Adrenergic alpha-1 Receptor Agonists

Name
Adrenergic alpha-1 Receptor Agonists
Accession Number
DBCAT000538  (DBCAT003342)
Description

Compounds that bind to and activate ADRENERGIC ALPHA-1 RECEPTORS.

Drugs
DrugDrug Description
MidodrineAn alpha-adrenergic antagonist used to treat orthostatic hypotension.
PhenylephrineAn alpha-1 adrenergic agonist used in the management of hypotension, generally in the surgical setting associated with the use of anesthetics.
MetaraminolFor the treatment and prevention of hypotension due to hemorrhage, spinal anesthesia, and shock associated with brain damage
MethoxamineAn alpha adrenergic agonist used to treat hypotension.
MephentermineA sympathomimetic agent used in the treatment of hypotension.
CirazolineCirazoline acts on a number of α adrenergic receptors. It is an agonist of α1A, partial agonist of α1B and α1D, and a nonselective antagonist of α2. It is believed...
EpinephrineA hormone and neurotransmitter used to treat allergic reactions, to restore cardiac rhythm, and to control mucosal congestion, glaucoma, and asthma.
PseudoephedrineAn alpha and beta adrenergic agonist used to treat nasal and sinus congestion, as well as allergic rhinitis.
OxymetazolineAn alpha-1A adrenoceptor agonist used to treat nasal congestion, allergic reactions of the eye, and facial erythema associated with rosacea.
BenzphetamineA sympathomimetic used to manage exogenous obesity short term.
4-MethoxyamphetamineNot Available
PhendimetrazineA sympathomimetic amine used as adjunct therapy for the short term management of exogenous obesity.
NorepinephrineA sympathomimetic used in the control of blood pressure during various hypotensive states and as an adjunct treatment during cardiac arrest.
DroxidopaA medication used to treat symptomatic neurogenic orthostatic hypotension (nOH) caused by dopamine beta-hydroxylase deficiency, non-diabetic autonomic neuropathy and primary autonomic failure caused by conditions such as Parkinson's disease.
XylometazolineA direct acting sympathomimetic agent used for the symptomatic treatment of nasal congestion and minor inflammation due to allergies or colds.
PergolideA long-acting dopamine agonist that is uncommonly used for the management of Parkinson's disease, due to the risk for cardiac valvulopathy.
BromocriptineA dopamine D2 receptor agonist used for the treatment of galactorrhea due to hyperprolactinemia and other prolactin-related conditions, as well as in early Parkinsonian Syndrome.
ApraclonidineAn alpha adrenergic agonist used to treat raised intraocular pressure.
DipivefrinA prodrug of epinephrine used in ophthalmic solutions to reduce intraocular pressure in chronic open-angle glaucoma.
ErgometrineAn ergot alkaloid used for the treatment of postpartum haemorrhage and post abortion hemorrhage in patients with uterine atony.
NaphazolineA sympathomimetic vasoconstrictor used for the symptomatic relief of redness and itching of the eye, and nasal congestion.
IsomethepteneIsometheptene is a sympathomimetic drug which causes vasoconstriction. It is used for treating migraines and tension headaches.
ClonidineAn alpha-2 adrenergic agonist used to treat hypertension and severe cancer pain, among other conditions, and to treat withdrawal symptoms from various substances. It is also used to aid in the diagnosis of pheochromocytoma and to prevent migraines.
TetryzolineAn alpha-adrenergic agonist used in the temporary symptomatic relief of discomfort and redness of the eyes due to minor irritations.
RacepinephrineA bronchodilator used to treat intermittent asthma.
DobutamineA beta-1 agonist used to treat cardiac decompensation in patients with organic heart disease or from cardiac surgery.
4-Bromo-2,5-dimethoxyphenethylamineNot Available
Drugs & Drug Targets
DrugTargetType
MidodrineAlpha-1A adrenergic receptortarget
MidodrineAlpha-1B adrenergic receptortarget
MidodrineCytochrome P450 2D6enzyme
MidodrineSolute carrier family 15 member 1transporter
MidodrineAlpha-1D adrenergic receptortarget
PhenylephrineAlpha-1A adrenergic receptortarget
PhenylephrineAlpha-1B adrenergic receptortarget
PhenylephrineAmine oxidase [flavin-containing] Aenzyme
PhenylephrineAlpha-1D adrenergic receptortarget
PhenylephrineCytochrome P450 1A2enzyme
PhenylephrineSulfotransferase 1A3/1A4enzyme
PhenylephrineAmine oxidase [flavin-containing] Benzyme
MetaraminolAlpha-1A adrenergic receptortarget
MethoxamineAlpha-1A adrenergic receptortarget
MethoxamineAlpha-1B adrenergic receptortarget
MethoxamineAlpha-1D adrenergic receptortarget
MephentermineAlpha adrenergic receptortarget
MephentermineBeta adrenergic receptortarget
CirazolineAlpha-1A adrenergic receptortarget
CirazolineAlpha-1B adrenergic receptortarget
CirazolineAlpha-1D adrenergic receptortarget
CirazolineAlpha-2 adrenergic receptorstarget
EpinephrineAlpha-1A adrenergic receptortarget
EpinephrineBeta-1 adrenergic receptortarget
EpinephrineBeta-2 adrenergic receptortarget
EpinephrineSolute carrier family 22 member 2transporter
EpinephrineSolute carrier family 22 member 1transporter
EpinephrineCytochrome P450 2C9enzyme
EpinephrineCytochrome P450 3A4enzyme
EpinephrineAlpha-1B adrenergic receptortarget
EpinephrineAlpha-1D adrenergic receptortarget
EpinephrineAlpha-2A adrenergic receptortarget
EpinephrineAlpha-2B adrenergic receptortarget
EpinephrineTumor necrosis factortarget
EpinephrineCatechol O-methyltransferaseenzyme
EpinephrineMonoamine oxidaseenzyme
PseudoephedrineAlpha-1A adrenergic receptortarget
PseudoephedrineAlpha-2A adrenergic receptortarget
PseudoephedrineBeta-2 adrenergic receptortarget
PseudoephedrineAmine oxidase [flavin-containing] Aenzyme
PseudoephedrineBeta-1 adrenergic receptortarget
PseudoephedrineSodium-dependent dopamine transportertarget
PseudoephedrineSodium-dependent noradrenaline transportertarget
PseudoephedrineSodium-dependent serotonin transportertarget
PseudoephedrineNuclear factor of activated T-cells, cytoplasmic 1target
PseudoephedrineTumor necrosis factortarget
PseudoephedrineNuclear factor NF-kappa-B p105 subunittarget
Pseudoephedrineactivator protein 1target
PseudoephedrineInterleukin-2target
PseudoephedrineSerum albumincarrier
PseudoephedrineSodium-dependent noradrenaline transportertransporter
PseudoephedrineSodium-dependent dopamine transportertransporter
PseudoephedrineSodium-dependent serotonin transportertransporter
OxymetazolineAlpha-1A adrenergic receptortarget
OxymetazolineAlpha-2A adrenergic receptortarget
OxymetazolineAlpha-2C adrenergic receptortarget
OxymetazolineAlpha-2B adrenergic receptortarget
OxymetazolineAlpha-1B adrenergic receptortarget
OxymetazolineAlpha-1D adrenergic receptortarget
BenzphetamineAlpha-2A adrenergic receptortarget
BenzphetamineAlpha-1A adrenergic receptortarget
BenzphetamineCytochrome P450 3A4enzyme
BenzphetamineCytochrome P450 2B6enzyme
BenzphetamineNADPH--cytochrome P450 reductaseenzyme
BenzphetamineSynaptic vesicular amine transportertarget
BenzphetamineSodium-dependent dopamine transportertarget
4-MethoxyamphetamineAlpha-1A adrenergic receptortarget
4-MethoxyamphetamineAlpha-2A adrenergic receptortarget
4-MethoxyamphetamineCytochrome P450 2D6enzyme
4-MethoxyamphetamineSodium-dependent dopamine transportertarget
4-MethoxyamphetamineSodium-dependent serotonin transportertarget
4-MethoxyamphetamineAmine oxidase [flavin-containing] Atarget
4-MethoxyamphetamineAmine oxidase [flavin-containing] Btarget
4-MethoxyamphetamineSynaptic vesicular amine transportertarget
PhendimetrazineAlpha-1A adrenergic receptortarget
PhendimetrazineAlpha-1B adrenergic receptortarget
PhendimetrazineSodium-dependent noradrenaline transportertarget
NorepinephrinePhenylalanine-4-hydroxylasetarget
NorepinephrineAlpha-1A adrenergic receptortarget
NorepinephrineAlpha-1B adrenergic receptortarget
NorepinephrineAlpha-1D adrenergic receptortarget
NorepinephrineAlpha-2A adrenergic receptortarget
NorepinephrineAlpha-2B adrenergic receptortarget
NorepinephrineAlpha-2C adrenergic receptortarget
NorepinephrineBeta-1 adrenergic receptortarget
NorepinephrineBeta-2 adrenergic receptortarget
NorepinephrineBeta-3 adrenergic receptortarget
NorepinephrineSolute carrier family 22 member 2transporter
NorepinephrineSolute carrier family 22 member 3transporter
NorepinephrineSolute carrier family 22 member 5transporter
NorepinephrineSolute carrier family 22 member 1transporter
NorepinephrinePOU domain, class 5, transcription factor 1transporter
NorepinephrineSodium-dependent noradrenaline transportertransporter
NorepinephrineSynaptic vesicular amine transportertarget
NorepinephrineChromaffin granule amine transportertarget
DroxidopaPhenylalanine-4-hydroxylasetarget
DroxidopaAlpha-1A adrenergic receptortarget
DroxidopaAlpha-1B adrenergic receptortarget
DroxidopaAlpha-1D adrenergic receptortarget
DroxidopaAlpha-2A adrenergic receptortarget
DroxidopaAlpha-2B adrenergic receptortarget
DroxidopaAlpha-2C adrenergic receptortarget
DroxidopaBeta-1 adrenergic receptortarget
DroxidopaBeta-2 adrenergic receptortarget
DroxidopaBeta-3 adrenergic receptortarget
DroxidopaAromatic-L-amino-acid decarboxylaseenzyme
DroxidopaMonocarboxylate transporter 10transporter
DroxidopaSodium-dependent noradrenaline transportertransporter
XylometazolineAlpha-2A adrenergic receptortarget
XylometazolineAlpha-1A adrenergic receptortarget
XylometazolineAlpha-1B adrenergic receptortarget
XylometazolineAlpha-1D adrenergic receptortarget
XylometazolineAlpha-2B adrenergic receptortarget
XylometazolineAlpha-2C adrenergic receptortarget
PergolideDopamine D2 receptortarget
PergolideDopamine D1 receptortarget
PergolideDopamine D3 receptortarget
Pergolide5-hydroxytryptamine receptor 1Atarget
PergolideAlpha-1A adrenergic receptortarget
PergolideAlpha-2 adrenergic receptorstarget
PergolideAlpha-1B adrenergic receptortarget
PergolideAlpha-1D adrenergic receptortarget
PergolideDopamine D4 receptortarget
PergolideDopamine D5 receptortarget
Pergolide5-hydroxytryptamine receptor 1Btarget
Pergolide5-hydroxytryptamine receptor 1Dtarget
Pergolide5-hydroxytryptamine receptor 2Atarget
Pergolide5-hydroxytryptamine receptor 2Btarget
Pergolide5-hydroxytryptamine receptor 2Ctarget
PergolideCytochrome P450 3A4enzyme
BromocriptineDopamine D2 receptortarget
BromocriptineCytochrome P450 3A4enzyme
Bromocriptine5-hydroxytryptamine receptor 1Dtarget
BromocriptineAlpha-2A adrenergic receptortarget
BromocriptineDopamine D3 receptortarget
Bromocriptine5-hydroxytryptamine receptor 1Atarget
BromocriptineAlpha-2C adrenergic receptortarget
BromocriptineAlpha-2B adrenergic receptortarget
Bromocriptine5-hydroxytryptamine receptor 2Btarget
BromocriptineDopamine D4 receptortarget
Bromocriptine5-hydroxytryptamine receptor 2Atarget
Bromocriptine5-hydroxytryptamine receptor 1Btarget
Bromocriptine5-hydroxytryptamine receptor 2Ctarget
BromocriptineDopamine D5 receptortarget
BromocriptineDopamine D1 receptortarget
BromocriptineAlpha-1A adrenergic receptortarget
BromocriptineAlpha-1B adrenergic receptortarget
BromocriptineAlpha-1D adrenergic receptortarget
Bromocriptine5-hydroxytryptamine receptor 7target
BromocriptineP-glycoprotein 1transporter
ApraclonidineAlpha-2A adrenergic receptortarget
ApraclonidineAlpha-1A adrenergic receptortarget
ApraclonidineAlpha-2B adrenergic receptortarget
DipivefrinAlpha-2A adrenergic receptortarget
DipivefrinCholinesterasetarget
DipivefrinBeta-2 adrenergic receptortarget
DipivefrinAlpha-1A adrenergic receptortarget
DipivefrinAcetylcholinesterasetarget
ErgometrineCytochrome P450 3A4enzyme
ErgometrineP-glycoprotein 1transporter
ErgometrineAlpha-1A adrenergic receptortarget
NaphazolineAlpha-1A adrenergic receptortarget
NaphazolineAlpha-2A adrenergic receptortarget
IsomethepteneAlpha-1A adrenergic receptortarget
IsomethepteneSynaptic vesicular amine transportertarget
ClonidineAlpha-2A adrenergic receptortarget
ClonidineCytochrome P450 2D6enzyme
ClonidineAlpha-2B adrenergic receptortarget
ClonidineAlpha-2C adrenergic receptortarget
ClonidineSolute carrier family 22 member 3transporter
ClonidineSolute carrier family 22 member 5transporter
ClonidineSolute carrier family 22 member 4transporter
ClonidineP-glycoprotein 1transporter
ClonidineCytochrome P450 1A2enzyme
ClonidineCytochrome P450 3A4enzyme
ClonidineCytochrome P450 1A1enzyme
ClonidineCytochrome P450 3A5enzyme
ClonidineAlpha-1A adrenergic receptortarget
ClonidineAlpha-1B adrenergic receptortarget
ClonidineAlpha-1D adrenergic receptortarget
ClonidineSerum albumincarrier
TetryzolineAlpha-1A adrenergic receptortarget
RacepinephrineAlpha-1A adrenergic receptortarget
RacepinephrineAlpha-1B adrenergic receptortarget
RacepinephrineAlpha-2A adrenergic receptortarget
RacepinephrineAlpha-2B adrenergic receptortarget
RacepinephrineAlpha-2C adrenergic receptortarget
RacepinephrineBeta-1 adrenergic receptortarget
RacepinephrineBeta-2 adrenergic receptortarget
RacepinephrineAlpha-1D adrenergic receptortarget
RacepinephrineBeta-3 adrenergic receptortarget
DobutamineBeta-1 adrenergic receptortarget
DobutamineCatechol O-methyltransferaseenzyme
DobutamineBeta-2 adrenergic receptortarget
DobutamineAlpha-1 adrenergic receptorstarget
DobutamineEstrogen receptor alphatarget
4-Bromo-2,5-dimethoxyphenethylamine5-hydroxytryptamine receptor 2Ctarget
4-Bromo-2,5-dimethoxyphenethylamine5-hydroxytryptamine receptor 2Atarget