Plantago seed
Identification
- Name
- Plantago seed
- Accession Number
- DB11097
- Description
Platango seeds refer to the seeds collected from various species of plantago trees. It is found in some laxatives for treating occasional constipation and restoring regularity in bowel movements. Its potential benefit in maintaining remission in ulcerative colitis has been studied 1.
Regardless, this agent is most predominantly used as a gentle laxative agent in many parts of the world that is more commonly referred as psyllium or psyllium husk.
- Type
- Biotech
- Groups
- Approved, Investigational
- Synonyms
- Psyllium
- Psyllium husk
Pharmacology
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Indications include the treatment of patients needing a high fibre regime, perhaps for: (a) the relief of constipation, including constipation in pregnancy and the maintenance of regularity; (b) the management of bowel function in patients with colostomy, ileostomy, hemorrhoids, anal fissure, chronic diarrhea with diverticular disease, irritable bowel syndrome, and ulcerative colitis 3.
- Associated Conditions
- Contraindications & Blackbox Warnings
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The active ingredient psyllium husk is comprised of the episperm and collapsed adjacent layers removed from the seeds of Plantago afar L. or Plantago indica L. 3. Psyllium husk is abundant in alimentary fibres and mucilages, with its mucilage content in particular being higher than that of other plantago species 3. Specifically, psyllium husk is capable of absorbing up to 40 times its own weight in water 3. Psyllium husk consists of 85% water-soluble fibre - it is subsequently partly fermentable (in vitro 72% unfermentable residue) and acts by hydration in the bowel 3.
Gastrointestinal tract motility and transit rate is capable of being modified by psyllium husk via mechanical stimulation of the gut wall as a result of the increase in intestinal bulk by water and the decrease in viscosity of the luminal contents 3. Taken with an adequate amount of liquid (at least 30 ml per 1 g of the agent), psyllium husk produces an increased volume of intestinal contents as a result of its highly bulking properties and therefore a stretch stimulus which triggers a defecation 3. Concurrently, the swollen mass of mucilage generates a lubricating layer that makes the transit of the intestinal contents easier 3.
- Mechanism of action
Psyllium seeds are comprised of dietary fibre which, when mixed with water forms a gel-like mass that works as a mild laxative Label. This gel-like mass subsequently moves down a patient's digestive system and makes stools softer by increasing their water contents Label. At the same time psyllium seed lubricates the intestine, which improves the transit of stools Label. Moreover, as the presence of the gel-like mass increases the stool bulk it also increases the tension and/or the stretch stimulus in the bowel wall which serves to trigger bowel movements Label.
The dietary fibre of which psyllium husk is comprised is fermented to various degrees by bacteria in the colon, resulting in production of carbon dioxide, hydrogen, methane, water, and short chain fatty acids, which are absorbed and brought into the hepatic circulation 3. In humans, such fibre reaches the large bowel in a highly polymerized form that is fermented to a limited extent, resulting in increased fecal concentration and excretion of short chain fatty acids 3.
- Absorption
Psyllium husk is capable of hydration and swelling to form a mucilage because it is only partially solubilized 3. The polysaccharide dietary fibres of which psyllium husk is comprised of need to be hydrolyzed to monosaccharides before intestinal absorption can occur 3. The sugar residues of the xylan backbone and side chains are joined by beta-linkages however, which cannot be broken by human digestive enzymes 3.
Less than 10% of the mucilage gets hydrolyzed in the stomach, with formation of free arabinose 3. Intestinal absorption of the free arabinose is about 85% to 93% 3. As a consequence, psyllium remains predominantly in the gastrointestinal tract as a 'bulk' agent that passes largely unchanged throughout the gut 4. The agent has remarkable water holding capacity because of its high hemicellulose content 4.
- Volume of distribution
Psyllium husk when administered as intended largely undergoes little absorption into the body and plasma.
- Protein binding
The protein binding of psyllium husk is not formally documented at this time. Regardless, because psyllium husk is largely not adsorbed when administered, it is believed that the drug may not exhibit any kind of protein binding 2.
- Metabolism
As psyllium remains largely in the gut as a 'bulk' agent that passes predominantly unchanged throughout the gastrointestinal tract, there is little opportunity for marked absorption into or metabolism by the body 4.
- Route of elimination
Psyllium husk when administered as indicated is usually excreted in the faeces 2.
- Half-life
The half-life of psyllium husk is not formally documented at this time. Regardless, because psyllium husk is largely not adsorbed when administered, it is believed that the drug may not exhibit any kind of half-life 2.
- Clearance
Psyllium husk when administered as intended largely undergoes little absorption into the body and plasma.
- Adverse Effects
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Overdose with psyllium husk can cause abdominal discomfort, flatulence, and/or intestinal obstruction 3.
The LD50 of psyllium husk administered orally to mice has been observed in some studies to occur in doses up to 2940 mg/kg or 3360 mg/kg in rats 5.
- Affected organisms
- Humans and other mammals
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAcetazolamide The risk or severity of adverse effects can be increased when Acetazolamide is combined with Plantago seed. Aclidinium The therapeutic efficacy of Plantago seed can be decreased when used in combination with Aclidinium. Alfentanil The therapeutic efficacy of Plantago seed can be decreased when used in combination with Alfentanil. Alloin The risk or severity of adverse effects can be increased when Plantago seed is combined with Alloin. Amantadine The therapeutic efficacy of Plantago seed can be decreased when used in combination with Amantadine. Amiloride The risk or severity of adverse effects can be increased when Amiloride is combined with Plantago seed. Amiodarone The therapeutic efficacy of Plantago seed can be decreased when used in combination with Amiodarone. Amitriptyline The therapeutic efficacy of Plantago seed can be decreased when used in combination with Amitriptyline. Amlodipine The therapeutic efficacy of Plantago seed can be decreased when used in combination with Amlodipine. Amobarbital The therapeutic efficacy of Plantago seed can be decreased when used in combination with Amobarbital. 
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- Not Available
Products
Comprehensive & structured drug product infoFrom application numbers to product codes, connect different identifiers through our commercial datasets.Easily connect various identifiers back to our datasets- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Bekunis Light Granules Tablet Oral Roha Arzneimittel Gmbh 1992-12-31 1999-03-04 Canada 
Best Choice Fiber Laxative Capsule 0.52 g/1 Oral Best Choice (Valu Merchandisers Company) 2019-05-16 Not applicable US 
Best Choice Fiber Therapy Orange Flavor Powder 3.4 g/12g Oral Best Choice (Valu Merchandisers Company) 2019-05-15 Not applicable US Best Choice Fiber Therapy original coarse Powder 3.4 g/7g Oral Best Choice (Valu Merchandisers Company) 2019-05-14 Not applicable US Bulk-forming Laxative Powder, for suspension 3.4 g/7g Oral Health Mart 2012-04-19 Not applicable US Careone Capsule 0.52 g/1 Oral Foodhold Usa 2019-04-16 Not applicable US CAREONE Orange Flavored Powder 3.4 g/5.8g Oral Foodhold Usa 2019-04-18 Not applicable US Clara Granule 2.45 g/5g Oral Handock Cosmetics Co., Ltd. 2017-03-03 Not applicable US Clara Granule 3.25 g/5g Oral Handock Cosmetics Inc 2011-11-11 2017-08-01 US Clara Granule 3.25 g/5g Oral Handock Cosmetics Inc 2011-08-26 Not applicable US - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Clara Plantago seed (2.45 g/5g) + Garcinia gummi-gutta fruit (0.45 g/5g) Granule Oral Handock Cosmetics Co., Ltd. 2017-03-03 Not applicable US Floralax Plantago seed (2.8 g) + Wheat (1 g) Powder Oral Flora Manufacturing And Distributing Ltd. 2002-08-29 2006-08-03 Canada Konsyl Overnight Relief Senna Prompt Plantago seed (500 mg/1) + Sennosides (9 mg/1) Capsule Oral Konsyl Pharmaceuticals, Inc. 2011-04-01 2018-07-01 US Metamucil Therapy for Regularity Plantago seed (3.4 g/12g) + Plantago seed (3.4 g/12g) Kit Oral Procter And Gamble 1989-03-31 2016-08-11 US Metamucil Therapy for Regularity Plantago seed (3.4 g/5.8g) + Plantago seed (3.4 g/5.8g) Kit Oral Procter And Gamble 1994-12-15 2016-08-11 US Metamucil Therapy for Regularity Plantago seed (3.4 g/12g) + Plantago seed (3.4 g/12g) Kit Oral Procter And Gamble 1989-03-31 2016-08-11 US Metamucil Therapy for Regularity Plantago seed (3.4 g/5.8g) + Plantago seed (3.4 g/5.8g) Kit Oral Procter And Gamble 1994-12-15 2016-08-11 US Multilax 1 Cap Plantago seed (378 mg) + Sennosides (92 mg) Capsule Oral Nature's Way Of Canada Ltd. 1984-12-31 2004-07-26 Canada Prodiem Plus Plantago seed (542 mg) + Sennosides (124 mg) Powder Oral Novartis 1996-07-30 2006-07-04 Canada Prodiem Plus Powder Plantago seed (542 mg) + Sennosides (124 mg) Powder Oral Rhone Poulenc Rorer 1993-12-31 1997-08-13 Canada - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Clara Plantago seed (2.45 g/5g) + Garcinia gummi-gutta fruit (0.45 g/5g) Granule Oral Handock Cosmetics Co., Ltd. 2017-03-03 Not applicable US Clara Plantago seed (3.25 g/5g) Granule Oral Handock Cosmetics Inc 2011-08-26 Not applicable US Clara Plantago seed (3.25 g/5g) Granule Oral Handock Cosmetics Inc 2011-11-11 2017-08-01 US
Categories
- Drug Categories
- Classification
- Not classified
Chemical Identifiers
- UNII
- 9C60Y73166
- CAS number
- 8063-16-9
References
- General References
- Fernandez-Banares F, Hinojosa J, Sanchez-Lombrana JL, Navarro E, Martinez-Salmeron JF, Garcia-Puges A, Gonzalez-Huix F, Riera J, Gonzalez-Lara V, Dominguez-Abascal F, Gine JJ, Moles J, Gomollon F, Gassull MA: Randomized clinical trial of Plantago ovata seeds (dietary fiber) as compared with mesalamine in maintaining remission in ulcerative colitis. Spanish Group for the Study of Crohn's Disease and Ulcerative Colitis (GETECCU). Am J Gastroenterol. 1999 Feb;94(2):427-33. [PubMed:10022641]
- Jennifer J. Yeager, Mary Beth Winton, Linda E. McCuistion, Kathleen DiMaggio (2018). Pharmacology: A Patient-Centered Nursing Process Approach. Elsevier Health Sciences. [ISBN:9780323399166]
- Electronic Medicines Compendium: Fybogel Orange Monograph [Link]
- Sigma Aldrich: Psyllium Profile [Link]
- European Medicines Agency: Community Herbal Monograph on Plantago afar L. et. Plantago indica L., semen [Link]
- DailyMed: Metamucil (psylllium husk) fiber therapy [Link]
- External Links
- AHFS Codes
- 56:12.00 — Cathartics and Laxatives
- 92:01.00* — Herbs and Natural Products
- FDA label
- Download (85.2 KB)
- MSDS
- Download (47.2 KB)
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Prevention Constipation / Incontinence 1 4 Completed Treatment Gastro-esophageal Reflux Disease (GERD) 1 4 Completed Treatment High Cholesterol 1 4 Recruiting Treatment Type 2 Diabetes Mellitus 1 2 Terminated Supportive Care Constipation-predominant Irritable Bowel Syndrome (IBS-C) 1 2, 3 Completed Treatment Fecal Incontinence 1 Not Available Completed Other Constipation 1 Not Available Completed Prevention Functional Disorder of Intestine 1 Not Available Completed Treatment Colonic Diseases, Functional 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Tablet Oral Granule Oral Granule Oral 2.45 g/5g Granule Oral 3.25 g/5g Powder Oral 6 g/6.0g Powder Oral 3.4 g/7.2g Powder Oral 3.4 g/5.78g Powder Oral 3.4 g/5.89g Granule, for solution Oral 3.4 g/7g Granule, for solution Oral 3.4 g/12g Granule, for solution Oral 3.5 g/5.8g Capsule Oral 0.52 g/1 Capsule Oral 520 mg/1 Powder, for suspension Oral 3.4 g/7g Granule, for solution Oral 3.4 g/5.4g Capsule Oral Granule, effervescent Oral Granule, effervescent Oral Granule, for solution Oral Granule Oral Liquid Oral Powder, for solution Oral 3.4 g/7g Capsule Oral .52 g/1 Granule Oral 2.75 g/5g Powder, for suspension Oral 3.4 g/5.8g Powder Oral 1 g/1g Capsule Oral 20 mg/1 Powder Oral 6 g/6g Granule Oral 4.3 g/6g Granule Oral 3.4 g/6.5g Granule Oral 6 g/9g Powder Topical 60 mg/1g Granule Oral 3.4 g/11g Granule Oral 3.4 g/12g Granule Oral 6 g/6g Capsule Oral Powder Oral 3.5 g/5.8g Granule Oral 3.5 g/5.8g Powder Topical 3.5 g/5.8g Powder, for solution Oral Kit Oral Powder Oral 3.3 g/5.95g Powder Oral 3.4 g/12g Powder Oral 2.45 g/5g Powder Oral 3.5 g/5g Powder Oral 3400 mg/1g Granule Oral 3.4 g/100g Powder Oral 3.4 g/11g Powder Oral 3.4 g/5.8g Powder Oral 3.4 g/7g Powder Oral 3.4 g/5.4g Powder Oral 15 g/99g Powder, for solution Oral 3.4 g/100g Powder Oral 3.4 g/5.79g Powder, for suspension Oral 3.4 g/11g Powder Oral Powder, for solution Oral 3.4 g/5.8g Powder Oral Powder Oral 2.4 g/12g Powder, for suspension Oral Powder, for solution Oral 3.4 g/5g Powder, for solution Oral 3.4 g/12g Granule, for solution Oral 3.4 g/100g Powder, for solution Oral 0.486 g/1g Powder, for solution Oral 0.604 g/1g Powder, for suspension Oral 3.4 g/12g Powder Oral 85.92 g Powder, for solution Oral Granule Capsule Oral 520 mg - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
Drug created on December 03, 2015 16:51 / Updated on April 23, 2021 04:04