Serotransferrin
Details
- Name
- Serotransferrin
- Kind
- protein
- Synonyms
- Beta-1 metal-binding globulin
- Siderophilin
- Transferrin
- Gene Name
- TF
- UniProtKB Entry
- P02787Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0055648|Serotransferrin MRLAVGALLVCAVLGLCLAVPDKTVRWCAVSEHEATKCQSFRDHMKSVIPSDGPSVACVK KASYLDCIRAIAANEADAVTLDAGLVYDAYLAPNNLKPVVAEFYGSKEDPQTFYYAVAVV KKDSGFQMNQLRGKKSCHTGLGRSAGWNIPIGLLYCDLPEPRKPLEKAVANFFSGSCAPC ADGTDFPQLCQLCPGCGCSTLNQYFGYSGAFKCLKDGAGDVAFVKHSTIFENLANKADRD QYELLCLDNTRKPVDEYKDCHLAQVPSHTVVARSMGGKEDLIWELLNQAQEHFGKDKSKE FQLFSSPHGKDLLFKDSAHGFLKVPPRMDAKMYLGYEYVTAIRNLREGTCPEAPTDECKP VKWCALSHHERLKCDEWSVNSVGKIECVSAETTEDCIAKIMNGEADAMSLDGGFVYIAGK CGLVPVLAENYNKSDNCEDTPEAGYFAVAVVKKSASDLTWDNLKGKKSCHTAVGRTAGWN IPMGLLYNKINHCRFDEFFSEGCAPGSKKDSSLCKLCMGSGLNLCEPNNKEGYYGYTGAF RCLVEKGDVAFVKHQTVPQNTGGKNPDPWAKNLNEKDYELLCLDGTRKPVEEYANCHLAR APNHAVVTRKDKEACVHKILRQQQHLFGSNVTDCSGNFCLFRSETKDLLFRDDTVCLAKL HDRNTYEKYLGEEYVKAVGNLRKCSTSSLLEACTFRRP
- Number of residues
- 698
- Molecular Weight
- 77049.175
- Theoretical pI
- 7.13
- GO Classification
- Functionsenzyme binding / iron chaperone activity / transmembrane transporter bindingProcessesactin filament organization / antibacterial humoral response / ERK1 and ERK2 cascade / intracellular iron ion homeostasis / iron ion transport / multicellular organismal-level iron ion homeostasis / osteoclast differentiation / positive regulation of bone resorption / positive regulation of cell motility / positive regulation of DNA-templated transcription / positive regulation of phosphorylation / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / regulation of iron ion transportComponentsclathrin-coated endocytic vesicle membrane / clathrin-coated pit / cytoplasmic vesicle / endoplasmic reticulum lumen / plasma membrane
- General Function
- Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation
- Specific Function
- enzyme binding
- Pfam Domain Function
- Transferrin (PF00405)
- Signal Regions
- 1-19
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0021268|Serotransferrin (TF) ATGAGGCTCGCCGTGGGAGCCCTGCTGGTCTGCGCCGTCCTGGGGCTGTGTCTGGCTGTC CCTGATAAAACTGTGAGATGGTGTGCAGTGTCGGAGCATGAGGCCACTAAGTGCCAGAGT TTCCGCGACCATATGAAAAGCGTCATTCCATCCGATGGTCCCAGTGTTGCTTGTGTGAAG AAAGCCTCCTACCTTGATTGCATCAGGGCCATTGCGGCAAACGAAGCGGATGCTGTGACA CTGGATGCAGGTTTGGTGTATGATGCTTACCTGGCTCCCAATAACCTGAAGCCTGTGGTG GCAGAGTTCTATGGGTCAAAAGAGGATCCACAGACTTTCTATTATGCTGTTGCTGTGGTG AAGAAGGATAGTGGCTTCCAGATGAACCAGCTTCGAGGCAAGAAGTCCTGCCACACGGGT CTAGGCAGGTCCGCTGGGTGGAACATCCCCATAGGCTTACTTTACTGTGACTTACCTGAG CCACGTAAACCTCTTGAGAAAGCAGTGGCCAATTTCTTCTCGGGCAGCTGTGCCCCTTGT GCGGATGGGACGGACTTCCCCCAGCTGTGTCAACTGTGTCCAGGGTGTGGCTGCTCCACC CTTAACCAATACTTCGGCTACTCGGGAGCCTTCAAGTGTCTGAAGGATGGTGCTGGGGAT GTGGCCTTTGTCAAGCACTCGACTATATTTGAGAACTTGGCAAACAAGGCTGACAGGGAC CAGTATGAGCTGCTTTGCCTGGACAACACCCGGAAGCCGGTAGATGAATACAAGGACTGC CACTTGGCCCAGGTCCCTTCTCATACCGTCGTGGCCCGAAGTATGGGCGGCAAGGAGGAC TTGATCTGGGAGCTTCTCAACCAGGCCCAGGAACATTTTGGCAAAGACAAATCAAAAGAA TTCCAACTATTCAGCTCTCCTCATGGGAAGGACCTGCTGTTTAAGGACTCTGCCCACGGG TTTTTAAAAGTCCCCCCCAGGATGGATGCCAAGATGTACCTGGGCTATGAGTATGTCACT GCCATCCGGAATCTACGGGAAGGCACATGCCCAGAAGCCCCAACAGATGAATGCAAGCCT GTGAAGTGGTGTGCGCTGAGCCACCACGAGAGGCTCAAGTGTGATGAGTGGAGTGTTAAC AGTGTAGGGAAAATAGAGTGTGTATCAGCAGAGACCACCGAAGACTGCATCGCCAAGATC ATGAATGGAGAAGCTGATGCCATGAGCTTGGATGGAGGGTTTGTCTACATAGCGGGCAAG TGTGGTCTGGTGCCTGTCTTGGCAGAAAACTACAATAAGAGCGATAATTGTGAGGATACA CCAGAGGCAGGGTATTTTGCTGTAGCAGTGGTGAAGAAATCAGCTTCTGACCTCACCTGG GACAATCTGAAAGGCAAGAAGTCCTGCCATACGGCAGTTGGCAGAACCGCTGGCTGGAAC ATCCCCATGGGCCTGCTCTACAATAAGATCAACCACTGCAGATTTGATGAATTTTTCAGT GAAGGTTGTGCCCCTGGGTCTAAGAAAGACTCCAGTCTCTGTAAGCTGTGTATGGGCTCA GGCCTAAACCTGTGTGAACCCAACAACAAAGAGGGATACTACGGCTACACAGGCGCTTTC AGGTGTCTGGTTGAGAAGGGAGATGTGGCCTTTGTGAAACACCAGACTGTCCCACAGAAC ACTGGGGGAAAAAACCCTGATCCATGGGCTAAGAATCTGAATGAAAAAGACTATGAGTTG CTGTGCCTTGATGGTACCAGGAAACCTGTGGAGGAGTATGCGAACTGCCACCTGGCCAGA GCCCCGAATCACGCTGTGGTCACACGGAAAGATAAGGAAGCTTGCGTCCACAAGATATTA CGTCAACAGCAGCACCTATTTGGAAGCAACGTAACTGACTGCTCGGGCAACTTTTGTTTG TTCCGGTCGGAAACCAAGGACCTTCTGTTCAGAGATGACACAGTATGTTTGGCCAAACTT CATGACAGAAACACATATGAAAAATACTTAGGAGAAGAATATGTCAAGGCTGTTGGTAAC CTGAGAAAATGCTCCACCTCATCACTCCTGGAAGCCTGCACTTTCCGTAGACCTTAA
- Chromosome Location
- 3
- Locus
- 3q22.1
- External Identifiers
Resource Link UniProtKB ID P02787 UniProtKB Entry Name TRFE_HUMAN GenBank Protein ID 339453 GenBank Gene ID M12530 GeneCard ID TF GenAtlas ID TF HGNC ID HGNC:11740 PDB ID(s) 1A8E, 1A8F, 1B3E, 1BP5, 1BTJ, 1D3K, 1D4N, 1DTG, 1FQE, 1FQF, 1JQF, 1N7W, 1N7X, 1N84, 1OQG, 1OQH, 1RYO, 1SUV, 2HAU, 2HAV, 2O7U, 2O84, 3FGS, 3QYT, 3S9L, 3S9M, 3S9N, 3SKP, 3V83, 3V89, 3V8X, 3VE1, 4H0W, 4X1B, 4X1D, 5DYH, 5H52, 5WTD, 5X5P, 5Y6K, 6CTC, 6D03, 6D04, 6D05, 6JAS, 6SOY, 6SOZ, 6UJ6, 7FFM, 7FFU, 7Q1L, 8BRC KEGG ID hsa:7018 NCBI Gene ID 7018 - General References
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Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Aluminium approved, investigational unknown target Details Iron Dextran approved, vet_approved unknown carrier substrate Details Bismuth subsalicylate approved, vet_approved unknown carrier Details Gallium nitrate approved, investigational unknown carrier binder Details Copper approved, investigational unknown target Details Cisplatin approved unknown target Details Dichlorvos vet_approved unknown target Details Isoflurophate approved, investigational, withdrawn unknown target Details Iron approved unknown target Details Zinc approved, investigational unknown target Details Chromium approved unknown carrier binder Details Rose bengal approved, investigational unknown carrier binder Details Ferric cation approved unknown carrier binder Details Zinc acetate approved, investigational unknown target Details Ferrous gluconate approved unknown target Details Ferrous succinate approved unknown target Details Ferrous ascorbate approved unknown target Details Ferrous fumarate approved unknown target Details Ferrous glycine sulfate approved unknown target Details Aluminium phosphate approved, investigational unknown target Details Aluminum acetate approved, investigational unknown target Details Tetraferric tricitrate decahydrate approved unknown carrier binder Details Chromic citrate experimental unknown carrier Details Chromic nitrate approved unknown carrier Details Chromium gluconate approved unknown carrier Details Chromium nicotinate approved, experimental unknown carrier Details Chromous sulfate approved unknown carrier Details Zinc chloride approved, investigational unknown target ligand Details Ferrous sulfate anhydrous approved unknown enzyme substrate Details Zinc sulfate, unspecified form approved, experimental unknown target ligand Details Ferumoxytol approved, investigational no carrier binder Details Gallium citrate Ga-67 approved no carrier binder Details Manganese cation approved, nutraceutical unknown carrier binder Details