa and decarboxylase inhibitor …
Matched Categories: … levodopa, decarboxylase inhibitor and COMT inhibitor ... levodopa and decarboxylase inhibitor …
Estrone
Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion of adrostenedione....
Approved
Spirapril
Spirapril is an ACE inhibitor antihypertensive drug used to treat hypertension. Spirapril is converted to the active spiraprilat after administration. ACE inhibitors are used primarily in treatment of hypertension and congestive heart failure.
Approved
Matched Description: … Spirapril is an ACE inhibitor antihypertensive drug used to treat hypertension. …
Voxilaprevir
Voxilaprevir is a Direct-Acting Antiviral (DAA) medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common...
Approved
Investigational
Matched Description: … infection and have previously been treated with an HCV regimen containing sofosbuvir without an NS5A inhibitor ... Vosevi is approved for use in patients with genotypes 1-6 who have been previously treated with an NS5A inhibitor ... retreatment options for patients who have previously received, and failed, a regimen containing an NS5A inhibitor …
Cangrelor
Cangrelor is an intravenous, direct-acting, reversible P2Y12 inhibitor for patients undergoing percutaneous coronary intervention (PCI) who have not been yet treated by oral P2Y12 inhibitors. An advantage Cangrelor provides over oral P2Y12 inhibitors (such as prasugrel, ticagrelor, and clopidogrel) is that it is an active drug not requiring metabolic conversion...
Approved
Matched Description: … Cangrelor is an intravenous, direct-acting, reversible P2Y12 inhibitor for patients undergoing percutaneous …
Matched Categories: … P2Y12 Platelet Inhibitor …
Matched Categories: … P2Y12 Platelet Inhibitor …
Telbivudine
Telbivudine is a synthetic thymidine nucleoside analog with specific activity against the hepatitis B virus. Telbivudine is orally administered, with good tolerance, lack of toxicity and no dose-limiting side effects.
Approved
Investigational
Matched Categories: … Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor …
Testosterone
Testosterone is a steroid sex hormone indicated to treat primary hypogonadism and hypogonadotropic hypogonadism.[L8983,L8935,L8938,L8986,L8989,L8992,L8995] Testosterone antagonizes the androgen receptor to induce gene expression that causes the growth and development of masculine sex organs and secondary sexual characteristics.[A187114,L8983,L8935,L8938,L8986,L8989,L8992,L8995]
Testosterone was isolated from samples and also synthesized in 1935.
Approved
Investigational
Stanozolol
Stanozolol is a synthetic anabolic steroid with therapeutic uses in treating hereditary angioedema. Stanozolol is derived from testosterone, and has been abused by several high profile professional athletes.
Approved
Vet approved
Plerixafor
Plerixafor is a small-molecule inhibitor of C-X-C chemokine receptor type 4 (CXCR4) that acts as a hematopoietic stem cell mobilizer.[A7117,L45678] It is used to stimulate the release of stem cells from the bone marrow into the blood in patients with non-Hodgkin's lymphoma (NHL) and multiple myeloma to stimulate their immune...
Approved
Investigational
Matched Description: … Plerixafor is a small-molecule inhibitor of C-X-C chemokine receptor type 4 (CXCR4) that acts as a hematopoietic ... [A7118,L45678]
As an inhibitor of CXCR4, plerixafor blocks the binding of its ligand, stromal cell-derived …
Thrombin alfa
Thrombin Alfa is a human coagulation protein produced via recombinant DNA technology from a genetically modified CHO cell line. Thrombin Alfa is identical in amino acid sequence and structurally similar to naturally occurring human thrombin. Thrombin Alfa precursor is secreted to culture medium as single chain form that is proteolytically...
Approved
Moclobemide
A reversible monoamine oxidase inhibitor (MAOI) selective for isoform A (RIMA) used to treat major depressive disorder. Most meta-analyses and most studies indicate that in the acute management of depression, moclobemide is more efficacious than placebo medication and similarly efficacious as tricyclic antidepressants (TCA) or selective serotonin reuptake inhibitors (SSRIs)....
Approved
Investigational
Matched Description: … A reversible monoamine oxidase inhibitor (MAOI) selective for isoform A (RIMA) used to treat major depressive …
Odevixibat
Odevixibat, or A4250, is an ileal sodium/bile acid cotransporter inhibitor indicated for the treatment of pruritus in patients older than 3 months, with progressive familial intrahepatic cholestasis (PFIC).[A236808,L34793] Odevixibat is the first approved non-surgical treatment option for PFIC. Previous therapies for PFIC included a bile acid sequestrant such as ursodeoxycholic...
Approved
Investigational
Matched Description: … Odevixibat, or A4250, is an ileal sodium/bile acid cotransporter inhibitor indicated for the treatment …
Matched Categories: … Ileal bile acid transport inhibitor ... Ileal Bile Acid Transporter Inhibitor …
Matched Categories: … Ileal bile acid transport inhibitor ... Ileal Bile Acid Transporter Inhibitor …
Foslevodopa
Foslevodopa is under investigation in clinical trial NCT04750226 (Study to Assess Adverse Events and Change in Disease Activity of 24-hour Continuous Subcutaneous Infusion of ABBV-951 in Adult Participants With Advanced Parkinson's Disease).
Approved
Investigational
Matched Categories: … foslevodopa and decarboxylase inhibitor …
Pirtobrutinib
Pirtobrutinib is a small molecule and a highly selective non-covalent inhibitor of Bruton’s tyrosine kinase (BTK). Its high selectivity has been associated with lower discontinuation rates due to adverse events and a lower incidence of atrial fibrillation. Unlike BTK covalent inhibitors, such as ibrutinib, that bind to the cysteine 481...
Approved
Investigational
Matched Description: … Pirtobrutinib is a small molecule and a highly selective non-covalent inhibitor of Bruton’s tyrosine …
Matched Categories: … Kinase Inhibitor …
Matched Categories: … Kinase Inhibitor …
Colesevelam
Colesevelam is a bile acid sequestrant. Colesevelam is used with exercise and diet changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol and certain fatty substances in the blood. It works by binding bile acids in the intestine. Bile acids are made when cholesterol is broken...
Approved
Displaying drugs 1 - 25 of 1275 in total