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Desvenlafaxine SNRI - Norepinephrine reuptake Inhibition Action Pathway
smpdb.ca/view/SMP0126425Drug action(ODV) commonly called desvenlafaxine potently and selectively inhibits the reuptake of both serotonin and norepinephrine at the presynaptic terminal. … Venlafaxine and desvenlafaxine are also weak inhibitors of dopamine reuptake.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Venlafaxine · Norepinephrine · Dopamine +6 moreEnzymes: Sodium-dependent noradrenaline transporterNorepinephrine Beta-1 Adrenergic Cardiac Action Pathway
smpdb.ca/view/SMP0126438Drug actionWhen taken pharmacologically it acts on the sympathetic nervous system in the heart and the blood vessels. It is mainly used pharmacologically for hypotension and vasodilatory shock states. … Myosin, with an ADP and phosphate attached, binds to actin to form a cross bridge. Myosin performs a powerstroke, drawing the actin filaments together.
Enzymes: Sodium/calcium exchanger 1Pseudoephedrine Action Pathway
smpdb.ca/view/SMP0125255Drug actionPseudophedrine also activates on beta receptors, and it inhibits sodium dependent dopamine and serotonin transporters, however not to the same effect or degree as it affects alpha receptors and the norepinephrine … Pseudoephedrine also inhibits sodium dependent noradrenaline receptors which prevents the reuptake of norepinephrine into the presynaptic neuron.
Drugs: Ascorbic acid · Norepinephrine · Pseudoephedrine · Dopamine · Calcium · Magnesium cation +1 moreEnzymes: Sodium-dependent noradrenaline transporterMethyldopa Action Pathway
smpdb.ca/view/SMP0125087Drug actionTwo types of alpha receptors, alpha 1 and alpha 2, both play a role in regulating blood pressure. … Phospholipase C converts phosphatidylinositol 4,5-bisphosphate to diacylglycerol and inositol 1,4,5-trisphosphate (IP3).
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Sapropterin · Norepinephrine · Dopamine +5 moreEnzymes: Sodium-dependent noradrenaline transporterDuloxetine SNRI - Dopamine Norepinephrine Inhibition Action Pathway
smpdb.ca/view/SMP0126450Drug actionIt blocks both sodium dependent serotonin and sodium dependent norepinephrine transporters from removing serotonin and norepinephrine respectively from the synaptic cleft. … The receptors that are being stimulated are 5-HT 2A, 2B, and 2C serotonin receptors and alpha 1 and beta 1 adrenergic receptors.
Enzymes: Sodium-dependent noradrenaline transporterMethylphenidate Norepinephrine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0126572Drug actionMethylphenidate binds and blocks the sodium-dependent noradrenaline transporter which prevents the synaptic norepinephrine from re-entering the presynaptic neuron. … Norepinephrine is then transported to the prefrontal cortex and released into the synapse when the neuron is stimulated and fires.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · ATP · Norepinephrine · Methylphenidate +7 moreEnzymes: Sodium-dependent noradrenaline transporterDextroamphetamine Dopamine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0126994Drug actionDextroamphetamine binds to the sodium-dependent dopamine transporter, which prevents dopamine from re-entering the presynaptic neuron. … Dextroamphetamine, known commonly as Adderall, is a drug related to amphetamine and is used mainly for treating ADHD and narcolepsy.
Enzymes: Sodium-dependent dopamine transporterCaffeine Cardiac Contraction Action Pathway
smpdb.ca/view/SMP0126520Drug actionCaffeine is a stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. … This means that much of the research is not well understood, and there is much conflicting data on caffeine.
Enzymes: Sodium/calcium exchanger 1Pramipexole Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126459Drug actionPramipexole is considered a non-ergot dopamine agonist that shows specificity and strong activity at the D2 subfamily of dopamine receptors in vitro, binding selectively and dopamine D2 receptors and showing … Pramipexole is indicated for the management of Parkinson's disease and symptomatic treatment of moderate to severe primary Restless Legs Syndrome (RLS).
Enzymes: Sodium-dependent dopamine transporterLevodopa Metabolism Pathway
smpdb.ca/view/SMP0125329MetabolicIt is a dopamine precursor and is used to synthesize dopamine in dopaminergic neurons. … The common adverse effects of Levodopa treatment are nausea, dizziness, headache, and somnolence.
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · NADH · Norepinephrine · Epinephrine +6 moreEnzymes: Neutral and basic amino acid transport protein rBAT