Severe, Chronic Pain (DBCOND0038329)

Identifiers

Synonyms

Chronic Severe Pain / Severe Chronic Pain / Chronic, severe Pain

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Fentanyl	An opioid analgesic used in anesthesia, for breakthrough cancer pain, or round the clock pain management.	Mu-type opioid receptortarget Delta-type opioid receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter Kappa-type opioid receptortarget ATP-dependent translocase ABCB1target Albumincarrier alpha1-acid glycoproteincarrier
Oxycodone	An opioid used in the management of moderate to severe pain.	Mu-type opioid receptortarget Kappa-type opioid receptortarget Delta-type opioid receptortarget Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Albumincarrier alpha1-acid glycoproteincarrier
Ziconotide	An N-type calcium channel antagonist used to manage patients with severe chronic pain who cannot tolerate, or who have not responded adequately to other treatments such as intrathecal morphine and systemic analgesics.	Voltage-dependent N-type calcium channel subunit alpha-1Btarget Voltage-dependent P/Q-type calcium channel subunit alpha-1Atarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01710917	A Non-interventional, Observational Study for Quality of Life (Overall Health Assessment) in Patients With Chronic Severe Pain During Targinact® Treatment	No drug interventions	Not Available	Not Available	unknown_status
NCT01710904	A Non-interventional, Observational Study for Targinact® Treatment in Patients With Chronic Severe Pain	Naloxone Oxycodone	Not Available	Not Available	completed
NCT01915147	A Study to Explore the Influence of Two Opioid Pain Medications on Bacterial Composition in the Gut and Other Gastrointestinal Aspects	No drug interventions	treatment	2	completed
NCT00699335	Matrifen® for Therapy of Severe Chronic Pain®	Fentanyl	Not Available	Not Available	completed
NCT02268812	Patient Registry of Intrathecal Pain Management in Europe for Prialt (Ziconotide Intrathecal Infusion) and Alternative Drugs for the Management of Severe, Chronic Pain.	No drug interventions	Not Available	Not Available	completed
NCT00556270	Efficacy of Matrifen in Patients Older Than 18 Years With Severe, Chronic Pain	Fentanyl	Not Available	Not Available	completed