Cytochrome P-450 CYP2E1 Inhibitors
- Cytochrome P-450 CYP2E1 Inhibitors
- Accession Number
Drug Drug Description Disulfiram A carbamate derivative used to treat alcohol addiction. Midostaurin An antineoplastic agent used to treat high-risk acute myeloid leukemia (AML) with specific mutations, aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated hematologic neoplasm (SM-AHN), or mast cell leukemia (MCL). Isoniazid An antibiotic used to treat mycobacterial infections; most commonly use in combination with other antimycobacterial agents for the treatment of active or latent tuberculosis. Clotrimazole A topical broad-spectrum antifungal agent used for the treatment of a wide variety of dermatophyte infections and candidiasis. Rhein No approved indication. Zucapsaicin A topical analgesic used as an adjunct to relieve severe pain of osteoarthritis of the knee in selected adult patients. Nabilone A synthetic delta-9-THC used in the treatment of anorexia and weight loss in HIV patients as well as nausea and vomiting in cancer chemotherapy. Ticlopidine A platelet aggregation inhibitor used in the prevention of conditions associated with thrombi, such as stroke and transient ischemic attacks (TIA). Nifedipine A dihydropyridine calcium channel blocker indicated for the management of several subtypes of angina pectoris, and hypertension. Rufinamide An antiepileptic drug used as adjunctive therapy to treat seizures associated with Lennox-Gastaut Syndrome (LGS). Econazole A topical antifungal used to treat tinea pedis, tinea cruris, tinea corporis, cutaneous candidiasis and tinea versicolor. Miconazole An azole antifungal with broad-spectrum activity used to treat fungal infections affecting the vagina, mouth and skin, including candidiasis. Nicotine A stimulatory alkaloid found in tobacco products that is often used for the relief of nicotine withdrawal symptoms and as an aid to smoking cessation. Chlorzoxazone A drug with muscle relaxant properties that is used as an adjunct to physical therapy and analgesics to treat stiffness and pain caused by a variety of musculoskeletal conditions. Fomepizole An inhibitor of alcohol dehydrogenase used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning. Ademetionine S-Adenosylmethionine (SAMe) is used as a drug in Europe for the treatment of depression, liver disorders, fibromyalgia, and osteoarthritis. It has also been introduced into the United States market as... Propofol A medication used in general anesthesia and for sedation. Alosetron A 5-HT3 antagonist used to treat diarrhea-predominant IBS. Bifonazole An azole antifungal drug used to treat fungal skin infections, such as dermatomycosis. Bromazepam A short-acting benzodiazepine with intermediate onset commonly used to treat panic disorders and severe anxiety. Chlorpromazine A phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children. Cimetidine A histamine H2 receptor antagonist used to manage GERD, peptic ulcer disease, and indigestion. Desipramine A tricyclic antidepressant used in the treatment of depression. Diclofenac An NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. Etoricoxib A selective COX-2 inhibitor used to relieve moderate post-surgical dental pain as a short-term treatment and inflammatory and painful symptoms of various forms of arthritis. Fluphenazine A phenothiazine used to treat patients requiring long-term neuroleptic therapy. Flurazepam A long-acting benzodiazepine with a rapid onset of action that is commonly used to treat insomnia. Imipramine A tricyclic antidepressant indicated for the treatment of depression and to reduce childhood enuresis. Isosorbide dinitrate A vasodilator used to treat angina in coronary artery disease. Itraconazole An antifungal agent used for the treatment of various fungal infections in immunocompromised and non-immunocompromised patients, such as pulmonary and extrapulmonary blastomycosis, histoplasmosis, and onychomycosis. Metyrapone A steroid 11-beta-monooxygenase inhibitor used to test hypothalamic-pituitary ACTH function. Nicotinamide An ingredient found in a variety of cosmetic products. Nortriptyline A tricyclic antidepressant used in the treatment of depression. Sildenafil A phosphodiesterase inhibitor used for the treatment of erectile dysfunction. Tegaserod A serotonin-4 (5-HT4) receptor agonist indicated for the treatment of constipation predominant irritable bowel syndrome (IBS-C) specifically in women under the age of 65. There is currently no safety or efficacy data for use of tegaserol in men. Methimazole A thionamide antithyroid agent that inhibits the actions of thyroid peroxidase, leading to a reduction in thyroid hormone synthesis and amelioration of hyperthyroidism. Thioridazine A phenothiazine antipsychotic used to treat schizophrenia and generalized anxiety disorder. Tioconazole An imidazole antifungal used to treat vulvovaginal candidiasis. Zafirlukast A leukotriene receptor antagonist used for prophylaxis and chronic treatment of asthma. Diethylstilbestrol Used in the treatment of prostate cancer. Previously used in the prevention of miscarriage or premature delivery in pregnant women prone to miscarriage or premature delivery. Indisulam Investigated for use/treatment in lung cancer. Aldesleukin A recombinant analog of interleukin-2 used to induce an adaptive immune response in the treatment of renal cell carcinoma. Clonazepam A long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders, severe anxiety, and seizures. Diazepam A long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. Flunitrazepam A benzodiazepine used to manage anxiety disorders and insomnia. Nitrazepam A long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders, severe anxiety, insomnia, and seizures. Ellagic acid Ellagic acid is being investigated for use in follicular lymphoma, brain injury in intrauterine growth restricted babies, obese adolescents, and solar lentigines. Diacerein An slow-onset anthraquinone IL-1 inhibitor used in the treatment of degenerative joint diseases like osteoarthritis. Azelastine A histamine H1-receptor antagonist used intranasally to treat allergic and vasomotor rhinitis and in an ophthalmic solution to treat allergic conjunctivitis. Dexfenfluramine For the management of obesity including weight loss and maintenance of weight loss in patients on a reduced calorie diet Methotrimeprazine A phenothiazine used in the management of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder. Vayarin ADHD in children, hypertriglyceridemia [L1502, L1503]. Ditiocarb A chelating agent that has been used to mobilize toxic metals from the tissues of man and experimental animals. It is the main metabolite of DISULFIRAM. Niacin A B vitamin used to treat hypertriglyceridemia and pellagra. Orphenadrine A muscarinic antagonist used as an adjunct for the symptomatic relief of musculoskeletal pain and discomfort. Osilodrostat An oral inhibitor of cortisol synthesis used to treat Cushing's disease by normalizing hypercortisolism. Favipiravir An antiviral used to manage influenza, and that has the potential to target other viral infections. Clascoterone An androgen receptor antagonist used for the topical treatment of acne vulgaris in patients 12 years of age and older. Menadione The primary known function of vitamin K is to assist in the normal clotting of blood, but it may also play a role in normal bone calcification. Rilpivirine A non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with other antiretrovirals to specifically treat human immunodeficiency virus type 1 (HIV-1). Ethambutol An antituberculosis agent used in the prophylaxis and treatment of tuberculosis (TB). Diosmin A citrus flavonoid medication used to support vascular health.
- Drugs & Drug Targets