Previtamin D(3)

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Previtamin D(3)
DrugBank Accession Number
DB15614
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
Thumb
Weight
Average: 384.648
Monoisotopic: 384.339216037
Chemical Formula
C27H44O
Synonyms
  • Precalciferol
  • Precholecalciferol
  • Previtamin D
  • Previtamin D(3)
  • Previtamin D3

Pharmacology

Indication

Not Available

Pharmacology
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Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcetyldigitoxinThe risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Previtamin D(3) is combined with Acetyldigitoxin.
AlfacalcidolThe risk or severity of adverse effects can be increased when Alfacalcidol is combined with Previtamin D(3).
Aluminum hydroxideThe serum concentration of Aluminum hydroxide can be increased when it is combined with Previtamin D(3).
Beclomethasone dipropionateThe therapeutic efficacy of Previtamin D(3) can be decreased when used in combination with Beclomethasone dipropionate.
BendroflumethiazideThe risk or severity of hypercalcemia can be increased when Bendroflumethiazide is combined with Previtamin D(3).
BenzthiazideThe risk or severity of hypercalcemia can be increased when Benzthiazide is combined with Previtamin D(3).
BetamethasoneThe therapeutic efficacy of Previtamin D(3) can be decreased when used in combination with Betamethasone.
Betamethasone phosphateThe therapeutic efficacy of Previtamin D(3) can be decreased when used in combination with Betamethasone phosphate.
BudesonideThe therapeutic efficacy of Previtamin D(3) can be decreased when used in combination with Budesonide.
CalcifediolThe risk or severity of adverse effects can be increased when Calcifediol is combined with Previtamin D(3).
Interactions
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Food Interactions
Not Available

Products

Products2
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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
CalceminPrevitamin D(3) (0.75 mg/1) + Boron (50 ug/1) + Zinc (2 mg/1)Tablet, film coatedOralBayer Healthcare Llc.2016-04-01Not applicableUS flag
Calcemin AdvancePrevitamin D(3) (3 mg/1) + Calcium carbonate (500 mg/1) + Magnesium oxide (40 mg/1) + Sodium borate decahydrate (2.45 mg/1) + Zinc oxide (7.5 mg/1)Tablet, film coatedOralBayer Healthcare Llc.2016-04-01Not applicableUS flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
HDA46400N5
CAS number
1173-13-3
InChI Key
YUGCAAVRZWBXEQ-WHTXLNIXSA-N
InChI
InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h10,12-13,19,21,24-26,28H,6-9,11,14-18H2,1-5H3/b13-12-/t21-,24+,25-,26+,27-/m1/s1
IUPAC Name
(1S)-3-[(1Z)-2-[(1R,3aR,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl]ethenyl]-4-methylcyclohex-3-en-1-ol
SMILES
[H][C@@]1(CC[C@@]2([H])C(\C=C/C3=C(C)CC[C@H](O)C3)=CCC[C@]12C)[C@H](C)CCCC(C)C

References

General References
Not Available
KEGG Compound
C07711
ChemSpider
4444516
ChEBI
8403
ZINC
ZINC000016343334

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Tablet, film coatedOral
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.000374 mg/mLALOGPS
logP7.38ALOGPS
logP7.07ChemAxon
logS-6ALOGPS
pKa (Strongest Acidic)18.31ChemAxon
pKa (Strongest Basic)-1.3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area20.23 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity124.3 m3·mol-1ChemAxon
Polarizability49.02 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on January 10, 2020 21:00 / Updated on June 12, 2020 16:53