Various Alimentary Tract and Metabolism Products

Name
Various Alimentary Tract and Metabolism Products
Accession Number
DBCAT002164
Description

Not Available

ATC Classification
Drugs
DrugDrug Description
Lipoic acidFor nutritional supplementation, also for treating dietary shortage or imbalance.
NitisinoneA hydroxyphenylpyruvate dioxygenase inhibitor used as an adjunct to dietary restrictions for the treatment of hereditary tyrosinemia type 1 (HT-1), which causes intolerance to tyrosine containing foods.
SapropterinA cofactor used as an adjunct to phenylalanine restriction in the treatment of phenylketonuria (PKU).
MiglustatA glucosylceramide synthase inhibitor used for the management of mild to moderate type I Gaucher disease for patients who are not candidates for whole enzyme replacement.
Benzoic acidAn antimicrobial food additive.
Phenylbutyric acidAn agent indicated for the adjunctive therapy for the management of chronic urea cycle disorders due to deficiencies in specific enzymes, including the neonatal-onset deficiency and late-onset disease with a history of hyperammonemic encephalopathy.
TeduglutideA glucagon-like peptide-2 (GLP-2) analog used to treat patients with Short Bowel Syndrome (SBS) who require parenteral nutritional support.
Glycerol phenylbutyrateA nitrogen-binding agent used to manage patients with urea cycle disorders who cannot be sufficiently managed amino acid supplementation and/or dietary restrictions.
EliglustatA glucosylceramide synthase used to treat type 1 Gaucher disease in patients who are CYP2D6 extensive, intermediate, or poor metabolizers, based on the FDA-approved test.
Anethole trithioneA medication used to treat dry mouth associated with medication or radiotherapy of the head and neck.
Zinc acetateA medication used to treat zinc deficiency.
MigalastatAn alpha-galactosidase A chaperone used for the treatment of Fabry disease in patients with an amenable galactosidase alpha gene (GLA) variant.
TriethylenetetramineA copper chelating agent used for the management of Wilson's disease in cases where penicillamine therapy is clinically inappropriate.
Uridine triacetateA pyrimidine analog used for the reversal of overdose, regardless of the presence of symptoms, and early-onset, severe or life-threatening CNS toxicity or cardiotoxicity of fluorouracil or capecitabine.
TelotristatA tryptophan hydroxylase inhibitor. Telotristat ethyl (brand name Xermelo) is a prodrug of telotristat.
Drugs & Drug Targets
DrugTargetType
Lipoic acidLipoyltransferase 1, mitochondrialtarget
Lipoic acidSodium-dependent multivitamin transportertarget
Lipoic acidLipoyl synthase, mitochondrialtarget
Lipoic acidNADPH--cytochrome P450 reductaseenzyme
Nitisinone4-hydroxyphenylpyruvate dioxygenasetarget
SapropterinPhenylalanine-4-hydroxylasetarget
SapropterinNitric oxide synthase, endothelialtarget
SapropterinTyrosine 3-monooxygenasetarget
SapropterinTryptophan 5-hydroxylase 1target
SapropterinProstaglandin G/H synthase 2enzyme
SapropterinP-glycoprotein 1transporter
MiglustatCeramide glucosyltransferasetarget
Benzoic acidCocaine esterasetarget
Benzoic acidD-amino-acid oxidasetarget
Benzoic acidChlorocatechol 1,2-dioxygenasetarget
Benzoic acid2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolasetarget
Benzoic acidNon-heme chloroperoxidasetarget
Benzoic acidOxygen-insensitive NAD(P)H nitroreductasetarget
Benzoic acidHydroxyquinol 1,2-dioxygenasetarget
Benzoic acidReplication proteintarget
Benzoic acidSolute carrier organic anion transporter family member 2B1transporter
Benzoic acidSolute carrier family 22 member 8transporter
Benzoic acidMonocarboxylate transporter 1transporter
Benzoic acidSolute carrier family 15 member 1target
Phenylbutyric acidAromatic-amino-acid aminotransferasetarget
Phenylbutyric acidThermolysintarget
Phenylbutyric acidCytochrome P450 2D6enzyme
TeduglutideGlucagon-like peptide 2 receptortarget
Glycerol phenylbutyratePancreatic triacylglycerol lipaseenzyme
Glycerol phenylbutyrateCytochrome P450 3A4enzyme
Glycerol phenylbutyrateCytochrome P450 2D6enzyme
EliglustatCeramide glucosyltransferasetarget
EliglustatCytochrome P450 2D6enzyme
EliglustatCytochrome P450 3A4enzyme
EliglustatP-glycoprotein 1transporter
Zinc acetateB1 bradykinin receptortarget
Zinc acetateMethylated-DNA--protein-cysteine methyltransferasetarget
Zinc acetateFructose-bisphosphate aldolase Atarget
Zinc acetateElongation factor 1-alpha 1target
Zinc acetateAlpha-enolasetarget
Zinc acetateGlyceraldehyde-3-phosphate dehydrogenase, testis-specifictarget
Zinc acetateNucleoside diphosphate kinase Atarget
Zinc acetateProtein disulfide-isomerasetarget
Zinc acetateProtein disulfide-isomerase A3target
Zinc acetatePeroxiredoxin-1target
Zinc acetatePhosphoserine phosphatasetarget
Zinc acetateTriosephosphate isomerasetarget
Zinc acetateElongation factor Tu, mitochondrialtarget
Zinc acetateEstrogen receptor alphatarget
Zinc acetateInterleukin-3target
Zinc acetateMetallothionein-2target
Zinc acetateCopper chaperone for superoxide dismutasetarget
Zinc acetateHistone deacetylase 1target
Zinc acetateHistone deacetylase 4target
Zinc acetateDNA-3-methyladenine glycosylasetarget
Zinc acetateSemenogelin-1target
Zinc acetateSuperoxide dismutase [Cu-Zn]target
Zinc acetateHistone deacetylase 8target
Zinc acetateApoptosis regulatory protein Sivatarget
Zinc acetateGlycine receptor subunit alpha-1target
Zinc acetateE3 ubiquitin-protein ligase Mdm2target
Zinc acetateInsulintarget
Zinc acetateUtrophintarget
Zinc acetateAspartoacylasetarget
Zinc acetateProtein S100-A8target
Zinc acetateProtein S100-A9target
Zinc acetateMatrix metalloproteinase-9target
Zinc acetateTumor protein p73target
Zinc acetateProtein S100-A2target
Zinc acetateCellular tumor antigen p53target
Zinc acetateMetallothionein-3target
Zinc acetateProgrammed cell death protein 6target
Zinc acetateDAN domain family member 5target
Zinc acetateMetallothionein-1Atarget
Zinc acetateAlpha-1B-glycoproteintarget
Zinc acetateAlpha-2-macroglobulintarget
Zinc acetateAngiotensinogentarget
Zinc acetateAlpha-2-HS-glycoproteintarget
Zinc acetateSerum amyloid P-componenttarget
Zinc acetateApolipoprotein A-Itarget
Zinc acetateApolipoprotein A-IItarget
Zinc acetateApolipoprotein A-IVtarget
Zinc acetateApolipoprotein B receptortarget
Zinc acetateApolipoprotein Etarget
Zinc acetateApolipoprotein L1target
Zinc acetateComplement C1q subcomponent subunit Btarget
Zinc acetateComplement C1q subcomponent subunit Ctarget
Zinc acetateComplement C1r subcomponenttarget
Zinc acetateComplement C1s subcomponenttarget
Zinc acetateComplement C3target
Zinc acetateComplement C4-Btarget
Zinc acetateC4b-binding protein alpha chaintarget
Zinc acetateC4b-binding protein beta chaintarget
Zinc acetateComplement C5target
Zinc acetateLys-63-specific deubiquitinase BRCC36target
Zinc acetateComplement component C8 alpha chaintarget
Zinc acetateComplement component C8 beta chaintarget
Zinc acetateComplement component C8 gamma chaintarget
Zinc acetateComplement factor Btarget
Zinc acetateComplement factor Htarget
Zinc acetateComplement factor Itarget
Zinc acetateClusterintarget
Zinc acetateCeruloplasmintarget
Zinc acetateCarboxypeptidase N catalytic chaintarget
Zinc acetateCarboxypeptidase N subunit 2target
Zinc acetateDermcidintarget
Zinc acetateDesmoplakintarget
Zinc acetateCoagulation factor XIItarget
Zinc acetateCoagulation factor XIII B chaintarget
Zinc acetateProthrombintarget
Zinc acetateFicolin-3target
Zinc acetateFibrinogen alpha chaintarget
Zinc acetateFibronectintarget
Zinc acetateGelsolintarget
Zinc acetateHemoglobin subunit alphatarget
Zinc acetateHemoglobin subunit betatarget
Zinc acetateHaptoglobin-related proteintarget
Zinc acetateHornerintarget
Zinc acetateInsulin-like growth factor-binding protein complex acid labile subunittarget
Zinc acetateIg alpha-1 chain C regiontarget
Zinc acetateIg mu chain C regiontarget
Zinc acetateImmunoglobulin kappa variable 1-17target
Zinc acetateIg kappa chain V-III region GOLtarget
Zinc acetateImmunoglobulin lambda variable 3-21target
Zinc acetateInter-alpha-trypsin inhibitor heavy chain H1target
Zinc acetateInter-alpha-trypsin inhibitor heavy chain H2target
Zinc acetateInter-alpha-trypsin inhibitor heavy chain H3target
Zinc acetateInter-alpha-trypsin inhibitor heavy chain H4target
Zinc acetateImmunoglobulin J chaintarget
Zinc acetateJunction plakoglobintarget
Zinc acetatePlasma kallikreintarget
Zinc acetateKininogen-1target
Zinc acetateKeratin, type II cytoskeletal 1target
Zinc acetateKeratin, type I cytoskeletal 10target
Zinc acetateKeratin, type I cytoskeletal 14target
Zinc acetateKeratin, type I cytoskeletal 16target
Zinc acetateKeratin, type II cytoskeletal 2 epidermaltarget
Zinc acetateKeratin, type II cytoskeletal 5target
Zinc acetateKeratin, type II cytoskeletal 6Atarget
Zinc acetateKeratin, type I cytoskeletal 9target
Zinc acetateAlpha-1-acid glycoprotein 2target
Zinc acetateN-acetylmuramoyl-L-alanine amidasetarget
Zinc acetateSerum paraoxonase/arylesterase 1target
Zinc acetatePregnancy zone proteintarget
Zinc acetateProtein S100-A7target
Zinc acetateSelenoprotein Ptarget
Zinc acetateAlpha-1-antitrypsintarget
Zinc acetateAlpha-1-antichymotrypsintarget
Zinc acetateKallistatintarget
Zinc acetateCorticosteroid-binding globulintarget
Zinc acetateHeparin cofactor 2target
Zinc acetateSex hormone-binding globulintarget
Zinc acetateSerotransferrintarget
Zinc acetateTransthyretintarget
Zinc acetateVitronectintarget
Zinc acetateAmyloid-like protein 1target
Zinc acetateAmyloid-like protein 2target
Zinc acetateAmyloid beta A4 proteintarget
Zinc acetatePoly [ADP-ribose] polymerase 1target
Zinc acetateCarbonic anhydrase 1enzyme
Zinc acetateCarboxypeptidase Eenzyme
Zinc acetateAlcohol dehydrogenase 1Cenzyme
Zinc acetateInsulin-degrading enzymeenzyme
Zinc acetateSuperoxide dismutase [Cu-Zn]enzyme
MigalastatAlpha-galactosidase Atarget
MigalastatUDP-glucuronosyltransferase 1-1enzyme
TriethylenetetramineGlypican-1transporter