Reaction: Clobazam to 1 product
- Reaction
- Reaction type
- N-demethylation
- Direction
- Major circulating metabolite?
- Yes
- Spontaneous?
- No
- Activity
- active
- References
- Giraud C, Tran A, Rey E, Vincent J, Treluyer JM, Pons G: In vitro characterization of clobazam metabolism by recombinant cytochrome P450 enzymes: importance of CYP2C19. Drug Metab Dispos. 2004 Nov;32(11):1279-86. [Article]
- FDA Approved Drug Products: ONFI® (clobazam) tablets, for oral use, CIV [Link]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role Cytochrome P450 2C19 Not Available Not Available confirmed Cytochrome P450 3A4 Not Available Not Available confirmed Cytochrome P450 2B6 Not Available Not Available confirmed Cytochrome P450 3A5 Not Available Not Available confirmed Cytochrome P450 3A7 Not Available Not Available confirmed Cytochrome P450 1A2 Not Available Not Available confirmed Cytochrome P450 2C8 Not Available Not Available confirmed Cytochrome P450 2C9 Not Available Not Available confirmed Cytochrome P450 2D6 Not Available Not Available confirmed Cytochrome P450 2C18 Not Available Not Available confirmed
