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Minaprine Amine oxidase Norepinephrine Antidepressant Action Pathway
smpdb.ca/view/SMP0126684Drug actionMinaprine is an amino-phenylpyridazine antidepressant. It is indicated in the treatment of various depressive states. Minaprine acts on many targets in the neurons. Firstly, this drug binds as an antagonist to the serotonin type 2 recept...
Enzymes: Sodium-dependent noradrenaline transporterMoclobemide Amine Oxidase Norepinephrine Antidepressant Action Pathway
smpdb.ca/view/SMP0126685Drug actionMoclobemide is a reversible monoamine oxidase inhibitor (MAOIs) selective for the isoform A (RIMA). This molecule is indicated in the treatment of major depressive disorder (MDD) and bipolar disorder. he monoamine oxidase is an enzyme th...
Enzymes: Sodium-dependent noradrenaline transporterPlaque, Dental
go.drugbank.com/conditions/DBCOND0092704Nelarabine Action Pathway
smpdb.ca/view/SMP0126649Drug actionNelarabine is an antineoplastic agent from the nucleoside analog drug class. This drug is indicated in the treatment of T-cell lymphoblastic leukemia, particularly T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymp...
Enzymes: Sodium/nucleoside cotransporter 2Duloxetine (SNRI) - Norepinephrine Reuptake Inhibiton
smpdb.ca/view/SMP0125000Drug actionIt blocks both sodium dependent serotonin and sodium dependent norepinephrine transporters from removing serotonin and norepinephrine respectively from the synaptic cleft.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Norepinephrine · Duloxetine · Dopamine +4 moreEnzymes: Sodium-dependent noradrenaline transporterAtomoxetine Action Pathway (New)
smpdb.ca/view/SMP0126353Drug actionAtomoxetine binds to the sodium-dependent noradrenaline transporter, this prevents the noradrenaline reuptake in the presynaptic neurons.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Atomoxetine · Sapropterin · Norepinephrine +5 moreEnzymes: Sodium-dependent noradrenaline transporterCocaine Norepinephrine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0126544Drug actionCocaine inhibits the sodium-dependent noradrenaline channel which causes norepinephrine to accumulate in the synapse.
Enzymes: Sodium-dependent noradrenaline transporterBupropion Action Pathway
smpdb.ca/view/SMP0125268Drug actionDopamine is released into the synapse where it is much more difficult for it to re-enter the presynaptic neuron due to bupropion inhibiting the sodium-dependent dopamine receptor. … Norepinephrine is released into the synapse where it accumulates because bupropion is weakly inhibiting the sodium-dependent noradrenaline receptor which prevents norepinephrine from re-entering the presynaptic
Enzymes: Sodium-dependent dopamine transporter, Sodium-dependent noradrenaline transporterSolriamfetol Action Pathway
smpdb.ca/view/SMP0126346Drug actionThose transporters are called sodium-dependent dopamine transporter and sodium-dependent noradrenaline transporter. This makes more dopamine and noradrenaline available in the synapses of the brain.
Enzymes: Sodium-dependent dopamine transporter, Sodium-dependent noradrenaline transporterNorepinephrine Neurological
smpdb.ca/view/SMP0130946PhysiologicalNorepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as both a hormone and neurotransmitter. The name "noradrenaline" (from Latin ad,...
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Norepinephrine · Dopamine · Levodopa +3 moreEnzymes: Sodium-dependent noradrenaline transporter