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Ascorbic Acid Deficiency
go.drugbank.com/conditions/DBCOND0118953Drugs: Ascorbic acidSynonyms: Ascorbic acid (vitamin C) deficiency, (Ascorbic acid (vitamin C) deficiency) or (scurvy)Congenital Bile Acid Synthesis Defect Type II
smpdb.ca/view/SMP0000314DiseaseChenodeoxycholic acid and cholic acid are decreased in plasma and urine. … Symptoms of this disease include cholestatic jaundice, atypical oxo and allo bile acids in urine and serum, liver failure, and steatosis.
Congenital Bile Acid Synthesis Defect Type III
smpdb.ca/view/SMP0000318DiseaseCBASIII is characterized by accumulation of bile acids in the urine. Symptoms include severe cholestasis, cirrhosis, and liver failure. … The synthesis of primary bile acids from cholesterol occurs via two pathways: the classic neutral pathway involving cholesterol 7-alpha-hydroxylase (CYP7A1), and the acidic pathway involving a distinct
Congenital Bile Acid Synthesis Defect Type II
smpdb.ca/view/SMP0125689DiseaseChenodeoxycholic acid and cholic acid are decreased in plasma and urine. … Symptoms of this disease include cholestatic jaundice, atypical oxo and allo bile acids in urine and serum, liver failure, and steatosis.
Metabolism and Physiological Effects of O-Sulfotyrosine
smpdb.ca/view/SMP0126811MetabolicO-Sulfotyrosine belongs to the class of organic compounds known as phenylalanine and derivatives. … Secreted proteins and extracellular parts of membrane proteins that pass through the Golgi apparatus may be sulfated.
Docusate
go.drugbank.com/drugs/DB11089ApprovedInvestigationalDocusate acts by increasing the amount of water the stool absorbs in the gut, making the stool softer and easier to pass [L1801]. Docusate can be orally or rectally administered. … Recently there has been pressure to stop prescribing docusate as it has been identified as an ineffective medicine[A176972,A176987,L5912].
Mixtures: Prenatal Vitamin No 53 Iron Fum Folic Acid Docusate CA DHA, PNV Ferrous Fumarate Docusate Folic AcidCategories: Alimentary Tract and Metabolism, Softener and Emollient LaxativesMetabolism and Physiological Effects of 3-Deoxyglucosone
smpdb.ca/view/SMP0125516MetabolicAn amino acid like arginine or lysine are combined with glucose to make a schiff base and water. The schiff base is unstable so it becomes the stable amadori product. … It normally is synthesized and accumulates with high serum glucose due to diabetes. 3-deoxyglucosone causes cell apoptosis and neurotoxicity.
Metabolism and Physiological Effects of Trimethylamine N-oxide (TMAO)
smpdb.ca/view/SMP0123192MetabolicCholine gets metabolized by the enzyme complex CutC/D into trimethylamine. This trimethylamine then enters a liver hepatocyte through portal circulation and gets metabolized by FMO3 to form TMAO. … First choline obtained from choline rich foods such as eggs or meat enter the gut and get metabolized to trimethylamine by gut microbes.
Deficiency of Vitamin D3
go.drugbank.com/conditions/DBCOND0054356Synonyms: Vitamin D deficiency, Deficiency of vitamin D>3<Ziconotide NMDA and Substance P Receptor Pain Inhibition Action Pathway
smpdb.ca/view/SMP0126347Drug actionTherefore substance P, CGRP, and glutamate are not released into the synapse and cannot activate the substance P receptors, CGRP receptors, or the N-Methyl-D-aspartic acid receptors on the post-synaptic … Ziconotide is a neurotoxic peptide derived from the cone snail Conus magus comprising 25 amino acids with three disulphide bonds.