P-glycoprotein substrates with a Narrow Therapeutic Index

Name
P-glycoprotein substrates with a Narrow Therapeutic Index
Accession Number
DBCAT004027
Description
Not Available
Drugs
DrugDrug Description
CyclosporineA steroid-sparing immunosuppressant used in organ and bone marrow transplants as well as inflammatory conditions such as ulcerative colitis, rheumatoid arthritis, and atopic dermatitis.
DigitoxinA cardiac glycoside used in the treatment and management of congestive cardiac insufficiency, arrhythmias and heart failure.
DigoxinA cardiac glycoside used in the treatment of mild to moderate heart failure and for ventricular response rate control in chronic atrial fibrillation.
PhenobarbitalA long-lasting barbiturate and anticonvulsant used in the treatment of all types of seizures, except for absent seizures.
PhenytoinAn anticonvulsant drug used in the prophylaxis and control of various types of seizures.
QuinidineA medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias.
SirolimusAn immunosuppressant used to prevent organ transplant rejections and to treat lymphangioleiomyomatosis.
TacrolimusA calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis.
TemsirolimusA antineoplastic agent used in the treatment of renal cell carcinoma (RCC) that works by inhibiting mTOR.
VincristineA vinca alkaloid used to treat acute leukemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and acute panmyelosis.
PaclitaxelA taxoid chemotherapeutic agent used as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary, and other various cancers including breast and lung cancer.
VinflunineA vinca alkaloid used to treat advanced or metastatic transitional cell carcinoma of the urothelial tract after a platinum containing treatment has failed.
VinblastineA vinca alkaloid used to treat breast cancer, testicular cancer, neuroblastoma, Hodgkin's and non-Hodgkins lymphoma, mycosis fungoides, histiocytosis, and Kaposi's sarcoma.
VenetoclaxA BCL-2 inhibitor used to treat chronic lymphocytic leukemia, small lymphocytic lymphoma, or acute myeloid leukemia.
VemurafenibA kinase inhibitor used to treat patients with Erdheim-Chester Disease who have the BRAF V600 mutation, and melanoma in patients who have the BRAF V600E mutation.
DactinomycinAn actinomycin used to treat a wide variety of cancers.
DaunorubicinAn anthracycline aminoglycoside used to induce remission of nonlymphocytic leukemia and acute lymphocytic leukemia.
Trastuzumab emtansineAn antineoplastic agent and antibody-drug conjugate used to treat HER2-overexpressing breast cancer.
DocetaxelA taxoid antineoplastic agent used in the treatment of various cancers, such as locally advanced or metastatic breast cancer, metastatic prostate cancer, gastric adenocarcinoma, and head and neck cancer.
DoxorubicinA medication used to treat various cancers and Kaposi's Sarcoma.
TopotecanAn antineoplastic agent used to treat ovarian cancer, small cell lung cancer, or cervical cancer.
EnasidenibAn isocitrate dehydrogenase-2 inhibitor used to treat relapsed or refractory acute myeloid leukemia with an isocitrate dehydrogenase-2 mutation.
EntrectinibEntrectinib is indicated for the treatment of metastatic ROS1-positive non-small cell lung cancer in adults. Entrectinib is also indicated in adults and children over 12 years old for the treatment...
ErlotinibAn EGFR tyrosine kinase inhibitor used to treat certain small cell lung cancers or advanced metastatic pancreatic cancers.
EtoposideA podophyllotoxin derivative used to treat testicular and small cell lung tumors.
BendamustineAn antineoplastic agent used for the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed following rituximab therapy.
IxabepiloneA microtubule inhibitor administered in combination with capecitabine or alone in the treatment of metastatic or locally advanced breast cancer that has shown inadequate response to taxanes and anthracyclines.
BinimetinibA medication used to treat metastatic melanoma with specific mutations.
BosutinibAn antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments.
MitoxantroneA chemotherapeutic agent used for the treatment of secondary progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis.
Brentuximab vedotinA CD30-directed antibody-drug conjugate used to treat various types of lymphoma.
TalazoparibA poly-ADP ribose polymerase inhibitor used to treat HER2-, BRCA mutated locally advanced or metastatic breast cancer.
CabazitaxelAn antineoplastic agent used for the treatment of hormone-refractory metastatic prostate cancer previously treated with a docetaxel-containing treatment regimen.
NilotinibA kinase inhibitor used for the chronic phase treatment of Chronic Myeloid Leukemia (CML) that is Philadelphia chromosome positive and for the treatment of CML that is resistant to therapy containing imatinib.
SorafenibA kinase inhibitor used in the treatment of unresectable liver carcinoma and advanced renal carcinoma.
CarfilzomibA proteasome inhibitor used either alone or in conjunction with a chemotherapy regimen to treat patients with relapsed or refractory multiple myeloma.
CeritinibAn antineoplastic kinase inhibitor used to treat anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) in patients with inadequate clinical response or intolerance to crizotinib.
CobimetinibAn antineoplastic agent and selective inhibitor of the mitogen-activated extracellular kinase (MEK) pathway used to treat unresectable or metastatic melanoma.
DabrafenibA kinase inhibitor used to treat patients with specific types of melanoma, non-small cell lung cancer, and thyroid cancer.
CopanlisibA medication used to treat relapsed follicular lymphoma who have attempted at least two other treatments.
DacomitinibA medication used to treat non small cell lung cancer with EGFR exon 19 deletion of exon 21 L858R substitution.
CrizotinibA receptor tyrosine kinase inhibitor used to treat metastatic non-small cell lung cancer (NSCLC) where the tumors have been confirmed to be anaplastic lymphoma kinase (ALK), or ROS1-positive.
DasatinibA tyrosine kinase inhibitor used for the treatment of lymphoblastic or chronic myeloid leukemia with resistance or intolerance to prior therapy.
ErdafitinibA fibroblast growth factor receptor tyrosine kinase inhibitor used to treat locally advanced or metastatic urothelial carcinoma.
IvosidenibAn isocitrate dehydrogenase-1 inhibitor used to treat acute myeloid leukemia with a susceptible mutation.
BortezomibA proteasome inhibitor used to treat multiple myeloma in patients who have not been successfully treated with at least two previous therapies.
TamoxifenA selective estrogen receptor modulator used to treat estrogen receptor positive breast cancer, reduce the risk of invasive breast cancer following surgery, or reduce the risk of breast cancer in high risk women.
ImipramineA tricyclic antidepressant indicated for the treatment of depression and to reduce childhood enuresis.
TrimipramineA tricyclic antidepressant used to treat depression.
MethotrexateAn antineoplastic agent used the treatment of a wide variety of cancers as well as severe psoriasis, severe rheumatoid arthritis, and juvenile rheumatoid arthritis.
GemcitabineA nucleoside metabolic inhibitor used as adjunct therapy in the treatment of certain types of ovarian cancer, non-small cell lung carcinoma, metastatic breast cancer, and as a single agent for pancreatic cancer.
RomidepsinA histone deacetylase (HDAC) inhibitor used to treat cutaneous and peripheral T-cell lymphoma.
TolvaptanA selective vasopressin V2-receptor antagonist to slow kidney function decline in patients at risk for rapidly progressing autosomal dominant polycystic kidney disease (ADPKD). Also used to treat hypervolemic and euvolemic hyponatremia.
PazopanibAn antineoplastic agent used in the treatment of advanced renal cell cancer and advanced soft tissue sarcoma in patients with prior chemotherapy.
AxitinibAn oral VEGFR and kinase inhibitor used for the treatment of advanced renal cell carcinoma after failure of one prior systemic therapy.
RegorafenibA kinase inhibitor used to treat patients with metastatic colorectal cancer, unresectable, locally advanced, or metastatic gastrointestinal stromal tumors, and hepatocellular carcinoma.
PonatinibA kinase inhibitor used to treat patients with various types of chronic myeloid leukemia (CML).
PomalidomideA thalidomide analogue used in combination with dexamethasone to treat patients with multiple myeloma.
IrinotecanAn antineoplastic enzyme inhibitor used to treat metastatic carcinoma of the colon or rectum.
IdelalisibAn antineoplastic kinase inhibitor used to treat chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL).
PanobinostatA non-selective histone deacetylase inhibitor used to treat multiple myeloma in combination with other antineoplastic agents.
OsimertinibA tyrosine kinase inhibitor used in the treatment of certain types of non-small cell lung carcinoma.
BelinostatA histone deacetylase (HDAC) inhibitor used for the treatment of patients with relapsed or refractory peripheral T-cell lymphoma (PTCL).
Inotuzumab ozogamicinAn antibody-drug conjugate used to treat B-cell precursor acute lymphoblastic leukemia (ALL).
AbemaciclibA medication used to treat HR+ HER2- advanced or metastatic breast cancer.
CabergolineA dopamine receptor agonist used for the treatment of hyperprolactinemic conditions due to various causes.
AmitriptylineA tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety.
PalbociclibAn endocrine-based chemotherapeutic agent used in combination with other antineoplastic agents to treat HER2-negative and HR-positive advanced or metastatic breast cancer.
FlecainideA class Ic antiarrhythmic agent used to manage atrial fibrillation and paroxysmal supraventricular tachycardias (PSVT).
AcenocoumarolAn anticoagulant drug used in the prevention of thromboembolic diseases in infarction and transient ischemic attacks, as well as management of deep vein thrombosis and myocardial infarction.
ZanubrutinibA kinase inhibitor used to treat mantle cell lymphoma, a type of B-cell non-Hodgkin lymphoma, in adults who previously received therapy.
BaricitinibA Janus kinase inhibitor used to treat moderate to severe rheumatoid arthritis that has responded poorly to at least one TNF antagonist.
NortriptylineA tricyclic antidepressant used in the treatment of depression.
EverolimusA mammalian target of rapamycin (mTOR) kinase inhibitor used to treat various types of malignancies.
Chloramphenicol succinateA broad-spectrum antibiotic agent used for the treatment of acute and severe infections caused by susceptible bacterial strains.
RucaparibAn anti-cancer agent used to treat recurrent ovarian, fallopian tube, or peritoneal cancer.
OlaparibA chemotherapeutic agent used to treat recurrent or advanced ovarian cancer and metastatic breast cancer in patients with specific mutations and prior history of chemotherapy.
TemozolomideAn alkylating agent used to treat glioblastoma multiforme and refractory anaplastic astrocytoma.
Drugs & Drug Targets
DrugTargetType
CyclosporineCalcium signal-modulating cyclophilin ligandtarget
CyclosporinePeptidyl-prolyl cis-trans isomerase Atarget
CyclosporineCalcineurin subunit B type 2target
CyclosporineCytochrome P450 3A5enzyme
CyclosporineCytochrome P450 3A4enzyme
CyclosporineP-glycoprotein 1transporter
CyclosporineBile salt export pumptransporter
CyclosporineIleal sodium/bile acid cotransportertransporter
CyclosporineSodium/bile acid cotransportertransporter
CyclosporineSolute carrier family 22 member 6transporter
CyclosporineMultidrug resistance-associated protein 7transporter
CyclosporineCanalicular multispecific organic anion transporter 1transporter
CyclosporineATP-binding cassette sub-family G member 2transporter
CyclosporineSolute carrier organic anion transporter family member 1B1transporter
CyclosporineCytochrome P450 2C19enzyme
CyclosporineCytochrome P450 2D6enzyme
CyclosporinePeptidyl-prolyl cis-trans isomerase F, mitochondrialtarget
CyclosporineSolute carrier organic anion transporter family member 1B3transporter
DigitoxinSodium/potassium-transporting ATPase subunit alpha-1target
DigitoxinSerum albumincarrier
DigitoxinCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DigitoxinCytochrome P450 3A4enzyme
DigitoxinSolute carrier organic anion transporter family member 1A2transporter
DigitoxinSolute carrier organic anion transporter family member 4C1transporter
DigitoxinP-glycoprotein 1transporter
DigoxinSodium/potassium-transporting ATPase subunit alpha-1target
DigoxinCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DigoxinP-glycoprotein 1transporter
DigoxinSolute carrier organic anion transporter family member 4C1transporter
DigoxinBile salt export pumptransporter
DigoxinSolute carrier organic anion transporter family member 1A2transporter
DigoxinOrganic solute transporter subunit alphatransporter
DigoxinOrganic solute transporter subunit betatransporter
DigoxinSolute carrier organic anion transporter family member 1B1transporter
PhenobarbitalGamma-aminobutyric acid receptor subunit alpha-1target
PhenobarbitalCytochrome P450 2C19enzyme
PhenobarbitalCytochrome P450 2C9enzyme
PhenobarbitalCytochrome P450 2B6enzyme
PhenobarbitalCytochrome P450 2C8enzyme
PhenobarbitalCytochrome P450 1A2enzyme
PhenobarbitalCytochrome P450 3A4enzyme
PhenobarbitalCanalicular multispecific organic anion transporter 2transporter
PhenobarbitalBile salt export pumptransporter
PhenobarbitalP-glycoprotein 1transporter
PhenobarbitalMultidrug resistance-associated protein 1transporter
PhenobarbitalSolute carrier organic anion transporter family member 2A1transporter
PhenobarbitalCanalicular multispecific organic anion transporter 1transporter
PhenobarbitalNeuronal acetylcholine receptor subunit alpha-4target
PhenobarbitalNeuronal acetylcholine receptor subunit alpha-7target
PhenobarbitalGlutamate receptor 2target
PhenobarbitalGlutamate receptor ionotropic, kainate 2target
PhenobarbitalCytochrome P450 2A6enzyme
PhenobarbitalCytochrome P450 2E1enzyme
PhenobarbitalCytochrome P450 3A5enzyme
PhenobarbitalCytochrome P450 1A1enzyme
PhenobarbitalCytochrome P450 2C18enzyme
PhenobarbitalCytochrome P450 3A7enzyme
PhenobarbitalCytochrome P450 4B1enzyme
PhenobarbitalNMDA receptortarget
PhenobarbitalNuclear receptor subfamily 1 group I member 2target
PhenobarbitalUDP-glucuronosyltransferase 1-1enzyme
PhenobarbitalUDP-glucuronosyltransferase 2B7enzyme
PhenytoinSodium channel protein type 5 subunit alphatarget
PhenytoinSodium channel protein type 1 subunit alphatarget
PhenytoinCytochrome P450 2C8enzyme
PhenytoinCytochrome P450 2C19enzyme
PhenytoinCytochrome P450 2C9enzyme
PhenytoinCytochrome P450 2B6enzyme
PhenytoinCytochrome P450 3A5enzyme
PhenytoinSerum albumincarrier
PhenytoinCytochrome P450 3A4enzyme
PhenytoinSolute carrier organic anion transporter family member 1C1transporter
PhenytoinP-glycoprotein 1transporter
PhenytoinCanalicular multispecific organic anion transporter 1transporter
PhenytoinCytochrome P450 11B1, mitochondrialenzyme
PhenytoinCytochrome P450 3A7enzyme
PhenytoinNuclear receptor subfamily 1 group I member 2target
PhenytoinSodium channel subunit beta-1target
PhenytoinSodium channel protein type 3 subunit alphatarget
PhenytoinUDP-glucuronosyltransferase 1-1enzyme
PhenytoinUDP-glucuronosyltransferase 1-6enzyme
PhenytoinUDP-glucuronosyltransferase 1-9enzyme
PhenytoinThyroxine-binding globulincarrier
PhenytoinPotassium voltage-gated channel subfamily H member 2target
PhenytoinVoltage-dependent L-type calcium channeltarget
PhenytoinSodium channel protein type 2 subunit alphatarget
PhenytoinSodium channel protein type 8 subunit alphatarget
PhenytoinGABA(A) Receptortarget
PhenytoinCytochrome P450 1A2enzyme
PhenytoinCytochrome P450 2A6enzyme
PhenytoinCytochrome P450 2D6enzyme
PhenytoinCytochrome P450 2E1enzyme
PhenytoinEpoxide hydrolase 1enzyme
PhenytoinUDP-glucuronosyltransferase 1-4enzyme
PhenytoinCatechol O-methyltransferaseenzyme
PhenytoinNAD(P)H dehydrogenase [quinone] 1enzyme
PhenytoinCytochrome P450 2C18enzyme
QuinidineSodium channel protein type 5 subunit alphatarget
QuinidineAlpha-1-acid glycoprotein 1carrier
QuinidinePotassium voltage-gated channel subfamily H member 2target
QuinidinePotassium channel subfamily K member 1target
QuinidinePotassium channel subfamily K member 6target
QuinidineCytochrome P450 1A2enzyme
QuinidineCytochrome P450 2E1enzyme
QuinidineCytochrome P450 1A1enzyme
QuinidineCytochrome P450 2D6enzyme
QuinidineCytochrome P450 3A4enzyme
QuinidineCytochrome P450 3A7enzyme
QuinidineSolute carrier family 22 member 2transporter
QuinidineSolute carrier family 22 member 1transporter
QuinidineSolute carrier family 22 member 5transporter
QuinidineP-glycoprotein 1transporter
QuinidineSolute carrier organic anion transporter family member 1A2transporter
QuinidineSolute carrier family 22 member 8transporter
QuinidineCanalicular multispecific organic anion transporter 1transporter
QuinidineSolute carrier family 22 member 4transporter
QuinidineSolute carrier organic anion transporter family member 1B1transporter
QuinidineCytochrome P450 2B6enzyme
QuinidineCytochrome P450 2C9enzyme
QuinidineAlpha-1A adrenergic receptortarget
QuinidineAlpha-1B adrenergic receptortarget
QuinidineAlpha-1D adrenergic receptortarget
QuinidineBile salt export pumptransporter
QuinidineCytochrome P450 2C8enzyme
QuinidineSerum albumincarrier
SirolimusPeptidyl-prolyl cis-trans isomerase FKBP1Atarget
SirolimusCytochrome P450 3A4enzyme
SirolimusSerine/threonine-protein kinase mTORtarget
SirolimusFibroblast growth factor 2target
SirolimusCytochrome P450 3A5enzyme
SirolimusCytochrome P450 3A7enzyme
SirolimusP-glycoprotein 1transporter
SirolimusSolute carrier organic anion transporter family member 1B1transporter
SirolimusMultidrug and toxin extrusion protein 1transporter
TacrolimusPeptidyl-prolyl cis-trans isomerase FKBP1Atarget
TacrolimusCytochrome P450 3A4enzyme
TacrolimusCytochrome P450 3A5enzyme
TacrolimusP-glycoprotein 1transporter
TacrolimusATP-binding cassette sub-family A member 5transporter
TacrolimusSerum albumincarrier
TacrolimusAlpha-1-acid glycoprotein 1carrier
TacrolimusSolute carrier organic anion transporter family member 1B1transporter
TemsirolimusSerine/threonine-protein kinase mTORtarget
TemsirolimusCytochrome P450 3A4enzyme
TemsirolimusCytochrome P450 3A5enzyme
TemsirolimusCytochrome P450 3A7enzyme
TemsirolimusCytochrome P450 2D6enzyme
TemsirolimusP-glycoprotein 1transporter
VincristineTubulin beta chaintarget
VincristineCytochrome P450 3A4enzyme
VincristineCytochrome P450 3A5enzyme
VincristineCytochrome P450 3A7enzyme
VincristineP-glycoprotein 1transporter
VincristineCanalicular multispecific organic anion transporter 2transporter
VincristineSolute carrier family 22 member 3transporter
VincristineMultidrug resistance-associated protein 1transporter
VincristineMultidrug resistance-associated protein 7transporter
VincristineCanalicular multispecific organic anion transporter 1transporter
VincristineBile salt export pumptransporter
VincristineATP-binding cassette sub-family G member 2transporter
VincristineTubulin alpha-4A chaintarget
VincristineRalA-binding protein 1transporter
VincristineSolute carrier organic anion transporter family member 1B1transporter
VincristineSolute carrier organic anion transporter family member 1B3transporter
PaclitaxelApoptosis regulator Bcl-2target
PaclitaxelTubulin beta-1 chaintarget
PaclitaxelCytochrome P450 2C8enzyme
PaclitaxelCytochrome P450 3A4enzyme
PaclitaxelCytochrome P450 3A5enzyme
PaclitaxelCytochrome P450 3A7enzyme
PaclitaxelBile salt export pumptransporter
PaclitaxelP-glycoprotein 1transporter
PaclitaxelMultidrug resistance-associated protein 1transporter
PaclitaxelMultidrug resistance-associated protein 7transporter
PaclitaxelCytochrome P450 19A1enzyme
PaclitaxelCytochrome P450 1B1enzyme
PaclitaxelSolute carrier organic anion transporter family member 1B3transporter
PaclitaxelNuclear receptor subfamily 1 group I member 2target
PaclitaxelMicrotubule-associated protein 4target
PaclitaxelMicrotubule-associated protein 2target
PaclitaxelMicrotubule-associated protein tautarget
PaclitaxelCanalicular multispecific organic anion transporter 1transporter
VinflunineATP-binding cassette sub-family B member 5transporter
VinflunineP-glycoprotein 1transporter
VinflunineSerum albumincarrier
Vinfluninealpha1-acid glycoproteincarrier
VinflunineCytochrome P450 3A4enzyme
VinflunineTubulin beta chaintarget
VinblastineTubulin beta chaintarget
VinblastineTranscription factor AP-1target
VinblastineCytochrome P450 3A4enzyme
VinblastineP-glycoprotein 1transporter
VinblastineMultidrug resistance-associated protein 1transporter
VinblastineCanalicular multispecific organic anion transporter 1transporter
VinblastineMultidrug resistance-associated protein 6transporter
VinblastineBile salt export pumptransporter
VinblastineTubulin alpha-1A chaintarget
VinblastineTubulin delta chaintarget
VinblastineTubulin epsilon chaintarget
VinblastineTubulin gamma-1 chaintarget
VinblastineCytochrome P450 2D6enzyme
VinblastineSolute carrier organic anion transporter family member 1B1transporter
VenetoclaxApoptosis regulator Bcl-2target
VenetoclaxCytochrome P450 3A4enzyme
VenetoclaxP-glycoprotein 1transporter
VenetoclaxATP-binding cassette sub-family G member 2transporter
VenetoclaxSolute carrier organic anion transporter family member 1B1transporter
VemurafenibSerum albumincarrier
VemurafenibAlpha-1-acid glycoprotein 1carrier
VemurafenibCytochrome P450 1A2enzyme
VemurafenibCytochrome P450 2D6enzyme
VemurafenibCytochrome P450 3A4enzyme
VemurafenibSerine/threonine-protein kinase B-raftarget
VemurafenibMultidrug resistance-associated protein 1transporter
VemurafenibATP-binding cassette sub-family G member 2transporter
VemurafenibCytochrome P450 2C9enzyme
VemurafenibCytochrome P450 2C8enzyme
VemurafenibCytochrome P450 2B6enzyme
VemurafenibP-glycoprotein 1transporter
DactinomycinDNAtarget
DactinomycinSolute carrier family 22 member 5transporter
DactinomycinP-glycoprotein 1transporter
DactinomycinMultidrug resistance-associated protein 6transporter
DactinomycinMultidrug resistance-associated protein 1transporter
DactinomycinATP-binding cassette sub-family G member 2transporter
DactinomycinDNA topoisomerase 2target
DaunorubicinDNAtarget
DaunorubicinXanthine dehydrogenase/oxidaseenzyme
DaunorubicinCytochrome P450 3A5enzyme
DaunorubicinNADPH--cytochrome P450 reductaseenzyme
DaunorubicinP-glycoprotein 1transporter
DaunorubicinMultidrug resistance-associated protein 1transporter
DaunorubicinCanalicular multispecific organic anion transporter 1transporter
DaunorubicinMultidrug resistance-associated protein 6transporter
DaunorubicinBile salt export pumptransporter
DaunorubicinMultidrug resistance-associated protein 7transporter
DaunorubicinATP-binding cassette sub-family G member 2transporter
DaunorubicinDNA topoisomerase 2-alphatarget
DaunorubicinDNA topoisomerase 2-betatarget
DaunorubicinCytochrome P450 1A1enzyme
DaunorubicinCytochrome P450 1B1enzyme
DaunorubicinCytochrome P450 3A4enzyme
Trastuzumab emtansineReceptor tyrosine-protein kinase erbB-2target
Trastuzumab emtansineP-glycoprotein 1transporter
Trastuzumab emtansineCytochrome P450 3A4enzyme
Trastuzumab emtansineCytochrome P450 3A5enzyme
DocetaxelApoptosis regulator Bcl-2target
DocetaxelTubulin beta-1 chaintarget
DocetaxelCytochrome P450 3A4enzyme
DocetaxelCytochrome P450 3A5enzyme
DocetaxelCytochrome P450 3A7enzyme
DocetaxelP-glycoprotein 1transporter
DocetaxelMultidrug resistance-associated protein 7transporter
DocetaxelCytochrome P450 1B1enzyme
DocetaxelMicrotubule-associated protein 2target
DocetaxelMicrotubule-associated protein 4target
DocetaxelMicrotubule-associated protein tautarget
DocetaxelSolute carrier organic anion transporter family member 1B3transporter
DocetaxelSolute carrier family 22 member 7transporter
DocetaxelATP-binding cassette sub-family G member 2transporter
DocetaxelCanalicular multispecific organic anion transporter 1transporter
DocetaxelMultidrug resistance-associated protein 1transporter
DocetaxelNuclear receptor subfamily 1 group I member 2target
DoxorubicinDNA topoisomerase 2-alphatarget
DoxorubicinDNAtarget
DoxorubicinCytochrome P450 3A4enzyme
DoxorubicinCytochrome P450 2D6enzyme
DoxorubicinCytochrome P450 2B6enzyme
DoxorubicinP-glycoprotein 1transporter
DoxorubicinCanalicular multispecific organic anion transporter 2transporter
DoxorubicinMultidrug resistance-associated protein 6transporter
DoxorubicinMultidrug resistance-associated protein 1transporter
DoxorubicinMultidrug resistance-associated protein 7transporter
DoxorubicinATP-binding cassette sub-family G member 2transporter
DoxorubicinBile salt export pumptransporter
DoxorubicinSolute carrier family 22 member 16transporter
DoxorubicinATP-binding cassette sub-family B member 8, mitochondrialtransporter
DoxorubicinCytochrome P450 1B1enzyme
DoxorubicinCarbonyl reductase [NADPH] 1enzyme
DoxorubicinCarbonyl reductase [NADPH] 3enzyme
DoxorubicinAlcohol dehydrogenase [NADP(+)]enzyme
DoxorubicinAldo-keto reductase family 1 member C3enzyme
DoxorubicinNAD(P)H dehydrogenase [quinone] 1enzyme
DoxorubicinXanthine dehydrogenase/oxidaseenzyme
DoxorubicinNitric oxide synthase, endothelialenzyme
DoxorubicinNitric oxide synthase, inducibleenzyme
DoxorubicinNitric oxide synthase, brainenzyme
DoxorubicinNADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrialenzyme
DoxorubicinNADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialenzyme
DoxorubicinNADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialenzyme
DoxorubicinNADPH--cytochrome P450 reductaseenzyme
DoxorubicinRalA-binding protein 1transporter
DoxorubicinCanalicular multispecific organic anion transporter 1transporter
DoxorubicinSerum albumincarrier
DoxorubicinNucleolar and coiled-body phosphoprotein 1target
TopotecanDNA topoisomerase I, mitochondrialtarget
TopotecanDNA topoisomerase 1target
TopotecanATP-binding cassette sub-family G member 2transporter
TopotecanP-glycoprotein 1transporter
TopotecanDNAtarget
TopotecanMultidrug and toxin extrusion protein 1transporter
TopotecanMultidrug and toxin extrusion protein 2transporter
EnasidenibCytochrome P450 1A2enzyme
EnasidenibCytochrome P450 2B6enzyme
EnasidenibIsocitrate dehydrogenase [NADP], mitochondrialtarget
EnasidenibCytochrome P450 2C8enzyme
EnasidenibCytochrome P450 2C9enzyme
EnasidenibCytochrome P450 2C19enzyme
EnasidenibCytochrome P450 2D6enzyme
EnasidenibCytochrome P450 3A4enzyme
EnasidenibUDP-glucuronosyltransferase 1-1enzyme
EnasidenibUDP-glucuronosyltransferase 1-3enzyme
EnasidenibUDP-glucuronosyltransferase 1-4enzyme
EnasidenibUDP-glucuronosyltransferase 1-9enzyme
EnasidenibUDP-glucuronosyltransferase 2B7enzyme
EnasidenibUDP-glucuronosyltransferase 2B15enzyme
EnasidenibP-glycoprotein 1transporter
EnasidenibATP-binding cassette sub-family G member 2transporter
EnasidenibSolute carrier family 22 member 6transporter
EnasidenibSolute carrier organic anion transporter family member 1B1transporter
EnasidenibSolute carrier family 22 member 2transporter
EnasidenibSolute carrier organic anion transporter family member 1B3transporter
EnasidenibSolute carrier family 22 member 8transporter
EntrectinibCytochrome P450 3A4enzyme
EntrectinibP-glycoprotein 1transporter
EntrectinibHigh affinity nerve growth factor receptortarget
EntrectinibBDNF/NT-3 growth factors receptortarget
EntrectinibNT-3 growth factor receptortarget
EntrectinibProto-oncogene tyrosine-protein kinase ROStarget
EntrectinibTyrosine-protein kinase JAK2target
EntrectinibActivated CDC42 kinase 1target
ErlotinibEpidermal growth factor receptortarget
ErlotinibCytochrome P450 3A4enzyme
ErlotinibATP-binding cassette sub-family G member 2transporter
ErlotinibP-glycoprotein 1transporter
ErlotinibNuclear receptor subfamily 1 group I member 2target
ErlotinibCytochrome P450 3A5enzyme
ErlotinibCytochrome P450 1A1enzyme
ErlotinibCytochrome P450 1A2enzyme
ErlotinibCytochrome P450 1B1enzyme
ErlotinibCytochrome P450 2D6enzyme
ErlotinibCytochrome P450 2C8enzyme
ErlotinibUDP-glucuronosyltransferase 1-1enzyme
ErlotinibSerum albumincarrier
ErlotinibAlpha-1-acid glycoprotein 1carrier
ErlotinibSolute carrier organic anion transporter family member 2B1transporter
EtoposideDNA topoisomerase 2-alphatarget
EtoposideCytochrome P450 3A4enzyme
EtoposideCanalicular multispecific organic anion transporter 2transporter
EtoposideMultidrug resistance-associated protein 6transporter
EtoposideP-glycoprotein 1transporter
EtoposideMultidrug resistance-associated protein 1transporter
EtoposideMultidrug resistance-associated protein 7transporter
EtoposideCanalicular multispecific organic anion transporter 1transporter
EtoposideATP-binding cassette sub-family G member 2transporter
EtoposideCytochrome P450 1A2enzyme
EtoposideCytochrome P450 2E1enzyme
EtoposideCytochrome P450 3A5enzyme
EtoposideUDP-glucuronosyltransferase 1-1enzyme
EtoposideDNA topoisomerase 2-betatarget
EtoposideGlutathione S-transferase theta-1enzyme
EtoposideGlutathione S-transferase Penzyme
EtoposideProstaglandin G/H synthase 2enzyme
EtoposideProstaglandin G/H synthase 1enzyme
BendamustineCytochrome P450 1A2enzyme
IxabepiloneTubulin beta-3 chaintarget
IxabepiloneCytochrome P450 3A4enzyme
IxabepiloneP-glycoprotein 1transporter
BinimetinibInterleukin-6target
BinimetinibTumor necrosis factortarget
BinimetinibInterleukin-1 betatarget
BinimetinibUDP-glucuronosyltransferase 1-1enzyme
BinimetinibCytochrome P450 1A2enzyme
BinimetinibCytochrome P450 2C19enzyme
BinimetinibMitogen-activated protein kinase kinase kinase 1target
BinimetinibDual specificity mitogen-activated protein kinase kinase 2target
BosutinibBreakpoint cluster region proteintarget
BosutinibTyrosine-protein kinase ABL1target
BosutinibTyrosine-protein kinase Lyntarget
BosutinibTyrosine-protein kinase HCKtarget
BosutinibProto-oncogene tyrosine-protein kinase Srctarget
BosutinibP-glycoprotein 1transporter
BosutinibCytochrome P450 3A4enzyme
BosutinibCyclin-dependent kinase 2target
BosutinibDual specificity mitogen-activated protein kinase kinase 1target
BosutinibDual specificity mitogen-activated protein kinase kinase 2target
BosutinibMitogen-activated protein kinase kinase kinase 2target
BosutinibCalcium/calmodulin-dependent protein kinase type II subunit gammatarget
BosutinibCytochrome P450 2C8enzyme
MitoxantroneDNA topoisomerase 2-alphatarget
MitoxantroneCytochrome P450 2E1enzyme
MitoxantroneP-glycoprotein 1transporter
MitoxantroneMultidrug resistance-associated protein 1transporter
MitoxantroneATP-binding cassette sub-family G member 2transporter
MitoxantroneDNAtarget
MitoxantroneCytochrome P450 1B1enzyme
MitoxantroneCytochrome P450 3A4enzyme
Brentuximab vedotinTumor necrosis factor receptor superfamily member 8target
Brentuximab vedotinCytochrome P450 3A4enzyme
Brentuximab vedotinATP-binding cassette sub-family B member 5transporter
TalazoparibPoly [ADP-ribose] polymerase 1target
TalazoparibPoly [ADP-ribose] polymerase 2target
TalazoparibP-glycoprotein 1transporter
TalazoparibATP-binding cassette sub-family G member 2transporter
CabazitaxelCytochrome P450 3A4enzyme
CabazitaxelCytochrome P450 3A5enzyme
CabazitaxelCytochrome P450 2C8enzyme
CabazitaxelP-glycoprotein 1transporter
CabazitaxelATP-binding cassette sub-family G member 2transporter
CabazitaxelTubulin alpha-4A chaintarget
CabazitaxelTubulin beta-1 chaintarget
CabazitaxelSolute carrier organic anion transporter family member 1B1transporter
CabazitaxelSolute carrier organic anion transporter family member 1B3transporter
NilotinibTyrosine-protein kinase ABL1target
NilotinibMast/stem cell growth factor receptor Kittarget
NilotinibCytochrome P450 2D6enzyme
NilotinibCytochrome P450 2C8enzyme
NilotinibCytochrome P450 2C9enzyme
NilotinibCytochrome P450 3A4enzyme
NilotinibP-glycoprotein 1transporter
NilotinibATP-binding cassette sub-family G member 2transporter
NilotinibUDP-glucuronosyltransferase 1-1transporter
NilotinibCytochrome P450 2B6enzyme
NilotinibSolute carrier organic anion transporter family member 1B1transporter
SorafenibSerine/threonine-protein kinase B-raftarget
SorafenibReceptor-type tyrosine-protein kinase FLT3target
SorafenibRAF proto-oncogene serine/threonine-protein kinasetarget
SorafenibVascular endothelial growth factor receptor 3target
SorafenibPlatelet-derived growth factor receptor betatarget
SorafenibMast/stem cell growth factor receptor Kittarget
SorafenibVascular endothelial growth factor receptor 2target
SorafenibCytochrome P450 3A4enzyme
SorafenibUDP-glucuronosyltransferase 1-9enzyme
SorafenibCytochrome P450 2B6enzyme
SorafenibCytochrome P450 2C8enzyme
SorafenibCytochrome P450 3A5enzyme
SorafenibCytochrome P450 3A7enzyme
SorafenibCytochrome P450 2C9enzyme
SorafenibMultidrug resistance-associated protein 4transporter
SorafenibP-glycoprotein 1transporter
SorafenibCanalicular multispecific organic anion transporter 1transporter
SorafenibATP-binding cassette sub-family G member 2transporter
SorafenibCytochrome P450 1A2enzyme
SorafenibCytochrome P450 2C19enzyme
SorafenibCytochrome P450 2D6enzyme
SorafenibUDP-glucuronosyltransferase 1-1enzyme
SorafenibRalA-binding protein 1transporter
SorafenibFibroblast growth factor receptor 1target
SorafenibProto-oncogene tyrosine-protein kinase receptor Rettarget
SorafenibVascular endothelial growth factor receptor 1target
SorafenibSolute carrier organic anion transporter family member 1B1transporter
CarfilzomibP-glycoprotein 1transporter
CarfilzomibProteasome subunit beta type-5target
CarfilzomibProteasome subunit beta type-9target
CarfilzomibProteasome subunit beta type-10target
CarfilzomibProteasome subunit beta type-8target
CarfilzomibProteasome subunit beta type-1target
CarfilzomibProteasome subunit beta type-2target
CeritinibALK tyrosine kinase receptortarget
CeritinibP-glycoprotein 1transporter
CeritinibCytochrome P450 2C9enzyme
CeritinibCytochrome P450 3A4enzyme
CobimetinibDual specificity mitogen-activated protein kinase kinase 1target
CobimetinibCytochrome P450 3A4enzyme
CobimetinibP-glycoprotein 1enzyme
CobimetinibSolute carrier organic anion transporter family member 1B1transporter
CobimetinibSolute carrier organic anion transporter family member 1B3transporter
CobimetinibATP-binding cassette sub-family G member 2transporter
CobimetinibP-glycoprotein 1transporter
DabrafenibCytochrome P450 3A4enzyme
DabrafenibCytochrome P450 2C8enzyme
DabrafenibP-glycoprotein 1transporter
DabrafenibATP-binding cassette sub-family G member 2transporter
DabrafenibSolute carrier organic anion transporter family member 1B1transporter
DabrafenibSolute carrier organic anion transporter family member 1B3transporter
DabrafenibSolute carrier family 22 member 6transporter
DabrafenibSolute carrier family 22 member 8transporter
DabrafenibSerine/threonine-protein kinase B-raftarget
DabrafenibRAF proto-oncogene serine/threonine-protein kinasetarget
DabrafenibSerine/threonine-protein kinase SIK1target
DabrafenibSerine/threonine-protein kinase Nek11target
DabrafenibLIM domain kinase 1target
DabrafenibCytochrome P450 2B6enzyme
DabrafenibCytochrome P450 2C9enzyme
DabrafenibCytochrome P450 2C19enzyme
DabrafenibCytochrome P450 1A2enzyme
CopanlisibPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformtarget
CopanlisibPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget
CopanlisibCytochrome P450 3A4enzyme
CopanlisibCytochrome P450 3A5enzyme
CopanlisibCytochrome P450 3A7enzyme
CopanlisibP-glycoprotein 1transporter
CopanlisibATP-binding cassette sub-family G member 2transporter
CopanlisibMultidrug and toxin extrusion protein 2transporter
CopanlisibSerum albumincarrier
CopanlisibCytochrome P450 1A1enzyme
DacomitinibCytochrome P450 2D6enzyme
DacomitinibSerum albumincarrier
DacomitinibCytochrome P450 3A4enzyme
DacomitinibCytochrome P450 2C9enzyme
DacomitinibUDP-glucuronosyltransferase 1-1enzyme
DacomitinibP-glycoprotein 1transporter
DacomitinibATP-binding cassette sub-family G member 2transporter
DacomitinibSolute carrier family 22 member 1transporter
DacomitinibEpidermal growth factor receptortarget
CrizotinibCytochrome P450 3A4enzyme
CrizotinibCytochrome P450 3A5enzyme
CrizotinibP-glycoprotein 1transporter
CrizotinibALK tyrosine kinase receptortarget
CrizotinibHepatocyte growth factor receptortarget
CrizotinibCytochrome P450 2B6enzyme
CrizotinibCytochrome P450 3A Subfamilyenzyme
DasatinibTyrosine-protein kinase ABL1target
DasatinibAbelson tyrosine-protein kinase 2target
DasatinibProto-oncogene tyrosine-protein kinase Srctarget
DasatinibTyrosine-protein kinase Fyntarget
DasatinibTyrosine-protein kinase Lcktarget
DasatinibTyrosine-protein kinase Yestarget
DasatinibMast/stem cell growth factor receptor Kittarget
DasatinibPlatelet-derived growth factor receptor betatarget
DasatinibEphrin type-A receptor 2target
DasatinibSignal transducer and activator of transcription 5Btarget
DasatinibCytochrome P450 3A4enzyme
DasatinibP-glycoprotein 1transporter
DasatinibATP-binding cassette sub-family G member 2transporter
DasatinibCytochrome P450 1A1enzyme
DasatinibCytochrome P450 1A2enzyme
DasatinibCytochrome P450 1B1enzyme
DasatinibCytochrome P450 3A5enzyme
DasatinibDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DasatinibTyrosine-protein kinase BTKtarget
DasatinibNuclear receptor subfamily 4 group A member 3target
DasatinibBreakpoint cluster region proteintarget
DasatinibTyrosine-protein kinase CSKtarget
DasatinibEphrin type-A receptor 5target
DasatinibEphrin type-B receptor 4target
DasatinibTyrosine-protein kinase Fgrtarget
DasatinibTyrosine-protein kinase FRKtarget
DasatinibHeat shock cognate 71 kDa proteintarget
DasatinibTyrosine-protein kinase Lyntarget
DasatinibMitogen-activated protein kinase kinase kinase MLTtarget
DasatinibMitogen-activated protein kinase 14target
DasatinibAmidophosphoribosyltransferasetarget
ErdafitinibCytochrome P450 2C9enzyme
ErdafitinibCytochrome P450 3A4enzyme
ErdafitinibFibroblast growth factor receptor 1target
ErdafitinibFibroblast growth factor receptor 2target
ErdafitinibFibroblast growth factor receptor 3target
ErdafitinibFibroblast growth factor receptor 4target
ErdafitinibP-glycoprotein 1transporter
ErdafitinibSolute carrier family 22 member 2transporter
ErdafitinibRET proto-oncogenetarget
ErdafitinibMacrophage colony-stimulating factor 1 receptortarget
ErdafitinibPlatelet-derived growth factor receptor alphatarget
ErdafitinibPlatelet-derived growth factor receptor betatarget
ErdafitinibMast/stem cell growth factor receptor Kittarget
ErdafitinibVascular endothelial growth factor receptor 2target
IvosidenibIsocitrate dehydrogenase [NADP] cytoplasmictarget
IvosidenibCytochrome P450 3A4enzyme
IvosidenibCytochrome P450 2B6enzyme
IvosidenibCytochrome P450 2C9enzyme
IvosidenibCytochrome P450 2C8enzyme
IvosidenibSolute carrier family 22 member 8transporter
IvosidenibP-glycoprotein 1transporter
BortezomibCytochrome P450 3A4enzyme
BortezomibCytochrome P450 2C19enzyme
BortezomibCytochrome P450 1A2enzyme
BortezomibCytochrome P450 2D6enzyme
BortezomibCytochrome P450 2C9enzyme
BortezomibProteasome subunit beta type-5target
BortezomibProteasome subunit beta type-1target
BortezomibP-glycoprotein 1transporter
BortezomibSolute carrier organic anion transporter family member 1B3transporter
TamoxifenEstrogen receptor alphatarget
TamoxifenEstrogen receptor betatarget
TamoxifenCytochrome P450 2C9enzyme
TamoxifenCytochrome P450 3A4enzyme
TamoxifenCytochrome P450 2D6enzyme
TamoxifenCytochrome P450 2C8enzyme
TamoxifenCytochrome P450 2B6enzyme
TamoxifenLiver carboxylesterase 1enzyme
TamoxifenCytochrome P450 3A5enzyme
TamoxifenCytochrome P450 1A1enzyme
TamoxifenCytochrome P450 1B1enzyme
TamoxifenCytochrome P450 2C19enzyme
TamoxifenDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
TamoxifenDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
TamoxifenCytochrome P450 3A7enzyme
TamoxifenP-glycoprotein 1transporter
TamoxifenATP-binding cassette sub-family G member 2transporter
TamoxifenCytochrome P450 19A1enzyme
TamoxifenCytochrome P450 2A6enzyme
TamoxifenCytochrome P450 2E1enzyme
TamoxifenUDP-glucuronosyltransferase 1-10enzyme
TamoxifenSulfotransferase 1A1enzyme
TamoxifenCanalicular multispecific organic anion transporter 1transporter
Tamoxifen3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerasetarget
TamoxifenProtein kinase Ctarget
TamoxifenAndrogen receptortarget
TamoxifenPotassium voltage-gated channel subfamily H member 2target
TamoxifenNuclear receptor subfamily 1 group I member 2target
TamoxifenEstrogen-related receptor gammatarget
TamoxifenSex hormone-binding globulintarget
TamoxifenBile salt export pumptransporter
TamoxifenThyroxine-binding globulincarrier
TamoxifenBile salt sulfotransferaseenzyme
TamoxifenCytochrome P450 1A2enzyme
TamoxifenUDP-glucuronosyltransferase 2B7enzyme
TamoxifenUDP-glucuronosyltransferase 2B17enzyme
TamoxifenEstrogen sulfotransferaseenzyme
TamoxifenATP-binding cassette sub-family A member 1transporter
TamoxifenMitogen-activated protein kinase 8target
TamoxifenSerum albumincarrier
ImipramineSodium-dependent noradrenaline transportertarget
ImipramineSodium-dependent serotonin transportertarget
ImipramineCytochrome P450 1A2enzyme
ImipramineCytochrome P450 2C19enzyme
ImipramineCytochrome P450 2D6enzyme
ImipramineHistamine H1 receptortarget
ImipramineAlpha-1A adrenergic receptortarget
Imipramine5-hydroxytryptamine receptor 2Atarget
ImipramineMuscarinic acetylcholine receptor M1target
ImipramineMuscarinic acetylcholine receptor M2target
ImipramineMuscarinic acetylcholine receptor M3target
ImipramineMuscarinic acetylcholine receptor M4target
ImipramineMuscarinic acetylcholine receptor M5target
ImipraminePotassium voltage-gated channel subfamily D member 2target
ImipraminePotassium voltage-gated channel subfamily D member 3target
ImipramineAlpha-1D adrenergic receptortarget
ImipramineAlpha-1-acid glycoprotein 1carrier
ImipramineSolute carrier family 22 member 2transporter
ImipramineSolute carrier family 22 member 3transporter
ImipramineP-glycoprotein 1transporter
ImipramineSolute carrier family 22 member 4transporter
ImipramineCytochrome P450 3A4enzyme
ImipramineCytochrome P450 2B6enzyme
ImipramineCytochrome P450 2C18enzyme
ImipramineCytochrome P450 2E1enzyme
ImipramineCytochrome P450 3A7enzyme
Imipramine5-hydroxytryptamine receptor 2Ctarget
ImipramineAlpha-1B adrenergic receptortarget
Imipramine5-hydroxytryptamine receptor 7target
ImipramineD(1) dopamine receptortarget
ImipramineDopamine D2 receptortarget
ImipraminePotassium voltage-gated channel subfamily H member 2target
ImipramineSodium-dependent dopamine transportertarget
Imipramine5-hydroxytryptamine receptor 1Atarget
Imipramine5-hydroxytryptamine receptor 6target
ImipraminePotassium voltage-gated channel subfamily H member 1target
ImipramineSerum albumincarrier
ImipramineAlpha-1-acid glycoprotein 2target
TrimipramineSodium-dependent serotonin transportertarget
TrimipramineSodium-dependent noradrenaline transportertarget
TrimipramineCytochrome P450 2D6enzyme
TrimipramineSodium-dependent dopamine transportertarget
Trimipramine5-hydroxytryptamine receptor 2Atarget
Trimipramine5-hydroxytryptamine receptor 1Atarget
TrimipramineAlpha-1A adrenergic receptortarget
TrimipramineAlpha-1B adrenergic receptortarget
TrimipramineDopamine D2 receptortarget
TrimipramineAlpha-2B adrenergic receptortarget
TrimipramineHistamine H1 receptortarget
TrimipramineCytochrome P450 2C19enzyme
TrimipramineP-glycoprotein 1transporter
TrimipramineCytochrome P450 2C9enzyme
Trimipramine5-hydroxytryptamine receptor 2Ctarget
Trimipramine5-hydroxytryptamine receptor 3Atarget
Trimipramine5-hydroxytryptamine receptor 1Dtarget
TrimipramineAlpha-2A adrenergic receptortarget
TrimipramineD(1) dopamine receptortarget
TrimipramineBeta adrenergic receptortarget
TrimipramineMuscarinic acetylcholine receptortarget
Trimipramine5-hydroxytryptamine receptor 1Ctarget
MethotrexateDihydrofolate reductasetarget
MethotrexateAldehyde oxidaseenzyme
MethotrexateMethylenetetrahydrofolate reductaseenzyme
MethotrexateSerum albumincarrier
MethotrexateCanalicular multispecific organic anion transporter 2transporter
MethotrexateMultidrug resistance-associated protein 4transporter
MethotrexateMultidrug resistance-associated protein 1transporter
MethotrexateSolute carrier family 22 member 6transporter
MethotrexateMultidrug resistance-associated protein 7transporter
MethotrexateSolute carrier family 22 member 8transporter
MethotrexateCanalicular multispecific organic anion transporter 1transporter
MethotrexateP-glycoprotein 1transporter
MethotrexateSolute carrier organic anion transporter family member 1A2transporter
MethotrexateMonocarboxylate transporter 1transporter
MethotrexateATP-binding cassette sub-family C member 11transporter
MethotrexateSolute carrier organic anion transporter family member 1B3transporter
MethotrexateSolute carrier family 22 member 11transporter
MethotrexateSolute carrier organic anion transporter family member 1C1transporter
MethotrexateSolute carrier organic anion transporter family member 3A1transporter
MethotrexateATP-binding cassette sub-family G member 2transporter
MethotrexateSolute carrier family 22 member 7transporter
MethotrexateSolute carrier organic anion transporter family member 1B1transporter
Methotrexate6-phosphogluconate dehydrogenase, decarboxylatingenzyme
MethotrexateProton-coupled folate transportertransporter
MethotrexateFolylpolyglutamate synthase, mitochondrialenzyme
MethotrexateGamma-glutamyl hydrolaseenzyme
MethotrexateDihydrofolate reductaseenzyme
MethotrexateThymidylate synthaseenzyme
MethotrexateBifunctional purine biosynthesis protein PURHenzyme
MethotrexateSolute carrier organic anion transporter family member 4C1transporter
MethotrexateFolate transporter 1transporter
MethotrexateFolate receptor alphatransporter
MethotrexateCytochrome P450 3A4enzyme
MethotrexateThymidylate synthasetarget
MethotrexateBifunctional purine biosynthesis protein PURHtarget
MethotrexateFolate receptor betatransporter
MethotrexateSolute carrier family 15 member 1transporter
MethotrexateProton-coupled amino acid transporter 1transporter
GemcitabineRibonucleoside-diphosphate reductase large subunittarget
GemcitabineUMP-CMP kinasetarget
GemcitabineThymidylate synthasetarget
GemcitabineCytidine deaminaseenzyme
GemcitabineDeoxycytidine kinaseenzyme
GemcitabineP-glycoprotein 1transporter
GemcitabineMultidrug resistance-associated protein 7transporter
GemcitabineEquilibrative nucleoside transporter 1transporter
GemcitabineDNAtarget
GemcitabineSodium/nucleoside cotransporter 1transporter
GemcitabineEquilibrative nucleoside transporter 2transporter
GemcitabineSolute carrier family 28 member 3transporter
RomidepsinCytochrome P450 3A4enzyme
RomidepsinCytochrome P450 3A5enzyme
RomidepsinP-glycoprotein 1transporter
RomidepsinSolute carrier organic anion transporter family member 1B3transporter
RomidepsinCytochrome P450 1A1enzyme
RomidepsinCytochrome P450 2B6enzyme
RomidepsinCytochrome P450 2C19enzyme
RomidepsinHistone deacetylase 1target
RomidepsinHistone deacetylase 2target
RomidepsinHistone deacetylase 4target
RomidepsinHistone deacetylase 6target
RomidepsinMultidrug resistance-associated protein 1target
TolvaptanVasopressin V2 receptortarget
TolvaptanCytochrome P450 3A4enzyme
TolvaptanP-glycoprotein 1transporter
TolvaptanVasopressin V1a receptortarget
PazopanibVascular endothelial growth factor receptor 1target
PazopanibVascular endothelial growth factor receptor 2target
PazopanibVascular endothelial growth factor receptor 3target
PazopanibPlatelet-derived growth factor receptor alphatarget
PazopanibPlatelet-derived growth factor receptor betatarget
PazopanibMast/stem cell growth factor receptor Kittarget
PazopanibCytochrome P450 3A4enzyme
PazopanibCytochrome P450 2D6enzyme
PazopanibCytochrome P450 2C8enzyme
PazopanibCytochrome P450 1A2enzyme
PazopanibP-glycoprotein 1transporter
PazopanibATP-binding cassette sub-family G member 2transporter
PazopanibSolute carrier organic anion transporter family member 1B1transporter
PazopanibUDP-glucuronosyltransferase 1-1transporter
PazopanibFibroblast growth factor receptor 3target
PazopanibTyrosine-protein kinase ITK/TSKtarget
PazopanibFibroblast growth factor 1target
PazopanibSH2B adapter protein 3target
AxitinibVascular endothelial growth factor receptor 1target
AxitinibVascular endothelial growth factor receptor 2target
AxitinibVascular endothelial growth factor receptor 3target
AxitinibCytochrome P450 3A4enzyme
AxitinibCytochrome P450 3A5enzyme
AxitinibCytochrome P450 1A2enzyme
AxitinibCytochrome P450 2C19enzyme
AxitinibUDP-glucuronosyltransferase 1-1enzyme
AxitinibP-glycoprotein 1transporter
AxitinibSolute carrier organic anion transporter family member 1B1transporter
RegorafenibCytochrome P450 3A4enzyme
RegorafenibUDP-glucuronosyltransferase 1-9enzyme
RegorafenibProto-oncogene tyrosine-protein kinase receptor Rettarget
RegorafenibVascular endothelial growth factor receptor 1target
RegorafenibVascular endothelial growth factor receptor 2target
RegorafenibVascular endothelial growth factor receptor 3target
RegorafenibMast/stem cell growth factor receptor Kittarget
RegorafenibPlatelet-derived growth factor receptor alphatarget
RegorafenibPlatelet-derived growth factor receptor betatarget
RegorafenibFibroblast growth factor receptor 1target
RegorafenibFibroblast growth factor receptor 2target
RegorafenibAngiopoietin-1 receptortarget
RegorafenibDiscoidin domain-containing receptor 2target
RegorafenibHigh affinity nerve growth factor receptortarget
RegorafenibEphrin type-A receptor 2target
RegorafenibRAF proto-oncogene serine/threonine-protein kinasetarget
RegorafenibSerine/threonine-protein kinase B-raftarget
RegorafenibCytochrome P450 2C8enzyme
RegorafenibCytochrome P450 2C9enzyme
RegorafenibCytochrome P450 2B6enzyme
RegorafenibMitogen-activated protein kinase 11target
RegorafenibTyrosine-protein kinase FRKtarget
RegorafenibTyrosine-protein kinase ABL1target
RegorafenibP-glycoprotein 1transporter
RegorafenibATP-binding cassette sub-family G member 2transporter
RegorafenibUDP-glucuronosyltransferase 1-1enzyme
PonatinibTyrosine-protein kinase ABL1target
PonatinibBreakpoint cluster region proteintarget
PonatinibMast/stem cell growth factor receptor Kittarget
PonatinibProto-oncogene tyrosine-protein kinase receptor Rettarget
PonatinibAngiopoietin-1 receptortarget
PonatinibReceptor-type tyrosine-protein kinase FLT3target
PonatinibCytochrome P450 3A4enzyme
PonatinibCytochrome P450 2C8enzyme
PonatinibCytochrome P450 2D6enzyme
PonatinibCytochrome P450 3A5enzyme
PonatinibP-glycoprotein 1transporter
PonatinibATP-binding cassette sub-family G member 2transporter
PonatinibFibroblast growth factor receptor 1target
PonatinibFibroblast growth factor receptor 2target
PonatinibFibroblast growth factor receptor 3target
PonatinibFibroblast growth factor receptor 4target
PonatinibTyrosine-protein kinase Lcktarget
PonatinibProto-oncogene tyrosine-protein kinase Srctarget
PonatinibTyrosine-protein kinase Lyntarget
PonatinibVascular endothelial growth factor receptor 2target
PonatinibPlatelet-derived growth factor receptor alphatarget
PomalidomideCytochrome P450 1A2enzyme
PomalidomideCytochrome P450 3A4enzyme
PomalidomideP-glycoprotein 1transporter
PomalidomideProtein cereblontarget
PomalidomideTumor necrosis factortarget
PomalidomideProstaglandin G/H synthase 2target
IrinotecanDNA topoisomerase I, mitochondrialtarget
IrinotecanDNA topoisomerase 1target
IrinotecanCytochrome P450 3A4enzyme
IrinotecanCytochrome P450 3A5enzyme
IrinotecanUDP-glucuronosyltransferase 1-1enzyme
IrinotecanUDP-glucuronosyltransferase 1-9enzyme
IrinotecanLiver carboxylesterase 1enzyme
IrinotecanCytochrome P450 3A7enzyme
IrinotecanCytochrome P450 2B6enzyme
IrinotecanSolute carrier family 22 member 3transporter
IrinotecanSolute carrier organic anion transporter family member 1B1transporter
IrinotecanMultidrug resistance-associated protein 1transporter
IrinotecanATP-binding cassette sub-family G member 2transporter
IrinotecanSerum albumincarrier
IrinotecanCocaine esteraseenzyme
IrinotecanCholinesteraseenzyme
IrinotecanP-glycoprotein 1transporter
IrinotecanCanalicular multispecific organic anion transporter 1transporter
IdelalisibPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget
IdelalisibATP-binding cassette sub-family G member 2transporter
IdelalisibP-glycoprotein 1transporter
IdelalisibAldehyde oxidaseenzyme
IdelalisibCytochrome P450 2C8enzyme
IdelalisibCytochrome P450 2C19enzyme
IdelalisibCytochrome P450 2B6enzyme
IdelalisibCytochrome P450 3A4enzyme
IdelalisibSolute carrier organic anion transporter family member 1B1transporter
IdelalisibSolute carrier organic anion transporter family member 1B3transporter
IdelalisibCytochrome P450 3A5enzyme
IdelalisibCytochrome P450 3A43enzyme
IdelalisibCytochrome P450 3A7enzyme
IdelalisibUDP-glucuronosyltransferase 1-4enzyme
PanobinostatCytochrome P450 2D6enzyme
PanobinostatCytochrome P450 3A4enzyme
PanobinostatP-glycoprotein 1transporter
PanobinostatHistone deacetylasetarget
OsimertinibEpidermal growth factor receptortarget
OsimertinibP-glycoprotein 1transporter
OsimertinibATP-binding cassette sub-family G member 2transporter
OsimertinibCytochrome P450 3A4enzyme
OsimertinibCytochrome P450 1A2enzyme
BelinostatHistone deacetylasetarget
BelinostatCytochrome P450 1A2enzyme
BelinostatUDP-glucuronosyltransferase 1-1enzyme
BelinostatCytochrome P450 2C8enzyme
BelinostatCytochrome P450 2C9enzyme
BelinostatP-glycoprotein 1transporter
BelinostatCytochrome P450 3A4enzyme
Inotuzumab ozogamicinP-glycoprotein 1transporter
Inotuzumab ozogamicinB-cell receptor CD22target
AbemaciclibMultidrug and toxin extrusion protein 1transporter
AbemaciclibMultidrug and toxin extrusion protein 2transporter
AbemaciclibCyclin-dependent kinase 4target
AbemaciclibCyclin-dependent kinase 6target
AbemaciclibSerum albumincarrier
Abemaciclibalpha1-acid glycoproteincarrier
AbemaciclibCytochrome P450 3A4enzyme
AbemaciclibP-glycoprotein 1transporter
AbemaciclibATP-binding cassette sub-family G member 2transporter
AbemaciclibSolute carrier family 22 member 2transporter
AbemaciclibCytochrome P450 1A2enzyme
AbemaciclibCytochrome P450 2B6enzyme
AbemaciclibCytochrome P450 2C8enzyme
AbemaciclibCytochrome P450 2C9enzyme
AbemaciclibCytochrome P450 2D6enzyme
CabergolineDopamine D2 receptortarget
Cabergoline5-hydroxytryptamine receptor 2Btarget
CabergolineDopamine D3 receptortarget
Cabergoline5-hydroxytryptamine receptor 2Atarget
CabergolineAlpha-2B adrenergic receptortarget
Cabergoline5-hydroxytryptamine receptor 1Dtarget
CabergolineDopamine D4 receptortarget
CabergolineAlpha-2A adrenergic receptortarget
Cabergoline5-hydroxytryptamine receptor 1Atarget
CabergolineAlpha-2C adrenergic receptortarget
CabergolineDopamine D5 receptortarget
CabergolineDopamine D1 receptortarget
Cabergoline5-hydroxytryptamine receptor 1Btarget
Cabergoline5-hydroxytryptamine receptor 2Ctarget
CabergolineCytochrome P450 3A4enzyme
Cabergoline5-hydroxytryptamine receptor 7target
CabergolineAlpha-1A adrenergic receptortarget
CabergolineAlpha-1B adrenergic receptortarget
CabergolineAlpha-1D adrenergic receptortarget
CabergolineBeta-1 adrenergic receptortarget
CabergolineBeta-2 adrenergic receptortarget
CabergolineD(1) dopamine receptortarget
CabergolineP-glycoprotein 1transporter
AmitriptylineSodium-dependent serotonin transportertarget
AmitriptylineSodium-dependent noradrenaline transportertarget
AmitriptylinePotassium voltage-gated channel subfamily KQT member 2target
AmitriptylineAlpha-2A adrenergic receptortarget
AmitriptylineCytochrome P450 1A2enzyme
AmitriptylineCytochrome P450 2C19enzyme
AmitriptylineCytochrome P450 2D6enzyme
AmitriptylineSerum albumincarrier
AmitriptylineAlpha-1-acid glycoprotein 1carrier
AmitriptylineHistamine H1 receptortarget
Amitriptyline5-hydroxytryptamine receptor 2Atarget
Amitriptyline5-hydroxytryptamine receptor 1Atarget
AmitriptylineAlpha-1A adrenergic receptortarget
AmitriptylineCytochrome P450 3A4enzyme
AmitriptylineCytochrome P450 3A5enzyme
AmitriptylinePotassium voltage-gated channel subfamily A member 1target
AmitriptylineAlpha-1D adrenergic receptortarget
AmitriptylineDelta-type opioid receptortarget
AmitriptylineKappa-type opioid receptortarget
AmitriptylineHigh affinity nerve growth factor receptortarget
AmitriptylineBDNF/NT-3 growth factors receptortarget
AmitriptylineCytochrome P450 2C9enzyme
AmitriptylineCytochrome P450 2B6enzyme
AmitriptylineCytochrome P450 2C8enzyme
AmitriptylineHistamine H2 receptortarget
AmitriptylineHistamine H4 receptortarget
AmitriptylineSigma non-opioid intracellular receptor 1target
Amitriptyline5-hydroxytryptamine receptor 2Ctarget
AmitriptylineAlpha-1B adrenergic receptortarget
Amitriptyline5-hydroxytryptamine receptor 7target
Amitriptyline5-hydroxytryptamine receptor 1Dtarget
AmitriptylineMu-type opioid receptortarget
Amitriptyline5-hydroxytryptamine receptor 1Btarget
Amitriptyline5-hydroxytryptamine receptor 6target
AmitriptylinePotassium voltage-gated channel subfamily KQT member 3target
AmitriptylineUDP-glucuronosyltransferase 2B10enzyme
Amitriptyline5-hydroxytryptamine receptor 1Ctarget
AmitriptylineMuscarinic acetylcholine receptortarget
AmitriptylineHERG human cardiac K+ channeltarget
AmitriptylineP-glycoprotein 1transporter
AmitriptylineUDP-glucuronosyltransferase 1-4enzyme
PalbociclibCyclin-dependent kinase 4target
PalbociclibCyclin-dependent kinase 6target
PalbociclibCytochrome P450 3A4enzyme
PalbociclibBile salt sulfotransferaseenzyme
PalbociclibP-glycoprotein 1transporter
PalbociclibATP-binding cassette sub-family G member 2transporter
PalbociclibSerum albumincarrier
PalbociclibSolute carrier family 22 member 1transporter
FlecainideSodium channel protein type 5 subunit alphatarget
FlecainideCytochrome P450 2D6enzyme
FlecainideSodium channel protein type 4 subunit alphatarget
FlecainideCytochrome P450 2C9enzyme
FlecainidePotassium voltage-gated channel subfamily H member 2target
Flecainidealpha1-acid glycoproteincarrier
FlecainideSerum albumincarrier
FlecainideCytochrome P450 1A2enzyme
FlecainideP-glycoprotein 1transporter
FlecainideMultidrug and toxin extrusion protein 1transporter
FlecainideRyanodine receptor 2target
AcenocoumarolVitamin K epoxide reductase complex subunit 1target
AcenocoumarolCytochrome P450 2C9enzyme
AcenocoumarolCytochrome P450 1A2enzyme
AcenocoumarolSerum albumincarrier
AcenocoumarolAlpha-1-acid glycoprotein 1carrier
AcenocoumarolCytochrome P450 2C19enzyme
AcenocoumarolCytochrome P450 3A4enzyme
AcenocoumarolP-glycoprotein 1transporter
ZanubrutinibCytochrome P450 3A4enzyme
ZanubrutinibP-glycoprotein 1transporter
ZanubrutinibCytochrome P450 2B6enzyme
ZanubrutinibTyrosine-protein kinase BTKtarget
ZanubrutinibEpidermal growth factor receptortarget
ZanubrutinibReceptor tyrosine-protein kinase erbB-2target
ZanubrutinibReceptor tyrosine-protein kinase erbB-4target
ZanubrutinibTyrosine-protein kinase ITK/TSKtarget
ZanubrutinibCytoplasmic tyrosine-protein kinase BMXtarget
ZanubrutinibTyrosine-protein kinase JAK2target
ZanubrutinibTyrosine-protein kinase Tectarget
ZanubrutinibTyrosine-protein kinase Blktarget
ZanubrutinibTyrosine-protein kinase JAK3target
ZanubrutinibProtein-tyrosine kinase 6target
ZanubrutinibTyrosine-protein kinase Fgrtarget
ZanubrutinibTyrosine-protein kinase FRKtarget
ZanubrutinibTyrosine-protein kinase Lcktarget
ZanubrutinibTyrosine-protein kinase TXKtarget
ZanubrutinibCytochrome P450 3A Subfamilyenzyme
BaricitinibSolute carrier family 22 member 8transporter
BaricitinibATP-binding cassette sub-family G member 2transporter
BaricitinibMultidrug and toxin extrusion protein 2transporter
BaricitinibCytochrome P450 3A4enzyme
BaricitinibTyrosine-protein kinase JAK1target
BaricitinibTyrosine-protein kinase JAK2target
BaricitinibSolute carrier family 22 member 6transporter
BaricitinibSolute carrier family 22 member 2transporter
BaricitinibSolute carrier organic anion transporter family member 1B3transporter
BaricitinibProtein-tyrosine kinase 2-betatarget
BaricitinibTyrosine-protein kinase JAK3target
BaricitinibP-glycoprotein 1transporter
NortriptylineSodium-dependent serotonin transportertarget
NortriptylineSodium-dependent noradrenaline transportertarget
NortriptylineCytochrome P450 1A2enzyme
NortriptylineCytochrome P450 2D6enzyme
NortriptylineSerum albumincarrier
NortriptylineAlpha-1-acid glycoprotein 1carrier
NortriptylineHistamine H1 receptortarget
Nortriptyline5-hydroxytryptamine receptor 2Atarget
NortriptylineAlpha-1A adrenergic receptortarget
Nortriptyline5-hydroxytryptamine receptor 1Atarget
NortriptylineCytochrome P450 3A4enzyme
NortriptylineCytochrome P450 3A5enzyme
NortriptylineAlpha-1D adrenergic receptortarget
NortriptylineCytochrome P450 2C19enzyme
NortriptylineCytochrome P450 2E1enzyme
Nortriptyline5-hydroxytryptamine receptor 2Ctarget
NortriptylineAlpha-1B adrenergic receptortarget
NortriptylineAlpha-2 adrenergic receptorstarget
NortriptylineBeta adrenergic receptortarget
NortriptylineDopamine D2 receptortarget
NortriptylineSigma receptortarget
Nortriptyline5-hydroxytryptamine receptor 1Ctarget
NortriptylineSodium-dependent noradrenaline transportertransporter
NortriptylineMuscarinic acetylcholine receptortarget
NortriptylineP-glycoprotein 1transporter
EverolimusSerine/threonine-protein kinase mTORtarget
EverolimusCytochrome P450 3A4enzyme
EverolimusSolute carrier organic anion transporter family member 1B1transporter
EverolimusSolute carrier organic anion transporter family member 1B3transporter
EverolimusSolute carrier organic anion transporter family member 1A2transporter
EverolimusCytochrome P450 2D6enzyme
EverolimusP-glycoprotein 1transporter
Chloramphenicol succinateDr hemagglutinin structural subunittarget
Chloramphenicol succinateSerum albumincarrier
Chloramphenicol succinateP-glycoprotein 1transporter
Chloramphenicol succinateChloramphenicol acetyltransferase 3enzyme
RucaparibPoly [ADP-ribose] polymerase 1target
RucaparibPoly [ADP-ribose] polymerase 2target
RucaparibPoly [ADP-ribose] polymerase 3target
RucaparibCytochrome P450 2D6enzyme
RucaparibCytochrome P450 1A2enzyme
RucaparibCytochrome P450 3A4enzyme
RucaparibP-glycoprotein 1transporter
RucaparibATP-binding cassette sub-family G member 2transporter
RucaparibMultidrug and toxin extrusion protein 1transporter
RucaparibMultidrug and toxin extrusion protein 2transporter
RucaparibSolute carrier family 22 member 1transporter
RucaparibMultidrug resistance-associated protein 4transporter
RucaparibSolute carrier organic anion transporter family member 1B1transporter
RucaparibSolute carrier organic anion transporter family member 1B3transporter
RucaparibSolute carrier family 22 member 6transporter
RucaparibSolute carrier family 22 member 8transporter
RucaparibCytochrome P450 3A5enzyme
RucaparibCytochrome P450 3A7enzyme
RucaparibCytochrome P450 3A43enzyme
RucaparibCytochrome P450 2C19enzyme
RucaparibCytochrome P450 2C9enzyme
RucaparibCytochrome P450 2C8enzyme
RucaparibUDP-glucuronosyltransferase 1-1enzyme
OlaparibPoly [ADP-ribose] polymerase 1target
OlaparibCytochrome P450 3A4enzyme
OlaparibCytochrome P450 2B6enzyme
OlaparibPoly [ADP-ribose] polymerase 2target
OlaparibPoly [ADP-ribose] polymerase 3target
OlaparibCytochrome P450 3A5enzyme
OlaparibP-glycoprotein 1transporter
OlaparibATP-binding cassette sub-family G member 2transporter
TemozolomideDNAtarget
TemozolomideSerum albumincarrier
TemozolomideAlpha-1-acid glycoprotein 1carrier
TemozolomideP-glycoprotein 1transporter
TemozolomideATP-binding cassette sub-family G member 2transporter