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Metabolism and Physiological Effects of Phenol sulphate
smpdb.ca/view/SMP0126844MetabolicIn experimental models of diabetes, phenol sulphate administration has been shown to induce albuminuria and podocyte damage. … Phenol sulphate can be found in most mammals (mice, rats, sheep, dogs, humans) and likely most animals. Phenol sulphate is a uremic toxin.
Metabolism and Physiological Effects of Androsterone sulfate
smpdb.ca/view/SMP0127012MetabolicSubsequently, 3α-androstanediol and 3α-etiocholanediol are converted by 17β-HSD into androsterone and etiocholanolone, which is followed by their conjugation and excretion. … Then, 5α-DHT and 5β-DHT are converted by 3α-HSD into 3α-androstanediol and 3α-etiocholanediol, respectively.
Drugs: Testosterone2-Hydroxyglutric Aciduria (D and L Form)
smpdb.ca/view/SMP0000136DiseaseA deficiency in this enzyme results in accumulation of D-2-Hydroxyglutaric acid in plasma, spinal fluid, and urine; oxoglutaric acid in urine; and gabba-aminobutyric acid in spinal fluid. … A deficiency in this enzyme results in accumulation of L-2-Hydroxyglutaric acid in plasma, spinal fluid, and urine; and L-lysine in plasma and spinal fluid.
Drugs: Pyridoxal phosphate · Pyruvic acid · Biotin · Aspartic acid · L-Glutamine · Adenosine phosphate +17 moreEnzymes: N-acetyl-D-glucosamine kinaseIntracellular Signalling Through Prostacyclin Receptor and Prostacyclin
smpdb.ca/view/SMP0000354SignalingProstacyclin binding to its receptor increases vasodilation and decreases platelet aggregation. … The receptor is a G-protein coupled receptor, upon its binding it activates G proteins causing the activation of adenylyl cyclase and production of cAMP messenger molecules. cAMP activates PKA (protein
Metabolism and Physiological Effects of Phenyl sulfate
smpdb.ca/view/SMP0123213MetabolicPhenyl sulphate is shown to cause albuminuria and diabetic kidney disease. … Phenyl sulphate is a phenolic compound that is formed through gut microbial metabolism from dietary tyrosine and a sulfation reaction in liver hepatic cells.
Metabolism and Physiological Effects of Para-cresol
smpdb.ca/view/SMP0123214MetabolicPara-cresol(P-cresol) is a phenolic compound that is formed through gut microbial metabolism from the amino acid tyrosine which is acquired from foods that are high in protein. … P-cresol is shown to be associated with cardiovascular disease and it can also inhibit endothelial cell proliferation.
Metabolism and Physiological Effects of Indoxyl Sulfate
smpdb.ca/view/SMP0123237MetabolicIt is also shown to cause vascular calcification and disrupt the electron transport chain and oxidative phosphorylation causing muscle atrophy … Indoxyl sulfate is an indole compound that is formed through gut microbial metabolism from dietary tryptophan and a sulfation reaction in liver hepatic cells.
Metabolism and Physiological Effects of N-Acetylserine
smpdb.ca/view/SMP0126556MetabolicN-Acetylserine can also be classified as an alpha amino acid or a derivatized alpha amino acid. … N-acyl-alpha amino acids are compounds containing an alpha amino acid which bears an acyl group at its terminal nitrogen atom.
Metabolism and Physiological Effects of N-Acetylthreonine
smpdb.ca/view/SMP0126703MetabolicThe human NatA complex co-translationally acetylates N-termini that bear a small amino acid (A, S, T, C, and occasionally V and G). … N-Acetylthreonine can also be classified as an alpha amino acid or a derivatized alpha amino acid.
Drugs: ThreonineMetabolism and Physiological Effects of N-Acetyltryptophan
smpdb.ca/view/SMP0126721MetabolicN-Acetyltryptophan can also be classified as an alpha amino acid or a derivatized alpha amino acid. … N-acyl-alpha amino acids are compounds containing an alpha amino acid which bears an acyl group at its terminal nitrogen atom.
Drugs: Tryptophan