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Phenelzine Amine Oxidase Norepinephrine Antidepressant Action Pathway
smpdb.ca/view/SMP0126682Drug actionThis drug is used as an antidepressant and it is also effective in the treatment of panic disorder and social anxiety disorder. … The first one is found in cells located in the periphery and breakdown serotonin, norepinephrine, epinephrine, dopamine, and tyramine.
Enzymes: Sodium-dependent noradrenaline transporterMinaprine Amine oxidase Norepinephrine Antidepressant Action Pathway
smpdb.ca/view/SMP0126684Drug actionThe first one is found in cells located in the periphery and breakdown serotonin, norepinephrine, epinephrine, dopamine, and tyramine. … Firstly, this drug binds as an antagonist to the serotonin type 2 receptors (C, B, and C). Secondly, it can also antagonize the dopamine D1 and D2 type receptors.
Enzymes: Sodium-dependent noradrenaline transporterMoclobemide Amine Oxidase Norepinephrine Antidepressant Action Pathway
smpdb.ca/view/SMP0126685Drug actionThere are 2 isoforms of this protein: A and B. The first one is found in cells located in the periphery and breakdown serotonin, norepinephrine, epinephrine, dopamine, and tyramine. … , norepinephrine, epinephrine, and dopamine.
Enzymes: Sodium-dependent noradrenaline transporterDuloxetine (SNRI) - Norepinephrine Reuptake Inhibiton
smpdb.ca/view/SMP0125000Drug actionIt blocks both sodium dependent serotonin and sodium dependent norepinephrine transporters from removing serotonin and norepinephrine respectively from the synaptic cleft. … The receptors that are being stimulated are 5-HT 2A, 2B, and 2C serotonin receptors and alpha 1 and beta 1 adrenergic receptors.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Norepinephrine · Duloxetine · Dopamine +4 moreEnzymes: Sodium-dependent noradrenaline transporterAtomoxetine Action Pathway (New)
smpdb.ca/view/SMP0126353Drug actionAtomoxetine binds to the sodium-dependent noradrenaline transporter, this prevents the noradrenaline reuptake in the presynaptic neurons. … Due to atomoxetine's noradrenergic activity, it also has effects on the cardiovascular system such as increased blood pressure and tachycardia.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Atomoxetine · Sapropterin · Norepinephrine +5 moreEnzymes: Sodium-dependent noradrenaline transporterCocaine Norepinephrine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0126544Drug actionCocaine inhibits the sodium-dependent noradrenaline channel which causes norepinephrine to accumulate in the synapse. … It primarily acts on sensory neurons in the nasal cavity, but also inhibits dopamine, serotonin, and norepinephrine re-uptake channels.
Enzymes: Sodium-dependent noradrenaline transporterEdema of the cerebrum
go.drugbank.com/conditions/DBCOND0024353Drugs: Betamethasone · Bupivacaine · Dexamethasone · Dextrose, unspecified form · Glycerin · Hydrocortisone succinate +6 moreBupropion Action Pathway
smpdb.ca/view/SMP0125268Drug actionDopamine is released into the synapse where it is much more difficult for it to re-enter the presynaptic neuron due to bupropion inhibiting the sodium-dependent dopamine receptor. … Norepinephrine is released into the synapse where it accumulates because bupropion is weakly inhibiting the sodium-dependent noradrenaline receptor which prevents norepinephrine from re-entering the presynaptic
Enzymes: Sodium-dependent dopamine transporter, Sodium-dependent noradrenaline transporterSolriamfetol Action Pathway
smpdb.ca/view/SMP0126346Drug actionThose transporters are called sodium-dependent dopamine transporter and sodium-dependent noradrenaline transporter. This makes more dopamine and noradrenaline available in the synapses of the brain. … Solriamfetol, also known as Sunosi, is a dopamine and norepinephrine reuptake inhibitor (DNRI).
Enzymes: Sodium-dependent dopamine transporter, Sodium-dependent noradrenaline transporterLidocaine NMDA Anesthetic Action Pathway
smpdb.ca/view/SMP0126262Drug actionIn particular, the lidocaine agent acts on sodium ion channels located on the internal surface of nerve cell membranes. … The resultant lidocaine cations are then capable of reversibly binding the sodium channels from the inside, keeping them locked in an open state that prevents nerve depolarization.
Enzymes: Sodium channel subunit beta-1, Sodium channel protein type 10 subunit alpha