Highest Risk QTc-Prolonging Agents
- Highest Risk QTc-Prolonging Agents
- Accession Number
Drugs demonstrating a high risk of QTc interval prolongation in animal or human studies.
Drug Drug Description Dofetilide A class III antiarrhythmic drug used for the maintenance of normal sinus rhythm and cardioversion in cases of atrial fibrillation and atrial flutter. Citalopram A selective serotonin reuptake inhibitor (SSRI) used in the treatment of depression. Ziprasidone An atypical antipsychotic used to manage schizophrenia, bipolar mania, and agitation in patients with schizophrenia. Anagrelide A platelet-reducing agent used to treat thrombocythemia, and its related complications, secondary to myeloproliferative neoplasms. Disopyramide A class 1A antiarrhythmic agent used to treat life-threatening ventricular arrhythmias. Ibutilide A class III antiarrhythmic agent used to correct atrial fibrillation and atrial flutter, which can be considered as an alternative to cardioversion. Quinine An alkaloid used to treat uncomplicated Plasmodium falciparum malaria. Fluoxetine A selective serotonin reuptake inhibitor used to treat major depressive disorder, bulimia, OCD, premenstrual dysphoric disorder, panic disorder, and bipolar I. Sotalol A methane sulfonanilide beta adrenergic antagonist used to treat life-threatening ventricular arrhythmias and to maintain sinus rhythm in atrial fibrillation or flutter. Toremifene A first generation nonsteroidal selective estrogen receptor modulator used to treat certain breast cancers. Cisapride A medication used to treat heartburn associated with GERD. Thioridazine A phenothiazine antipsychotic used to treat schizophrenia and generalized anxiety disorder. Mifepristone A cortisol receptor blocker used to treat Cushing's syndrome, and to terminate pregnancies up to 70 days gestation. Flupentixol A thioxanthene neuroleptic used to treat schizophrenia and depression. Quinidine A medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias. Procainamide A medication used to treat life threatening ventricular arrhythmias. Pimozide An antipsychotic used to manage debilitating motor and phonic tics in patients with Tourette's Disorder. Amiodarone A class III antiarrhythmic indicated for the treatment of recurrent hemodynamically unstable ventricular tachycardia and recurrent ventricular fibrillation. Arsenic trioxide A chemotherapeutic agent used in the treatment of refractory or relapsed acute promyelocytic leukemia in patients with prior retinoid and anthracycline chemotherapy. Escitalopram A selective serotonin re-uptake inhibitor used in the treatment of major depressive disorder (MDD), generalized anxiety disorder (GAD), and other select psychiatric disorders such as obsessive-compulsive disorder (OCD). Domperidone A dopamine receptor antagonist used as a peristaltic stimulant and anti-emetic agent for dyspepsia, indigestion, epigastric pain, nausea, and vomiting. Paliperidone An atypical antipsychotic used in the treatment of schizophrenia and other schizoaffective or delusional disorders. Zuclopenthixol An antipsychotic indicated for the management of schizophrenia. The acuphase formulation is indicated for initial treatment of acute psychosis or exacerbation of psychosis, while the depot formulation is best for maintenance. Tetrabenazine A vesicular monoamine transporter 2 (VMAT) inhibitor used for the management of chorea associated with Huntington's Disease. Dronedarone An antiarrhythmic agent used in the reduce the risk of hospitalization in patients with paroxysmal or persistent atrial fibrillation. Nilotinib A kinase inhibitor used for the chronic phase treatment of Chronic Myeloid Leukemia (CML) that is Philadelphia chromosome positive and for the treatment of CML that is resistant to therapy containing imatinib. Iloperidone An atypical antipsychotic agent used for the acute treatment of schizophrenia in adults. Vandetanib An antineoplastic kinase inhibitor used to treat symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease. Asenapine An atypical antipsychotic used to treat patients with bipolar I disorder and patients with schizophrenia. Artemether An antimalarial agent used in combination with lumefantrine for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum. Lumefantrine An antimalarial agent used in combination with artemether for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum. Vemurafenib A kinase inhibitor used to treat patients with Erdheim-Chester Disease who have the BRAF V600 mutation, and melanoma in patients who have the BRAF V600E mutation. Eliglustat A glucosylceramide synthase used to treat type 1 Gaucher disease in patients who are CYP2D6 extensive, intermediate, or poor metabolizers. Lithium cation A drug used for the management of bipolar disorder and other psychiatric conditions. Romidepsin A histone deacetylase (HDAC) inhibitor used to treat cutaneous T-cell lymphoma. Valproic acid An anticonvulsant used to control complex partial seizures and both simple and complex absence seizures. Temafloxacin For the treatment of lower respiratory tract infections, genital and urinary infections like prostatitis, and skin infections. Grepafloxacin A fluoroquinolone antibiotic used to treat various gram positive and gram negative bacterial infections. Trovafloxacin An antibiotic used to treat gonorrhea and chlamydia. Astemizole A second generation antihistamine used to treat allergy symptoms. Bepridil For the treatment of hypertension, and chronic stable angina (classic effort-associated angina). Cocaine An ester local anesthetic used during diagnostic procedures and surgeries in or through the nasal cavities. Halofantrine An antimalarial used for the treatment of severe malaria. Sparfloxacin A fluoroquinolone antibiotic used to treat bacterial respiratory infections and sinusitis. Terfenadine An antihistamine for the treatment of allergy symptoms. Terodiline Not Annotated Imatinib A tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. Erlotinib An EGFR tyrosine kinase inhibitor used to treat certain small cell lung cancers or advanced metastatic pancreatic cancers. Ribociclib A kinase inhibitor used to treat HR+, HER2- advanced or metastatic breast cancer. Macimorelin A medication used to treat adult growth hormone deficiency. Deutetrabenazine A vesicular monoamine transporter 2 inhibitor used for the symptomatic treatment of tardive dyskinesia and chorea associated with Huntington's disease. Clemastine An antihistamine with sedative and anticholinergic effects used to treat the symptoms of allergic rhinitis. Ivabradine A HCN channel blocker used to reduce the risk of hospitalization for worsening heart failure in adult patients and for treatment of stable symptomatic heart failure as a result of dilated cardiomyopathy in pediatric patients. Glasdegib A sonic hedgehog receptor inhibitor used to treat newly diagnosed acute myeloid leukemia in patients over 75 years who cannot receive intense chemotherapy.
- Drugs & Drug Targets