Muscle Relaxants, Centrally Acting Agents
- Name
- Muscle Relaxants, Centrally Acting Agents
- Accession Number
- DBCAT002177 (DBCAT000429, DBCAT002521, DBCAT003685)
- Description
A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358)
- ATC Classification
- Drugs
Drug Drug Description Afloqualone Not Annotated Arbaclofen Placarbil Investigated for the treatment of spasticity in multiple sclerosis, acute back spasms, and GERD. Baclofen A GABA-ergic agonist used to manage severe spasticity of cerebral or spinal origin in adult and pediatric patients. Bendazol Bendazol is a small molecule drug. Bendazol has a monoisotopic molecular weight of 208.1 Da. Bromazepam A short-acting benzodiazepine with intermediate onset commonly used to treat panic disorders and severe anxiety. Carisoprodol A centrally acting muscle relaxant used to relieve the discomfort associated with various musculoskeletal conditions. Chlormezanone Used in the management of anxiety and in the treatment of muscle spasm. Chlorphenesin A phenol ether used to treat painful muscular conditions. Chlorproethazine Not Annotated Chlorzoxazone A drug with muscle relaxant properties that is used as an adjunct to physical therapy and analgesics to treat stiffness and pain caused by a variety of musculoskeletal conditions. Clonazepam A long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders, severe anxiety, and seizures. Cyclobenzaprine A skeletal muscle relaxant that works on the brainstem to treat muscle spasms of local origin. Dantrolene A direct-acting skeletal muscle relaxant used for the treatment of management of the fulminant hypermetabolism of skeletal muscle leading to malignant hyperthermia crisis. Diazepam A long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. Donepezil An acetylcholinesterase inhibitor used to treat the behavioral and cognitive effects of Alzheimer's Disease and other types of dementia. Eperisone An antispasmodic that functions through voltage-gated channel blockade, notably with little to no sedation, effective in relaxing skeletal muscles and vascular smooth muscles. Eszopiclone A sedative-hypnotic used in the treatment of insomnia, improving both the latency phase and the maintenance phase of sleep. Etizolam A thienodiazepine derivative used to treat anxiety and insomnia. Febarbamate Not Annotated Fenyramidol A muscle relaxant indicated in the symptomatic treatment of musculoskeletal pain and spasms. Fludiazepam Used for the short-term treatment of anxiety disorders. Flunitrazepam A benzodiazepine used to manage anxiety disorders and insomnia. Lorazepam A short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and seizures. Medazepam A long-acting benzodiazepine used for its sedative and anxiolytic properties. Mephenesin A cresol glyceryl ether used to treat muscle spasticity in Parkinson's and Multiple Sclerosis. Mephenoxalone A muscle relaxant indicated in the treatment of painful muscle spasms and cramps. Meprobamate An anxiolytic drug used for the short-term management of anxiety symptoms. Metaxalone A muscle relaxant used to treat muscle pain or spasm. Methaqualone For the treatment of insomnia, and as a sedative and muscle relaxant. Methocarbamol A CNS depressant indicated with rest, physical therapy and other treatments to control the discomfort associated with various acute musculoskeletal conditions. Nitrazepam A long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders, severe anxiety, insomnia, and seizures. Orphenadrine A muscarinic antagonist used as an adjunct for the symptomatic relief of musculoskeletal pain and discomfort. Phenprobamate A skeletal muscle relaxant indicated in the treatment of pain caused by muscle spasms. Pregabalin An anticonvulsant drug used to treat neuropathic pain conditions and fibromyalgia, and for the treatment of partial onset seizures in combination with other anticonvulsants. Pridinol An atropine-like muscle relaxant indicated in the treatment of muscle pain associated with muscle tightness. Quinine An alkaloid used to treat uncomplicated Plasmodium falciparum malaria. Rilmakalim Rilmakalim is a small molecule drug. The usage of the INN stem '-kalim' in the name indicates that Rilmakalim is a potassium channel activator, antihypertensive. Rilmakalim has a monoisotopic molecular... Styramate Not Annotated Temazepam A short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and insomnia. Tetrazepam Not Annotated Thiocolchicoside A semi-synthetic colchicine derivative used as an analgesic and anti-inflammatory. Tizanidine An alpha-2 adrenergic agonist used for the short-term treatment of muscle spasticity. Tolperisone A muscle relaxant used to relieve spasticity after stroke in adults. Xylazine A non-opioid and clonidine analog with analgesic and muscle relaxant properties used as a tranquilizer used in veterinary medicine. Y-27632 Y-27632 is an inhibitor of Rho-associated protein kinase. It inhibits calcium sensitization to affect smooth muscle relaxation. Zoxazolamine Not Annotated