Accession Number

The 8-hydroxy derivatives inhibit various enzymes and their halogenated derivatives, though neurotoxic, are used as topical anti-infective agents, among other uses.

ATC Classification
DrugDrug Description
DiiodohydroxyquinolineUsed in the treatment of amoebiasis.
OxyquinolineA medication used in combination with other medications to restore vaginal pH.
DecoquinateDecoquinate is used in veterinary to delay the growth and reproduction of coccidian parasites.
Kynurenic AcidKynurenic Acid is under investigation in clinical trial NCT02340325 (FS2 Safety and Tolerability Study in Healthy Volunteers).
OxamniquineFor treatment of Schistosomiasis caused by Schistosoma mansoni
ProcaterolA beta-2 adrenergic receptor agonist and bronchodilator used for the treatment of asthma and chronic obstructive pulmonary disease (COPD).
ChloroxineAn antibacterial agent used for the treatment of dandruff and mild to moderately severe seborrheic dermatitis of the scalp.
5,7-Dichlorokynurenic acidNot Available
ClioquinolAn antifungal cream used to treat a variety of fungal infections.
TilbroquinolTilbroquinol was approved in France, Morocco, and Saudi Arabia but it has been withdrawn in France and Saudi Arabia markets mainly due to its hepatotoxicity risk outweighing the drug benefit...
ChlorquinaldolChlorquinaldol was used historically as a topical antiseptic agent for skin infections. It maintains use in European countries as a combination vaginal tablet with promestriene for use in the treatment...
BroxyquinolineNot Annotated
CloxyquinNot Annotated
Drugs & Drug Targets
Kynurenic AcidAryl hydrocarbon receptortarget
Kynurenic AcidG-protein coupled receptor 35target
OxamniquineCytochrome P450 2D6enzyme
ProcaterolBeta-2 adrenergic receptortarget
5,7-Dichlorokynurenic acidGlutamate receptor ionotropic, NMDA 1target