Selective Cyclooxygenase 2 Inhibitors (NSAIDs)

Name
Selective Cyclooxygenase 2 Inhibitors (NSAIDs)
Accession Number
DBCAT000887  (DBCAT003694)
Description

A subclass of cyclooxygenase inhibitors with specificity for CYCLOOXYGENASE-2.

Drugs
DrugDrug Description
AceclofenacAceclofenac is indicated for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.
BromfenacAn NSAID used to treat postoperative pain and inflammation of the eye.
CarprofenFor use as a pain reliever in the treatment of joint pain and post-surgical pain.
CelecoxibAn NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, menstrual symptoms, and to reduce polyps is familial adenomatous polyposis.
CimicoxibInvestigated for use/treatment in depression.
EtodolacAn NSAID used to treat osteoarthritis and rheumatoid arthritis, as well as acute pain.
EtoricoxibA selective COX-2 inhibitor used to relieve moderate post-surgical dental pain as a short-term treatment and inflammatory and painful symptoms of various forms of arthritis.
FirocoxibUsed for the treatment of pain inflammation and fever in horses and dogs.
LumiracoxibFor the acute and chronic treatment of the signs and symptoms of osteoarthritis of the knee in adults.
MeloxicamAn NSAID used to treat osteoarthritis in adults, rheumatoid arthritis in adults, and juvenile rheumatoid arthritis in pediatrics.
NabumetoneAn NSAID used to treat osteoarthritis and rheumatoid arthritis.
NepafenacAn ophthalmic NSAID used for the symptomatic treatment of pain and inflammation associated with cataract surgery.
Niflumic acidA cyclooxygenase-2 inhibitor used to alleviate inflammation, pain, and edema associated with acute and chronic inflammatory conditions, such as rheumatoid arthritis, osteoarthritis, post-operative inflammatory conditions, and physical trauma.
NimesulideA cyclooxygenase 2 inhibitor used to treat acute pain and primary dysmenorrhea.
ParecoxibA selective COX-2 inhibitor and NSAID used for the short-term management of perioperative pain.
PolmacoxibPolmacoxib has been used in trials studying the treatment of Osteoarthritis, Osteoarthritis, Hip, Osteoarthritis, Knee, Localized Primary Osteoarthritis of Hip, and Localized Primary Osteoarthritis of Knee.
RobenacoxibRobenacoxib is a non-steroidal anti-inflammatory drug used in veterinary medicine for the relief of pain and inflammation in cats and dogs.
RofecoxibA COX-2 inhibitor NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, primary dysmenorrhea, and migraine attacks.
TalniflumateTalnifumate is a phthalidyl ester of nifumic acid, which has potent analgesic and anti-inflammatory effects and is widely used to treat inflammatory disorders, such as rheumatoid arthritis and osteoarthritis ,...
ValdecoxibA COX-2 inhibitor used to treat osteoarthritis and dysmenorrhoea.
Drugs & Drug Targets
DrugTargetType
AceclofenacProstaglandin G/H synthase 1target
AceclofenacProstaglandin G/H synthase 2target
AceclofenacCytochrome P450 2C9enzyme
BromfenacHuman Cyclooxygenasestarget
BromfenacProstaglandin G/H synthase 2enzyme
BromfenacProstaglandin G/H synthase 2target
BromfenacProstaglandin G/H synthase 1target
CarprofenSolute carrier family 22 member 6transporter
CarprofenProstaglandin G/H synthase 1target
CarprofenProstaglandin G/H synthase 2target
CelecoxibCytochrome P450 3A4enzyme
CelecoxibSignal transducer and activator of transcription 3target
CelecoxibSialidase-1target
CelecoxibProstaglandin G/H synthase 2enzyme
CelecoxibBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
CelecoxibATP-dependent translocase ABCB1transporter
CelecoxibCadherin-11target
CelecoxibBile salt export pumptransporter
CelecoxibCarbonic anhydrase 3target
CelecoxibCarbonic anhydrase 2target
CelecoxibCytochrome P450 2C8enzyme
CelecoxibATP-binding cassette sub-family C member 4transporter
CelecoxibCytochrome P450 2D6enzyme
CelecoxibCytochrome P450 2C9enzyme
Celecoxib3-phosphoinositide-dependent protein kinase 1target
CelecoxibProstaglandin G/H synthase 2target
CimicoxibProstaglandin G/H synthase 2enzyme
CimicoxibProstaglandin G/H synthase 2target
EtodolacProstaglandin G/H synthase 2target
EtodolacRetinoic acid receptor RXR-alphatarget
EtodolacUDP-glucuronosyltransferase 2B7enzyme
EtodolacUDP-glucuronosyltransferase 1A10enzyme
EtodolacUDP-glucuronosyltransferase 1A3enzyme
EtodolacSolute carrier family 22 member 6transporter
EtodolacAlbumincarrier
EtodolacUDP-glucuronosyltransferase 1A9enzyme
EtodolacCytochrome P450 2C9enzyme
EtodolacProstaglandin G/H synthase 1target
EtoricoxibProstaglandin G/H synthase 2target
EtoricoxibCytochrome P450 3A4enzyme
EtoricoxibCytochrome P450 2E1enzyme
EtoricoxibCytochrome P450 2C19enzyme
EtoricoxibCytochrome P450 1A2enzyme
EtoricoxibCytochrome P450 2D6enzyme
EtoricoxibCytochrome P450 2C9enzyme
FirocoxibProstaglandin G/H synthase 2target
FirocoxibProstaglandin G/H synthase 2target
LumiracoxibCytochrome P450 2C19enzyme
LumiracoxibCytochrome P450 1A2enzyme
LumiracoxibUDP-glucuronosyltransferase 1A9enzyme
LumiracoxibCytochrome P450 2C9enzyme
LumiracoxibProstaglandin G/H synthase 1target
LumiracoxibProstaglandin G/H synthase 2target
MeloxicamHuman vesicular glutamate transporterstransporter
MeloxicamAlbumincarrier
MeloxicamCytochrome P450 2C8enzyme
Meloxicam6-phosphogluconate dehydrogenase, decarboxylatingenzyme
MeloxicamATP-binding cassette sub-family C member 4transporter
MeloxicamProstaglandin G/H synthase 2target
MeloxicamCytochrome P450 2C9enzyme
MeloxicamProstaglandin G/H synthase 1target
MeloxicamCytochrome P450 3A4enzyme
NabumetoneAlbumincarrier
NabumetoneAldo-keto reductase family 1 member C4enzyme
NabumetoneAldo-keto reductase family 1 member C2enzyme
NabumetoneAldo-keto reductase family 1 member C1enzyme
Nabumetone11-beta-hydroxysteroid dehydrogenase 1enzyme
NabumetoneCytochrome P450 2C9enzyme
NabumetoneCytochrome P450 1A2enzyme
NabumetoneMyeloperoxidaseenzyme
NabumetoneProstaglandin G/H synthase 2target
NabumetoneProstaglandin G/H synthase 1target
NepafenacProstaglandin G/H synthase 2target
NepafenacProstaglandin G/H synthase 1target
NepafenacHuman Cyclooxygenasestarget
Niflumic acidCytosolic phospholipase A2target
Niflumic acidProstaglandin G/H synthase 1target
Niflumic acidProstaglandin G/H synthase 2target
Niflumic acidChloride channel protein ClC-Katarget
Niflumic acidPhospholipase A2target
Niflumic acidUDP-glucuronosyltransferase 1A9target
Niflumic acidUDP-glucuronosyltransferase 1A9enzyme
Niflumic acidMonocarboxylate transporter 2transporter
Niflumic acidMonocarboxylate transporter 1transporter
NimesulideProstaglandin G/H synthase 2target
NimesulideGroup IIE secretory phospholipase A2target
NimesulideLactotransferrintarget
NimesulideCytochrome P450 3A4enzyme
NimesulideTumor necrosis factor ligand superfamily member 10target
ParecoxibProstaglandin G/H synthase 2target
ParecoxibLactotransferrintarget
ParecoxibCytochrome P450 2C9enzyme
ParecoxibCytochrome P450 3A4enzyme
PolmacoxibCarbonic anhydrase 2target
PolmacoxibProstaglandin G/H synthase 2target
PolmacoxibCarbonic anhydrase 1target
RobenacoxibProstaglandin G/H synthase 2target
RofecoxibCytochrome P450 2C9enzyme
RofecoxibCytochrome P450 2C8enzyme
RofecoxibProstaglandin G/H synthase 1enzyme
RofecoxibATP-binding cassette sub-family C member 4transporter
RofecoxibCytochrome P450 1A2enzyme
RofecoxibCytochrome P450 3A4enzyme
RofecoxibElastintarget
RofecoxibProstaglandin G/H synthase 2target
TalniflumateProstaglandin G/H synthase 1target
TalniflumateProstaglandin G/H synthase 2target
TalniflumateChloride channel protein ClC-Katarget
TalniflumateProstaglandin G/H synthase 1enzyme
TalniflumateProstaglandin G/H synthase 2enzyme
ValdecoxibCarbonic anhydrase 3target
ValdecoxibCarbonic anhydrase 2target
ValdecoxibUDP-glucuronosyltransferase 1A9enzyme
ValdecoxibCytochrome P450 3A4enzyme
ValdecoxibCytochrome P450 2C9enzyme
ValdecoxibProstaglandin G/H synthase 2target