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Displaying results 91 - 100 of 138753 in total
  1. Pathway

    Metabolism and Physiological Effects of N-Acetyl-3-Methylhistidine

    smpdb.ca/view/SMP0126795
    Metabolic

    N-Acetyl-3-methylhistidine, an N-acetyl-L-amino acid, belongs to the class of organic compounds known as histidine and derivatives. … Higher circulating levels of five of these N-acetylated amino acids, namely, N-δ-acetylornithine, N-acetyl-1-methylhistidine, N-acetyl-3-methylhistidine, N-acetylhistidine, and N2,N5-diacetylornithine,

    Drugs: Histidine · Ademetionine
  2. Pathway

    Metabolism and Physiological Effects of N-alpha-Acetyl-L-arginine

    smpdb.ca/view/SMP0125530
    Metabolic

    Arginnosuccinate is synthesized from citrulline and aspartic acid by the enzyme argininosuccinate synthase. That is catalyzed by argininosuccinate lyase to produce arginine and fumaric acid. … Glutamine is consumed through food and taken into the blood through the intestines. It is transported to the liver where it is transported in via an amino acid transport.

    Drugs: Pyridoxal phosphate · Arginine · Aspartic acid · Ornithine · L-Glutamine · Adenosine phosphate +10 more
    Enzymes: Neutral amino acid transporter A, Low affinity cationic amino acid transporter 2
  3. Pathway

    Ziconotide NMDA and Substance P Receptor Pain Inhibition Action Pathway

    smpdb.ca/view/SMP0126347
    Drug action

    Therefore substance P, CGRP, and glutamate are not released into the synapse and cannot activate the substance P receptors, CGRP receptors, or the N-Methyl-D-aspartic acid receptors on the post-synaptic … such as intrathecal morphine and systemic analgesics.

    Drugs: Glutamic acid · Calcium · Sar9, Met (O2)11-Substance P · Ziconotide
  4. Pathway

    Icosapent Prostaglandin G/H synthase 1 and 2 anti-inflammatory Action Pathway

    smpdb.ca/view/SMP0126557
    Drug action

    Furthermore, it influences the function and binds to the Carbohydrate responsive element binding protein (ChREBP) and a fatty acid receptor (G-coupled receptor) called GP40. … Icosapent is an important polyunsaturated fatty acid (eicosapentaenoic acid (EPA)). It is mostly found in fish oils.

    Drugs: Glutathione · Icosapent · Dinoprostone · Calcium · Mesoheme · Prostaglandin G2 +1 more
  5. Pathway

    Fish oil Prostaglandin G/H synthase 1 and 2 anti-inflammatory Action Pathway

    smpdb.ca/view/SMP0126563
    Drug action

    Fish oil is made of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). … These are responsible for the conversion of arachidonic acid (an omega-6 fatty acid) into prostaglandins and thromboxanes, which are important mediators of inflammation and pain.

    Drugs: Glutathione · Icosapent · Dinoprostone · Calcium · Mesoheme · Prostaglandin G2 +1 more
  6. Pathway

    Fatty Acid Metabolism

    smpdb.ca/view/SMP0000051
    Metabolic

    Fatty acids constitute a large energy source for the body. The cellular membrane is also made up of fatty acids. During starvation times, fatty acids can provide energy to humans for numerous days. … When ATP is needed, ATP may be generated by increasing fatty acid metabolism. Fatty acid metabolism is essentially the reverse reaction of fatty acid synthesis.

    Drugs: Adenosine phosphate · NADH · ATP · Levocarnitine · Magnesium cation · Flavin adenine dinucleotide +2 more
    Enzymes: Long-chain-fatty-acid--CoA ligase 1
  7. Pathway

    Gadopentetic acid Metabolism

    smpdb.ca/view/SMP0126898
    Metabolic

    It is a complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid (DTPA), that is given to enhance the image in cranial and spinal MRIs. … It is used with magnetic resonance imaging (MRI) in adults, and pediatric patients (2 years of age and older) to visualize lesions with abnormal vascularity in the brain (intracranial lesions), spine and

    Drugs: Gadopentetic acid
  8. Pathway

    Citric Acid Cycle

    smpdb.ca/view/SMP0000057
    Metabolic

    The citric acid cycle is named after citrate or citric acid, a tricarboxylic acid that is both consumed and regenerated through this pathway. … as amino acid synthesis and oxidative phosphorylation (OxPhos).

    Drugs: Pyruvic acid · Biotin · Succinic acid · NADH · ATP · Magnesium cation +4 more
  9. Pathway

    Fatty Acid Biosynthesis

    smpdb.ca/view/SMP0000456
    Metabolic

    The production of palmitic acid can be summarized as the successive addition of two carbons to an initial acetyl moiety primer. After 7 cycles palimitic acid is released. … The biosynthesis of fatty acids primarily occurs in liver and lactating mammary glands.

    Drugs: Biotin · Acetoacetic acid · Butenoic Acid · Malonic acid · (R)-3-hydroxytetradecanoic acid · Lauric acid +8 more
    Enzymes: Fatty acid synthase
  10. Pathway

    Gadoteric acid Metabolism

    smpdb.ca/view/SMP0126924
    Metabolic

    Gadoteric acid is indicated for intravenous use with magnetic resonance imaging (MRI) in brain (intracranial), spine and associated tissues in adult and pediatric patients (2 years of age and older) to … Gadoteric acid is a diagnostic contrast agent used with magnetic resonance imaging to provide contrast enhancement for intracranial and spinal lesions with abnormal blood brain barrier or abnormal vascularity

    Drugs: Gadoteric acid