- Accession Number
- DBCAT000496 (DBCAT003001)
A group of often glycosylated macrocyclic compounds formed by chain extension of multiple PROPIONATES cyclized into a large (typically 12, 14, or 16)-membered lactone. Macrolides belong to the POLYKETIDES class of natural products, and many members exhibit ANTIBIOTIC properties.
- ATC Classification
Drug Drug Description Erythromycin A macrolide antibiotic used to treat and prevent a variety of bacterial infections. Roxithromycin An antibiotic used to treat a variety of susceptible bacterial infections. Josamycin A macrolide antibiotic used for the treatment of various susceptible bacterial infections. Dirithromycin An antibiotic used to treat a variety of respiratory, skin, and other infections. Telithromycin An ketolide used to treat community acquired pneumonia of mild to moderate severity. Fidaxomicin A macrolide antibiotic used to treat diarrhea associated with Clostridium difficile infection. Solithromycin Investigated for the treatment of community-acquired pneumonia (CAP). Troleandomycin For the treatment of bacterial infection. Miocamycin Miocamycin is a macrolide type antimicrobial . This drug may be marketed in Japan for clinical use as it is listed in the Japanese pharmacopeia . It has shown to... Flurithromycin Not Annotated Rokitamycin Not Annotated Midecamycin A macrolide antibiotic used to treat a variety of infections caused by susceptible bacteria. Spiramycin A macrolide antimicrobial agent used in the treatment of various bacterial infections. Azithromycin A macrolide antibiotic used to treat a variety of bacterial infections. Candicidin Used in the topical treatment of vulvovaginal candidiasis. Clarithromycin A macrolide antibiotic used for the treatment of a wide variety of bacterial infections such as acute otitis, pharyngitis, tonsillitis, respiratory tract infections, uncomplicated skin infections, and helicobacter pylori infection. Everolimus A mammalian target of rapamycin (mTOR) kinase inhibitor used to treat various types of malignancies. Epothilone D Investigated for use/treatment in colorectal cancer, lung cancer, breast cancer, solid tumors, and prostate cancer. Patupilone Investigated for use/treatment in ovarian cancer, lung cancer, brain cancer, breast cancer, and gastric cancer. 6-Deoxyerythronolide B Not Available Ixabepilone A microtubule inhibitor administered in combination with capecitabine or alone in the treatment of metastatic or locally advanced breast cancer that has shown inadequate response to taxanes and anthracyclines. KOS-1584 Investigated for use/treatment in solid tumors. Ridaforolimus Investigated for use/treatment in solid tumors, sarcoma, cancer/tumors (unspecified), endometrial cancer, prostate cancer, and bone metastases. Temsirolimus A antineoplastic agent used in the treatment of renal cell carcinoma (RCC) that works by inhibiting mTOR. AVE9633 Investigated for use/treatment in leukemia (myeloid). Coltuximab ravtansine Investigated for use/treatment in lymphoma (non-hodgkin's). Cethromycin A ketolide antibiotic with broad-spectrum activity against Gram-positive, Gram-negative, and atypical bacteria that may be useful for treating several conditions including community-acquired pneumonia, inhalation anthrax, plague, and tularemia. Mitemcinal Investigated for use/treatment in gastroparesis and irritable bowel syndrome (IBS). Brefeldin A A metabolite from Penicillium brefeldianum that exhibits a wide range of antibiotic activity. Kitasamycin Kitasamycin is a macrolide antibiotic derived from Streptomyces kitasatoensis. Carbomycin Carbomycin, also called magnamycin, is crystalline macrolide antibiotic. This antibacterial is obtained from Streptomyces halstedii and it presents a large inhibitory effect against Gram-positive bacteria and some Mycoplasma strains. The... Doramectin Doramectin is a veterinary drug approved by the Food and Drug Administration for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in... Eprinomectin Not Annotated Oleandomycin Oleandomycin is a macrolide antibiotic, though it is less effective than erythromycin. It is synthesized from strains of Streptomyces antibioticus. Selamectin Selamectin is a topical parasiticide and antihelminthic used on dogs and cats to treat and prevent infections of heartworms, fleas, ear mites, sarcoptic mange, and certain types of ticks in... Tildipirosin Tildipirosin is a veterinary antibiotic. Tilmicosin Tilmicosin is a macrolide antibiotic. It is used in veterinary medicine for the treatment of bovine respiratory disease and ovine respiratory disease associated with Mannheimia haemolytica. Tylosin Tylosin is a bacteriostatic macrolide antibiotic and feed additive used in veterinary medicine. It has a broad spectrum of activity against Gram-positive organisms and a limited range of Gram-negative organisms.... Tylvalosin Not Annotated Bryostatin 1 Bryostatin 1 has been investigated for the treatment of HIV Infection and Alzheimer's Disease. Lorvotuzumab mertansine Lorvotuzumab mertansine has been used in trials studying the treatment of SCLC, Leukemia, Ovarian Cancer, Multiple Myeloma, and Merkel Cell Carcinoma, among others. Epofolate Epofolate has been used in trials studying the treatment of Advanced Solid Tumors. Epofolate (BMS-753493) is a folate conjugate of the epothilone analog BMS-748285 that was designed to selectively target... Sagopilone Sagopilone has been used in trials studying the treatment of Melanoma, Neoplasms, CNS Disease, Breast Cancer, and Breast Neoplasms, among others. It is a so-called fully synthetic epothilone and is... Mepartricin A medication indicated in the treatment of benign prostatic hyperplasia, vaginal candidiasis, or trichomoniasis. Sirolimus An mTOR inhibitor immunosuppressant used to prevent organ transplant rejections, treat lymphangioleiomyomatosis, and treat adults with perivascular epithelioid cell tumors. Umirolimus Not Annotated Clindamycin A lincosamide antibiotic used to treat serious infections caused by susceptible anaerobic, streptococcal, staphylococcal, and pneumococcal bacteria. Josamycin propionate Not Annotated Indatuximab ravtansine Indatuximab ravtansine is under investigation in clinical trial NCT01001442 (Safety and Dose Determining Multi-dose Study of BT062 in Patients With Relapsed or Refractory Multiple Myeloma). Nafithromycin Nafithromycin is under investigation in clinical trial NCT02903836 (Phase II Study of Oral Nafithromycin in CABP). Carrimycin Not Available Cantuzumab mertansine Not Annotated
- Drugs & Drug Targets