Thyroid Products

Name
Thyroid Products
Accession Number
DBCAT002707  (DBCAT000094, DBCAT000659, DBCAT000660, DBCAT000819, DBCAT001787, DBCAT002275, DBCAT002276, DBCAT002355, DBCAT003607, DBCAT003652, DBCAT003797)
Description

A glycoprotein hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Thyrotropin stimulates THYROID GLAND by increasing the iodide transport, synthesis and release of thyroid hormones (THYROXINE and TRIIODOTHYRONINE). Thyrotropin consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the pituitary glycoprotein hormones (TSH; LUTEINIZING HORMONE and FSH), but the beta subunit is unique and confers its biological specificity.

ATC Classification
Drugs
DrugDrug Description
Thyrotropin alfaA recombinant form of thyroid stimulating hormone used in diagnostic testing for thyroid cancer and alongside radioactive agents to destroy thyroid tissue.
TiratricolA metabolite of T3 and T4 thyroid hormones; promoted for hyperlipidemia, localized lipodystrophy, and obesity. Tiratricol has been used in trials studying the treatment of Allan-Herndon-Dudley Syndrome.
LiothyronineA thyroid hormone replacement therapy used to treat hypothyroidism, to suppress TSH, and to help in the diagnosis of hyperthyroidism.
LevothyroxineA synthetic T4 hormone used to treat hypothyroidism that can be used along with surgery and radioiodine therapy to manage thyrotropin-dependent well-differentiated thyroid cancer.
LiotrixMay be used to treat primary, secondary or tertiary hypothyroidism. May also be used to suppress thyroid stimulating hormone (TSH) secretion in patients with simple (nontoxic) goiter, subacute or chronic...
Thyroid, porcineA naturally-occurring peptide hormone used for the replacement therapy for hypothyroidism of any etiology, treatment for euthyroid goiters, and management of thyroid cancers.
FollitropinA form of recombinant human follicle stimulating hormone used to stimulate follicle development in women with primary ovarian hypogonadism and in men with hypogonadotropic hypogonadism.
TeriparatideA recombinant parathyroid hormone used for the treatment of osteoporosis.
3,5-diiodothyropropionic acidDITPA has been investigated in Congestive Heart Failure.
CarbimazoleFor the treatment of hyperthyroidism and thyrotoxicosis. It is also used to prepare patients for thyroidectomy.
PropylthiouracilA thiourea antithyroid agent used to treat hyperthyroidism.
MethimazoleA thionamide antithyroid agent that inhibits the actions of thyroid peroxidase, leading to a reduction in thyroid hormone synthesis and amelioration of hyperthyroidism.
DibromotyrosineNot Available
Potassium perchlorateNo current FDA- or EMA-approved therapeutic indications.
MethylthiouracilNot Annotated
BenzylthiouracilNot Annotated
Potassium IodideAn oral antithyroid agent used for the prevention of radioactive iodine uptake into the thyroid gland during a nuclear radiation emergency.
ProtirelinA synthetic analogue of thyrotropin-releasing hormone that has been used during diagnostic tests to evaluate function of the thyroid gland.
Parathyroid hormoneAn analog of human parathyroid hormone (PTH) used to treat hypocalcemia caused by hypoparathyroidism.
Salmon calcitoninA synthetic peptide form of calcitonin used to inhibit bone resorption in the treatment of hypercalcemia, osteoporosis, and Paget's disease.
AbaloparatideA parathyroid hormone-related protein (PTHrP) analog used for the treatment of osteoporosis in postmenopausal women with a high risk of fracture.
ThyrotropinThyrotropin is under investigation in clinical trial NCT01348191 (Detection of Thyrotrophin Receptor in Human Myometrium).
ElcatoninNot Annotated
3,5-DiiodotyrosineA product from the iodination of MONOIODOTYROSINE. In the biosynthesis of thyroid hormones, diiodotyrosine residues are coupled with other monoiodotyrosine or diiodotyrosine residues to form T4 or T3 thyroid hormones...
Tetraiodothyroacetic acidNot Available
Drugs & Drug Targets
DrugTargetType
Thyrotropin alfaThyrotropin receptortarget
TiratricolThyroid hormone receptor betatarget
LiothyronineThyroid hormone receptor betatarget
LiothyronineThyroid hormone receptor alphatarget
LiothyronineThyroxine-binding globulincarrier
LiothyronineTransthyretincarrier
LiothyronineSerum albumincarrier
LiothyronineP-glycoprotein 1transporter
LiothyronineSolute carrier family 22 member 8transporter
LiothyronineMonocarboxylate transporter 10transporter
LiothyronineSolute carrier organic anion transporter family member 4A1transporter
LiothyronineSolute carrier organic anion transporter family member 1C1transporter
LiothyronineSolute carrier organic anion transporter family member 1A2transporter
LiothyronineSodium/bile acid cotransportertransporter
LiothyronineSolute carrier organic anion transporter family member 4C1transporter
LiothyronineSolute carrier organic anion transporter family member 1B3transporter
LiothyronineSolute carrier organic anion transporter family member 1B1transporter
LiothyronineLarge neutral amino acids transporter small subunit 1transporter
LiothyronineProliferating cell nuclear antigentarget
LiothyronineUDP-glucuronosyltransferase 1-1enzyme
LevothyroxineThyroid hormone receptor alphatarget
LevothyroxineThyroid hormone receptor betatarget
LevothyroxineCytochrome P450 2C8enzyme
LevothyroxineTransthyretincarrier
LevothyroxineSerum albumincarrier
LevothyroxineThyroxine-binding globulincarrier
LevothyroxineP-glycoprotein 1transporter
LevothyroxineMonocarboxylate transporter 8transporter
LevothyroxineSolute carrier organic anion transporter family member 1C1transporter
LevothyroxineSolute carrier organic anion transporter family member 1A2transporter
LevothyroxineSolute carrier organic anion transporter family member 1B1transporter
LevothyroxineSolute carrier organic anion transporter family member 1B3transporter
LevothyroxineSolute carrier organic anion transporter family member 4A1transporter
LevothyroxineLarge neutral amino acids transporter small subunit 1transporter
LevothyroxineUDP-glucuronosyltransferase 1-1enzyme
LevothyroxineSolute carrier organic anion transporter family member 2B1transporter
LevothyroxineIntegrin alpha-Vtarget
LevothyroxineIntegrin beta-3target
LevothyroxineP-glycoprotein 1enzyme
LiotrixThyroid hormone receptor alphatarget
LiotrixThyroid hormone receptor betatarget
LiotrixCytochrome P450 2C8enzyme
LiotrixSolute carrier organic anion transporter family member 1A2transporter
LiotrixSolute carrier organic anion transporter family member 1B1transporter
LiotrixSolute carrier organic anion transporter family member 1B3transporter
LiotrixSolute carrier organic anion transporter family member 4C1transporter
LiotrixSodium/bile acid cotransportertransporter
LiotrixSolute carrier organic anion transporter family member 1C1transporter
LiotrixSolute carrier organic anion transporter family member 4A1transporter
LiotrixSolute carrier family 22 member 8transporter
LiotrixMonocarboxylate transporter 8transporter
LiotrixMonocarboxylate transporter 10transporter
LiotrixP-glycoprotein 1transporter
LiotrixTransthyretincarrier
LiotrixThyroxine-binding globulincarrier
LiotrixSerum albumincarrier
LiotrixCytochrome P450 3A4enzyme
Thyroid, porcineThyroxine-binding globulincarrier
Thyroid, porcineSerum albumincarrier
Thyroid, porcineTransthyretincarrier
Thyroid, porcineMonocarboxylate transporter 8transporter
Thyroid, porcineSolute carrier organic anion transporter family member 1C1transporter
Thyroid, porcineSolute carrier organic anion transporter family member 3A1transporter
Thyroid, porcineSolute carrier organic anion transporter family member 4A1transporter
Thyroid, porcineLarge neutral amino acids transporter small subunit 1transporter
Thyroid, porcineSodium/bile acid cotransportertransporter
Thyroid, porcineType I iodothyronine deiodinaseenzyme
Thyroid, porcineType II iodothyronine deiodinaseenzyme
Thyroid, porcineThyroxine 5-deiodinaseenzyme
Thyroid, porcineThyroid hormone receptor alphatarget
Thyroid, porcineThyroid hormone receptor betatarget
Thyroid, porcineSulfotransferase 1A1enzyme
Thyroid, porcineSulfotransferase 1A2enzyme
Thyroid, porcineSulfotransferase 1A3/1A4enzyme
Thyroid, porcineSulfotransferase family cytosolic 1B member 1enzyme
Thyroid, porcineSulfotransferase 1C2enzyme
Thyroid, porcineEstrogen sulfotransferaseenzyme
FollitropinFollicle-stimulating hormone receptortarget
TeriparatideParathyroid hormone/parathyroid hormone-related peptide receptortarget
3,5-diiodothyropropionic acidCytochrome P450 3A4enzyme
CarbimazoleThyroid peroxidasetarget
CarbimazoleCytochrome P450 19A1enzyme
PropylthiouracilThyroid peroxidasetarget
PropylthiouracilMyeloperoxidaseenzyme
PropylthiouracilDopamine beta-hydroxylaseenzyme
PropylthiouracilCytochrome P450 1A1enzyme
MethimazoleThyroid peroxidasetarget
MethimazoleCytochrome P450 1A2enzyme
MethimazoleCytochrome P450 2A6enzyme
MethimazoleCytochrome P450 2B6enzyme
MethimazoleCytochrome P450 2C19enzyme
MethimazoleCytochrome P450 2C9enzyme
MethimazoleCytochrome P450 2D6enzyme
MethimazoleCytochrome P450 2E1enzyme
MethimazoleCytochrome P450 3A4enzyme
MethimazoleDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DibromotyrosineErythropoietin receptortarget
Potassium perchlorateSodium/iodide cotransportertarget
Potassium perchlorateSerum albumincarrier
Potassium IodideTyrosinetarget
ProtirelinThyrotropin Releasing Hormone Receptortarget
Parathyroid hormoneParathyroid hormone/parathyroid hormone-related peptide receptortarget
Parathyroid hormoneParathyroid hormone 2 receptortarget
Salmon calcitoninCalcitonin receptortarget
AbaloparatideParathyroid hormone/parathyroid hormone-related peptide receptortarget
3,5-DiiodotyrosinecAMP-dependent protein kinase inhibitor alphatarget
3,5-DiiodotyrosinecAMP-dependent protein kinase catalytic subunit alphatarget
3,5-DiiodotyrosineAlpha-amylase G-6target
3,5-DiiodotyrosineTrypsin-1target
3,5-DiiodotyrosineNickel-binding periplasmic proteintarget
3,5-DiiodotyrosineIodotyrosine dehalogenase 1target
Tetraiodothyroacetic acidTransthyretincarrier