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Displaying results 1021 - 1030 of 10000 in total
  1. Pathway

    Metabolism and Physiological Effects of N-Formyl-L-Methionine

    smpdb.ca/view/SMP0126765
    Metabolic

    Since fMet is present in proteins made by mitochondria and chloroplasts, more recent theories do not see it as a molecule that the immune system can use to distinguish self from non-self. … Instead, fMet-containing oligopeptides and proteins appear to be released by the mitochondria of damaged tissues as well as by damaged bacteria, and can thus qualify as an "alarm" signal, as discussed

    Drugs: Adenosine phosphate · Methionine · ATP · N-Acetylmethionine · Pyrophosphoric acid
  2. Pathway

    Metabolism and Physiological Effects of N-Acetyl-1-Methylhistidine

    smpdb.ca/view/SMP0126802
    Metabolic

    N-Acetyl-1-methylhistidine is an acetylated derivative of 1-methylhistidine and a very strong basic compound (based on its pKa). … N-Acetyl-1-methylhistidine belongs to the class of organic compounds known as histidine and derivatives.

    Drugs: Histidine · Ademetionine · 1-Methylhistidine
  3. Pathway

    Excitatory Neural Signalling Through 5-HTR 6 and Serotonin

    smpdb.ca/view/SMP0000312
    Signaling

    The 5-HT6 receptor is primarily expressed in the brain and is involved in glutamatergic and cholinergic neuronal activity.

    Drugs: ATP · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acid
  4. Pathway

    Metabolism and Physiological Effects of Trimethylamine N-oxide (TMAO)

    smpdb.ca/view/SMP0123192
    Metabolic

    When this compound enters into systemic circulation it is shown to be a major uremic toxin when high levels of it are retained in the blood and not excreted in urine. … Trimethylamine N-oxide(TMAO) is a uremic toxin compound that can be metabolized from dietary choline. There are 2 metabolic reactions that occur in order to get TMAO.

    Drugs: Choline · Flavin adenine dinucleotide
  5. Pathway

    Metabolism and Physiological Effects of N-Acetyl-L-Alanine

    smpdb.ca/view/SMP0126554
    Metabolic

    N-terminal acetylation of proteins is a widespread and highly conserved process in eukaryotes that is involved in protection and stability of proteins. … Excessive amounts N-acetyl amino acids can be detected in the urine with individuals with aminoacylase I deficiency, a genetic disorder.

    Drugs: Alanine
  6. Drug

    Aurothioglucose

    go.drugbank.com/drugs/DB09121
    ApprovedWithdrawn

    Contemporary research on the effect of gold salts treatment began in 1935, primarily to reduce inflammation and to slow disease progression in patients with rheumatoid arthritis [A32326]. … and others, which are far more effective.

    Categories: Antiinflammatory and Antirheumatic ProductsProducts: Solganal Inj 50mg/ml
  7. Drug

    Pentaerythritol tetranitrate

    go.drugbank.com/drugs/DB06154
    ApprovedWithdrawn

    It is formed by reacting pentaerythritol (C5H12O4), an alcohol commonly used in paints and varnishes, with nitric acid (HNO2). The reacting solution is chilled to precipitate the PETN. … It is recognized by the FDA to be a coronary vasodilator in the treatment of heart conditions such as angina [L2395].

    Categories: Vasodilators Used in Cardiac DiseasesProducts: Peritrate Tab 10mg, Peritrate Tab 20mg
  8. Drug

    Eftrenonacog alfa

    go.drugbank.com/drugs/DB11608
    Approved

    Eftrenonacog alfa was developed and marketed as Alprolix for intravenous injection by Biogen. It was first approved by the FDA in March 2014 and later approved by the EMA in May 2016. … It is an X-linked genetic disease caused by mutation of the gene for coagulation protein factor IX (FIX), leading to decreased levels of endogenous factor IX and increased susceptibility to recurrent bleeding

    Synonyms: Recombinant human coagulation factor IX, FC Fusion protein, Coagulation factor IX recombinant immunoglubulin g1 fusion proteinCategories: Enzymes and Coenzymes, Amino Acids, Peptides, and Proteins
  9. Drug

    Gonadorelin

    go.drugbank.com/drugs/DB00644
    ApprovedInvestigationalVet approved

    GnRH is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pituitary. … Gonadorelin is another name for gonadotropin-releasing hormone (GnRH). It is a synthetic decapeptide prepared using solid phase peptide synthesis.

    Mixtures: Relisorm 500 for Inj.-pws Liq-kit IV Sc, Relisorm 100 for Inj.-pws Liq-kit Sc IVCategories: Pituitary and Hypothalamic Hormones and Analogues, Sex Hormones and Insulins
  10. Drug

    Pindolol

    go.drugbank.com/drugs/DB00960
    ApprovedInvestigational

    [L32353] Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythmia. … Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension.

    Categories: pindolol and other diureticsProducts: Apo-pindol Tab 10mg, Nu-pindol Tab 10mg