Agents Against Leishmaniasis and Trypanosomiasis

Agents Against Leishmaniasis and Trypanosomiasis
Accession Number

Not Available

ATC Classification
DrugDrug Description
NitrofuralA topical antibacterial for the prevention and treatment of bacterial infections of the skin.
PentamidineAn antifungal agent used to treat Pneumocystis pneumonia in patients infected with HIV.
SuraminFor treatment of human sleeping sickness, onchocerciasis and other diseases caused by trypanosomes and worms.
Sodium stibogluconateFor the treatment of various types of a protozoal infection called leishmaniasis, which may result from sandfly bites in tropical and temperate parts of the world. Also investigated for use/treatment...
EflornithineA medication used topically to reduce unwanted facial hair growth in women. The postulated mechanism of action is through irreversible inhibition of ornithine decarboxylase (ODC) in the skin.
NifurtimoxAn antiparasitic drug used for the treatment of Chagas disease (Trypanosoma cruzi infection).
BenznidazoleA trypanocidal agent used to treat Chagas disease.
MelarsoprolMelarsoprol is under investigation in clinical trial NCT00330148 (Randomized Clinical Trial of Three Drug Combinations for Late-Stage Gambiense Human African Trypanosomiasis).
Meglumine antimoniateNot Annotated
AcetarsolAn anti infective used to treat a wide variety of infections in the body.
FexinidazoleAn orally bioavailable 2-substituted 5-nitroimidazole used to treat early- and late-stage human African trypanosomiasis caused by Trypanosoma brucei gambiense.
MiltefosineAn antileishmanial agent used to treat leishmaniasis, a group of disease caused by parasites of the Leishmania type.
Drugs & Drug Targets
NitrofuralGlutathione reductasetarget
NitrofuralXanthine dehydrogenase/oxidaseenzyme
PentamidineCytochrome P450 2C19enzyme
PentamidinetRNA (cytosine(38)-C(5))-methyltransferasetarget
PentamidineCytochrome P450 2D6enzyme
PentamidineCytochrome P450 1A1enzyme
PentamidineCytochrome P450 3A5enzyme
PentamidineCytochrome P450 4A11enzyme
SuraminNAD-dependent protein deacylase sirtuin-5, mitochondrialtarget
SuraminComplement control protein C3target
SuraminPhospholipase A2, membrane associatedtarget
SuraminP2Y purinoceptor 2target
SuraminFollicle-stimulating hormone receptortarget
SuraminRyanodine receptor 1target
SuraminArylsulfatase Aenzyme
SuraminCytosolic phospholipase A2enzyme
Sodium stibogluconateDNA topoisomerase 1target
EflornithineOrnithine decarboxylasetarget
NifurtimoxATP-binding cassette sub-family G member 2transporter
NifurtimoxSerum albumincarrier
NifurtimoxGlyceraldehyde-3-phosphate dehydrogenase, glycosomaltarget
FexinidazoleCytochrome P450 1A2enzyme
FexinidazoleCytochrome P450 2B6enzyme
FexinidazoleCytochrome P450 2C19enzyme
FexinidazoleCytochrome P450 3A4enzyme
FexinidazoleCytochrome P450 3A5enzyme
FexinidazoleDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
FexinidazoleCytochrome P450 2D6enzyme
FexinidazoleSolute carrier organic anion transporter family member 1B1transporter
FexinidazoleSolute carrier organic anion transporter family member 1B3transporter
FexinidazoleSolute carrier family 22 member 2transporter
FexinidazoleSolute carrier family 22 member 6transporter
FexinidazoleSolute carrier family 22 member 8transporter
FexinidazoleMultidrug and toxin extrusion protein 1transporter
FexinidazoleMultidrug and toxin extrusion protein 2transporter
MiltefosinePhospholipase D1enzyme
MiltefosineP-glycoprotein 1target