Recurrent Glioblastoma Multiforme (GBM) (DBCOND0033964)

Identifiers

Synonyms

Recurrent Glioblastoma Multiforme(GBM) / Recurrent Glioblastoma Multiforme / Recurrent Glioblastoma Multiforme (rGBM) / Recurrent GBM

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Carmustine	An alkylating agent used in the treatment of various malignancies, including brain tumours and multiple myeloma, among others.	Glutathione reductase, mitochondrialtarget DNAtarget RNAtarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05053880	A Study to Evaluate Safety and Efficacy of ACT001 and Anti-PD-1 in Patients With Surgically Accessible Recurrent Glioblastoma Multiforme	Dimethylaminomicheliolide Pembrolizumab	treatment	1 / 2	unknown_status
NCT06616727	The Safety and Efficacy of SNC-109 CAR-T Cells Therapy the rGBM	No drug interventions	treatment	1	enrolling_by_invitation
NCT00290771	Efficacy and Safety of Imatinib Mesylate Plus Hydroxyurea (HU) in Patients With Recurrent Glioblastoma Multiforme (GBM)	Hydroxyurea Imatinib	treatment	2	terminated
NCT04782609	Study of Icapamespib (PU-AD) in Patients With Recurrent Malignant Glioma	Icapamespib	treatment	1	terminated
NCT02062827	Genetically Engineered HSV-1 Phase 1 Study for the Treatment of Recurrent Malignant Glioma	No drug interventions	treatment	1	active_not_recruiting
NCT03423628	A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer	No drug interventions	treatment	1	recruiting
NCT04689087	A Prospective, Open-label, Single-arm Clinical Study	No drug interventions	prevention	Not Available	unknown_status
NCT01934361	Phase Ib/II Study of Buparlisib Plus Carboplatin or Lomustine in Patients With Recurrent Glioblastoma Multiforme	Buparlisib Carboplatin Lomustine	treatment	1	completed
NCT00379470	Effect of NovoTTF-100A in Recurrent Glioblastoma Multiforme (GBM)	No drug interventions	treatment	3	completed
NCT00306618	Safety and Efficacy Study of Panzem NCD to Treat Glioblastoma	2-Methoxyestradiol	treatment	2	completed
NCT00562419	CT-322 in Treating Patients With Recurrent Glioblastoma Multiforme and Combination Therapy With Irinotecan	Irinotecan Pegdinetanib	treatment	2	unknown_status
NCT01576666	Phase Ib, Dose Escalation Study of Oral LDE225 in Combination With BKM120 in Patients With Advanced Solid Tumors	Buparlisib Sonidegib	other	1	completed
NCT00509301	Safety & Radiation Distribution Study of Cotara® in Patients With Recurrent Glioblastoma Multiforme	No drug interventions	treatment	1	completed
NCT04915404	Berubicin in Adult Patients With Recurrent Glioblastoma Multiforme (WHO Grade IV)	Berubicin	treatment	1 / 2	terminated
NCT01738646	Ph II SAHA and Bevacizumab for Recurrent Malignant Glioma Patients	Bevacizumab Vorinostat	treatment	2	completed
NCT01737346	Procarbazine and Lomustine in Recurrent Glioblastoma	Lomustine Procarbazine	treatment	2	unknown_status
NCT00747253	Monteris AutoLITT™ FIM Safety Trial for Recurrent/Progressive Brain Tumors	No drug interventions	treatment	1	completed
NCT01464177	Hypofractionated Stereotactic Radiotherapy in Recurrent Glioblastoma Multiforme	No drug interventions	treatment	2	active_not_recruiting
NCT00883298	Bi-weekly Temozolomide Plus Bevacizumab for Adult Patients With Recurrent Glioblastoma Multiforme	Bevacizumab Temozolomide	treatment	2	completed
NCT05868083	The Safety and Efficacy of SNC-109 CAR-T Cells Therapy the Recurrent Glioblastoma	No drug interventions	treatment	1	recruiting
NCT00597493	Ph. 2 Sorafenib + Protracted Temozolomide in Recurrent GBM	Sorafenib Temozolomide	treatment	2	completed
NCT00071539	Safety and Efficacy Study to Treat Recurrent Grade 4 Malignant Brain Tumors	No drug interventions	treatment	2	completed
NCT01756729	Post-approval Study of NovoTTF-100A in Recurrent GBM Patients	No drug interventions	treatment	4	terminated
NCT00481455	Phase 2 Study of Panzem Nanocrystal Colloidal Dispersion (NCD) in Combination With Fixed-Dose Temozolomide to Patients With Recurrent Glioblastoma Multiforme (GBM)	2-Methoxyestradiol Temozolomide	treatment	2	completed
NCT03068650	Expanded Access (Compassionate Use) Treatment Protocol Rindopepimut	Rindopepimut	Not Available	Not Available	no_longer_available
NCT05370508	A Study of Sonodynamic Therapy Using SONALA-001 and Exablate 4000 Type 2.0 in Subjects With Recurrent GBM	No drug interventions	treatment	1 / 2	terminated
NCT04681677	Recurrent GBM Treated With Neurosurgical Resection and IORT Using the Xoft Axxent eBx System and Bevacizumab	Bevacizumab	treatment	2	terminated
NCT04763031	Recurrent GBM With Maximal Neurosurgical Removal and Treatment With IORT	No drug interventions	treatment	Not Available	terminated