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Dimethylglycine Dehydrogenase Deficiency
smpdb.ca/view/SMP0000484DiseaseDimethylglycine dehydrogenase deficiency, also called DMGDH deficiency and dimethylglycinuria, is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of glycine metabolism caused by a defective DMGDH gene. DMGDH code...
Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 more3-Phosphoglycerate Dehydrogenase Deficiency
smpdb.ca/view/SMP0000721Disease3-Phosphoglycerate dehydrogenase deficiency is a disorder of L-serine biosynthesis that is characterized by congenital microcephaly, psychomotor retardation, and seizures.The disorder is caused by homozygous or compound heterozygous or h...
Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 moreDihydropyrimidine Dehydrogenase Deficiency (DHPD)
smpdb.ca/view/SMP0000179DiseaseDihydropyrimidine Dehydrogenase Deficiency (DHPD; Thymine-uraciluria) is a rare autosomal recessive disorder caused by a mutation in the DPYD gene which codes for dihydropyrimidine dehydrogenase. A deficiency in this enzyme results in ac...
Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 moreDimethylglycine Dehydrogenase Deficiency
smpdb.ca/view/SMP0000242DiseaseDimethylglycine dehydrogenase deficiency, also called DMGDH deficiency and dimethylglycinuria, is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of glycine metabolism caused by a defective DMGDH gene. DMGDH code...
Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 more3-Phosphoglycerate Dehydrogenase Deficiency
smpdb.ca/view/SMP0125581Disease3-Phosphoglycerate dehydrogenase deficiency is a disorder of L-serine biosynthesis that is characterized by congenital microcephaly, psychomotor retardation, and seizures.The disorder is caused by homozygous or compound heterozygous or h...
Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 moreTenofovir Disoproxil Action Pathway
smpdb.ca/view/SMP0125902Drug actionLess viral proteins are therefore produced, and there is a reduction in new viruses being formed. … Tenofovir disoproxil is absorbed and converted to its active form, tenofovir, a nucleoside monophosphate (nucleotide) analog.
Formate dehydrogenase H
go.drugbank.com/bio_entities/BE0001446TargetEscherichia coli (strain K12)Decomposes formic acid to hydrogen and carbon dioxide under anaerobic conditions in the absence of exogenous electron acceptors.
Aromatase
go.drugbank.com/bio_entities/BE0002090TargetEnzymeHumansAlternatively, the third oxidative reaction yields a 19-norsteroid and formic acid. … acid (PubMed:20385561).
Caffeine Metabolism
smpdb.ca/view/SMP0000028MetabolicIn the lysosome, these metabolites undergo further metabolism into methyluric acids before being excreted in the urine. … In the liver, the cytochrome P450 oxidase enzyme system and specifically CYP1A2 metabolizes caffeine into paraxanthine to increase lipolysis and increase free fatty acids and glycerol levels in the blood
Drugs: NADH · Caffeine · Theophylline · Theobromine · Mesoheme · Flavin adenine dinucleotide +1 moreArtesunate Action Pathway
smpdb.ca/view/SMP0125858Drug actionOnce in the parasite iDHA reacts with heme, which generats free radicals which inhibit protein and nucleic acid synthesis of the Plasmodium parasites.