Cisplatin is a platinum based chemotherapy agent used to treat various sarcomas, carcinomas, lymphomas, and germ cell tumors. It was the first member of its class, which now also includes carboplatin and oxaliplatin.
- Mechanism
- Curator reviewed
Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations.
- Primary indication
- For the treatment of metastatic testicular tumors, metastatic ovarian tumors and advanced bladder cancer.Curator reviewed · 5 structured indications
- Formula / weight
- Cl2H6N2Pt · 300.05 g/mol (avg)
- First approval
- Canada, 2010 · United States, 2000
- Also known as
- (SP-4-2)-DIAMMINEDICHLOROPLATINUM · CDDP · Cis-DDP · CIS-DIAMMINEDICHLOROPLATINUM · CIS-DIAMMINEDICHLOROPLATINUM II
- Code names
- NSC-119875
- Brand names
Resolves to
LXZZYRPGZAFOLE-UHFFFAOYSA-LSMILES[H][N]([H])([H])[Pt](Cl)(Cl)[N]([H])([H])[H]What you can answer from here — as of September 20, 2026
Which drugs share a target with Cisplatin, and which of those have an active Phase 3 trial?
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