- Accession Number
- DBCAT002211 (DBCAT000521)
Substances that are destructive to protozoans.
- ATC Classification
Drug Drug Description Pyrimethamine An antiparasitic drug used in the prevention and treatment of toxoplasmosis and malaria. Mefloquine An antimalarial agent used in the prophylaxis and treatment of malaria caused by Plasmodium falciparum and Plasmodium vivax. Quinine An alkaloid used to treat uncomplicated Plasmodium falciparum malaria. Chloroquine An antimalarial drug used to treat susceptible infections with P. vivax, P. malariae, P. ovale, and P. falciparum. It is also used for second line treatment for rheumatoid arthritis. Amodiaquine An antimalarial drug. Pentamidine An antifungal agent used to treat Pneumocystis pneumonia in patients infected with HIV. Primaquine An antimalarial indicated to prevent relapse of vivax malaria. Quinacrine For the treatment of giardiasis and cutaneous leishmaniasis and the management of malignant effusions. Atovaquone An antimicrobial indicated for the prevention and treatment of Pneumocystis jirovecii pneumonia (PCP) and for the prevention and treatment of Plasmodium falciparum malaria. Proguanil A medication indicated for prophylaxis and treatment of Plasmodium falciparum malaria. Halofantrine An antimalarial used for the treatment of severe malaria. Hydroxychloroquine An antimalarial medication used to treat uncomplicated cases of malaria and for chemoprophylaxis in specific regions. Also a disease modifying anti-rheumatic drug (DMARD) indicated for treatment of rheumatoid arthritis and lupus erythematosus. Fumagillin Not Available Suramin For treatment of human sleeping sickness, onchocerciasis and other diseases caused by trypanosomes and worms. Sodium stibogluconate For the treatment of various types of a protozoal infection called leishmaniasis, which may result from sandfly bites in tropical and temperate parts of the world. Also investigated for use/treatment... Eflornithine A medication used topically to reduce unwanted facial hair growth in women. The postulated mechanism of action is through irreversible inhibition of ornithine decarboxylase (ODC) in the skin. Artemether An antimalarial agent used in combination with lumefantrine for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum. Lumefantrine An antimalarial agent used in combination with artemether for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum. Diloxanide Diloxanide is used alone as a primary agent in the treatment of asymptomatic (cyst passers) intestinal amebiasis caused by Entamoeba histolytica. Diloxanide may also be used concurrently, or sequentially, with... Artesunate Artesunate is an artemesinin derivative indicated for the initial treatment of severe malaria. Artenimol For the treatment of uncomplicated Plasmodium falciparum infection in adults, children, and infants aged 6 months and up weighing over 5 kg [FDA Label]. Used in combination with DB13941. Nifurtimox An antiparasitic drug used for the treatment of Chagas disease (Trypanosoma cruzi infection). Benznidazole A trypanocidal agent used to treat Chagas disease. Nimorazole Nimorazole has been used in trials studying the treatment of Hypoxia, Radiotherapy, Hypoxic Modification, Gene Profile, Gene Signature, and Head and Neck Squamous Cell Carcinoma, among others. Melarsoprol Melarsoprol is under investigation in clinical trial NCT00330148 (Randomized Clinical Trial of Three Drug Combinations for Late-Stage Gambiense Human African Trypanosomiasis). Pyronaridine A benzonaphthyridine derivative indicated in the treatment of acute malaria caused by P. falciparum or P. vivax in area with low rates of infection and low resistance to artemisinin. Etofamide Etofamide is used as an antiamoebic agent. Etofamide, under the brand name Kitnos, was marketed in Brazil by Pfizer but has been discontinued . Emetine Not Annotated Meglumine antimoniate Not Annotated Artemotil Artemotil, also known as β-arteether, is a semi-synthetic derivative of artemisinin and a fast acting blood schizonticide specifically indicated for the treatment of chloroquine-resistant Plasmodium falciparum malaria and cerebral malaria... Paromomycin An aminoglycoside antibiotic used in the treatment of acute and chronic intestinal amebiasis, and as an adjunct for the management of hepatic coma. Nitazoxanide A thiazolide anti-infective used to treat infections by protozoa, helminths, anaerobic bacteria, microaerophilic bacteria, and viruses. Piperaquine For the treatment of uncomplicated Plasmodium falciparum infection in adults, children, and infants aged 6 months and up weighing over 5 kg [FDA Label]. Used in combination with DB11638. Dapsone A sulfone drug used to treat acne vulgaris, Hansen's disease, and dermatitis herpetiformis. Doxycycline A tetracycline antibiotic used to treat a wide variety of bacterial infections. Sulfadiazine A sulfonamide antibiotic used in a variety of infections, such as urinary tract infections, trachoma, and chancroid. Furazolidone A drug for the treatment of infectious diarrhea. Sulfametopyrazine An antibiotic used in the treatment or prevention of bacterial infections and malaria. Amphotericin B An antifungal used to treat fungal infections in neutropenic patients, cryptococcal meningitis in HIV infection, fungal infections, and leishmaniasis. Quinidine A medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias. Tinidazole A nitroimidazole used to treat trichomoniasis, giardiasis, amebiasis, and bacterial vaginosis. Metronidazole A nitroimidazole used to treat trichomoniasis, amebiasis, inflammatory lesions of rosacea, and bacterial infections, as well as prevent postoperative infections. Posaconazole A triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. Sulfadoxine A long acting sulfonamide used for the treatment or prevention of malaria. Sinefungin Sinefungin is a solid. This compound belongs to the purine nucleosides and analogues. These are compounds comprising a purine base attached to a sugar. The proteins that adenosyl-ornithine target include... 5'-S-methyl-5'-thioadenosine Not Available Diminazene Diminazene, also known as Diminazine, 4,4'-(Diazoamino)benzamidine, 4,4'-(1-triazene-1,3-diyl)bis-benzenecarboximidamide, diminazine aceturate, or Diminazene aceturate, is a trypanocidal agent. Major brands of Diminazene are Berenil, Pirocide, Ganasag, and Azidin. This substance is a... Radicicol Not Available Salicylhydroxamic Acid Not Available Geneticin Geneticin (also known as G418) is an aminoglycoside antibiotic similar in structure to gentamicin B1, produced by Micromonospora rhodorangea. Geneticin blocks polypeptide synthesis by inhibiting the elongation step in both... Halofuginone For the treatment of scleroderma, cancer, and restenosis. Andrographolide Investigated for use/treatment in ulcerative colitis. Spiramycin A macrolide antimicrobial agent used in the treatment of various bacterial infections. Lonidamine Investigated for use/treatment in benign prostatic hyperplasia, prostate disorders, and cancer/tumors (unspecified). Tafenoquine An antiparasitic agent used for the treatment and prevention of relapse of Vivax malaria. Anisomycin Anisomycin (sometimes known as flagecidin), is an antibiotic retrieved from the bacteria Streptomyces griseolus. This drug acts to inhibit bacterial protein and DNA synthesis. Puromycin Puromycin is an antibiotic that prevents bacterial protein translation. It is utilized as a selective agent in laboratory cell cultures. Puromycin is toxic to both prokaryotic and eukaryotic cells, resulting... Miltefosine An antileishmanial agent used to treat leishmaniasis, a group of disease caused by parasites of the Leishmania type. Chlortetracycline The first tetracycline antibiotic most commonly used for veterinary purposes. Diiodohydroxyquinoline Used in the treatment of amoebiasis. Amprolium Amprolium is a coccidiostat used in poultry. Decoquinate Decoquinate is used in veterinary to delay the growth and reproduction of coccidian parasites. Dichlorophen Dichlorophen is an antimicrobial agent shown to exert activity against cestodes, protozoa, fungi, and bacteria. It is often combined with toluene to remove parasites including ascarids, tapeworm, and hookworm from... Diclazuril Diclazuril is a coccidiostat. Febantel Not Annotated Lasalocid Lasalocid is an agent that presents antibacterial and coccidiostat activities. It is produced by strains of Streptomyces lasaliensis. Monensin Monensin is a polyether isolated from Streptomyces cinnamonensis that presents antibiotic properties. It is widely used in ruminant animal feeds. Narasin Narasin is an agent with coccidiostatic and antibacterial properties. Nicarbazin Not Annotated Phenothiazine Phenothiazine (PTZ) is an organic thiazine compound. Roxarsone Roxarsone is an organoarsenic molecule added to poultry feed. The addition of this compound to poultry feed improves weight gain and feed efficiency as well as prevent the growth of... Sulfaquinoxaline Sulfaquinoxaline is a veterinary medicine which can be given to cattle and sheep to treat coccidiosis.It is available in Pakistan with Sanna Laboratories in combination with Amprolium and Vitamin K... Zoalene Dinitolmide is a fodder additive for prophylaxis against coccidiosis infections in poultry. Imidocarb Imidocarb is a urea derivative used in veterinary medicine as an antiprotozoal agent for the treatment of infection with Babesia and other parasites. Robenidine Robenidine is identified as a coccidiostat drug, which slows both the growth and reproductive cycles of coccidian parasites. Robenidine is used to control coccidiosis, a lethal infection in poultry which... Salinomycin Not Annotated Misonidazole Misonidazole is under investigation in clinical trial NCT00038038 (Assessment of Head and Neck Tumor Hypoxia Using 18F-Fluoromisonidazole). Chlorproguanil Chlorproguanil has been used in trials studying the treatment of MALARIA. It is a dichloro-derivative of chloroguanide. Secnidazole A nitroimidazole antibiotic used to treat bacterial vaginosis. Ornidazole A nitroimidazole agent indicated in the treatment of infections such as trichomoniasis, amebiasis, and giardiasis. Propamidine Not Annotated Mepartricin A medication indicated in the treatment of benign prostatic hyperplasia, vaginal candidiasis, or trichomoniasis. Niridazole Not Annotated Nifuratel A nitrofuran derivative indicated in the treatment of leucorrhea, vulvovaginal infections, and urinary tract infections. Nitrofural A topical antibacterial for the prevention and treatment of bacterial infections of the skin. Trimetrexate A folate antagonist used for the treatment of moderate-to-severe Pneumocystis carinii pneumonia (PCP) in immunocompromised patients as an alternative therapy in combination with leucovorin. Arsthinol Antiprotozoal agent effective against amoebiasis and yaws. Artemisinin A medication indicated in the treatment of malaria. Teclozan An antiprotozoal agent indicated in the treatment of intestinal amebiasis. Tilbroquinol Tilbroquinol was approved in France, Morocco, and Saudi Arabia but it has been withdrawn in France and Saudi Arabia markets mainly due to its hepatotoxicity risk outweighing the drug benefit... Propenidazole Not Annotated Chiniofon Not Annotated Phanquinone Not Annotated Clefamide Not Annotated Difetarsone Not Annotated Tenonitrozole Not Annotated Clioquinol An antifungal cream used to treat a variety of fungal infections. Acetarsol An anti infective used to treat a wide variety of infections in the body. Chlorquinaldol Chlorquinaldol was used historically as a topical antiseptic agent for skin infections. It maintains use in European countries as a combination vaginal tablet with promestriene for use in the treatment... Azanidazole Not Annotated Broxyquinoline Not Annotated Tetrandrine Not Annotated Diloxanide furoate Diloxanide is used alone as a primary agent in the treatment of asymptomatic (cyst passers) intestinal amebiasis caused by Entamoeba histolytica. Diloxanide may also be used concurrently, or sequentially, with... Betulinic Acid Betulinic Acid has been used in trials studying the treatment of Dysplastic Nevus Syndrome. Fexinidazole An orally bioavailable 2-substituted 5-nitroimidazole used to treat early- and late-stage human African trypanosomiasis caused by Trypanosoma brucei gambiense. Dehydroemetine Not Annotated Cycloguanil Cycloguanil is the active metabolite of proguanil. Pafuramidine Investigated for use/treatment in pneumonia, trypanosomiasis, malaria, HIV infection, and infectious and parasitic disease (unspecified). Artefenomel Artefenomel has been investigated for the treatment of Malaria. Mizoribine Mizoribine has been investigated for the treatment of Rheumatoid Arthritis. Naphthoquine Naphthoquine is under investigation in clinical trial NCT01930331 (Safety, Tolerability, Pharmacokinetics and Efficacy of ARCO). Homidium Homidium is a group II compound with trypanocidal effects.
- Drugs & Drug Targets