Advanced Liver Fibrosis (DBCOND0157990)

Identifiers

Synonyms

Not Available

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Resmetirom	A thyroid hormone receptor-beta agonist used to treat noncirrhotic nonalcoholic steatohepatitis (NASH) with moderate to advanced liver fibrosis in adults.	Cytochrome P450 2C8enzyme UDP-glucuronosyltransferase 1A4enzyme UDP-glucuronosyltransferase 1A9enzyme Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Organic anion transporter 3transporter Bile salt export pumptransporter Thyroid hormone receptor betatarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05939947	A Clinical Trial of ALE.F02 in Patients With Advanced Liver Fibrosis and/or With Mild Cirrhosis	Lixudebart	basic_science	1	recruiting
NCT05880173	SCREaning of Advanced Liver Fibrosis Using Non-Invasive Tests in General Population	No drug interventions	screening	Not Available	recruiting