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Displaying results 91 - 100 of 134683 in total
  1. Pathway

    Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin

    smpdb.ca/view/SMP0000338
    Signaling

    LHCGRs are found in the ovary, testis, and many extragonadal tissues.In the ovary, the LHCG receptor is necessary for follicular maturation and ovulation, as well as luteal function. … In the male the LHCGR has been identified on the Leydig cells that are critical for testosterone production, and support spermatogenesis.

    Drugs: ATP · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acid
  2. Pathway

    Metabolism and Physiological Effects of N-Acetyl-3-Methylhistidine

    smpdb.ca/view/SMP0126795
    Metabolic

    N-Acetyl-3-methylhistidine, an N-acetyl-L-amino acid, belongs to the class of organic compounds known as histidine and derivatives. … N-Acetyl-3-methylhistidine is an acetylated derivative of 3-methylhistidine and a very strong basic compound (based on its pKa).

    Drugs: Histidine · Ademetionine
  3. Pathway

    Metabolism and Physiological Effects of N-alpha-Acetyl-L-arginine

    smpdb.ca/view/SMP0125530
    Metabolic

    Arginnosuccinate is synthesized from citrulline and aspartic acid by the enzyme argininosuccinate synthase. That is catalyzed by argininosuccinate lyase to produce arginine and fumaric acid. … In the blood it works as a uremic toxin to cause kidney damage, cardiovascular disease and neurological deficits.

    Drugs: Pyridoxal phosphate · Arginine · Aspartic acid · Ornithine · L-Glutamine · Adenosine phosphate +10 more
  4. Pathway

    Ziconotide NMDA and Substance P Receptor Pain Inhibition Action Pathway

    smpdb.ca/view/SMP0126347
    Drug action

    N-type channel activate lightly myelinated Aδ- and C-fibres, which mediate the release of neurotransmitters substance P, calcitonin gene-related peptide (CGRP), and glutamate. … Therefore substance P, CGRP, and glutamate are not released into the synapse and cannot activate the substance P receptors, CGRP receptors, or the N-Methyl-D-aspartic acid receptors on the post-synaptic

    Drugs: Glutamic acid · Calcium · Sar9, Met (O2)11-Substance P · Ziconotide
  5. Pathway

    Icosapent Prostaglandin G/H synthase 1 and 2 anti-inflammatory Action Pathway

    smpdb.ca/view/SMP0126557
    Drug action

    Icosapent is an important polyunsaturated fatty acid (eicosapentaenoic acid (EPA)). It is mostly found in fish oils. … This molecule also inhibits the arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families because it inhibits the prostaglandin G/H synthase 1 and 2 (COX-1 and COX-2).

    Drugs: Glutathione · Icosapent · Dinoprostone · Calcium · Mesoheme · Prostaglandin G2 +1 more
  6. Pathway

    Activated charcoal Drug Metabolism

    smpdb.ca/view/SMP0130520
    Metabolic

    Activated charcoal passes through the liver and is then excreted from the body mainly through the kidney. … Activated charcoal is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.

    Drugs: Activated charcoal
  7. Pathway

    Sodium tetradecyl sulfate Drug Metabolism

    smpdb.ca/view/SMP0130614
    Metabolic

    Sodium tetradecyl sulfate passes through the liver and is then excreted from the body mainly through the kidney. … Sodium tetradecyl sulfate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.

    Drugs: Sodium tetradecyl sulfate
  8. Pathway

    Sulfate/Sulfite Metabolism

    smpdb.ca/view/SMP0000041
    Metabolic

    This pathway illustrates the conversion of sulfite to sulfate (via sulfate oxidase) and subsequent generation of adenylylsulfate (APS) via 3'-phosphoadenosine 5'-phosphosulfate synthase 2. … Finally, this preservation property goes beyond merely wines, and finds utility in dried fruits, potatoes, etc.

    Drugs: ATP · Estrone · Magnesium cation · Mesoheme · Propyl alcohol · Phenol +2 more
    Enzymes: Sulfite oxidase, mitochondrial
  9. Pathway

    Glycerin Drug Metabolism

    smpdb.ca/view/SMP0130649
    Metabolic

    Glycerin passes through the liver and is then excreted from the body mainly through the kidney. … Glycerin is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.

    Drugs: Glycerin
  10. Pathway

    Castor Oil Action Pathway

    smpdb.ca/view/SMP0174887
    Drug action

    Castor Oil may also promote ulcer healing by increasing mucus and bicarbonate secretion and thickening the mucosal bilayer so the mucosa can generate new cells. … Castor Oil stimulates prostaglandin receptors on parietal cells in the stomach to reduce gastric acid secretion. Castor Oil activates prostaglandin EP3 receptors in parietal cells.

    Drugs: ATP · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Pyrophosphoric acid +1 more