Hemophilia A With Inhibitors (DBCOND0032571)

Identifiers

Synonyms
Hemophilia A With Inhibitor / Haemophilia A With Inhibitors / Haemophilia A with inhibitor / Hemophilia A with inhibitor (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Coagulation factor VIIa Recombinant Human
A form of recombinant human coagulation Factor VII used to treat hemophilia A and B.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT03093480
A Study to Evaluate Efficacy of rFVIIIFc for Immune Tolerance Induction (ITI) in Severe Hemophilia A Participants With Inhibitors Undergoing the First ITI Treatment (verITI-8 Study)treatment4completed
NCT01105546
rFVIIa Prophylaxis in Children With Hemophilia A and Inhibitorstreatment2unknown_status
NCT00221195
Efficacy Study of Activated Prothrombin Complex for Prevention of Bleeds in Hemophilia A With Inhibitorsprevention2 / 3completed
NCT00231751
The Malmö International Brother Study (MIBS)No drug interventionsNot AvailableNot Availablecompleted
NCT02448680
A Phase III Study on the Safety, Pharmacokinetics and Efficacy of Coagulation Factor VIIaNo drug interventionstreatment3completed
NCT03002480
Individualizing Hemophilia Bypassing Agent Therapy Utilizing ThromboelastographyNo drug interventionstreatmentNot Availablewithdrawn
NCT00212472
International Immune Tolerance StudytreatmentNot Availableterminated
NCT02020369
Phase III Study of Coagulation FVIIa (Recombinant) in Congenital Hemophilia A or B Patients With Inhibitorstreatment3completed
NCT02484638
Study of Recombinant Factor VIIa Fusion Protein (rVIIa-FP, CSL689) for On-demand Treatment of Bleeding Episodes in Patients With Hemophilia A or B With Inhibitorstreatment2 / 3terminated
NCT06568302
The Long-term Safety and Efficacy of SerpinPC in Subjects with Hemophilia Who Completed a Sponsored SerpinPC Clinical Trialtreatment3recruiting
NCT04647227
SEVENFACT® for Bleeding Events in Hemophilia With Inhibitorstreatment4recruiting
NCT06010953
SS109 and NovoSeven ® PK / PD Profile, and Preliminary Efficacy and Safety of SS109 on Demand TreatmentNo drug interventionstreatment1 / 2completed
NCT05651061
A Phase I of SS109 in Hemophilia A or and B With InhibitorsNo drug interventionstreatment1completed
NCT03372993
Prospective, Non-interventional Study to Evaluate Immunogenicity of AryoSevenNo drug interventionsNot AvailableNot Availablecompleted
NCT04723693
An Exploration of the Impact of Emicizumab on the Lives of People With Haemophilia and Inhibitors and Their FamiliesNo drug interventionsNot AvailableNot Availablecompleted
NCT04489537
Study of Coagulation Factor VIIa Marzeptacog Alfa (Activated) in Subjects With Hemophilia A or BNo drug interventionstreatment3terminated
NCT03204539
INdividualized ITI Based on Fviii(ATE) Protection by VWFtreatment4terminated
NCT06320626
Pharmacokinetic-guided Dosing of EmicizumabNo drug interventionstreatment4recruiting
NCT04548791
Study of Coagulation Factor VIIa Marzeptacog Alfa (Activated) in Subjects With Inherited Bleeding Disorderstreatment1 / 2terminated
NCT03818529
ATHN 8: Previously Untreated Patients (PUPs) Matter StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT04592692
A Pharmacokinetic and Clotting Activity Study of FVIII-PEGLiptreatment2unknown_status
NCT04805801
The Safety of Emicizumab SC Injection in Korean Hemophilia A Patients With/Without FVIII InhibitorsNot AvailableNot Availablerecruiting
NCT06357572
Real-life Clinical FEIBA Samples Measured Using the Version A of the HemA EnzySystemNo drug interventionsNot AvailableNot Availablecompleted
NCT03951103
rFVIIIFc (Elocta®) ITI Chart Review in Patients With Haemophilia ANo drug interventionsNot AvailableNot Availablecompleted
NCT00166387
Hemophilia Inhibitor Genetics Study (HIGS)No drug interventionsNot AvailableNot Availablecompleted
NCT04789954
Study on the Dose-response Relationship of Pharmacodynamic Parameters in Patients With Hemophilia With Inhibitorstreatment0completed
NCT03407651
Study of Coagulation Factor VIIa Variant Marzeptacog Alfa (Activated) in Adult Subjects With Hemophilia A and Btreatment2completed
NCT04072237
Study of Coagulation Faction VIIa Variant Marzeptacog Alfa (Activated) in Adult Subjects With HemophiliaNo drug interventionsdiagnostic1completed
NCT06312475
Efficacy and Safety of KN057 Prophylaxis in Patients With Haemophilia A or B With InhibitorsNo drug interventionstreatment3recruiting
NCT04205175
A Study to Evaluate the Safest Dose Range for FEIBA in Hemophilia A Patients With Inhibitors on Emicizumabtreatment4active_not_recruiting
NCT05888870
ITI Using SCT800 Alone or Combining Daratumumab in Hemophilia A Adolescents and Adults With High Titer Inhibitortreatment4recruiting
NCT04768699
Study of Recombinant Human Coagulation Factor VIIa for Injection (FⅦa) in Patients With Hemophilia.treatment1unknown_status
NCT03619863
ATHN 7: Hemophilia Natural History StudyNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT03598725
Low-dose ITI Strategy for Children in Hemophilia A With High-titer Inhibitor and Poor ITI Risk in Chinatreatment4unknown_status
NCT02554526
Basic Study of Combination Therapy Based on APCC-induced FVllI Activation in Hemophilia A Patients With InhibitorsNo drug interventionsNot AvailableNot Availableunknown_status
NCT04684940
Safety, Tolerability, and Efficacy Study of Valoctocogene Roxaparvovec in Hemophilia A With Active or Prior Inhibitorstreatment1 / 2active_not_recruiting
NCT04303572
The Hemophilia Inhibitor Eradication Trialtreatment3terminated
NCT05053139
A Research Study Investigating Mim8 in Adults and Adolescents With Haemophilia A With or Without InhibitorsNo drug interventionstreatment3recruiting
NCT05685238
A Research Study Looking at Long-term Treatment With Mim8 in People With Haemophilia A (FRONTIER 4)No drug interventionstreatment3recruiting
NCT00571584
High Dose of Activated Recombinant Human Factor VII for Treatment of Mild/Moderate Joint Bleeds in Haemophilia Patients With Inhibitorstreatment4completed
NCT03196284
A Trial Evaluating the Efficacy and Safety of Prophylactic Administration of Concizumab in Haemophilia A and B Patients With Inhibitorstreatment2completed
NCT00703911
Observational Registry of NovoSeven® Used as On-demand Treatment of Bleeds in Patients With Haemophilia A and B With InhibitorsNot AvailableNot Availablecompleted
NCT01563471
Safety and Tolerability of Intravenous Doses of Activated Recombinant Human Factor VII in Healthy Volunteerstreatment1completed
NCT00882778
PROPACT: Retrospective Prophylaxis Patient Case CollectionNot AvailableNot Availablecompleted
NCT01988532
Impact of Pain on Functional Impairment and Quality of Life in Adults With HemophiliaNo drug interventionsNot AvailableNot Availablecompleted
NCT00710619
Observational Patient Diary Study of Treatment Doses for Patients With Haemophilia With Inhibitors to Factors VIII and IXNot AvailableNot Availablecompleted
NCT01561924
Prediction of the Efficacy of Activated Recombinant Human Factor VII in Adult Congenital Haemophilia A or B Patients With Inhibitors by Use of Thromboelastographydiagnostic1completed
NCT00108758
Efficacy of NovoSeven® in Bleeding Prophylaxis in Hemophiliatreatment2completed
NCT01561391
Safety and Efficacy of Activated Recombinant Human Factor VII in Haemophilia Patients With Inhibitors During and After Major Surgerytreatment4completed
NCT01949792
A Trial Investigating the Pharmacokinetics and Pharmacodynamics of rFVIIa in Patients With Haemophilia A or B With or Without Inhibitorstreatment1completed
NCT01503567
Epidemiological Study on Haemophilia Care and Orthopaedic Status in Developing CountriesNo drug interventionsNot AvailableNot Availablecompleted
NCT01579968
Non-Interventional Study of NovoSeven® Used in Patients With Haemophilia A and B With Inhibitors When Undergoing SurgeryNot AvailableNot Availablecompleted
NCT01830712
A Long-term Assessment of Physical Activity, Range of Motion, and Functional Status Following Elective Orthopedic Surgery in Hemophilia Patients With InhibitorsNot AvailableNot Availablecompleted
NCT04083781
Research Study to Look at How Well the Drug Concizumab Works in Your Body if You Have Haemophilia With Inhibitorstreatment3active_not_recruiting
NCT03741881
A Study Following People With Haemophilia A and B, With or Without Inhibitors, When on Usual Treatment (Explorer™6)No drug interventionsNot AvailableNot Availablecompleted
NCT01579955
Non-Interventional Study of NovoSeven® Used in Patients With Haemophilia A and B With Inhibitors Under Normal Clinical PracticeNot AvailableNot Availablecompleted
NCT01392547
Efficacy and Safety of NNC 0078-0000-0007 in Patients With Congenital Haemophilia and Inhibitorstreatment3completed
NCT00951405
Safety and Efficacy of 3 Different Doses of Long Acting Factor VII in Haemophilia A or B Patients With Inhibitorsprevention2completed
NCT00108797
Trial of NovoSeven® in Haemophilia - Joint Bleedstreatment4completed
NCT02541942
Pharmacogenetic Testing of Saliva Samples From Patients With Five or More Exposure Days to rFVIIa Analogue in the Adept™2 TrialNo drug interventionsother2completed
NCT01586936
Non-Interventional Study of NovoSeven® Used as On-demand Treatment of Bleeds in Patients With Haemophilia A and B With InhibitorsNot AvailableNot Availablecompleted
NCT01561417
Bioequivalence of NovoSeven® and a NovoSeven® Formulation Stable at Room Temperature in Healthy Male Subjectstreatment1completed
NCT01322620
Survey Evaluating the Psychosocial Effects of Living With HaemophiliaNo drug interventionsNot AvailableNot Availablecompleted
NCT02241694
To Quantify the Range of Main Psychosocial Factors Affecting Patients and Caregivers in Their Daily LivesNo drug interventionsNot AvailableNot Availablecompleted
NCT02084810
Investigating the Bioequivalence of Eptacog Alfa A 6 mg and NovoSeven® in Healthy Male Subjectstreatment1withdrawn
NCT05878938
A Research Study Looking at How Safe it is to Switch From Emicizumab to Mim8 in People With Haemophilia A (FRONTIER 5)No drug interventionstreatment3active_not_recruiting