Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ ALL) (DBCOND0046443)

Identifiers

Synonyms
Philadelphia Chromosome Positive Acute Lymphocytic Leukemia / Philadelphia Chromosome Positive (Ph+) Acute Lymphocytic Leukemia (ALL) / Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ALL) / Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia Ph+ ALL / Philadephia positive acute lymphoblastic leukemia / Ph+ Acute Lymphoblastic Leukemia / Acute Lymphoblastic Leukemia Ph Positive / Acute Lymphoblastic Leukemia (Philadelphia Chromosome Positive) / PH+ ALL / Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia / Ph+ Acute Lymphoblastic Leukemia (Ph+ALL) / Philadelphia Chromsome Positive Acute Lymphoblastic Leukemia / Ph+ Acute Lymphoblastic Leukemia (ALL) / Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia / Acute Lymphoblastic Leukemia (ALL) Philadelphia Chromosome-positive (Ph+) / Philadelphia Positive Acute Lymphoblastic Leukemia / Philadelphia-positive acute lymphoblastic leukemia / Philadelphia chromosome-positive acute lymphoblastic leukemia (morphologic abnormality) / Philadelphia chromosome-positive acute lymphoblastic leukemia (disorder)

Associated Data

Indicated Drugs and Targets
Not Available
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT00154349
Efficacy Study of Imatinib Mesylate to Treat Philadelphia-Positive Acute Lymphocytic Leukemiatreatment2completed
NCT01883219
TKI Therapy Based on Molecular Monitoring in Allogeneic-HSCT Recipients With Philadelphia Chromosome-positive Acute Lymphoblastic LeukemiaNo drug interventionstreatment2unknown_status
NCT03624530
Effect of Prophylactic TKI Therapy Post-transplants on Ph+ ALL Undergoing Allo-HSCT With MRD Positive Pre-transplantstreatment2 / 3unknown_status
NCT00860535
Growth Factor Signature (GFS) Pilot Study (MK0000-098)(COMPLETED)No drug interventionsdiagnostic1terminated
NCT03589326
A Study of Ponatinib Versus Imatinib in Adults With Acute Lymphoblastic Leukemiatreatment3active_not_recruiting
NCT03595917
ABL001 + Dasatinib + Prednisone + Blinatumomab in BCR-ABL+ B-ALL or CMLtreatment1recruiting
NCT01667133
A Study of Ponatinib in Japanese Participants With Chronic Myeloid Leukemia (CML) and Ph+ Acute Lymphoblastic Leukemia (ALL)treatment1 / 2completed
NCT01592136
Expanded Access Program of PonatinibNot AvailableNot Availableapproved_for_marketing
NCT01066468
Glivec/Gleevec Pediatric (Age 1 to Less Than 4) PK Study in CML, Ph+ ALL Patients and Other Glivec/Gleevec® Indicated Hematological Disorders.Not Available1terminated
NCT01207440
Ponatinib for Chronic Myeloid Leukemia (CML) Evaluation and Ph+ Acute Lymphoblastic Leukemia (ALL)treatment2completed
NCT02690922
Low-dose Chemotherapy Combine With Tyrosine Kinase Inhibitor to Treat ph+ Acute Lymphoblastic Leukemia Patientstreatment4unknown_status
NCT04747912
Study of Chemotherapy-Free Induction Regimen for Ph+ Acute Lymphoblastic Leukemia With Inotuzumab Ozogamicin (InO)treatment2recruiting
NCT01491763
Chemotherapy and Imatinib in Young Adults With Acute Lymphoblastic Leukemia Ph (BCR-ABL) POSITIVEtreatment4unknown_status
NCT01376427
Treatment of Acute Lymphoblastic Leukemia Ph '(BCR / ABL) Positive Patients Aged > 55 YearstreatmentNot Availableunknown_status
NCT00109707
A Study of Oral AMN107 in Adults With Chronic Myelogenous Leukemia (CML) or Other Hematologic Malignanciestreatment1 / 2completed
NCT00384228
A Phase l/ll Study of AMN107 in Adult Patients With Glivec-intolerant CML or Relapsed-refractory Ph+ALLtreatment1 / 2completed
NCT04722848
Sequential Treatment With Ponatinib and Blinatumomab vs Chemotherapy and Imatinib in Newly Diagnosed Adult Ph+ ALLtreatment3recruiting
NCT03678454
Iclusig® (Ponatinib) in Clinical Practice for the Treatment of Chronic Myeloid Leukemia or Ph+ Acute Lymphoblastic Leukemia in BelgiumNo drug interventionsNot AvailableNot Availablecompleted
NCT06051409
A Study of Olverembatinib in Patients With Newly Diagnosed Ph+ALL.treatment3recruiting
NCT05603156
A Study of Olverembatinib Combined With Inotuzumab Ozogamicin in the Treatment ph+ ALL With MRD Persistent PositivetreatmentNot Availablenot_yet_recruiting
NCT04554459
Ponatinib Plus Reduced-intensity Chemotherapy in the First-line Treatment of Adult Patients With Ph+ ALLtreatment2terminated
NCT01028716
Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignanciestreatment2terminated
NCT01030718
Rollover Study of BMS-354825 in Patients With CML and Ph+ALLtreatment1 / 2completed
NCT05594784
Olverembatinib Combined With Reduced-Intensity Chemotherapy and Venetoclax for de Novo Ph+ ALLtreatment2recruiting
NCT06061094
Randomized Trial in Adult de Novo Ph Positive ALL With Chemotherapy, Imatinib or Ponatinib, Blinatumomab and SCTtreatment2recruiting
NCT03414450
Evaluation of ETC-1907206 With Dasatinib in Advanced Haematologic Malignanciestreatment1withdrawn
NCT01528085
Evaluation of Efficacy and Safety of Nilotinib in Combination With Chemotherapy in Elderly Patients With Philadelphia Chromosome Positive Acute Lymphoblastic Leukemiatreatment2completed
NCT02081378
A Phase I Study of Oral Asciminib (ABL001) in Patients With CML or Ph+ ALLtreatment1completed
NCT03647215
CALLS: CML and Ph+ALL Low Level Mutation Prevalence SurveyNo drug interventionsNot AvailableNot Availablecompleted
NCT03709017
Iclusig PMS in CML or Ph+ALL PatientsNot AvailableNot Availableactive_not_recruiting
NCT01222013
Study for Safety and Efficacy Evaluation of Imatinib Mesylate in Children With Acute Lymphoblastic Leukemia (ALL) Philadelphia Chromosome-positive (Ph+)treatment2suspended
NCT06481228
Efficacy and Safety of TKI Combined With Chemotherapy and Sequential CAR-T Cells in ND Adult Patients With Ph+ ALLtreatmentNot Availablenot_yet_recruiting
NCT00500006
A Phase I Dose Escalation Combination Study in Patients With Chronic Myelogenous Leukemia (CML) and Philadelphia Chromosome-Positive (Ph+) Acute Lymphoblastic Leukemia (ALL)(0457-009)(TERMINATED)treatment1terminated
NCT00907517
Study of SCH 900776 (MK-8776) With and Without Cytarabine in Participants With Acute Leukemias (P05247)treatment1terminated
NCT00199186
Study Comparing Imatinib With Chemotherapy as Induction in Elderly Patients With Philadelphia Positive Acute Lymphoblastic Leukemia (ALL)treatment2unknown_status
NCT04260022
Study of HQP1351 in Subjects With Refractory CML and Ph+ ALLtreatment1recruiting
NCT01761682
Acute Lymphoblastic Leukemia Registry at Asan Medical CenterNo drug interventionsNot AvailableNot Availableterminated
NCT00101595
Dasatinib (BMS-354825) in Subjects With Lymphoid Blast Phase Chronic Myeloid Leukemia or Philadelphia Chromosome Positive Acute Lymphoblastic Leukemiatreatment2completed
NCT01914484
Phase I/II Study of Nilotinib/Ruxolitinb Therapy for TKI Resistant Ph-Leukemiatreatment1 / 2completed
NCT01724879
Study of Frontline Dasatinib Plus Chemotherapy in Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (PH+ALL)treatment2completed
NCT00123487
Advanced Chronic Myelogenous Leukemia (CML) - Follow On: Study of BMS-354825 in Subjects With CMLtreatment3completed
NCT00464113
Study of XL228 in Subjects With Chronic Myeloid Leukemia or Philadelphia-Chromosome-Positive Acute Lymphocytic Leukemiatreatment1terminated
NCT01100658
Effects of Methylphenidate on Attention Deficits in Childhood Cancer SurvivorstreatmentNot Availableterminated
NCT05495035
Study for Safety and Efficacy of Olverembatinib Combined With APG-2575 in Children With Relapsed/Refractory Ph + ALLtreatment1recruiting
NCT03821727
SCT in Ph Positive Acute Lymphoblastic LeukemiaNo drug interventionsNot AvailableNot Availablecompleted
NCT00103701
BMS-354825 in Patients With Chronic Accelerated, or Blast Phase Chronic Myelogenous Leukemia or Philadelphia Positive Acute Lymphoblastic Leukemiatreatment1completed
NCT01310010
Study of Dasatinib to Treat Philadelphia Positive Acute Lymphoblastic Leukemiatreatment2completed
NCT05024357
A Study of TKI Maintenance Therapy Following Allo-HSCT in Newly Diagnosed Ph+ Adult ALLtreatmentNot Availableunknown_status
NCT05026229
A Study of Dasatinib Plus Reduced Intensive Consolidation Chemotherapy in Ph+ Adult ALLtreatmentNot Availableunknown_status