Muscle Relaxants, Centrally Acting Agents
- Muscle Relaxants, Centrally Acting Agents
- Accession Number
- DBCAT002177 (DBCAT000429, DBCAT002521, DBCAT003685)
A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358)
- ATC Classification
Drug Drug Description Meprobamate An anxiolytic drug used for the short-term management of anxiety symptoms. Chlorphenesin A phenol ether used to treat painful muscular conditions. Fludiazepam Used for the short-term treatment of anxiety disorders. Xylazine Xylazine is a clonidine analog which acts as an agonist at α2 adrenoceptors. Veterinarians also use xylazine as an emetic, especially in cats. Chlorproethazine Not Annotated Medazepam A long-acting benzodiazepine used for its sedative and anxiolytic properties. Baclofen A GABA-ergic agonist used to manage severe spasticity of cerebral or spinal origin in adult and pediatric patients. Chlorzoxazone A drug with muscle relaxant properties that is used as an adjunct to physical therapy and analgesics to treat stiffness and pain caused by a variety of musculoskeletal conditions. Carisoprodol A centrally acting muscle relaxant used to relieve the discomfort associated with various musculoskeletal conditions. Methocarbamol A CNS depressant indicated with rest, physical therapy and other treatments to control the discomfort associated with various acute musculoskeletal conditions. Tizanidine An alpha-2 adrenergic agonist used for the short-term treatment of muscle spasticity. Cyclobenzaprine A skeletal muscle relaxant that works on the brainstem to treat muscle spasms of local origin. Orphenadrine A muscarinic antagonist used as an adjunct for the symptomatic relief of musculoskeletal pain and discomfort. Chlormezanone Used in the management of anxiety and in the treatment of muscle spasm. Dantrolene A direct-acting skeletal muscle relaxant used for the treatment of management of the fulminant hypermetabolism of skeletal muscle leading to malignant hyperthermia crisis. Eperisone An antispasmodic that functions through voltage-gated channel blockade, notably with little to no sedation, effective in relaxing skeletal muscles and vascular smooth muscles. Thiocolchicoside A semi-synthetic colchicine derivative used as an analgesic and anti-inflammatory. Febarbamate Not Annotated Tetrazepam Not Annotated Phenprobamate A skeletal muscle relaxant indicated in the treatment of pain caused by muscle spasms. Styramate Not Annotated Fenyramidol A muscle relaxant indicated in the symptomatic treatment of musculoskeletal pain and spasms. Mephenesin A cresol glyceryl ether used to treat muscle spasticity in Parkinson's and Multiple Sclerosis. Pridinol An atropine-like muscle relaxant indicated in the treatment of muscle pain associated with muscle tightness. Tolperisone Investigated for use/treatment in neurologic disorders, spinal cord injuries, muscle spasm, back pain, and multiple sclerosis. Metaxalone A muscle relaxant used to treat muscle pain or spasm. Bromazepam A short-acting benzodiazepine with intermediate onset commonly used to treat panic disorders and severe anxiety. Diazepam A long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. Clonazepam A long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders, severe anxiety, and seizures. Flunitrazepam A benzodiazepine used to manage anxiety disorders and insomnia. Lorazepam A long-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and seizures. Nitrazepam A long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders, severe anxiety, insomnia, and seizures. Temazepam A short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and insomnia. Eszopiclone A sedative-hypnotic used in the treatment of insomnia, improving both the latency phase and the maintenance phase of sleep. Etizolam A thienodiazepine derivative used to treat anxiety and insomnia. Methaqualone For the treatment of insomnia, and as a sedative and muscle relaxant. Arbaclofen Placarbil Investigated for the treatment of spasticity in multiple sclerosis, acute back spasms, and GERD. Donepezil An acetylcholinesterase inhibitor used to treat the behavioral and cognitive effects of Alzheimer's Disease and other types of dementia. Mephenoxalone A muscle relaxant indicated in the treatment of painful muscle spasms and cramps. Pregabalin An anticonvulsant drug used to treat neuropathic pain conditions and fibromyalgia, and for the treatment of partial onset seizures in combination with other anticonvulsants. Quinine An alkaloid used to treat uncomplicated Plasmodium falciparum malaria. Y-27632 Y-27632 is an inhibitor of Rho-associated protein kinase. It inhibits calcium sensitization to affect smooth muscle relaxation.
- Drugs & Drug Targets