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Valsartan Action Pathway (New)
smpdb.ca/view/SMP0124970Drug actionValsartan is angiotensin receptor blocker (ARB) which block the action of angiotensin II by binding to the type 1 angiotensin II receptor. Angiotensin II is a critical circulating peptide hormone that has powerful vasoconstrictive effect...
Alprazolam Action Pathway
smpdb.ca/view/SMP0125056Drug actionAlprazolam is a triazolobenzodiazepine with intermediate onset commonly used to treat panic disorders and generalized anxiety in addition to anxiety associated with depression. Alprazolam is also indicated, either as a standard or extend...
Thiocolchicoside Action Pathway (New)
smpdb.ca/view/SMP0125071Drug actionThiocolchicoside is a semi-synthetic colchicine derivative used as skeletal muscle-relaxant drug used in the treatment of orthopedic, traumatic and rheumatologic disorders. It is indicated as an adjuvant drug in the treatment of painful ...
Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate +2 moreGamma-Aminobutyric Acid Biosynthesis
smpdb.ca/view/SMP0125090MetabolicGlutamate is catalyzed in the neuron with the enzyme Glutamate decarboxylase-1 to synthesize GABA and a byproduct of carbon dioxide. GABA is transported into a synaptic vesicle by Vesicular inhibitory amino acid transporter. The vesicle ...
Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate +2 morePregabalin Action Pathway
smpdb.ca/view/SMP0125115Drug actionPregabalin is an anticonvulsant drug used to treat neuropathic pain conditions and fibromyalgia, and for the treatment of partial onset seizures in combination with other anticonvulsants. Pregabalin is structurally similar to gamma-amino...
Ethanol GABA Agonist Action Pathway
smpdb.ca/view/SMP0125151Drug actionEthanol, commonly seen in the form of various alcohols as well as hand sanitizer, is a drug that is injected intrathecally. Ethanol's effects are mainly seen in the brain where it binds to many receptors. The main effects are seen by the...
Caffeine Nervous Action Pathway
smpdb.ca/view/SMP0125297Drug actionCaffeine is a central nervous system stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. Consistent intake of caffeine increases the population of adenosine receptors, which can poten...
Drugs: Pyridoxal phosphate · Glutamic acid · Caffeine · Norepinephrine · Adenosine · Calcium +1 moreTyrosinemia Type I
smpdb.ca/view/SMP0125591DiseaseTyrosinemia type I, also known as fumarylacetoacetase or FAH deficiency, is the most severe type of tyrosinemia, a buildup of tyrosine in the body. It is caused by an autosomal recessive mutation in the the FAH gene that encodes for fuma...
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 moreMonoamine Oxidase-A Deficiency (MAO-A)
smpdb.ca/view/SMP0125595DiseaseMomoamine oxidase A (MAO-A) deficiency, or Brunner syndrome, is an X-linked recessive genetic disorder caused by a mutation in the MAOA gene that encodes for monoamine oxidase A. As such it is almost exclusively found in men. MAO-A is an...
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 moreGABA-Transaminase Deficiency: beta-alanine
smpdb.ca/view/SMP0125596DiseaseGABA-transaminase deficiency, also known as gamma-amino butyric acid transaminase (GABA-T) deficiency, is an extremely rare autosomal recessive inborn error of metabolism (IEM) that is caused by a defect in the ABAT gene, which codes for...