Pregnenolone

DB02789ApprovedInvestigationalWithdrawnSmall molecule

A 21-carbon steroid, derived from cholesterol and found in steroid hormone-producing tissues. Pregnenolone is the precursor to gonadal steroid hormones and the adrenal corticosteroids.

Formula / weight: C₂₁H₃₂O₂ · 316.4776 g/mol (avg)

Resolves to

Compound

UNII73R90F7MQ8CAS145-13-1ChEMBLCHEMBL253363ChEBI16581PubChem8955KEGGD00143

Clinical / RWD

RxNorm114052

Structure

InChIKeyORNBQBCIOKFOEO-QGVNFLHTSA-NSMILES[H][C@@]12CC[C@H](C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@@H](O)CC[C@]12C

Targets

P11474ESRRAO75469NR1I2O00204SULT2B1

Transporters

Q3KNW5SLC10A6

What you can answer from here — as of September 23, 2026

3Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

1TransporterSubstrate / inhibitor direction, not just membership

Listed above

109Drug interactionsStructured to mechanism, not free text

32Clinical trialsPhase, status and sponsor resolved per trial

1Marketed productAcross 1 country and 1 labeller

7+ReferencesStructured and connected to the statements they support

Which drugs share a target with Pregnenolone, and which of those have an active Phase 3 trial?

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