Heartburn (DBCOND0004515)

Identifiers

Synonyms

Pyrosis / Heartburn (finding) / Epigastric pain / Indigestion / Dyspepsia / Indigestion (finding)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Alginic acid	Indicated for the management of gastric reflux, reflux oesophagitis, hiatus hernia, heartburn (including heartburn of pregnancy) and similar gastric distress .	No drug targets
Almasilate	Almasilate is indicated for use as an antacid for the neutralization of excess stomach acid . It is subsequently also used for the symptomatic treatment of diseases where it is...	No drug targets
Aluminium glycinate	A medication indicated to treat heartburn, indigestion, acid reflux, ulcers, and gas.	No drug targets
Aluminum hydroxide	An antacid used for the symptomatic relief of heartburn, acid indigestion, and sour stomach.	No drug targets
Alverine	A smooth muscle relaxant used to relieve abdominal pain associated with gastrointestinal conditions like heartburn, flatulence, and Irritable Bowel Syndrome.	5-hydroxytryptamine receptor 1Atarget
Belladonna	No therapeutic indications.	No drug targets
Bismuth subsalicylate	An antidiarrheal and anti-inflammatory agent used for symptomatic treatment of nausea, indigestion, upset stomach, diarrhea, and other temporary discomforts of the stomach and gastrointestinal tract.	Albumincarrier Serotransferrincarrier
Calcium carbonate	An ionic compound used as a calcium supplement or antacid used for the symptomatic relief of heartburn, acid indigestion, and sour stomach.	No drug targets
Cimetidine	A histamine H2 receptor antagonist used to manage GERD, peptic ulcer disease, and indigestion.	Histamine H2 receptortarget Cytochrome P450 1A2enzyme Cytochrome P450 2D6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme ATP-dependent translocase ABCB1transporter Solute carrier family 22 member 2transporter Solute carrier family 22 member 1transporter Solute carrier family 22 member 3transporter Organic cation/carnitine transporter 2transporter Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Multidrug and toxin extrusion protein 1transporter Solute carrier family 22 member 4transporter Solute carrier family 22 member 11transporter Solute carrier family 22 member 7transporter Cytochrome P450 11B1, mitochondrialenzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2E1enzyme Flavin-containing monooxygenase 3enzyme Flavin-containing monooxygenase 1enzyme Bile salt export pumptransporter Multidrug and toxin extrusion protein 2transporter Albumincarrier
Citric acid	An anti-chelation additive used in blood collection tubes and as a flavoring and preservative agent in various cosmetic and pharmaceutical products.	Beta-lactamase 2target Aldo-keto reductase family 1 member B1target Citrate synthase, mitochondrialtarget Proto-oncogene tyrosine-protein kinase Srctarget Ribonuclease pancreatictarget Isocitrate dehydrogenase [NADP]target Eosinophil cationic proteintarget Beta-lactamasetarget Fumarate hydratase class IItarget 6-phosphogluconolactonasetarget L-amino-acid oxidasetarget Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1target Cytochrome c peroxidasetarget Hepatocyte growth factor-regulated tyrosine kinase substratetarget Invasintarget Intron-associated endonuclease 1target Short tail fiber protein gp12target Malate dehydrogenase, mitochondrialtarget N5-carboxyaminoimidazole ribonucleotide mutasetarget 50S ribosomal protein L4target Carboxypeptidase Btarget Hexon proteintarget Riboflavin biosynthesis proteintarget Beta-fructosidasetarget Putative stringent starvation protein Atarget Citrate synthasetarget RNA 3'-terminal phosphate cyclasetarget U6 snRNA-associated Sm-like protein LSm6target Pleckstrin homology domain-containing family A member 1target Fe(3+)-binding periplasmic proteintarget Signal recognition particle receptor FtsYtarget Nicotinate-nucleotide adenylyltransferasetarget N utilization substance protein B homologtarget Complement component C8 gamma chaintarget Ribonucleoside-diphosphate reductase subunit betatarget Glutamine synthetase 1target 2-methylcitrate synthasetarget Prostaglandin F synthasetarget Adenine phosphoribosyltransferasetarget Glucose-1-phosphate thymidylyltransferasetarget Glyoxalase family proteintarget Laccase domain protein YfiHtarget Ribose-5-phosphate isomerase Atarget GMP synthase [glutamine-hydrolyzing]target Inosine triphosphate pyrophosphatasetarget Lysozymetarget Glycerol uptake operon antiterminator regulatory proteintarget 3-carboxy-cis,cis-muconate cycloisomerasetarget Pyruvate decarboxylasetarget Solute carrier organic anion transporter family member 2B1transporter Metallo-beta-lactamase type 2target Transient receptor potential cation channel subfamily V member 4target Lanosterol 14-alpha demethylasetarget
Dexlansoprazole	A proton pump inhibitor used to treat erosive esophagitis, heartburn, and gastroesophageal reflux disease (GERD).	Potassium-transporting ATPase alpha chain 1target Cytochrome P450 2C19enzyme Cytochrome P450 3A4enzyme Potassium-transporting ATPase subunit betatarget N(G),N(G)-dimethylarginine dimethylaminohydrolase 1target
Dihydroxyaluminum sodium carbonate	A medication used to treat heartburn.	No drug targets
Esomeprazole	A proton pump inhibitor used to treat GERD, reduce the risk of NSAID associated gastric ulcers, eradicate H. pylori, and to treat conditions causing gastric acid hypersecretion.	Potassium-transporting ATPase alpha chain 1target Cytochrome P450 2C19enzyme Cytochrome P450 3A4enzyme N(G),N(G)-dimethylarginine dimethylaminohydrolase 1target ATP-dependent translocase ABCB1transporter Organic anion transporter 3transporter Potassium-transporting ATPase subunit betatarget
Famotidine	A histamine H2 receptor antagonist used to treat duodenal ulcers, benign gastric ulcers, GERD, and Zollinger-Ellison syndrome.	Histamine H2 receptortarget Solute carrier family 22 member 2transporter Organic anion transporter 3transporter Multidrug and toxin extrusion protein 1transporter Cytochrome P450 1A2enzyme Solute carrier family 22 member 6transporter
Hydrotalcite	An antacid indicated in the treatment of heartburn and excess gastric acid.	No drug targets
L-tartaric acid	Tartaric Acid is primarily indicated in conditions like Antiscorbutic, Antiseptic.	No drug targets
Magaldrate	An antacid used to treat various conditions in the GI tract, such as esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux.	No drug targets
Magnesium carbonate	An antacid used for symptomatic relief of heartburn, indigestion, and upset stomach.	Transient receptor potential cation channel subfamily M member 6transporter Solute carrier family 41 member 3transporter Metal transporter CNNM2transporter Transient receptor potential cation channel subfamily M member 7transporter Glutamate (NMDA) receptortarget
Magnesium hydroxide	An inorganic compound used as a laxative and antacid.	No drug targets
Magnesium oxide	A compound commonly used as a laxative for the symptomatic relief of acid indigestion and upset stomach, and in health supplements for cardiovascular and neuromuscular health.	No drug targets
Magnesium trisilicate	An antacid used for the symptomatic treatment of peptic ulcers.	No drug targets
Omeprazole	A proton pump inhibitor used to treat GERD associated conditions such as heartburn and gastric acid hypersecretion, and to promote healing of tissue damage and ulcers caused by gastric acid and H. pylori infection.	Potassium-transporting ATPase alpha chain 1target Cytochrome P450 2C19enzyme Cytochrome P450 3A4enzyme Cytochrome P450 2C9enzyme Cytochrome P450 1A2enzyme ATP-binding cassette sub-family C member 3transporter ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Cytochrome P450 1A1enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2C18enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2D6enzyme Aryl hydrocarbon receptortarget Potassium-transporting ATPase subunit betatarget
Pantoprazole	A proton pump inhibitor used to treat erosive esophagitis, gastric acid hypersecretion, and to promote healing of tissue damage caused by gastric acid.	Potassium-transporting ATPase alpha chain 1target Cytochrome P450 2C19enzyme Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Organic anion transporter 3transporter N(G),N(G)-dimethylarginine dimethylaminohydrolase 1target Potassium-transporting ATPase subunit betatarget
Rabeprazole	A proton pump inhibitor used to help gastrointestinal ulcers heal, to treat symptoms of gastroesophageal reflux disease (GERD), to eradicate Helicobacter pylori, and to treat hypersecretory conditions such as Zollinger-Ellison Syndrome.	Potassium-transporting ATPase alpha chain 1target Cytochrome P450 3A4enzyme Cytochrome P450 2C19enzyme Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Cytochrome P450 1A1enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2D6enzyme Cytochrome P450 2C8enzyme
Ranitidine	A histamine H2 antagonist used to treat duodenal ulcers, Zollinger-Ellison syndrome, gastric ulcers, GERD, and erosive esophagitis.	Histamine H2 receptortarget Cytochrome P450 1A2enzyme Cytochrome P450 2D6enzyme Solute carrier family 22 member 1transporter ATP-dependent translocase ABCB1transporter Organic anion transporter 3transporter Cytochrome P450 3A4enzyme Acetylcholinesterasetarget Solute carrier family 22 member 2transporter Acetylcholinesteraseenzyme
Silodrate	Not Annotated	No drug targets
Simethicone	An anti-flatulence agent used to relieve pressure, bloating, and symptoms referred to as gas.	No drug targets
Sodium bicarbonate	A compound used for the symptomatic treatment of heartburn, acid indigestion, and upset stomach as well as the treatment of metabolic acidosis associated with conditions such as severe renal disease and circulatory insufficiency due to shock.	Electrogenic sodium bicarbonate cotransporter 1transporter Sodium bicarbonate cotransporter 3transporter Electroneutral sodium bicarbonate exchanger 1transporter Electrogenic sodium bicarbonate cotransporter 4transporter Hydrogen ionstarget Sodium-driven chloride bicarbonate exchangertransporter Voltage-dependent T-type calcium channel subunit alpha-1Htarget A-type voltage-gated potassium channel KCND3target
Sodium citrate	An ingredient used for the anticoagulation of whole blood as part of automated apheresis procedures.	Mitochondrial 2-oxodicarboxylate carriertransporter Solute carrier family 13 member 2transporter Na(+)/citrate cotransportertransporter Tricarboxylate transport protein, mitochondrialtransporter Carbonic anhydrase 4target
Vonoprazan	A potassium-competitive acid blocker used in the treatment of acid-related disorders and as an adjunct to Helicobacter pylori eradication.	Hydrogen potassium ATPasetarget Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2D6enzyme ATP-dependent translocase ABCB1transporter Albumincarrier Alpha-1-acid glycoprotein 1carrier

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00236184	E3810-A001-313: Efficacy and Safety of 10 mg Rabeprazole for Treating Heartburn in Frequent Sufferers	Rabeprazole	treatment	3	completed
NCT01199679	Rubber Band Ligation and Mucosectomy for Gastroesophageal Reflux Disease (GERD)	No drug interventions	treatment	Not Available	terminated
NCT05247333	Implementation of a Minor Ailment Service in Community Pharmacy Practice	No drug interventions	health_services_research	Not Available	completed
NCT01095133	Do Acid Sensing Ion Channels Contribute to Heartburn?	Amiloride	treatment	1	completed
NCT01338077	Efficacy and Safety of Sodium Alginate Oral Suspension to Treat Non-erosive Gastro-esophageal Reflux Disease	Alginic acid Omeprazole	treatment	3	completed
NCT00382577	Efficacy and Safety of Itopride vs Placebo in Heartburn	Itopride	treatment	3	completed
NCT00637845	Study Comparing Esomeprazole Magnesium 40mg Once Daily Versus Lansoprazole 30 mg Twice Daily in Symptom Control of Subjects With Persistent Gastrooesophageal Reflux Disease (GERD)	Esomeprazole Lansoprazole	treatment	4	completed
NCT00536328	What is the Predictive Value of the Reflux Impact Scale	No drug interventions	Not Available	Not Available	terminated
NCT00944671	A Study to Assess the Bioequivalence of Famotidine/Antacid Combination Tablets Compared to Famotidine/Antacid EZ Chew Tablets (0208C-145)(COMPLETED)	Calcium carbonate Famotidine Magnesium hydroxide	treatment	1	completed
NCT01928888	Placebo Controlled Phase IV Study to Compare the Efficacy and Safety of a Single Dose of Oral Talcid, a Single Dose of Oral Famotidine and a Single Dose of Placebo in Patients With Acute Heartburn Episodes	Famotidine Hydrotalcite	treatment	4	completed
NCT04153552	Upset Stomach Relief for Mild and Moderate Indigestion and Heartburn	No drug interventions	other	Not Available	completed
NCT06098742	Comparative Pharmacodynamics and Pharmacodynamics Equivalence of Antareit 800 mg/10 ml Oral Suspension and Riopan 800 mg Chewable Tablets in Healthy Volunteers	No drug interventions	other	Not Available	recruiting
NCT00553449	Open Label Study Evaluating Different Dosing Regimens of Rabeprazole in Gastro-esophageal Reflux Disease (GERD) Patients With Night-time Heartburn Symptoms.	Rabeprazole	treatment	3	completed
NCT00481949	Assessment of Gastro-esophageal Reflux Using Endo-Flip vs Bravo	No drug interventions	Not Available	Not Available	completed
NCT01696734	Domperidone in Treating Patients With Gastrointestinal Disorders	Domperidone	treatment	3	recruiting
NCT00243724	HEARD (Long Term) Study - Histology of the Esophagus in Acid-Related Disease	Esomeprazole	treatment	3	completed
NCT02623816	Symptom Control Satisfaction With Proton Pump Inhibitor Regimen	Omeprazole	treatment	4	completed
NCT00471796	A Comparison of Factors of Symptoms Generation and Evaluation of Role of Biofeedback in Patients With Different Types of Functional Esophageal Disorders (Functional Heartburn and Functional Chest Pain)	No drug interventions	treatment	Not Available	unknown_status
NCT00588939	Confocal Laser Microscopy in Non Erosive Reflux Disease	No drug interventions	Not Available	Not Available	completed
NCT01370525	Efficacy of Esomeprazole in Patients With Frequent Heartburn	Esomeprazole	treatment	3	completed
NCT00171457	The Effects of Tegaserod on Mechanical Sensitivity of the Esophagus and Stomach in Patients With Heartburn and Dyspepsia.	Tegaserod	treatment	3	completed
NCT06293326	A First-in-Human Study to Learn How Well a Bi-Layer Calcium Carbonate Antacid Tablet Works Compared to a Standard, Non-Layered Calcium Carbonate Tablet in Healthy Male Participants	Calcium carbonate	other	1	completed
NCT05976165	A Study of Breath Testing for Small Intestinal Bacterial Overgrowth	No drug interventions	treatment	Not Available	recruiting
NCT06075082	The Effect of the LEFT Smartwatch App as Sleep Positional Therapy for Nocturnal Gastroesophageal Reflux Symptoms.	No drug interventions	treatment	Not Available	recruiting
NCT01915173	Response to Supplement and Placebo in GERD	No drug interventions	treatment	Not Available	completed
NCT03867591	Fermented Soy and Heartburn Symptom Relief	No drug interventions	treatment	Not Available	completed
NCT06094062	Smartphone App-assisted PPI	No drug interventions	health_services_research	Not Available	recruiting
NCT00524329	Esomeprazole And Symptomatic Response In Patients With Or Without An Elevated Risk For Non-Steroidal Anti-Inflammatory Drug (NSAID)-Associated GI Damage	No drug interventions	Not Available	Not Available	completed
NCT00236392	A Study of Efficacy and Safety of "On-demand" Maintenance Therapy With Rabeprazole in Patients With Non-erosive Reflux Disease (NERD)	Rabeprazole	treatment	3	completed
NCT04252144	Study of Dietary Patterns and Food Diversity in Russian GERD Patients	No drug interventions	prevention	Not Available	unknown_status
NCT03531372	Mipolixin® Compared to Poliprotect® in Moderate Functional Dyspepsia and Heartburn.	No drug interventions	treatment	Not Available	completed
NCT01149395	Can E-cadherin Found in Tissue/Blood be Valuable in Identifying & Monitoring Patients With Post-proton Pump Inhibitor (PPI)-Responsive Heartburn	Dexlansoprazole	basic_science	1	completed
NCT01370538	Efficacy of Esomeprazole in Patients With Frequent Heartburn	Esomeprazole	treatment	3	completed
NCT05629143	Primary carE PPi dEprescRibing Trial	Alginic acid	treatment	4	recruiting
NCT02105090	Efficacy Study of Articaine Lozenge to Enhance the Procedural Compliance of the Adults Undergoing Gastroduodenoscopy	Epinephrine Sodium chloride	treatment	4	unknown_status
NCT00390390	Efficacy/Safety of Lansoprazole in Patients With Frequent Heartburn	Lansoprazole	treatment	3	completed
NCT05131802	Bile Reflux Gastropathy: Prevalence and Risk Factors After Therapeutic Biliary Interventions	No drug interventions	Not Available	Not Available	completed
NCT00842387	Evaluation Study of a Management Strategy for Gastroesophageal Reflux Disease (GERD)	No drug interventions	Not Available	Not Available	completed
NCT01005251	Investigate the Effect of Different Doses of Lesogaberan (AZD3355) as add-on to PPI in GERD Patients With Partial Response to PPI	Lesogaberan	treatment	2	completed
NCT01249651	To Assess the Efficacy of Esomeprazole 40 mg Once Daily in Subjects Who Still Had Heartburn After Receiving Rabeprazole	Esomeprazole	treatment	4	completed
NCT02146053	Questionnaire to Assess Gastrointestinal Symptoms of Oral Iron.	No drug interventions	basic_science	0	completed
NCT06391177	A Study to Evaluate Vonoprazan Concentrations in Breast Milk of Healthy Lactating Women Receiving Vonoprazan 20 mg Once Daily or Vonoprazan 20 mg Twice Daily	Vonoprazan	basic_science	1	recruiting
NCT00236197	E3810-A001-312: Efficacy and Safety of 10 mg Rabeprazole for Treating Heartburn in Frequent Sufferers	Rabeprazole	treatment	3	completed
NCT05195528	A Study to Evaluate the Efficacy and Safety of Vonoprazan Compared to Placebo for Relief of Heartburn in Participants With Symptomatic Non-Erosive Gastroesophageal Reflux Disease (NERD)	Vonoprazan	treatment	3	completed
NCT01587885	Comparison of Two Omeprazole-Containing Products for Relief of Frequent Heartburn (MK-0764A-036)	Omeprazole Sodium bicarbonate	treatment	4	completed
NCT01037452	Proof of Concept Study Efficacy of an Antacid/Lansoprazole Combination for Relief of Heartburn	Calcium carbonate Lansoprazole Magnesium hydroxide	treatment	2	completed
NCT01129713	Comparison of Nexium Versus Secretol in the Healing and Controlling of Symptoms in GERD Patients With Severe EE.	Esomeprazole Lansoprazole Omeprazole	treatment	1 / 2	unknown_status
NCT05363618	Tolerability Study of Panosyl-Isomaltooligosaccharides (PIMO) and a Placebo in Subjects With Heartburn	No drug interventions	other	Not Available	completed
NCT00703534	Validation of Patient-reported Outcomes Measures for the Assessment of Gastroesophageal Reflux Disease (GERD) Symptoms	Aluminum hydroxide Dimethicone Lesogaberan Magnesium hydroxide Silicon dioxide	Not Available	2	completed
NCT00373334	Safety and Efficacy Study of Axid Use in Infants Suffering From Gastroesophageal Reflux Disease (GERD)	Nizatidine	treatment	3	completed
NCT06552624	Comparative Pharmacodynamics and Pharmacodynamics Equivalence of Antareit 800 mg Chewable Tablets and Riopan 800 mg Chewable Tablets in Healthy Volunteers	Magaldrate	other	Not Available	completed
NCT00206024	Acid-Associated Heartburn Symptoms and Dose of Esomeprazole	Esomeprazole	treatment	4	completed
NCT02096458	Sensory Evaluation of Dexlansoprazole Delayed-Release Orally Disintegrating Tablets	Dexlansoprazole	treatment	1	completed
NCT04799158	A Study to Evaluate the Efficacy and Safety of Vonoprazan Compared to Placebo in Participants With Symptomatic Non-Erosive Gastroesophageal Reflux Disease	Vonoprazan	treatment	2	completed
NCT02277886	Esomeprazole Plus Alginate vs. Esomeprazole Alone for Treatment of Nighttime Reflux Symptom and Sleep Disturbances	Alginic acid Esomeprazole	treatment	4	unknown_status
NCT00389948	Efficacy/Safety of Lansoprazole in Patients With Frequent Heartburn	No drug interventions	treatment	3	completed
NCT00625274	A Randomized, Open-Label, Comparative 3-Way Treatment Crossover Study of 24-Hour Intragastric pH Profile of Once Daily Oral Administration of Esomeprazole 40mg, Lansoprazole 30mg, and Pantoprazole 40mg at Steady State in NSAID-Using Patients	Esomeprazole Lansoprazole Pantoprazole	treatment	4	completed
NCT00216489	A Study of the Safety of Rabeprazole Administered to Adults With Gastroesophageal Reflux Disease (GERD)	Rabeprazole	treatment	4	completed
NCT02873689	Efficacy and Safety of Dexlansoprazole on Heartburn Relief in Chinese Patients	Dexlansoprazole	treatment	3	completed
NCT05901740	Prevalence of Fuctional Heartburn in Patients With IBS .	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT01337804	A Study to Compare Omeprazole Administered as Zegerid® Powder and as Prilosec® Capsule in Healthy Participants (P08050)(CL2010-12)	Omeprazole Sodium bicarbonate	treatment	1	completed
NCT00579410	Comparison of Acid Reflux at Two Levels in the Esophagus Using the BRAVO Capsule	No drug interventions	Not Available	Not Available	completed
NCT04560595	Remote Guided Caffeine Reduction	No drug interventions	treatment	Not Available	completed
NCT02708355	Pilot Study To Investigate The Association Between Acid Control And Heartburn Symptoms After Proton Pump Inhibitor Treatment	Esomeprazole	basic_science	4	completed
NCT00945750	A Study to Assess the Bioequivalence of Famotidine Chewable Tablets and Film-Coated Tablets (0208-144)	Famotidine	treatment	1	completed
NCT00472550	Esomeprazole and Gastric Emptying of Beer	Esomeprazole	treatment	4	completed