Trazodone is a serotonin uptake inhibitor used to treat major depressive disorder. Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants.
- Mechanism
- Curator reviewed · 8 references
The mechanism of action of trazodone is not fully understood, however, it is known to inhibit the reuptake of serotonin and block both histamine and alpha-1-adrenergic receptors. Despite the fact that trazodone is frequently considered a selective serotonin reuptake inhibitor, several reports have shown that other mechanisms including antagonism at serotonin 5-HT1a, 5-HT1c, and 5-HT2 receptor subtypes may occur. The strongest antagonism of trazodone is reported to occur at the serotonin 5-HT21c receptors, preventing serotonin uptake. In addition to acting on serotonin receptors, trazodone has been shown to inhibit serotonin transporters. The antidepressant effects of trazodone result from the inhibition of receptor uptake, which normally decreases circulating neurotransmitters, contributing to depressive symptoms.
- Primary indication
- Trazodone is indicated for the treatment of major depressive disorder (MDD).Curator reviewed · 12 structured indications
- Formula / weight
- C19H22ClN5O · 371.864 g/mol (avg)
- First approval
- Canada, 1997 · United States, 1987
- Code names
- J10.767K
- Brand names
Resolves to
PHLBKPHSAVXXEF-UHFFFAOYSA-NSMILESClC1=CC=CC(=C1)N1CCN(CCCN2N=C3C=CC=CN3C2=O)CC1What you can answer from here — as of September 16, 2026
Which drugs share a target with Trazodone, and which of those have an active Phase 3 trial?
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