Macrolides

Name
Macrolides
Accession Number
DBCAT000496  (DBCAT003001)
Description

A group of often glycosylated macrocyclic compounds formed by chain extension of multiple PROPIONATES cyclized into a large (typically 12, 14, or 16)-membered lactone. Macrolides belong to the POLYKETIDES class of natural products, and many members exhibit ANTIBIOTIC properties.

ATC Classification
Drugs
DrugDrug Description
ErythromycinA macrolide antibiotic used to treat and prevent a variety of bacterial infections.
RoxithromycinUsed to treat respiratory tract, urinary and soft tissue infections.
JosamycinFor the treatment of bacterial infections.
DirithromycinFor the treatment of the following mild-to-moderate infections caused by susceptible strains of microorganisms: acute bacterial exacerbations of chronic bronchitis, secondary bacterial infection of acute bronchitis, community-acquired pneumonia, pharyngitis/tonsilitis, and...
TelithromycinAn ketolide used to treat community acquired pneumonia of mild to moderate severity.
FidaxomicinA macrolide antibiotic used to treat diarrhea associated with Clostridium difficile infection.
SolithromycinInvestigated for the treatment of community-acquired pneumonia (CAP).
TroleandomycinFor the treatment of bacterial infection.
MiocamycinMiocamycin is a macrolide type antimicrobial . This drug may be marketed in Japan for clinical use as it is listed in the Japanese pharmacopeia . It has shown to...
FlurithromycinNot Annotated
RokitamycinNot Annotated
MidecamycinMidecamycin was used for the treatment of infections in the oral cavity, upper and lower respiratory tracts and skin and soft tissue infections. The alone use of midecamycin was mainly...
SpiramycinA macrolide antimicrobial agent used in the treatment of various bacterial infections.
AzithromycinA macrolide antibiotic used to treat a variety of bacterial infections.
CandicidinUsed in the topical treatment of vulvovaginal candidiasis.
ClarithromycinA macrolide antibiotic used for the treatment of a wide variety of bacterial infections such as acute otitis, pharyngitis, tonsillitis, respiratory tract infections, uncomplicated skin infections, and helicobacter pylori infection.
EverolimusA mammalian target of rapamycin (mTOR) kinase inhibitor used to treat various types of malignancies.
Epothilone DInvestigated for use/treatment in colorectal cancer, lung cancer, breast cancer, solid tumors, and prostate cancer.
PatupiloneInvestigated for use/treatment in ovarian cancer, lung cancer, brain cancer, breast cancer, and gastric cancer.
6-Deoxyerythronolide BNot Available
IxabepiloneA microtubule inhibitor administered in combination with capecitabine or alone in the treatment of metastatic or locally advanced breast cancer that has shown inadequate response to taxanes and anthracyclines.
KOS-1584Investigated for use/treatment in solid tumors.
RidaforolimusInvestigated for use/treatment in solid tumors, sarcoma, cancer/tumors (unspecified), endometrial cancer, prostate cancer, and bone metastases.
TemsirolimusA antineoplastic agent used in the treatment of renal cell carcinoma (RCC) that works by inhibiting mTOR.
AVE9633Investigated for use/treatment in leukemia (myeloid).
Coltuximab ravtansineInvestigated for use/treatment in lymphoma (non-hodgkin's).
CethromycinA ketolide antibiotic with broad-spectrum activity against Gram-positive, Gram-negative, and atypical bacteria that may be useful for treating several conditions including community-acquired pneumonia, inhalation anthrax, plague, and tularemia.
MitemcinalInvestigated for use/treatment in gastroparesis and irritable bowel syndrome (IBS).
Brefeldin AA metabolite from Penicillium brefeldianum that exhibits a wide range of antibiotic activity.
KitasamycinKitasamycin is a macrolide antibiotic derived from Streptomyces kitasatoensis.
CarbomycinCarbomycin, also called magnamycin, is crystalline macrolide antibiotic. This antibacterial is obtained from Streptomyces halstedii and it presents a large inhibitory effect against Gram-positive bacteria and some Mycoplasma strains. The...
DoramectinDoramectin is a veterinary drug approved by the Food and Drug Administration for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in...
EprinomectinNot Annotated
OleandomycinOleandomycin is a macrolide antibiotic, though it is less effective than erythromycin. It is synthesized from strains of Streptomyces antibioticus.
SelamectinSelamectin is a topical parasiticide and antihelminthic used on dogs and cats to treat and prevent infections of heartworms, fleas, ear mites, sarcoptic mange, and certain types of ticks in...
TildipirosinTildipirosin is a veterinary antibiotic.
TilmicosinTilmicosin is a macrolide antibiotic. It is used in veterinary medicine for the treatment of bovine respiratory disease and ovine respiratory disease associated with Mannheimia haemolytica.
TylosinTylosin is a bacteriostatic macrolide antibiotic and feed additive used in veterinary medicine. It has a broad spectrum of activity against Gram-positive organisms and a limited range of Gram-negative organisms....
TylvalosinNot Annotated
Bryostatin 1Bryostatin 1 has been investigated for the treatment of HIV Infection and Alzheimer's Disease.
Lorvotuzumab mertansineLorvotuzumab mertansine has been used in trials studying the treatment of SCLC, Leukemia, Ovarian Cancer, Multiple Myeloma, and Merkel Cell Carcinoma, among others.
EpofolateEpofolate has been used in trials studying the treatment of Advanced Solid Tumors.
SagopiloneSagopilone has been used in trials studying the treatment of Melanoma, Neoplasms, CNS Disease, Breast Cancer, and Breast Neoplasms, among others. It is a so-called fully synthetic epothilone and is...
Mirvetuximab SoravtansineMirvetuximab Soravtansine has been used in trials studying the treatment of Ovarian cancer, Endometrial Cancer, Fallopian tube cancer, Epithelial Ovarian Cancer, and Primary Peritoneal Cancer, among others.
MepartricinNot Annotated
SirolimusAn immunosuppressant used to prevent organ transplant rejections and to treat lymphangioleiomyomatosis.
UmirolimusNot Annotated
ClindamycinA lincosamide antibiotic used to treat serious infections caused by susceptible anaerobic, streptococcal, staphylococcal, and pneumococcal bacteria.
Drugs & Drug Targets
DrugTargetType
Erythromycin23S ribosomal RNAtarget
ErythromycinCytochrome P450 3A4enzyme
ErythromycinCytochrome P450 3A7enzyme
ErythromycinP-glycoprotein 1transporter
ErythromycinSolute carrier organic anion transporter family member 1B1transporter
ErythromycinMotilin receptortarget
ErythromycinPotassium voltage-gated channel subfamily H member 2target
ErythromycinCytochrome P450 3A5enzyme
ErythromycinSolute carrier organic anion transporter family member 1B3transporter
ErythromycinBile salt export pumptransporter
ErythromycinCanalicular multispecific organic anion transporter 1transporter
ErythromycinSolute carrier organic anion transporter family member 1A2transporter
Roxithromycin50S ribosomal protein L10target
RoxithromycinP-glycoprotein 1target
RoxithromycinCytochrome P450 3A4enzyme
RoxithromycinCytochrome P450 2B6enzyme
Josamycin50S ribosomal protein L4target
Dirithromycin23S ribosomal RNAtarget
DirithromycinCytochrome P450 3A4enzyme
Telithromycin23S ribosomal RNAtarget
TelithromycinCytochrome P450 3A4enzyme
TelithromycinSolute carrier organic anion transporter family member 1B1transporter
TelithromycinSolute carrier organic anion transporter family member 1B3transporter
FidaxomicinP-glycoprotein 1transporter
FidaxomicinRNA polymerase sigma factortarget
FidaxomicinCytochrome P450 3A4enzyme
SolithromycinCytochrome P450 3A4enzyme
TroleandomycinCytochrome P450 3A5enzyme
TroleandomycinCytochrome P450 3A43enzyme
Troleandomycin50S ribosomal protein L4target
Troleandomycin50S ribosomal protein L32target
TroleandomycinP-glycoprotein 1transporter
TroleandomycinCytochrome P450 2C8enzyme
TroleandomycinCytochrome P450 3A4enzyme
TroleandomycinNuclear receptor subfamily 1 group I member 2target
TroleandomycinCytochrome P450 3A7enzyme
MiocamycinCytochrome P450 3A4enzyme
FlurithromycinCytochrome P450 3A4enzyme
RokitamycinCytochrome P450 3A4enzyme
MidecamycinCytochrome P450 3A4enzyme
Spiramycin50S ribosomal protein L3target
Azithromycin23S ribosomal RNAtarget
AzithromycinP-glycoprotein 1transporter
AzithromycinCytochrome P450 3A4enzyme
AzithromycinProtein-arginine deiminase type-4target
AzithromycinCanalicular multispecific organic anion transporter 1transporter
CandicidinErgosteroltarget
CandicidinCytochrome P450 3A4enzyme
Clarithromycin50S ribosomal protein L10target
ClarithromycinCytochrome P450 3A4enzyme
ClarithromycinCytochrome P450 3A5enzyme
ClarithromycinP-glycoprotein 1transporter
ClarithromycinSolute carrier family 22 member 7transporter
ClarithromycinPotassium voltage-gated channel subfamily H member 2target
ClarithromycinSolute carrier organic anion transporter family member 1B1target
ClarithromycinSolute carrier organic anion transporter family member 1B3target
ClarithromycinBile salt export pumptransporter
ClarithromycinSolute carrier organic anion transporter family member 1B1transporter
ClarithromycinSolute carrier organic anion transporter family member 1B3transporter
EverolimusSerine/threonine-protein kinase mTORtarget
EverolimusCytochrome P450 3A4enzyme
EverolimusSolute carrier organic anion transporter family member 1B1transporter
EverolimusSolute carrier organic anion transporter family member 1B3transporter
EverolimusSolute carrier organic anion transporter family member 1A2transporter
EverolimusCytochrome P450 2D6enzyme
EverolimusP-glycoprotein 1transporter
Epothilone DTubulin alpha-3C/D chaintarget
Epothilone DTubulin beta chaintarget
Epothilone DTubulin beta-1 chaintarget
Epothilone DTubulin beta-4B chaintarget
Epothilone DTubulin beta-4A chaintarget
Epothilone DTubulin alpha-4A chaintarget
Epothilone DTubulin beta-3 chaintarget
Epothilone DTubulin alpha-1C chaintarget
Epothilone DTubulin alpha-8 chaintarget
Epothilone DTubulin alpha-1B chaintarget
Epothilone DTubulin alpha-1A chaintarget
Epothilone DCytochrome P450 3A4enzyme
PatupiloneTubulin alpha-3C/D chaintarget
PatupiloneTubulin beta chaintarget
PatupiloneTubulin beta-1 chaintarget
PatupiloneTubulin beta-4B chaintarget
PatupiloneTubulin beta-4A chaintarget
PatupiloneTubulin alpha-4A chaintarget
PatupiloneTubulin beta-3 chaintarget
PatupiloneTubulin alpha-1C chaintarget
PatupiloneTubulin alpha-8 chaintarget
PatupiloneTubulin alpha-1B chaintarget
PatupiloneTubulin alpha-1A chaintarget
PatupiloneCytochrome P450 3A4enzyme
6-Deoxyerythronolide B6-deoxyerythronolide B hydroxylasetarget
6-Deoxyerythronolide BCytochrome P450 3A4enzyme
IxabepiloneTubulin beta-3 chaintarget
IxabepiloneCytochrome P450 3A4enzyme
IxabepiloneP-glycoprotein 1transporter
KOS-1584Cytochrome P450 3A4enzyme
RidaforolimusSerine/threonine-protein kinase mTORtarget
RidaforolimusCytochrome P450 3A4enzyme
TemsirolimusSerine/threonine-protein kinase mTORtarget
TemsirolimusCytochrome P450 3A4enzyme
TemsirolimusCytochrome P450 3A5enzyme
TemsirolimusCytochrome P450 3A7enzyme
TemsirolimusCytochrome P450 2D6enzyme
TemsirolimusP-glycoprotein 1transporter
AVE9633Myeloid cell surface antigen CD33target
AVE9633Cytochrome P450 3A4enzyme
Coltuximab ravtansineB-lymphocyte antigen CD19target
Coltuximab ravtansineCytochrome P450 3A4enzyme
Cethromycin23S ribosomal RNAtarget
CethromycinCytochrome P450 3A5enzyme
CethromycinCytochrome P450 3A4enzyme
CethromycinP-glycoprotein 1transporter
MitemcinalMotilin receptortarget
MitemcinalCytochrome P450 3A4enzyme
Brefeldin ACytohesin-2target
Brefeldin AADP-ribosylation factor 1target
Brefeldin ACytochrome P450 3A4enzyme
KitasamycinCytochrome P450 3A4enzyme
CarbomycinCytochrome P450 3A4enzyme
DoramectinCytochrome P450 3A4enzyme
EprinomectinCytochrome P450 3A4enzyme
OleandomycinCytochrome P450 3A4enzyme
SelamectinCytochrome P450 3A4enzyme
TildipirosinCytochrome P450 3A4enzyme
TilmicosinCytochrome P450 3A4enzyme
TylosinCytochrome P450 3A4enzyme
TylvalosinCytochrome P450 3A4enzyme
Bryostatin 1Cytochrome P450 3A4enzyme
Bryostatin 1Protein kinase C alpha typetarget
Bryostatin 1Protein kinase C epsilon typetarget
Bryostatin 1Caspase-8target
Bryostatin 1Protein unc-13 homolog Btarget
Bryostatin 1Serine/threonine-protein kinase D1target
Bryostatin 1T-lymphocyte activation antigen CD86target
Bryostatin 1Prostaglandin G/H synthase 2target
Bryostatin 1G1/S-specific cyclin-D1target
Bryostatin 1Tumor necrosis factortarget
Lorvotuzumab mertansineCytochrome P450 3A4enzyme
EpofolateCytochrome P450 3A4enzyme
SagopiloneCytochrome P450 3A4enzyme
Mirvetuximab SoravtansineCytochrome P450 3A4enzyme
MepartricinCytochrome P450 3A4enzyme
SirolimusPeptidyl-prolyl cis-trans isomerase FKBP1Atarget
SirolimusCytochrome P450 3A4enzyme
SirolimusSerine/threonine-protein kinase mTORtarget
SirolimusFibroblast growth factor 2target
SirolimusCytochrome P450 3A5enzyme
SirolimusCytochrome P450 3A7enzyme
SirolimusP-glycoprotein 1transporter
SirolimusSolute carrier organic anion transporter family member 1B1transporter
SirolimusMultidrug and toxin extrusion protein 1transporter
ClindamycinCytochrome P450 3A4enzyme
ClindamycinCytochrome P450 3A5enzyme
ClindamycinAlpha-1-acid glycoprotein 1carrier
ClindamycinP-glycoprotein 1transporter
Clindamycin50S ribosomal protein L1target