Aminopyridines

Name
Aminopyridines
Accession Number
DBCAT000588
Description

Pyridines substituted in any position with an amino group. May be hydrogenated, but must retain at least one double bond.

Drugs
DrugDrug Description
MilrinoneA PDE-III inhibitor with inotropic, lusitropic, and vasodilatory properties used for the short-term treatment of acute decompensated heart failure.
TripelennamineA histamine H1 antagonist used to treat hypersensitivity reactions, coughs, and the common cold.
AmrinoneA positive inotropic agent and phosphodiesterase inhibitor used in the management of treatment of congestive heart failure.
PhenazopyridineA local anesthetic used for the symptomatic relief of pain, burning, urgency, frequency, and general discomfort caused by lower urinary tract irritations that are a result of infection, trauma, surgery, endoscopic procedures, or the passage of equipment or catheters.
DalfampridineA potassium channel blocker used for the improvement of motor function in patients with multiple sclerosis (MS).
MepyramineAn antihistamine agent used for the symptomatic treatment of allergy, hypersensitivity reactions, and pruritic skin disorders.
CrizotinibA receptor tyrosine kinase inhibitor used to treat metastatic non-small cell lung cancer (NSCLC) where the tumors have been confirmed to be anaplastic lymphoma kinase (ALK), or ROS1-positive.
MethapyrileneMethapyrilene, formerly marketed in many drug products, was shown to be a potent carcinogen. Manufacturers voluntarily withdrew methapyriline drug products from the market in May and June 1979.
PhenaridinePhenaridine (2,5-Dimethylfentanyl) is a synthetic fentanyl derivative opioid. It was developed in 1972, and is used for surgical anasthesia in Russia. Phenaridine has similar effects to fentanyl. In rat studies,...
AmifampridineA voltage gated potassium channel blocker used to treat Lambert-Eaton myasthenic syndrome.
Drugs & Drug Targets
DrugTargetType
MilrinonecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
TripelennamineHistamine H1 receptortarget
TripelennamineCytochrome P450 2D6enzyme
TripelennamineSerum albumincarrier
AmrinoneTumor necrosis factortarget
AmrinonecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
AmrinonecGMP-inhibited 3',5'-cyclic phosphodiesterase Btarget
AmrinonecAMP-specific 3',5'-cyclic phosphodiesterase 4 (PDE4)target
AmrinonecAMP-specific 3',5'-cyclic phosphodiesterase 3target
PhenazopyridineSodium channel protein type 1 subunit alphatarget
PhenazopyridineGroup A nerve fiberstarget
DalfampridineCytochrome P450 2E1enzyme
DalfampridinePotassium voltage-gated channel subfamily D member 2target
DalfampridinePotassium voltage-gated channel subfamily D member 3target
DalfampridinePotassium voltage-gated channel subfamily A member 1target
DalfampridinePotassium voltage-gated channel subfamily A member 4target
DalfampridinePotassium voltage-gated channel subfamily A member 2target
DalfampridinePotassium voltage-gated channel subfamily A member 3target
DalfampridinePotassium voltage-gated channel subfamily A member 5target
DalfampridinePotassium voltage-gated channel subfamily A member 6target
DalfampridinePotassium voltage-gated channel subfamily A member 7target
DalfampridinePotassium voltage-gated channel subfamily A member 10target
DalfampridinePotassium voltage-gated channel subfamily B member 1target
DalfampridinePotassium voltage-gated channel subfamily B member 2target
DalfampridinePotassium voltage-gated channel subfamily C member 1target
DalfampridinePotassium voltage-gated channel subfamily C member 2target
DalfampridinePotassium voltage-gated channel subfamily C member 3target
DalfampridinePotassium voltage-gated channel subfamily D member 1target
DalfampridineSolute carrier family 22 member 2transporter
MepyramineCytochrome P450 2D6enzyme
MepyramineHistamine H1 receptortarget
MepyramineSolute carrier family 22 member 4transporter
MepyramineSolute carrier family 22 member 5transporter
CrizotinibCytochrome P450 3A4enzyme
CrizotinibCytochrome P450 3A5enzyme
CrizotinibP-glycoprotein 1transporter
CrizotinibALK tyrosine kinase receptortarget
CrizotinibHepatocyte growth factor receptortarget
CrizotinibCytochrome P450 2B6enzyme
CrizotinibCytochrome P450 3A Subfamilyenzyme
CrizotinibSerum albumincarrier
Crizotinibalpha1-acid glycoproteincarrier
CrizotinibProto-oncogene tyrosine-protein kinase ROStarget
CrizotinibMacrophage-stimulating protein receptortarget
AmifampridineArylamine N-acetyltransferase 1enzyme
AmifampridineArylamine N-acetyltransferase 2enzyme
AmifampridinePotassium voltage-gated channel subfamily A member 1target