NCT02238730
Ultrabrief Right Unilateral and Brief Pulse Bitemporal Electroconvulsive Therapy No drug interventions treatment Not Available withdrawn NCT05196971
A Study To Evaluate The Safety, Tolerability And Pharmacokinetics of HS-10345 In Treatment-Resistant Depression No drug interventions treatment 1 completed NCT02556606
Ketamine for Treatment Resistant Late-Life Depression treatment 3 completed NCT01998958
A Study to Evaluate the Safety and Efficacy of Intranasal Esketamine in Treatment-resistant Depression treatment 2 completed NCT03667872
Efficacy and Safety of DBS in Patients With Treatment-Resistant Depression No drug interventions treatment Not Available unknown_status NCT02263872
Minocycline as an Adjunct for the Treatment of Depressive Symptoms: Pilot Randomized Controlled Trial treatment 4 completed NCT06511908
Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression No drug interventions treatment 2 not_yet_recruiting NCT04783103
Neuromodulation in the Elderly Depressed: a Brain Imaging Pilot Study No drug interventions treatment Not Available recruiting NCT02153502
Efficacy, Safety, and Tolerability Study of AVP-786 as an Adjunctive Therapy in Patients With Major Depressive Disorder With an Inadequate Response to Antidepressant Treatment treatment 2 completed NCT03109002
An Epidemiology Study of Treatment Resistant Depression in the United States (US) No drug interventions Not Available Not Available completed NCT03829579
Pre-Approval Access to Esketamine Nasal Spray for the Treatment of Treatment-Resistant Depression (TRD) Not Available Not Available approved_for_marketing NCT02994433
NMDA Receptor Antagonist Nitrous Oxide Targets Affective Brain Circuits treatment 1 terminated NCT05390593
Treatment for Major Depressive Disorder With Intermittent Theta-burst Stimulation No drug interventions treatment Not Available unknown_status NCT04216888
Biomarkers of Response to Ketamine in Depression: MRI and Blood Assays Before and After Open Label Intranasal Ketamine basic_science 2 / 3 completed NCT03360942
Long Term Follow-up of Deep Brain Stimulation for Treatment-Resistant Depression No drug interventions Not Available Not Available active_not_recruiting NCT04428099
Healthy Lifestyle Promotion as Adjunctive Teletherapy for Treatment-resistant Major Depression No drug interventions treatment Not Available unknown_status NCT02422186
A Study to Evaluate the Efficacy, Safety, and Tolerability of Intranasal Esketamine Plus an Oral Antidepressant in Elderly Participants With Treatment-resistant Depression treatment 3 completed NCT06323486
Accelerated Bilateral Sequential Theta Burst Stimulation in Older Adults With Treatment-resistant Depression No drug interventions treatment Not Available recruiting NCT04701866
Music as an Intervention to Improve Hemodynamic Tolerability of Ketamine in Depression No drug interventions treatment Not Available completed NCT03756129
Proof of Concept Study Evaluating the Efficacy and Safety of MIJ821 in Patients With Treatment-resistant Depression treatment 2 completed NCT02452892
Low Field Magnetic Stimulation (LFMS) in Subjects With Treatment-Resistant Depression (TRD) No drug interventions treatment Not Available completed NCT05870501
Synaptic Imaging and Network Activity in Treatment Resistant Depression basic_science Not Available recruiting NCT02493868
A Study of Intranasal Esketamine Plus an Oral Antidepressant for Relapse Prevention in Adult Participants With Treatment-resistant Depression treatment 3 completed NCT05117710
IMPase in Treatment-resistant Depression basic_science 1 recruiting NCT05887310
In Vitro Modeling of Drug-resistant Psychiatric Disorders Using Induced Pluripotent Cells No drug interventions Not Available Not Available enrolling_by_invitation NCT04599855
A Study of Esketamine Nasal Spray, Administered as Monotherapy, in Adult Participants With Treatment-resistant Depression treatment 4 completed NCT02577250
Ketamine Infusions for PTSD and Treatment-Resistant Depression treatment 1 completed NCT05641623
OSU6162 as add-on in SSRI/SNRI-resistant Depression treatment 2 recruiting NCT03004521
Lithium Versus Quetiapine in Treatment Resistant Depression treatment 4 unknown_status NCT04239651
rTMS With and Without iCBT For the Treatment of Resistant Depression (TRD) No drug interventions treatment Not Available completed NCT03373253
Treatment-Resistant Depression Cohort in Europe No drug interventions Not Available Not Available completed NCT05581797
Psilocybin-assisted Interpersonal Therapy for Depression No drug interventions treatment Not Available completed NCT06110507
Chronic Anergic-anhedonic Depression Open Trial No drug interventions Not Available Not Available recruiting NCT01179009
Treatment Resistant Depression (Pilot) treatment Not Available completed NCT03051256
Safety, Tolerability, PK Profile, and Symptom Response of a 7-Day Dosing With 25 mg or 50 mg Daily of REL-1017 in MDD treatment 2 completed NCT04469959
Dopaminergic Dysfunction in Late-Life Depression treatment 2 recruiting NCT03283670
Inhaled Nitrous Oxide for Treatment-Resistant Depression: Optimizing Dosing Strategies treatment 2 completed NCT03434041
A Study to Evaluate the Efficacy, Pharmacokinetics, Safety and Tolerability of Flexible Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant Depression treatment 3 completed NCT03887624
Investigate the Clinical Responses of Ethosuximide in Patients With Treatment-Resistant Depression. treatment 0 terminated NCT04956016
Effects of a Classic High-frequency rTMS Treatment Versus a Deep rTMS Treatment No drug interventions treatment Not Available recruiting NCT06431386
Behavioural Activation Therapy and Esketamine for Resistant Depression treatment Not Available recruiting NCT05008939
Sevoflurane for Treatment-Resistant Depression treatment Not Available unknown_status NCT04977674
Glutamate and Opioid Mechanisms of Antidepressant Response to Ketamine basic_science 0 completed NCT02691520
Epidemiology of Treatment Resistant Depression in Taiwan No drug interventions Not Available Not Available completed NCT03207282
Treatment Resistant Depression in America Latina No drug interventions Not Available Not Available completed NCT03852160
A Study of Esketamine Nasal Spray Plus a New Standard-of-care Oral Antidepressant or Placebo Nasal Spray Plus a New Standard-of-care Oral Antidepressant in Adult and Elderly Participants With Treatment-resistant Depression treatment 3 withdrawn NCT03851380
Improving Brain Stimulation Through Imaging No drug interventions Not Available Not Available recruiting NCT01898429
Deep Brain Stimulation (DBS) for Treatment-Resistant Depression (TRD) No drug interventions treatment Not Available completed NCT05570344
rTMS With and Without Text4Support for the Treatment of Resistant Depression. No drug interventions treatment Not Available recruiting NCT01983904
DBS for Treatment Resistant Depression No drug interventions treatment Not Available completed NCT02782104
A Long-term Safety Study of Esketamine Nasal Spray in Treatment-resistant Depression treatment 3 completed NCT02942368
Adaptive tDCS for Treatment-Resistant MDD No drug interventions treatment Not Available active_not_recruiting NCT04159012
NESBID: Neuro-Stimulation of the Brain in Depression No drug interventions treatment Not Available active_not_recruiting NCT02610712
Clinical Trial of the Use of Ketamine in Treatment Resistant Depression treatment 4 unknown_status NCT03626181
Biomarkers of Theta Burst Stimulation in Major Depressive Disorder No drug interventions treatment Not Available unknown_status