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Displaying results 1001 - 1010 of 10000 in total
  1. Target

    Neuronal acetylcholine receptor subunit alpha-7

    go.drugbank.com/bio_entities/BE0002341
    TargetHumans

    Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter … receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction.

    Synonyms: nAChR7
  2. Pathway

    Isosorbide Mononitrate Action Pathway

    smpdb.ca/view/SMP0125275
    Drug action

    It is then metabolized in the cytosol into nitric oxide by P450 enzymes, xanthine oxidoreductase (XO), glutathione-S-transferase (GST), or cytosolic aldehyde dehydrogenase isoforms.

    Drugs: Nitric Oxide · Isosorbide mononitrate · Potassium cation · Calcium · Magnesium cation · Pyrophosphoric acid
    Enzymes: Glutathione S-transferase Mu 1
  3. Pathway

    Ruxolitinib Mechanism of Action Action Pathway

    smpdb.ca/view/SMP0126971
    Drug action

    Ruxolitinib is a medication used to manage and treat myelofibrosis, polycythemia vera, and steroid-refractory acute graft-versus-host disease. It is in the Janus Kinase inhibitor class of medications. Ruxolitinib is a selective and poten...

    Drugs: Ruxolitinib
    Enzymes: S-phase kinase-associated protein 2
  4. Pathway

    Intracellular Signalling Through Adenosine Receptor A2a and Adenosine

    smpdb.ca/view/SMP0000320
    Signaling

    The adenosine receptor A2a activates G(s) proteins which lead to the activation of adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (protein kinase A) which phosphorylates

    Drugs: ATP · Adenosine · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Pyrophosphoric acid
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  5. Pathway

    Intracellular Signalling Through Adenosine Receptor A2b and Adenosine

    smpdb.ca/view/SMP0000321
    Signaling

    The adenosine receptor A2b activates G(s) proteins which lead to the activation of adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (protein kinase A) which phosphorylates

    Drugs: ATP · Adenosine · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Pyrophosphoric acid
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  6. Pathway

    Dipivefrin A2-Adrenergic Vasocontriction Action Pathway

    smpdb.ca/view/SMP0126098
    Drug action

    Dipivefrin is a prodrug of epinephrine used in ophthalmic solutions to reduce intraocular pressure in chronic open-angle glaucoma. It is available as ophthalmic solution (eye drops). Dipivefrin is a prodrug with little or no pharmacologi...

    Drugs: ATP · Dipivefrin · Epinephrine · Calcium · Magnesium cation · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
  7. Pathway

    Pergolide Mechanism of Action Action Pathway

    smpdb.ca/view/SMP0126635
    Drug action

    The dopamine D2 receptor is a 7-transmembrane G-protein coupled receptor associated with Gi proteins. In lactotrophs, stimulation of dopamine D2 receptor causes inhibition of adenylyl cyclase, which decreases intracellular cAMP concentra...

    Drugs: Pyridoxal phosphate · Tyrosine · ATP · Dopamine · Pergolide · Levodopa +5 more
    Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  8. Pathway

    Duloxetine SNRI - Dopamine Norepinephrine Inhibition Action Pathway

    smpdb.ca/view/SMP0126450
    Drug action

    Duloxetine is a serotonin norepinephrine reuptake inhibitor used to treat generalized anxiety disorder, neuropathic pain, osteoarthritis, and stress incontinence. It blocks both sodium dependent serotonin and sodium dependent norepinephr...

    Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · ATP · Norepinephrine · Duloxetine +8 more
    Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  9. Pathway

    Solriamfetol Action Pathway

    smpdb.ca/view/SMP0126346
    Drug action

    Solriamfetol, also known as Sunosi, is a dopamine and norepinephrine reuptake inhibitor (DNRI). This drug is indicated for the daytime treatment of sleepiness associated with narcolepsy or obstructive sleep apnea. Solriamfetol was given ...

    Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · ATP · Norepinephrine · Dopamine +8 more
    Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  10. Pathway

    Caffeine Cardiac Contraction Action Pathway

    smpdb.ca/view/SMP0126520
    Drug action

    Caffeine is a stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. The cardiovascular effects are extensive and can help with headaches, migraines, or other types of pain in certain ci...

    Drugs: Ascorbic acid · ATP · Caffeine · Norepinephrine · Dopamine · Calcium +1 more
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1