- OAT3/SLC22A8 Inhibitors
- Accession Number
Drugs which inhibit organic anion transporter 3.
Drug Drug Description Ivosidenib An isocitrate dehydrogenase-1 inhibitor used to treat acute myeloid leukemia and cholangiocarcinoma in adults with a susceptible IDH1 mutation. Lenvatinib A receptor tyrosine kinase inhibitor used for the treatment of metastatic thyroid cancer, advanced renal cell carcinoma in combination with everolimus, and unresectable hepatocellular carcinoma. Teriflunomide A pyrimidine synthesis inhibitor with anti-inflammatory and immunomodulatory properties used to treat patients with the relapsing-remitting form of multiple sclerosis. Probenecid A medication used to treat gouty arthritis, tophaceous gout, and hyperuricemia. Taurocholic acid The product of conjugation of cholic acid with taurine. Its sodium salt is the chief ingredient of the bile of carnivorous animals. It acts as a detergent to solubilize fats... Salicylic acid An acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. Quinidine A medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias. Benzylpenicillin A penicillin used for the treatment of infections caused by gram-positive cocci, in particular streptococcal infections. This form of penicillin is typically used in intravenous or long-acting injectable formulations due to poor oral absorption. Ouabain For the treatment of atrial fibrillation and flutter and heart failure Indomethacin A nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. Ibuprofen An NSAID and non-selective COX inhibitor used to treat mild-moderate pain, fever, and inflammation. Guanidine A strong organic base used to treat muscle weakness and fatigue associated with the myasthenic complications of Eaton-Lambert syndrome. Glutaric Acid Not Available Furosemide A loop diuretic used to treat hypertension and edema in congestive heart failure, liver cirrhosis, renal disease, and hypertension. Diclofenac An NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. Cholic Acid A bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. Bumetanide A sulfamyl diuretic used to treat edema in congestive heart failure, hepatic and renal disease, and nephrotic syndrome. Cilastatin A renal dehydropeptidase inhibitor used to prevent degradation of imipenem. Both medications are used together to treat a variety of infections. Piroxicam An NSAID used to treat the symptoms of osteoarthritis and rheumatoid arthritis. Aminohippuric acid A hippuric acid derivative injection utilized in the measurement of effective renal plasma flow (ERPF) and functional capacity of the renal excretory system. Caprylic acid Caprylic acid is an eight-carbon chain fatty acid, also known systematically as octanoic acid. It is found naturally in coconuts and breast milk. It is an oily liquid with a... Cimetidine A histamine H2 receptor antagonist used to manage GERD, peptic ulcer disease, and indigestion. Aspartame Used as a diet supplement and sugar substitute. Tetracycline An antibiotic used to treat a wide variety of susceptible infections. Oxytetracycline A tetracycline antibiotic used to treat a wide variety of susceptible bacterial infections. Minocycline A tetracycline analog used to treat a wide variety of infections in the body. Ganciclovir A DNA polymerase inhibitor used to treat cytomegalovirus and herpetic keratitis of the eye. Acyclovir A guanosine analog used to treat herpes simplex, varicella zoster, herpes zoster. Dinoprostone A prostaglandin used to induce labor or abortion as well as to treat nonmetastatic gestational trophoblastic disease. Cefalotin A broad-spectrum cephalosporin antibiotic used for the treatment of serious bacterial infections in various locations, such as the urinary tract, skin, bone, and lower respiratory tract. Cefoperazone A broad-spectrum cephalosporin antibiotic used for the treatment of bacterial infections in various locations, including the respiratory tract, abdomen, skin, and female genital tracts. Cefazolin A broad-spectrum cephalosporin antibiotic mainly used for the treatment of skin bacterial infections and other moderate to severe bacterial infections in the lung, bone, joint, stomach, blood, heart valve, and urinary tract. Cefamandole A beta-lactam antibiotic used in the treatment of various infections caused by susceptible strains of bacteria, such as lower respiratory infections, urinary tract infections, skin infections, and bone and joint infections. Cefadroxil A cephalosporin antibiotic used in the treatment of various bacterial infections, such as urinary tract infections, skin and skin structure infections, and tonsillitis. Ceftriaxone A broad-spectrum cephalosporin antibiotic used for the treatment of bacterial infections in various locations, such as in the respiratory tract, skin, soft tissue, and urinary tract. Cefotaxime A third generation cephalosporin used to treat susceptible Gram negative and Gram positive bacterial infections. Phenylbutazone An NSAID used to treat backache and ankylosing spondylitis. Ketoprofen An NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, dysmenorrhea, mild to moderate muscle pain, postoperative pain, and postpartum pain. Famotidine A histamine H2 receptor antagonist used to treat duodenal ulcers, benign gastric ulcers, GERD, and Zollinger-Ellison syndrome. Liothyronine A thyroid hormone replacement therapy used to treat hypothyroidism, to suppress TSH, and to help in the diagnosis of hyperthyroidism. Methotrexate An antineoplastic agent used the treatment of a wide variety of cancers as well as severe psoriasis, severe rheumatoid arthritis, and juvenile rheumatoid arthritis. Conjugated estrogens A mixture of estrogens used in estrogen replacement therapy for menopause and hypoestrogenism, used in the treatment of various malignancies, and used in the treatment of postmenopausal osteoporosis. Tenoxicam An anti inflammatory analgesic used to treat mild to moderate pain as well as the signs and symptoms of rheumatoid arthritis and osteoarthritis. Enalapril A prodrug of an ACE inhibitor used to treat hypertension and congestive heart failure. trans-2-hydroxycinnamic acid Not Available Cephalexin A first generation cephalosporin used to treat certain susceptible bacterial infections. Valproic acid An anticonvulsant used to control complex partial seizures and both simple and complex absence seizures. Melatonin An endogenous hormone produced by the pineal gland that regulates sleep-wake cycles and when provided exogenously has beneficial effects on sleep-onset latency; available as an over-the-counter supplement. Benzoic acid An antimicrobial food additive. Mercaptopurine An antineoplastic agent used to treat acute lymphocytic leukemia. Novobiocin For the treatment of infections due to staphylococci and other susceptible organisms Liotrix May be used to treat primary, secondary or tertiary hypothyroidism. May also be used to suppress thyroid stimulating hormone (TSH) secretion in patients with simple (nontoxic) goiter, subacute or chronic... Cefacetrile A broad-spectrum first-generation cephalosporin used for the treatment of susceptible bacterial infections. Zidovudine A dideoxynucleoside used in the treatment of HIV infection. Dabrafenib A kinase inhibitor used to treat patients with specific types of melanoma, non-small cell lung cancer, and thyroid cancer. Topiroxostat Indicated for the treatment of gout and hyperurcemia in Japan. Ataluren A medication used for the treatment of Duchenne muscular dystrophy. Enasidenib An isocitrate dehydrogenase-2 inhibitor used to treat relapsed or refractory acute myeloid leukemia with an isocitrate dehydrogenase-2 mutation. Letermovir An antiviral medication used to treat CMV infections and disease in adult CMV-seropositive recipients of an allogeneic hematopoietic stem cell transplant (HSCT). Dolutegravir An antiviral agent used for the treatment of HIV-1 infections in combination with other antiretroviral agents. Rucaparib A poly (ADP-ribose) polymerase (PARP) inhibitor used to treat recurrent ovarian and prostate cancers in previously treated adults. Baricitinib A Janus kinase inhibitor used to treat moderate to severe rheumatoid arthritis that has responded poorly to at least one TNF antagonist. Apalutamide An androgen receptor inhibitor used to treat non metastatic, castration resistant prostate cancer. Avatrombopag A thrombopoietin receptor agonist used to treat thrombocytopenia in patients with chronic liver disease who are scheduled to undergo a procedure. Cefaclor A second generation cephalosporin used to treat a wide variety of infections in the body. Cefotiam A cephalosporin antibiotic used to treat a variety of bacterial infections. Ceftibuten A third-generation cephalosporin antibiotic commonly used in the treatment of acute bacterial exacerbations of chronic bronchitis (ABECB), acute bacterial otitis media, pharyngitis, and tonsillitis. Ceftizoxime A third-generation cephalosporin antibiotic used in the treatment of various bacterial infections, including lower respiratory tract infection, urinary tract infection, and gonorrhea. Cefaloridine Cephaloridine or cefaloridine is a first generation semisynthetic cephalosporin. It is derived from cephalosporin C and is a zwitterion at physiological pH. Leucovorin A folate analog used to treat the toxic effects of methotrexate and other folate antagonists, to treat megaloblastic anemia, and to provide palliative treatment of colorectal cancer. Rosuvastatin An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. Rifampicin An antibiotic used to treat several types of mycobacterial infections including Mycobacterium avium complex, leprosy, and in combination with other antibacterials to treat latent or active tuberculosis. Cabotegravir An HIV-1 integrase inhibitor used for treatment and pre-exposure prophylaxis of HIV-1 infection. Pradigastat Pradigastat has been used in trials studying the treatment of Non-alcoholic Fatty Liver Disease (NAFLD). Lansoprazole A proton pump inhibitor used to help gastrointestinal ulcers heal, to treat symptoms of gastroesophageal reflux disease (GERD), to eradicate Helicobacter pylori, and to treat hypersecretory conditions such as Zollinger-Ellison Syndrome. Acetylsalicylic acid A salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events. Pantoprazole A proton pump inhibitor used to treat erosive esophagitis, gastric acid hypersecretion, and to promote healing of tissue damage caused by gastric acid. Esomeprazole A proton pump inhibitor used to treat GERD, reduce the risk of NSAID associated gastric ulcers, eradicate H. pylori, and to treat conditions causing gastric acid hypersecretion. Pravastatin An HMG-CoA reductase inhibitor used to lower lipid levels and to reduce the risk of cardiovascular events, including myocardial infarction and stroke. Tazobactam A beta lactamase inhibitor administered with antibiotics such as piperacillin and ceftolozane to prevent their degradation, resulting in increased efficacy. Pretomanid Part of a three-drug regimen used for the treatment of extensively drug-resistant and multidrug-resistant pulmonary tuberculosis. Latanoprost An isopropyl ester prodrug used to treat increased intraocular pressure. Gemfibrozil A lipid regulator that is used in the reduction of serum triglyceride levels in high-risk patients with hyperlipidemia. Dronedarone An antiarrhythmic agent used in the reduce the risk of hospitalization in patients with paroxysmal or persistent atrial fibrillation. Tafamidis A medication used to treat transthyretin-mediated amyloidosis. Rimegepant An oral CGRP receptor antagonist used for the acute treatment of migraines with or without aura in adults. Favipiravir An antiviral used to manage influenza, and that has the potential to target other viral infections. Osilodrostat An oral inhibitor of cortisol synthesis used to treat Cushing's disease by normalizing hypercortisolism. Hydroflumethiazide A thiazide diuretic used to treat hypertension as well as edema due to congestive heart failure and liver cirrhosis. Artesunate Artesunate is an artemesinin derivative indicated for the initial treatment of severe malaria. Linezolid An oxazolidinone antibiotic used to treat infections by susceptible strains of aerobic Gram-positive bacteria. Cloxacillin An antibiotic agent used for the treatment of beta-hemolytic streptococcal and pneumococcal infections as well as staphylococcal infections. Brincidofovir An oral lipid prodrug of cidofovir used in the treatment of human smallpox disease. Fexinidazole An orally bioavailable 2-substituted 5-nitroimidazole used to treat early- and late-stage human African trypanosomiasis caused by Trypanosoma brucei gambiense. Lorlatinib An anaplastic lymphoma kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer. Olaparib A poly (ADP-ribose) polymerase (PARP) inhibitor used to treat ovarian cancer, breast cancer, pancreatic cancer, and prostate cancer. Linzagolix A selective gonadotropin-releasing hormone (GnRH) receptor antagonist used for the symptomatic treatment of uterine fibroids. Olutasidenib An isocitrate dehydrogenase-1 (IDH1) inhibitor indicated for the treatment of patients with relapsed or refractory acute myeloid leukemia with a susceptible IDH1 mutation as detected by an FDA-approved test.
- Drugs & Drug Targets